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  • 1
    Digitale Medien
    Digitale Medien
    Springer
    Cellular and molecular life sciences 22 (1966), S. 513-514 
    ISSN: 1420-9071
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Medizin
    Notizen: Resumen La administraci'on de sedormid o AIA durante cuatro días, o una sola inyección de AIA reducen las excreciones de bilirubina y urobilinas en ratas. El mecanismo probable de la falla de la excretión de estos pigmentos puede ser atribuida a una inhibitión de la actividad de la UDPG-glucoronil transferasa.
    Materialart: Digitale Medien
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 2
    ISSN: 1437-3262
    Schlagwort(e): Pelagic processes ; Vertical flux Norwegian-Greenland Sea
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Geologie und Paläontologie
    Notizen: Abstract Pelagic processes and their relation to vertical flux have been studied in the Norwegian and Greenland Seas since 1986. Results of long-term sediment trap deployments and adjoining process studies are presented, and the underlying methodological and conceptional background is discussed. Recent extension of these investigations at the Barents Sea continental slope are also presented. With similar conditions of input irradiation and nutrient conditions, the Norwegian and Greenland Seas exhibit comparable mean annual rates of new and total production. Major differences can be found between these regions, however, in the hydrographic conditions constraining primary production and in the composition and seasonal development of the plankton. This is reflected in differences in the temporal patterns of vertical particle flux in relation to new production in the euphotic zone, the composition of particles exported and in different processes leading to their modification in the mid-water layers. In the Norwegian Sea heavy grazing pressure during early spring retards the accumulation of phytoplankton stocks and thus a mass sedimentation of diatoms that is often associated with spring blooms. This, in conjunction with the further seasonal development of zooplankton populations, serves to delay the annual peak in sedimentation to summer or autumn. Carbonate sedimentation in the Norwegian Sea, however, is significantly higher than in the Greenland Sea, where physical factors exert a greater control on phytoplankton development and the sedimentation of opal is of greater importance. In addition to these comparative long-term studies a case study has been carried out at the continental slope of the Barents Sea, where an emphasis was laid on the influence of resuspension and across-slope lateral transport with an analysis of suspended and sedimented material.
    Materialart: Digitale Medien
    Standort Signatur Einschränkungen Verfügbarkeit
    BibTip Andere fanden auch interessant ...
  • 3
    Digitale Medien
    Digitale Medien
    Springer
    Virchows Archiv 403 (1984), S. 41-57 
    ISSN: 1432-2307
    Schlagwort(e): Human myeloid leukemia cell lines ; Nude mice ; Transplantation ; Metastasis ; In vivo differentiation
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary Cells from the established human myeloid cell lines KG-1, KG-1a, and HL-60, transplanted subcutaneously (sc) into nude mice, developed discrete tumors (myelosarcomas). These myelosarcomas had a host's age-associated pattern of growth identical to that of experimental tumors produced by sc transplantation of cells derived from malignant solid neoplasias. Thus, leukemia cells yielded either localized myelosarcomas at the site of inoculation or a disseminated neoplastic growth after inoculation inadult (more than 4 weeks old) ornewborn (1–3 days old) nude mice, respectively. Human myeloid leukemia cells proliferating in the nude mice preserved the human karyotype and a surface antigenic determinant and did not influence the hematopoietic tissues of the host. The KG-1 and HL-60 cell lines consistently attained varying degrees of differentiation along the myeloid series in vitro, and these features were maintained during proliferation in the mice. Furthermore, cells of the variant subline KG-1a, which had a blastic morphology, developed signs of differentiation that were not seen in culture. The presence of readily identifiable markers, such as cytoplasmic granules containing myeloperoxidase, in the cell lines tested makes these models particularly useful for studying the influence of a biological environment on cell differentiation and its influence on tumor growth. These experimental systems are also suitable for investigating the mechanism(s) of metastases and for in vivo experimental therapeutic trials.
