In:
FEBS Letters, Wiley, Vol. 487, No. 2 ( 2000-12-29), p. 229-233
Kurzfassung:
In lymphocytes, glucocorticoids (GC)‐ and interleukin‐4‐signaling pathways are known to interact, as evidenced by inhibition of IL‐4‐mediated proliferation by dexamethasone or suppression of GC‐induced apoptosis by IL‐4. In this study, we characterized the molecular basis for this reciprocal interference. We report that, in murine CTLL‐2 cells, IL‐4 inhibits GC‐induced MMTV (mouse mammary tumor virus) promoter transactivation, and that GC suppress IL‐4‐induced transactivation of a STAT6 (signal transducers and activators of transcription 6)‐responsive promoter without affecting IL‐4‐stimulated STAT6 DNA‐binding. Moreover, we evidenced a physical association between GC receptor and STAT6, which proved to be functionally relevant, since STAT6 overexpression increased the IL‐4 inhibitory effect on GC‐induced MMTV transactivation.
Materialart:
Online-Ressource
ISSN:
0014-5793
,
1873-3468
DOI:
10.1016/S0014-5793(00)02297-3
Sprache:
Englisch
Verlag:
Wiley
Publikationsdatum:
2000
ZDB Id:
1460391-3
SSG:
12
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