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  • Springer Science and Business Media LLC  (48)
  • 1
    Online Resource
    Online Resource
    Springer Science and Business Media LLC ; 2023
    In:  Aging Clinical and Experimental Research Vol. 35, No. 3 ( 2023-01-04), p. 639-647
    In: Aging Clinical and Experimental Research, Springer Science and Business Media LLC, Vol. 35, No. 3 ( 2023-01-04), p. 639-647
    Abstract: Elderly patients are susceptible to postoperative infections with increased mortality. Analyzing with a deep learning model, the perioperative factors that could predict and/or contribute to postoperative infections may improve the outcome in elderly. This was an observational cohort study with 2014 elderly patients who had elective surgery from 28 hospitals in China from April to June 2014. We aimed to develop and validate deep learning-based predictive models for postoperative infections in the elderly. 1510 patients were randomly assigned to be training dataset for establishing deep learning-based models, and 504 patients were used to validate the effectiveness of these models. The conventional model predicted postoperative infections was 0.728 (95% CI 0.688–0.768) with the sensitivity of 66.2% (95% CI 58.2–73.6) and specificity of 66.8% (95% CI 64.6–68.9). The deep learning model including risk factors relevant to baseline clinical characteristics predicted postoperative infections was 0.641 (95% CI 0.545–0.737), and sensitivity and specificity were 34.2% (95% CI 19.6–51.4) and 88.8% (95% CI 85.6–91.6), respectively. Including risk factors relevant to baseline variables and surgery, the deep learning model predicted postoperative infections was 0.763 (95% CI 0.681–0.844) with the sensitivity of 63.2% (95% CI 46–78.2) and specificity of 80.5% (95% CI 76.6–84). Our feasibility study indicated that a deep learning model including risk factors for the prediction of postoperative infections can be achieved in elderly. Further study is needed to assess whether this model can be used to guide clinical practice to improve surgical outcomes in elderly.
    Type of Medium: Online Resource
    ISSN: 1720-8319
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2023
    detail.hit.zdb_id: 2119282-0
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  • 2
    In: BMC Public Health, Springer Science and Business Media LLC, Vol. 22, No. 1 ( 2022-10-07)
    Abstract: Metabolic syndrome (MetS) is characterized by a cluster of signs of metabolic disturbance and has caused a huge burden on the health system. The study aims to explore the prevalence and characteristics of MetS defined by different criteria in the Chinese population. Methods Using the data of the China Hypertension Survey (CHS), a nationally representative cross-sectional study from October 2012 to December 2015, a total of 28,717 participants aged 35 years and above were included in the analysis. The MetS definitions of the International Diabetes Federation (IDF), the updated US National Cholesterol Education Program Adult Treatment Panel III (the revised ATP III), and the Joint Committee for Developing Chinese Guidelines (JCDCG) on Prevention and Treatment of Dyslipidemia in Adults were used. Multivariable logistic regression was used to identify factors associated with MetS. Results The prevalence of MetS diagnosed according to the definitions of IDF, the revised ATP III, and JCCDS was 26.4%, 32.3%, and 21.5%, respectively. The MetS prevalence in men was lower than in women by IDF definition (22.2% vs. 30.3%) and by the revised ATP III definition (29.2% vs. 35.4%), but the opposite was true by JCDCG (24.4%vs 18.5%) definition. The consistency between the three definitions for men and the revised ATP III definition and IDF definition for women was relatively good, with kappa values ranging from 0.77 to 0.89, but the consistency between the JCDCG definition and IDF definition (kappa = 0.58) and revised ATP III definition (kappa = 0.58) was poor. Multivariable logistic regression showed that although the impact and correlation intensity varied with gender and definition, area, age, education, smoking, alcohol use, and family history of cardiovascular disease were factors related to MetS. Conclusions The prevalence and characteristics of the MetS vary with the definition used in the Chinese population. The three MetS definitions are more consistent in men but relatively poor in women. On the other hand, even if estimated according to the definition of the lowest prevalence, MetS is common in China.
