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  • 1
    Digitale Medien
    Digitale Medien
    Oxford, UK : Blackwell Science Inc
    Journal of metamorphic geology 20 (2002), S. 0 
    ISSN: 1525-1314
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Geologie und Paläontologie
    Notizen: SHRIMP U–Pb ages have been obtained for zircon in granitic gneisses from the aureole of the Rogaland anorthosite–norite intrusive complex, both from the ultrahigh temperature (UHT; 〉900 °C pigeonite-in) zone and from outside the hypersthene-in isograd. Magmatic and metamorphic segments of composite zircon were characterised on the basis of electron backscattered electron and cathodoluminescence images plus trace element analysis. A sample from outside the UHT zone has magmatic cores with an age of 1034 ± 7 Ma (2σ, n = 8) and 1052 ± 5 Ma (1σ, n = 1) overgrown by M1 metamorphic rims giving ages between 1020 ± 7 and 1007 ± 5 Ma. In contrast, samples from the UHT zone exhibit four major age groups: (1) magmatic cores yielding ages over 1500 Ma (2) magmatic cores giving ages of 1034 ± 13 Ma (2σ, n = 4) and 1056 ± 10 Ma (1σ, n = 1) (3) metamorphic overgrowths ranging in age between 1017 ± 6 Ma and 992 ± 7 Ma (1σ) corresponding to the regional M1 Sveconorwegian granulite facies metamorphism, and (4) overgrowths corresponding to M2 UHT contact metamorphism giving values of 922 ± 14 Ma (2σ, n = 6). Recrystallized areas in zircon from both areas define a further age group at 974 ± 13 Ma (2σ, n = 4). This study presents the first evidence from Rogaland for new growth of zircon resulting from UHT contact metamorphism. More importantly, it shows the survival of magmatic and regional metamorphic zircon relics in rocks that experienced a thermal overprint of c. 950 °C for at least 1 Myr. Magmatic and different metamorphic zones in the same zircon are sharply bounded and preserve original crystallization age information, a result inconsistent with some experimental data on Pb diffusion in zircon which predict measurable Pb diffusion under such conditions. The implication is that resetting of zircon ages by diffusion during M2 was negligible in these dry granulite facies rocks. Imaging and Th/U–Y systematics indicate that the main processes affecting zircon were dissolution-reprecipitation in a closed system and solid-state recrystallization during and soon after M1.
    Materialart: Digitale Medien
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  • 2
    ISSN: 1525-1314
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Geologie und Paläontologie
    Notizen: Foliated garnet-bearing amphibolites occur within the West Bore Shear Zone, cutting through granulite facies gneisses of the Strangways Metamorphic Complex. In the amphibolites, large euhedral garnet (up to 3 cm) occurs within fine-grained recrystallized leucocratic diffusion haloes of plagioclase–quartz. The garnet and their haloes include a well-developed vertical foliation, also present in the matrix. This foliation is the same as that cutting through the unconformably overlying Neoproterozoic Heavitree Quartzite. The textures indicate syn- to late kinematic growth of the amphibolite facies mineral assemblages.All mineral assemblages record an arrested prograde reaction history. Noteworthy is the growth of garnet at the expense of hornblende and plagioclase, and the breakdown of staurolite–hornblende to give plagioclase–gedrite. These dehydration reactions indicate increasing P–T  conditions during metamorphism, and suggest heating towards the end of a period of intense deformation. Temperature estimates for the garnet–amphibolite and related staurolite–hornblende assemblages from the shear zone are about 600 °C. Pressure is estimated at about 5 kbar.An Sm–Nd isochron gives an age of 381±7 Ma for the peak metamorphism and associated deformation. This age determination confirms that amphibolite facies conditions prevailed during shear zone development within the Strangways Metamorphic Complex during the Alice Springs Orogeny. These temperature conditions are significantly higher than those expected at this depth assuming a normal geothermal gradient. The Alice Springs Orogeny was associated with significant crustal thickening, allowing exhumation of the granulite facies, Palaeoproterozoic, lower crust. Along-strike variations of the tectonic style suggest a larger amount of crustal shortening in the eastern part of the Alice Springs Orogeny.
    Materialart: Digitale Medien
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  • 3
    Digitale Medien
    Digitale Medien
    Oxford, UK : Blackwell Science Ltd
    British journal of dermatology 143 (2000), S. 0 
    ISSN: 1365-2133
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Medizin
    Notizen: Erythema elevatum diutinum (EED) is a type of leucocytoclastic vasculitis of unknown aetiology. We report a patient with unusually widespread and disabling EED that had been unresponsive to corticosteroids and antibiotics, but resolved on dapsone. Biopsies of fresh lesions showed typical features of leucocytoclastic vasculitis, with prominent neutrophil infiltration, marked expression of the β2-integrins CR3 and LFA-1, and increased mast cell numbers. Older lesions exhibited granulation tissue and fibrosis, macrophages were more dominant, β2-integrins were expressed less markedly, and mast cell numbers were lower. In vitro chemotaxis of the patient’s peripheral blood neutrophils prior to treatment showed increased random migration and directed migration towards interleukin-8 (by 424%), but a profoundly decreased responsiveness towards the bacterial peptide analogue N-formyl-methionyl-leucyl-phenylalanine (fMLP) (by 98%). These values returned to normal after dapsone treatment and clinical improvement 5 months later. These findings support the concept that in EED, activation via cytokines such as interleukin-8 allows a selective recruitment of leucocytes to tissue sites, while immune complexes and bacterial peptides sustain the persistent local inflammatory infiltrate and the leucocytoclastic vasculitis.
