In:
The Journal of Clinical Pharmacology, Wiley, Vol. 35, No. 3 ( 1995-03), p. 302-305
Abstract:
The pharmacokinetics of triamcinolone acetonide were studied after intravenous (2 mg), oral (5 mg), and inhaled (2 mg) administration. Triamcinolone acetonide concentrations were measured in plasma by high‐performance liquid chromatography/radioimmunoassay. After intravenous administration, triamcinolone acetonide was eliminated with a total body clearance of 37 L/h and a half‐life of 2.0 hours. The volume of distribution was 103 L, and oral bioavailability averaged 23%. Absorption was rapid, achieving maximum triamcinolone acetonide levels of 10.5 ng/mL after 1 hour. After inhalation, bioavailability averaged 22% with maximum levels of 2.0 ng/mL observed after 2.1 hours. The resulting systemic levels for all three treatments caused a significant decrease in the number of lymphocytes in blood.
Type of Medium:
Online Resource
ISSN:
0091-2700
,
1552-4604
DOI:
10.1002/jcph.1995.35.issue-3
DOI:
10.1002/j.1552-4604.1995.tb04064.x
Language:
English
Publisher:
Wiley
Publication Date:
1995
detail.hit.zdb_id:
2010253-7
SSG:
15,3
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