ISSN:
1434-808X
Keywords:
Schlüsselwörter
;
Menschliche embryonale Stammzellen •¶Pluripotenz • Zellkerntransfer • Klonieren • Gewebetransplantation
;
Key words
;
Human embryonic stem cells • Pluripotency • Nuclear transfer • Therapeutic cloning • Tissue transplantation
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Description / Table of Contents:
Summary Technological advances in the last two years in mammalian nuclear transfer techniques and the establishment of human embryonic stem cell lines formed the background of the International Workshop on „Embryonic Stem Cells and Nuclear Transfer Strategies“ organized at the Gene Center, Munich, September 1999. The aim of the meeting was to bring together scientists working in the stem cell field and those working on somatic nuclear transfer techniques to discuss the present status and prospects of both technologies for basic and applied research and future use in medicine and livestock breeding. „Biology of Embryonic Stem Cells“, „Nuclear Transfer Strategies“, and „Stem Cell Differentiation – Cell Therapy“ were the main topics of the meeting. It became clear that we are far from understanding the processes involved in stem cell self-renewal and differentiation and the mechanisms resulting in reprogramming of nuclei from somatic cells after transfer into enucleated oocytes. However, data were presented that showed the enormous potential of the embryonic stem cell technology for tissue transplantation in the future. Before any use of this technology in combination with any cloning technology for human cell therapy will be possible, further research including animal models and stem cell differentiation approaches in culture (i. e., identification of differentiation factors, selective differentiation strategies, reporter gene assays) is necessary to understand the basic principles of pluripotent stem cell differentiation and the mechanisms involved in reprogramming somatic cell nuclei.
Notes:
Zusammenfassung Am 9. und 10. September 1999 fand im Genzentrum München ein internationaler Workshop zum Thema ,,Stem cells and nuclear transfer strategies – present state and future prospects“ statt. Organisatoren und Chairmen waren Anna M. Wobus (IPK Gatersleben), Eckhard Wolf (Genzentrum München) und Henning M. Beier (Anatomie und Reproduktionsbiologie der RWTH Aachen). International anerkannte Experten hielten folgende Vorträge: Jonathan Van Blerkom (Boulder, Co/USA) ,,The oocyte – the ultimate stem cell“, Austin Smith (Edinburgh/UK) ,,Control of stem cell pluripotency and differentiation“, Hans R. Schöler (Philadelphia, Pa/USA) ,,Oct-4 expression in ES cells and early embryogenesis“, Keith H. S. Campbell (Roslin/UK) ,,Viable offspring derived from fetal and adult mammalian cells – applications and progress“, Jose B. Cibelli (Worcester, Mass./USA) ,,Genetic modification by somatic cell nuclear transplantation“, Oliver Brüstle (Bonn) ,,Transplantation of embryonic stem cell-derived neural precursors“, Anthony D. Ho (Heidelberg) ,,Symmetry of division of haematopoietic stem cells“, Axel Haverich (Hannover) ,,Modern strategies of cell and tissue repair – Requirements of transplantation therapy“. Bei diesem Workshop wurde eine Fülle von wissenschaftlichen Daten präsentiert, die das enorme Potential der embryonalen Stammzelltechnologie für die zukünftige Gewebetransplantation deutlich machte. Über 150 Wissenschaftler aus Deutschland, Europa und den USA nahmen an diesem Workshop teil.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/s004440050006
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