    Type of Medium: Online Resource
    ISSN: 1471-2458
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2022
    detail.hit.zdb_id: 2041338-5
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  • 3
    Online Resource
    Online Resource
    Springer Science and Business Media LLC ; 2014
    In:  International Journal of Biometeorology Vol. 58, No. 7 ( 2014-9), p. 1583-1592
    In: International Journal of Biometeorology, Springer Science and Business Media LLC, Vol. 58, No. 7 ( 2014-9), p. 1583-1592
    Type of Medium: Online Resource
    ISSN: 0020-7128 , 1432-1254
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2014
    detail.hit.zdb_id: 1459227-7
    SSG: 12
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  • 4
    Online Resource
    Online Resource
    Springer Science and Business Media LLC ; 2018
    In:  Journal of Meteorological Research Vol. 32, No. 3 ( 2018-6), p. 351-366
    In: Journal of Meteorological Research, Springer Science and Business Media LLC, Vol. 32, No. 3 ( 2018-6), p. 351-366
    Type of Medium: Online Resource
    ISSN: 2095-6037 , 2198-0934
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2018
    detail.hit.zdb_id: 2782783-5
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  • 5
    In: Scientific Data, Springer Science and Business Media LLC, Vol. 10, No. 1 ( 2023-05-15)
    Abstract: The Mekong River basin (MRB) is a transboundary basin that supports livelihoods of over 70 million inhabitants and diverse terrestrial-aquatic ecosystems. This critical lifeline for people and ecosystems is under transformation due to climatic stressors and human activities (e.g., land use change and dam construction). Thus, there is an urgent need to better understand the changing hydrological and ecological systems in the MRB and develop improved adaptation strategies. This, however, is hampered partly by lack of sufficient, reliable, and accessible observational data across the basin. Here, we fill this long-standing gap for MRB by synthesizing climate, hydrological, ecological, and socioeconomic data from various disparate sources. The data— including groundwater records digitized from the literature—provide crucial insights into surface water systems, groundwater dynamics, land use patterns, and socioeconomic changes. The analyses presented also shed light on uncertainties associated with various datasets and the most appropriate choices. These datasets are expected to advance socio-hydrological research and inform science-based management decisions and policymaking for sustainable food-energy-water, livelihood, and ecological systems in the MRB.
    Type of Medium: Online Resource
    ISSN: 2052-4463
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2023
    detail.hit.zdb_id: 2775191-0
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  • 6
    Online Resource
    Online Resource
    Springer Science and Business Media LLC ; 2013
    In:  Molecular Medicine Vol. 19, No. 1 ( 2013-01), p. 357-366
    In: Molecular Medicine, Springer Science and Business Media LLC, Vol. 19, No. 1 ( 2013-01), p. 357-366
    Abstract: Damage-associated molecular pattern (DAMP) molecules are essential for the initiation of innate inflammatory responses to infection and injury. The prototypic DAMP molecule, high-mobility group box 1 (HMGB1), is an abundant architectural chromosomal protein that has location-specific biological functions: within the nucleus as a DNA chaperone, within the cytosol to sustain autophagy and outside the cell as a DAMP molecule. Recent research indicates that aberrant activation of HMGB1 signaling can promote the onset of inflammatory and autoimmune diseases, raising interest in the development of therapeutic strategies to control their function. The importance of HMGB1 activation in various forms of liver disease in relation to liver damage, steatosis, inflammation, fibrosis, tumorigenesis and regeneration is discussed in this review.