    Materialart: Digitale Medien
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  • 4
    Digitale Medien
    Digitale Medien
    Copenhagen : Munksgaard International Publishers
    Experimental dermatology 9 (2000), S. 0 
    ISSN: 1600-0625
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Medizin
    Notizen: Abstract: H1-type antihistamines have recently been reported to inhibit cytokine secretion from human and murine mast cells and basophils. In order to confirm and expand these studies, we have compared several H1-blockers and the H2-blocker ranitidine for their effect on TNF-α, IL-3, 6, 8 and GM-CSF release from human leukemic mast (HMC-1) and basophilic (KU812) cells, compared to dexamethasone. Cells were stimulated for 24 h with phorbol myristate acetate (25 ng/ml) and calcium ionophore A 23187 (2.5×10−7 M) alone or with the drugs added at 10−4 to 10−15 M, and production of cytokines was measured by ELISA. All antihistamines caused a dose-dependent inhibition of TNF-α release from HMC-1 cells, with maximal effects at 10−12 M for azelastine, 10−9 M for loratadine and cetirizine, and 10−8 M for ranitidine. The inhibitory potency of H1-blockers on cytokines from HMC-1 cells was TNF-α 〉IL-8≥IL-6≥IL-3, with no significant effects on GM-CSF. In KU812 cells which failed to secrete TNF-α and GM-CSF, the sequence was IL-6 〉IL-8 after preincubation. Dexamethasone inhibited all cytokines, but ranitidine only TNF-α and IL-3. Antihistamines had no effect on calcium flux in resting or stimulated cells. At the mRNA level, inhibition was only seen with KU812 cells and IL-8 in the presence of azelastine at 10−10 M. These data show thus distinct inhibitory patterns for different antihistamines during cytokine production from human mast cells and basophils which may contribute to the anti-inflammatory effects of these drugs during treatment of allergic diseases.
    Materialart: Digitale Medien
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  • 5
    Digitale Medien
    Digitale Medien
    Springer
    Der Nervenarzt 71 (2000), S. 751-757 
    ISSN: 1433-0407
    Schlagwort(e): Schlüsselwörter Eugen Bleuler ; Ethik ; Euthanasie ; Moral insanity ; Keywords Eugen Bleuler ; Ethic ; Euthanasia ; Moral insanity
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Beschreibung / Inhaltsverzeichnis: Abstract The name Eugen Bleuler is almost exclusively linked with matters concerning the nosology of schizophrenia, general psychopathology, and the relationship of clinical psychiatry with psychoanalysis. His bibliography lists various works dealing with contemporary themes about legislation, the fight against alcoholism, and, for the most part from later years, with themes about general psychology. In this article, material from Bleuler's texts are reviewed, including some which have been inaccessible up to now, which either allow interpretative conclusions on ethical grounds or have this explicitly as a topic. In particular, the analysis focuses on Bleuler's work “The Scientific Fundamentals of Ethics”, published in 1939. Written in a time widely viewed as disorientated, the author coherently and systemically comments on the issue of a ‘new’ ethic. The antireligious and antiphilosophical positions already demonstrable in some of his earlier works will be shown. According to his conception of a scientifically based ethic, the idea of social suitability is of utmost importance and also recognisable in the animal world as a general principle of nature. Bleuler perceives the ethical ‘instinct’ as inherent; its absence characterises the image of an ‘moral idiot’, which was already a theme in his earlier works. His statements about matters concerning euthanasia are presented and, furthermore, it will be attempted to construct from his texts an underlying global view. Concerning these ethical issues, it also can be shown once more that the elderly Bleuler was hardly influenced by psychoanalytical perspectives.
    Notizen: Zusammenfassung Der Name Eugen Bleulers wird fast ausschließlich in Zusammenhang mit Fragen der Schizophrenielehre, der allgemeinen Psychopathologie und der Beziehung von klinischer Psychiatrie und Psychoanalyse gebracht. Das Schriftenverzeichnis Bleulers weist jedoch auch verschiedene Arbeiten auf, die sich vor allem mit weltanschaulichen Fragen beschäftigen. In der vorliegenden Arbeit werden Inhalte teilweise bisher unzugänglicher Bleuler-Texte vorgestellt, die entweder interpretative Rückschlüsse auf ethische Grundpositionen erlauben oder diese ausdrücklich zum Thema haben. Insbesondere konzentriert sich die Textanalyse auf die 1936 erschienene Arbeit Bleulers über “Die naturwissenschaftlichen Grundlagen der Ethik”. Der Vorstellung von sozialer Zweckhaftigkeit der Ethik, die als allgemeines Naturprinzip gleichermaßen in der Tierwelt erkennbar sei, kommt hier eine große Bedeutung zu. Den ethischen “Instinkt” sieht Bleuler als angeboren; sein Fehlen charakterisiert die “moralische Idiotie”. Es werden Aussagen Bleulers zu Fragen der Euthanasie vorgestellt; weiterhin wird versucht, auf das Weltbild des Verfassers zu schliessen.
    Materialart: Digitale Medien
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  • 6
    Publikationsdatum: 2018-02-16
    Repository-Name: EPIC Alfred Wegener Institut
    Materialart: Article , peerRev
    Format: application/pdf
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  • 7
    facet.materialart.
    Unbekannt
    In:  African Journal of Earth Sciences : special abstract issue ; 30 (4a)
    Publikationsdatum: 2020-02-12
    Schlagwort(e): 550 - Earth sciences
    Materialart: info:eu-repo/semantics/conferenceObject
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  • 8
    facet.materialart.
    Unbekannt
    In:  Berichte der Deutschen Mineralogischen Gesellschaft : Beihefte zum European Journal of Mineralogy ; 16,1
    Publikationsdatum: 2020-02-12
    Schlagwort(e): 550 - Earth sciences
    Materialart: info:eu-repo/semantics/conferenceObject
    Standort Signatur Einschränkungen Verfügbarkeit
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