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  • 1
    Keywords: Electronic books.
    Type of Medium: Online Resource
    Pages: 1 online resource (728 pages)
    Edition: 1st ed.
    ISBN: 9783832586089
    Language: German
    Note: Intro -- Einleitung -- 1 Der Gegenstand der Humanontogenetik und ihre Ziele -- 2 Methoden und einige unabdingbare methodologische und wissenschaftstheoretische Voraussetzungen humanontogenetischer Forschung -- 3 Die biopsychosoziale Einheit Mensch und die Menschenbilder -- 4 Die Phasen der Entwicklung in der Ontogenese -- 5 Das hierarchische System der Kompetenzen -- 6 Die Ökologie der Humanontogenese -- 7 Die sensiblen Phasen in der Entwicklung des Individuums -- 8 Das Zeitwesen Mensch - homo temporalis -- 9 Souveränität - der souveräne Mensch -- Nachwort zur ersten Auflage (2015) -- Nachwort zur zweiten Auflage (2021) -- Literatur -- Personenregister.
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  • 2
    Keywords: Oncogenic viruses. ; Cancer-Genetic aspects. ; Human genetics. ; Electronic books.
    Type of Medium: Online Resource
    Pages: 1 online resource (714 pages)
    Edition: 1st ed.
    ISBN: 9783832592363
    DDC: 616.9920194
    Language: German
    Note: Intro -- 1 Der Gegenstand der Humanontogenetik und ihre Ziele -- 2 Methoden und einige unabdingbare methodologische und wissenschaftstheoretische Voraussetzungen humanontogenetischer Forschung -- 3 Die biopsychosoziale Einheit Mensch und die Menschenbilder -- 4 Die Phasen der Entwicklung in der Ontogenese -- 5 Das hierarchische System der Kompetenzen -- 6 Die Ökologie der Humanontogenese -- 7 Die sensiblen Phasen in der Entwicklung des Individuums -- 8 Das Zeitwesen Mensch - homo temporalis -- 9 Souveränität - der souveräne Mensch.
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  • 3
    Online Resource
    Online Resource
    Berlin : Logos Verlag Berlin
    Keywords: Electronic books
    Description / Table of Contents: Intro -- Zur wissenschaftlichen Biografie von Gerhard Rosenfeld (Karla Horstmann-Hegel) -- Im Gedenken an Gerhard Rosenfeld: Erziehung - Moral - Entwicklung ( Karl-Friedrich Wessel) -- Motivation, Situation und Moral. Zum wissenschaftlichen Werk von Gerhard Rosenfeld Karla Horstmann-Hegel -- Widerspruchsdialektik in den Schriften von Gerhard Rosenfeld (Dieter Kirchhöfe)r -- Erinnerungen an Gerhard Rosenfeld (Ulrike Sayatz) -- DOKUMENTE (1947-1970) -- Objektive Gesetzmäßigkeit aus der Sicht des Verhältnisses von Philosophie und Psychologie (1974, Nachdruck) (Gerhard Rosenfeld &amp -- Karl-Friedrich Wessel) -- Zur Evolution der individuellen Freiheit (1975, Nachdruck) (Gerhard Rosenfeld &amp -- Karl-Friedrich Wessel).
    Type of Medium: Online Resource
    Pages: 1 online resource (220 pages)
    ISBN: 9783832587376
    Series Statement: Berliner Studien Zur Wissenschaftsphilosophie und Humanontogenetik Ser. v.39
    Language: German
    Note: Description based on publisher supplied metadata and other sources
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  • 4
    ISSN: 1364-6753
    Keywords: Keywords: spinocerebellar ataxia, SCA2, trinucleotide repeat expansion, octogenarians, repeat instability
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: ABSTRACT Autosomal dominant spinocerebellar ataxias (SCA) are a group of clinically and genetically heterogeneous neurodegenerative disorders which lead to progressive cerebellar ataxia. A gene responsible for SCA type 2 has been mapped to human chromosome 12 and the disease causing mutation has been identified as an unstable and expanded (CAG)n trinucleotide repeat. We investigated the (CAG)n repeat length of the SCA2 gene in 842 patients with sporadic ataxia and in 96 German families with dominantly inherited SCA which do not harbor the SCA1 or MJD1/SCA3 mutation, respectively. The SCA2 (CAG)n expansion was identified in 71 patients from 54 families. The (CAG)n stretch of the affected allele varied between 36 and 64 trinucleotide units. Significant repeat expansions occurred most commonly during paternal transmission. Analysis of the (CAG)n repeat lengths with the age of onset in 41 patients revealed an inverse correlation. Two hundred and forty-one apparently healthy octogenerians carried alleles between 16 and 31 repeats. One 50-year old, healthy individual had 34 repeats; she had transmitted an expanded allele to her child. The small difference between ‘normal’ and disease alleles makes it necessary to define the extreme values of their ranges. With one exception, the trinucleotide expansion was not observed in 842 ataxia patients without a family history of the disease. The SCA2 mutation causes the disease in nearly 14% of autosomal dominant SCA in Germany.
    Type of Medium: Electronic Resource
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  • 5
    ISSN: 1432-1203
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract Neurodegenerative disorders, including spinocerebellar ataxias (SCA), Huntington disease (HD) and dentatorubral-pallidoluysian atrophy (DRPLA), are associated with unstable CAG repeats. To investigate the mitotic stability of the repetitive element in the genes for SCA1, SCA3, HD, and DRPLA we extracted DNA from up to 13 tissue samples from four deceased individuals with progressive neurological disorders and neuropathological signs. Due to the formalin fixation of some tissues the genomic DNA was highly degraded and unsuitable for amplification of fragments longer than 150 bp. After size selection and primer extension preamplification, specific analyses could be performed even for expanded alleles. In all four patients the SCA1 mutation could be demonstrated, in one case with remarkable somatic heterogeneity of the elongated allele, whereas alleles of the normal range were stable in all tissues examined.
    Type of Medium: Electronic Resource
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  • 6
    ISSN: 1432-1106
    Keywords: Key words Cerebellum ; Motor cortex ; Event-related potentials ; EEG ; Response force
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  The cerebellum is certainly involved in fine coordination of movements, but has no efferences of its own to the muscles. Thus, it can exert its influence only via other cerebral areas that have those efferences. This study investigated in patients with cerebellar atrophy how cortical motor areas are affected by dysfunction of the cerebellum. The main question was whether the patients’ slow cortical electroencephalogram (EEG) potentials during key-press preparation and execution would be generally altered or would be specifically altered when fine coordination was needed. In the coordination task, right- and left-hand keys had to be pressed simultaneously with different forces, under visual feedback. Control tasks were to press with both hands equally or with one hand only. The patients indeed had a performance deficit in the coordination task. Their cortical EEG potentials were already drastically reduced in the simple tasks, but were enhanced by the same amount as in healthy subjects when more coordination was needed. These results suggest that the cerebellum is not exclusively active in fine coordination, but is generally involved in any kind of preparatory and executive activity, whereas the motor cortex becomes more active with fine coordination. The role of the cerebellum might be to provide the motor cortex with information needed for coordinating movements. In cerebellar atrophy, this altered input may be sufficient for the motor cortex in controlling simple tasks, but not for complex ones.
    Type of Medium: Electronic Resource
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