    Type of Medium: Online Resource
    ISSN: 1076-1551 , 1528-3658
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2013
    detail.hit.zdb_id: 1475577-4
    detail.hit.zdb_id: 1283676-X
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  • 7
    In: Scientific Reports, Springer Science and Business Media LLC, Vol. 6, No. 1 ( 2016-11-10)
    Abstract: Prostate cancer is the second most common cause of cancer-related deaths worldwide. The mucin 1 (MUC1) oncoprotein is highly expressed in human prostate cancers with aggressive features. However, the role for MUC1 in occurrence and progression of castration-resistant prostate cancer (CRPC) remained elusive. In this study, we showed that solamargine, a major steroidal alkaloid glycoside, inhibited the growth of CRPC cells, which was enhanced in the presence of metformin. Furthermore, we found that solamargine increased phosphorylation of AMPKα, whereas reducing the protein expression and promoter activity of MUC1. A greater effect was observed in the presence of metformin. In addition, solamargine reduced NF-κB subunit p65 protein expression. Exogenously expressed p65 resisted solamargine-reduced MUC1 protein and promoter activity. Interestingly, exogenously expressed MUC1 attenuated solamargine-stimulated phosphorylation of AMPKα and, more importantly reversed solamargine-inhibited cell growth. Finally, solamargine increased phosphorylation of AMPKα, while inhibiting MUC1, p65 and tumor growth were observed in vivo . Overall, our results show that solamargine inhibits the growth of CRPC cells through AMPKα-mediated inhibition of p65, followed by reduction of MUC1 expression in vitro and in vivo . More importantly, metformin facilitates the antitumor effect of solamargine on CRPC cells.
    Type of Medium: Online Resource
    ISSN: 2045-2322
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2016
    detail.hit.zdb_id: 2615211-3
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  • 8
    Online Resource
    Online Resource
    Springer Science and Business Media LLC ; 2016
    In:  Scientific Reports Vol. 6, No. 1 ( 2016-02-12)
    In: Scientific Reports, Springer Science and Business Media LLC, Vol. 6, No. 1 ( 2016-02-12)
    Abstract: Identifying the areas at risk of ecosystem transformation and the main contributing factors to the risk is essential to assist ecological adaptation to climate change. We assessed the risk of ecosystem shifts in China using the projections of four global gridded vegetation models (GGVMs) and an aggregate metric. The results show that half of naturally vegetated land surface could be under moderate or severe risk at the end of the 21 st century under the middle and high emission scenarios. The areas with high risk are the Tibetan Plateau region and an area extended northeastward from the Tibetan Plateau to northeast China. With the three major factors considered, the change in carbon stocks is the main contributing factor to the high risk of ecosystem shifts. The change in carbon fluxes is another important contributing factor under the high emission scenario. The change in water fluxes is a less dominant factor except for the Tibetan Plateau region under the high emission scenario. Although there is considerable uncertainty in the risk assessment, the geographic patterns of the risk are generally consistent across different scenarios. The results could help develop regional strategies for ecosystem conservation to cope with climate change.
    Type of Medium: Online Resource
    ISSN: 2045-2322
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2016
    detail.hit.zdb_id: 2615211-3
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  • 9
    Online Resource
    Online Resource
    Springer Science and Business Media LLC ; 2015
    In:  Climatic Change Vol. 130, No. 4 ( 2015-6), p. 505-518
    In: Climatic Change, Springer Science and Business Media LLC, Vol. 130, No. 4 ( 2015-6), p. 505-518
    Type of Medium: Online Resource
    ISSN: 0165-0009 , 1573-1480
    RVK:
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2015
    detail.hit.zdb_id: 751086-X
    detail.hit.zdb_id: 1477652-2
    SSG: 14
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  • 10
    Online Resource
    Online Resource
    Springer Science and Business Media LLC ; 2007
    In:  Water Resources Management Vol. 21, No. 10 ( 2007-9-4), p. 1703-1715
    In: Water Resources Management, Springer Science and Business Media LLC, Vol. 21, No. 10 ( 2007-9-4), p. 1703-1715
    Type of Medium: Online Resource
    ISSN: 0920-4741 , 1573-1650
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2007
    detail.hit.zdb_id: 2016360-5
    SSG: 14
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