    Materialart: Digitale Medien
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 4
    ISSN: 1432-2307
    Schlagwort(e): Cyclic hematopoiesis ; Bone marrow ; Ultrastructure ; Nuclearcytoplasmic asynchrony ; Döhle-like bodies
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary The pathogenesis of cyclic hematopoiesis (CH) in the grey collie dog is still unknown. It has been proposed that periodic bursts of necrosis of the bone marrow neutrophils would induce cyclic arrests of the stem cell differentiation. In the present study, the sequential changes undergone by the erythroid and neutrophil series of the bone marrow of CH dogs were evaluated by electron microscopy. Erythroid cells presented quantitative periodic oscillations but the morphologic features of both immature and mature cells were normal. On the contrary, nonspecific necrotic changes were observed to occur in the myeloid series. Those abnormalities, which were more marked between days 9 and 11 of the cycle, mainly involved the immature cells and, to a lesser extent, the mature neutrophils. The number of necrotic cells was variable in different cycles, but always represented a small portion of the myeloid cells. In addition, few bone marrow macrophages displayed signs of phagocytic activity containing cell debris. The ultrastructural changes of the myeloid series were accompanied by an abnormal decrease of peroxidase activity and the permanence of large acid phosphatase-positive Golgi complexes in mature neutrophils, as defined by morphologic criteria. Döhle-like arrays of rough endoplasmic reticulum were present in many cells. Our findings suggest that an asynchronic development of myelocytes occurs as a result of regulatory abnormalities related to the congenital defect of the bone marrow which interferes with the differentiation and maturation of the stem cells. Necrosis in some myeloid cells would be a secondary phenomenon rather than a causal factor for the cyclic arrest of cell maturation as has been previously submitted. Furthermore, the small size of the necrotic cell population could not justify the production of “inhibitors” in sufficient amounts as to block the normal evolution of the bone marrow stem cell pool.
    Materialart: Digitale Medien
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 5
    Digitale Medien
    Digitale Medien
    Springer
    Cellular and molecular life sciences 29 (1973), S. 951-953 
    ISSN: 1420-9071
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Medizin
    Notizen: Zusammenfassung Es wird festgestellt, dass der Einfluss von Lipidperoxyden nicht für die Entstehung gewisser Formen der Lebernekrose verantwortlich gemacht werden können.
    Materialart: Digitale Medien
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 6
    Publikationsdatum: 2019-09-23
    Beschreibung: Pelagic processes and their relation to vertical flux have been studied in the Norwegian and Greenland Seas since 1986. Results of long-term sediment trap deployments and adjoining process studies are presented, and the underlying methodological and conceptional background is discussed. Recent extension of these investigations at the Barents Sea continental slope are also presented. With similar conditions of input irradiation and nutrient conditions, the Norwegian and Greenland Seas exhibit comparable mean annual rates of new and total production. Major differences can be found between these regions, however, in the hydrographic conditions constraining primary production and in the composition and seasonal development of the plankton. This is reflected in differences in the temporal patterns of vertical particle flux in relation to new production in the euphotic zone, the composition of particles exported and in different processes leading to their modification in the mid-water layers. In the Norwegian Sea heavy grazing pressure during early spring retards the accumulation of phytoplankton stocks and thus a mass sedimentation of diatoms that is often associated with spring blooms. This, in conjunction with the further seasonal development of zooplankton populations, serves to delay the annual peak in sedimentation to summer or autumn. Carbonate sedimentation in the Norwegian Sea, however, is significantly higher than in the Greenland Sea, where physical factors exert a greater control on phytoplankton development and the sedimentation of opal is of greater importance. In addition to these comparative long-term studies a case study has been carried out at the continental slope of the Barents Sea, where an emphasis was laid on the influence of resuspension and across-slope lateral transport with an analysis of suspended and sedimented material.
    Materialart: Article , PeerReviewed
    Format: text
    Standort Signatur Einschränkungen Verfügbarkeit
    BibTip Andere fanden auch interessant ...
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