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  • 1
    In: Coatings, MDPI AG, Vol. 7, No. 12 ( 2017-12-05), p. 223-
    Type of Medium: Online Resource
    ISSN: 2079-6412
    Language: English
    Publisher: MDPI AG
    Publication Date: 2017
    detail.hit.zdb_id: 2662314-6
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  • 2
    In: International Journal of Molecular Sciences, MDPI AG, Vol. 18, No. 7 ( 2017-07-17), p. 1546-
    Type of Medium: Online Resource
    ISSN: 1422-0067
    Language: English
    Publisher: MDPI AG
    Publication Date: 2017
    detail.hit.zdb_id: 2019364-6
    SSG: 12
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  • 3
    Online Resource
    Online Resource
    MDPI AG ; 2022
    In:  International Journal of Molecular Sciences Vol. 23, No. 24 ( 2022-12-12), p. 15738-
    In: International Journal of Molecular Sciences, MDPI AG, Vol. 23, No. 24 ( 2022-12-12), p. 15738-
    Abstract: Bacterial pneumonia is one of the leading causes of death worldwide and exerts a significant burden on health-care resources. Antibiotics have long been used as first-line drugs for the treatment of bacterial pneumonia. However, antibiotic therapy and traditional antibiotic delivery are associated with important challenges, including drug resistance, low bioavailability, and adverse side effects; the existence of physiological barriers further hampers treatment. Fortunately, these limitations may be overcome by the application of nanotechnology, which can facilitate drug delivery while improving drug stability and bioavailability. This review summarizes the challenges facing the treatment of bacterial pneumonia and also highlights the types of nanoparticles that can be used for antibiotic delivery. This review places a special focus on the state-of-the-art in nanomaterial-based approaches to the delivery of antibiotics for the treatment of pneumonia.
    Type of Medium: Online Resource
    ISSN: 1422-0067
    Language: English
    Publisher: MDPI AG
    Publication Date: 2022
    detail.hit.zdb_id: 2019364-6
    SSG: 12
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  • 4
    In: Sensors, MDPI AG, Vol. 19, No. 2 ( 2019-01-21), p. 430-
    Abstract: Identification of drought is essential for many environmental and agricultural applications. To further understand drought, this study presented spatial and temporal variations of drought based on satellite derived Vegetation Condition Index (VCI) on annual (Jan–Dec), seasonal monsoon (Jun–Nov) and pre-monsoon (Mar–May) scales from 1982–2015 in Nepal. The Vegetation Condition Index (VCI) obtained from NOAA, AVHRR (National Oceanic and Atmospheric Administration, Advanced Very High Resolution Radiometer) and climate data from meteorological stations were used. VCI was used to grade the drought, and the Mann–Kendall test and linear trend analysis were conducted to examine drought trends and the Pearson correlation between VCI and climatic factors (i.e., temperature and precipitation) was also acquired. The results identified that severe drought was identified in 1982, 1984, 1985 and 2000 on all time scales. However, VCI has increased at the rate of 1.14 yr−1 (p = 0.04), 1.31 yr−1 (p = 0.03) and 0.77 yr−1 (p = 0.77) on the annual, seasonal monsoon and pre-monsoon scales, respectively. These increased VCIs indicated decreases in drought. However, spatially, increased trends of drought were also found in some regions in Nepal. For instance, northern areas mainly in the Trans-Himalayan regions identified severe drought. The foothills and the lowlands of Terai (southern Nepal) experienced normal VCI, i.e., no drought. Similarly, the Anomaly Vegetation Condition Index (AVCI) was mostly negative before 2000 which indicated deficient soil moisture. The exceedance probability analysis results on the annual time scale showed that there was a 20% chance of occurring severe drought (VCI ≤ 35%) and a 35% chance of occurring normal drought (35% ≤ VCI ≤ 50%) in Nepal. Drought was also linked with climates in which temperature on the annual and seasonal monsoon scales was significant and positively correlated with VCI. Drought occurrence and trends in Nepal need to be further studied for comprehensive information and understanding.
