Publication Date:
2017-04-28
Description:
PARP3 is a promoter of chromosomal rearrangements and limits G4 DNA Nature Communications, Published online: 27 April 2017; doi:10.1038/ncomms15110 Chromosomal rearrangements are key events in the pathogenesis of a range of disorders. Here the authors utilize a zinc finger nuclease translocation reporter to identify PARP3 as a regulator of these events at sites enriched for G quadruplex DNA.
Electronic ISSN:
2041-1723
Topics:
Biology
,
Chemistry and Pharmacology
,
Natural Sciences in General
,
Physics
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