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  • 1
    Electronic Resource
    Electronic Resource
    Stoffwechselprodukte von Mikroorganismen. 231. Mitteilung230. Mitteilung s. [1].. Bafilomycin-A1-21-O-(α-L-rhamnopyranosid): Strukturaufklärung durch chemische Verknüpfung mit Bafilomycin A1 und Leucanicidin (1985)
    New York, NY : Wiley-Blackwell
    Helvetica Chimica Acta 68 (1985), S. 83-94 
    Details
    ISSN: 0018-019X
    Keywords: Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Isolation of Bafilomycin-A1-21-O-(α-L-rhamnopyranoside). Structural Determination by Chemical Correlation with Bafilomycin A1 and LeucanicidinFrom cultures of an actinomycete strain, the known antifungal and insecticidal antibiotic leucanicidin (1) and a hitherto unknown antifungal antibiotic, bafilomycin-A1-21-O-(α-L-rhamnopyranoside) (2), were isolated. The latter is spectroscopically closely related to 1 and bafilomycin A1 (3) and gave degradation products identical with compounds obtained by analogous degradation of 1 and 3.
    Additional Material: 5 Tab.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/hlca.19850680111
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Stoffwechselprodukte von Mikroorganismen. 236. Mitteilung235. Mitteilung: [1]. Schwefelhaltige Ansa-Verbindungen des Naphthomycin-Typus (1986)
    New York, NY : Wiley-Blackwell
    Helvetica Chimica Acta 69 (1986), S. 1356-1364 
    Details
    ISSN: 0018-019X
    Keywords: Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Metabolites of Microorganisms. Sulfur-Containing Ansa Compounds of the Naphthomycin TypeFrom a strain of Streptomyces (Tü 2357) in addition to naphthomycin A, 4 new yellow pigments were isolated and their structures determined by spectroscopic comparison with naphthomycin A. Whereas the naphthomycins D and E are simple derivatives of naphthomycin A, having OH and H, respectively, instead of Cl, the naphthomycins F and G contain an N-acetylcysteine residue linked to the aromatic moiety by a thioether group. Degradations with O3 yielded identical products from the naphthomycins A, D, F, and G, showing coincident configurations in parts of the molecules. Naphthomycin F shows some biological activity against gram-positive bacteria and fungi, although much weaker than naphthomycin A. The naphthomycins D, E, and G are inactive against microorganisms.
    Additional Material: 4 Tab.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/hlca.19860690610
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  • 3
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    Intronic promoters and their noncoding transcripts: A new source of cancer-associated genes (2012)
    Wiley-Blackwell
    Details
    Publication Date: 2012-08-29
    Description: Recent studies of mammalian genomes suggest that alternative promoters are associated with various disorders, including cancer. Here we present an intronic promoter of the murine proteinase 3 gene, which drives the expression of an alternative mRNA in intron 2 of the prtn3 gene. The proximal promoter sequences were identified and a series of promoter deletion constructs were used to identify the sequence elements that are required for basal promoter activity. Expression of the homeobox transcription factor CUX1 p75 isoform was found to suppress the activity of the alternative PR3 promoter. Data base analyses, multiple alignments and expression data showed that the intronic PR3 promoter is active in leukemia and other tumor cells as well as in mouse embryo, male mammary gland and bone marrow. In the spleen, the transcript is exclusively expressed by Gr-1 int /CD11b + cells, which are also known as myeloid-derived suppressor cells (MDSCs). In humans, an alternative transcript of the PR3-gene could be detected in the bone marrow and in various cancer cell lines but not in primary leukemia cells, suggesting a species-overarching function of this kind of promoter. Therefore, the alternative PR3 promoter and its mRNA may be useful tools to investigate the fate of hematopoietic stem cells. © 2012 Wiley Periodicals, Inc.
    Print ISSN: 0899-1987
    Electronic ISSN: 1098-2744
    Topics: Medicine
    Published by Wiley-Blackwell
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  • 4
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    First-pass myocardial perfusion imaging with whole-heart coverage using L1-SPIRiT accelerated variable density spiral trajectories (2015)
    Wiley-Blackwell
    Details
    Publication Date: 2015-11-06
    Description: Purpose To design and evaluate two-dimensional (2D) L1-SPIRiT accelerated spiral pulse sequences for first-pass myocardial perfusion imaging with whole heart coverage capable of measuring eight slices at 2 mm in-plane resolution at heart rates up to 125 beats per minute (BPM). Methods Combinations of five different spiral trajectories and four k-t sampling patterns were retrospectively simulated in 25 fully sampled datasets and reconstructed with L1-SPIRiT to determine the best combination of parameters. Two candidate sequences were prospectively evaluated in 34 human subjects to assess in vivo performance. Results A dual density broad transition spiral trajectory with either angularly uniform or golden angle in time k-t sampling pattern had the largest structural similarity and smallest root mean square error from the retrospective simulation, and the L1-SPIRiT reconstruction had well-preserved temporal dynamics. In vivo data demonstrated that both of the sampling patterns could produce high quality perfusion images with whole-heart coverage. Conclusion First-pass myocardial perfusion imaging using accelerated spirals with optimized trajectory and k-t sampling pattern can produce high quality 2D perfusion images with whole-heart coverage at the heart rates up to 125 BPM. Magn Reson Med, 2015. © 2015 Wiley Periodicals, Inc.
    Print ISSN: 0740-3194
    Electronic ISSN: 1522-2594
    Topics: Medicine
    Published by Wiley-Blackwell
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