    Type of Medium: Online Resource
    ISSN: 1424-8220
    Language: English
    Publisher: MDPI AG
    Publication Date: 2019
    detail.hit.zdb_id: 2052857-7
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  • 5
    In: Water, MDPI AG, Vol. 14, No. 9 ( 2022-04-29), p. 1429-
    Abstract: A warming climate will intensify the water cycle, resulting in an exacerbation of water resources crises and flooding risks in the Lancang–Mekong River Basin (LMRB). The mitigation of these risks requires accurate streamflow and flood simulations. Process-based and data-driven hydrological models are the two major approaches for streamflow simulations, while a hybrid of these two methods promises advantageous prediction accuracy. In this study, we developed a hybrid physics-data (HPD) methodology for streamflow and flood prediction under the physics-guided neural network modeling framework. The HPD methodology leveraged simulation information from a process-based model (i.e., VIC-CaMa-Flood) along with the meteorological forcing information (precipitation, maximum temperature, minimum temperature, and wind speed) to simulate the daily streamflow series and flood events, using a long short-term memory (LSTM) neural network. This HPD methodology outperformed the pure process-based VIC-CaMa-Flood model or the pure observational data driven LSTM model by a large margin, suggesting the usefulness of introducing physical regularization in data-driven modeling, and the necessity of observation-informed bias correction for process-based models. We further developed a gradient boosting tree method to measure the information contribution from the process-based model simulation and the meteorological forcing data in our HPD methodology. The results show that the process-based model simulation contributes about 30% to the HPD outcome, outweighing the information contribution from each of the meteorological forcing variables ( 〈 20%). Our HPD methodology inherited the physical mechanisms of the process-based model, and the high predictability capability of the LSTM model, offering a novel way for making use of incomplete physical understanding, and insufficient data, to enhance streamflow and flood predictions.
    Type of Medium: Online Resource
    ISSN: 2073-4441
    Language: English
    Publisher: MDPI AG
    Publication Date: 2022
    detail.hit.zdb_id: 2521238-2
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  • 6
    In: Sustainability, MDPI AG, Vol. 11, No. 3 ( 2019-02-01), p. 761-
    Abstract: River channel occupation has made cities in the mountainous areas more vulnerable to floodwater out of river channels during rapid global urbanization. A better understanding of the influence of river channel occupation on urban flood disasters can serve as a reference in planning effective urban flood control strategies. In this study, taking a flood event that occurred on July 26th, 2017 in a city on the Loess Plateau as an example, field surveys, dynamics detection of the river channel using remote sensing technology, and scenario simulations with a two-dimensional flow and sediment model were utilized to quantitatively analyze the impacts of river channel occupation on urban inundation and sedimentation. The results show that river channel dynamics reduced by construction can be successfully detected using the combination of high-resolution images and Landsat time-series images. The variation of the water level–discharge relationship caused by the narrowing of the river channel and the increase of the flood-water level caused by water-blocking bridges/houses result in a significant reduction of the flood discharge capacity. The contribution of the narrowing of the river channel was 72.3% for the total area inundated by floodwater, whereas 57.2% of urban sedimentation was caused by the construction of bridges/houses within the river channel. Sustainable flood mitigation measures were also recommended according to the investigations and research findings in this study in order to reduce the social, environmental and economic damages caused by floods.
    Type of Medium: Online Resource
    ISSN: 2071-1050
    Language: English
    Publisher: MDPI AG
    Publication Date: 2019
    detail.hit.zdb_id: 2518383-7
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  • 7
    Online Resource
    Online Resource
    MDPI AG ; 2023
    In:  Remote Sensing Vol. 15, No. 11 ( 2023-05-31), p. 2868-
    In: Remote Sensing, MDPI AG, Vol. 15, No. 11 ( 2023-05-31), p. 2868-
    Abstract: Land use and management practices (LUMPs) play a critical role in regulating soil loss. The cover-management factor (C-factor) in Universal Soil Loss Equation (USLE)-type models is an important parameter for quantifying the effects of LUMPs on soil erosion. However, accurately determining the C-factor, particularly for large-scale assessments using USLE-type models, remains challenging. This study aims to address this gap by analyzing and comparing the methods used for C-factor quantification in 946 published articles, providing insights into their strengths and weaknesses. Through our analysis, we identified six main categories of methods for C-factor quantification in USLE-type modeling. Many studies have relied on empirical C-factor values for different land-use types or calculated C-factor values based on vegetation indices (VIs) in large study areas ( 〉 100 km2). However, we found that no single method could robustly estimate C-factor values for large-scale studies. For small-scale investigations, conducting experiments or consulting the existing literature proved to be more feasible. In the context of large-scale studies, employing methods based on VIs for C-factor quantification can enhance our understanding of the relationship between vegetation changes and soil erosion potential, particularly when considering spatial and spatiotemporal variations. For the global scale, we recommend the combined use of different equations. We suggest further efforts to develop C-factor datasets at large scales by synthesizing field-level experiment data and combining high-resolution satellite imagery. These efforts will facilitate the development of effective soil conservation practices, ensuring sustainable land use and environmental protection.
    Type of Medium: Online Resource
    ISSN: 2072-4292
    Language: English
    Publisher: MDPI AG
    Publication Date: 2023
    detail.hit.zdb_id: 2513863-7
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  • 8
    In: Water, MDPI AG, Vol. 12, No. 3 ( 2020-02-26), p. 630-
    Abstract: In this study, we corrected the bias in the Princeton forcing dataset, i.e., precipitation, maximum and minimum temperatures, and wind speed, by adjusting its long-term mean monthly climatology to match observations for the period 1988–2012 using the delta-ratio method. To this end, we collected meteorological data from 97 stations covering the domain of Iran. We divided Iran into three climatic zones based on the De Martonne classification, i.e., Arid, Humid, and Per-Humid zones, and then applied the delta-ratio method for each climatic zone separately to adjust the bias. After adjustment, the new datasets were compared to the observations in 1958–1987. Results based on four skill scores, including the Nash Sutcliffe efficiency (NSE), percent bias (PBIAS), root-mean-square error (RMSE), and R2, indicate that the adjustment greatly improved the quality of the gridded dataset, specifically, precipitation, maximum temperature, and wind speed. For example, NSE for annual precipitation during the validation time period increased from −0.03 to 0.72, PBIAS reduced from 29.2% to 6.6%, RMSE decreased by 182.44 mm, and R2 increased from 0.06 to 0.75. Assessing the results in different climatic zones of Iran reveals that precipitation improved more significantly in the Per-Humid zone followed by the Humid zone, while maximum temperature improved better in the Arid areas. For wind speed, the values improved comparably in the three climate zones. However, the delta values for monthly minimum temperature calculated during the adjustment time period cannot be applied in the validation time period, due to the fact that the Princeton climate data cannot follow the behavior of minimum temperature during the validation phase. In short, we showed that a simple bias adjustment approach, along with minimum observed station data, can significantly improve the performance of global gridded datasets.
    Type of Medium: Online Resource
    ISSN: 2073-4441
    Language: English
    Publisher: MDPI AG
    Publication Date: 2020
    detail.hit.zdb_id: 2521238-2
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  • 9
    Online Resource
    Online Resource
    MDPI AG ; 2014
    In:  Sustainability Vol. 6, No. 10 ( 2014-10-23), p. 7334-7357
    In: Sustainability, MDPI AG, Vol. 6, No. 10 ( 2014-10-23), p. 7334-7357
    Type of Medium: Online Resource
    ISSN: 2071-1050
    Language: English
    Publisher: MDPI AG
    Publication Date: 2014
    detail.hit.zdb_id: 2518383-7
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  • 10
    In: Forests, MDPI AG, Vol. 9, No. 6 ( 2018-06-05), p. 329-
    Type of Medium: Online Resource
    ISSN: 1999-4907
    Language: English
    Publisher: MDPI AG
    Publication Date: 2018
    detail.hit.zdb_id: 2527081-3
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