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  • 1
    Electronic Resource
    Electronic Resource
    Temperature course and distribution during plasma heating with a microwave device (2003)
    Oxford, UK : Blackwell Science Ltd
    Anaesthesia 58 (2003), S. 0 
    Details
    ISSN: 1365-2044
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Summary In spite of the much shorter thawing times, the use of microwave devices for heating units of fresh frozen plasma is still being discussed. Concerns about general and localised overheating are the main arguments against the use of microwave devices. We evaluated the warming of fresh frozen plasma using the recently introduced Transfusio-therm 2000® microwave blood warmer. Units of fresh frozen plasma were weighed and the heating times were recorded. The surface temperature of the fresh frozen plasma bags during heating was recorded every 10 s. Temperature variation on the surface was examined by measuring the difference between peripheral and centrally placed temperature sensors. After heating, plasma temperature was determined using a calibrated thermometer. There were no signs of overheating during the heating process. The surface temperature of three units of fresh frozen plasma heated simultaneously (n = 45) was 34.0°C (SD, 1.5°C) after a mean heating time of 23.2 min (SD, 1.1 min). The mean (SD) temperature difference was −0.6 (0.5)°C and the mean (SD) plasma temperature was 33.6 (0.8)°C. Heating one fresh frozen plasma unit at a time (n = 20), the mean (SD) heating time was 6.3 (0.4) min. The surface temperature after heating was 34.3 (0.2)°C, the mean (SD) temperature difference was −0.6 (0.4)°C and the mean (SD) plasma temperature after heating 33.1 (0.6)°C. We conclude that no general or localised overheating of fresh frozen plasma occurs during or after heating with the microwave blood warmer.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1365-2044.2003.03086.x
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  • 2
    Electronic Resource
    Electronic Resource
    Der Einfluss verschiedener Volumenersatzmittel auf die Funktion von neutrophilen Granulozyten in vitro (2000)
    Springer
    Der Anaesthesist 49 (2000), S. 196-201 
    Details
    ISSN: 1432-055X
    Keywords: Schlüsselwörter Kolloidale Volumenersatzmittel ; Neutrophile Granulozyten ; Phagozytose ; Oxidativer Burst ; Komplementrezeptoren ; Key words Kolloids ; Neutrophils ; Phagocytosis ; Oxidative burst ; Complement receptor expression
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Abstract Introduction: The influence of kolloids on the immune system is not well documented. In this study we investigated the effects of gelatine, hydroxyethylstarch (HES), human albumine, and dextrane on neutrophil function and receptor expression by flow cytometry. Methods: Whole blood of healthy volunteers was incubated for 30 minutes with either gelatine, HES (6% and 10%), dextrane 40 and 60, or human albumin 20%. Phagocytic capacity was determined by uptake of fluorescein-isothiocyanate labeled bacteria, the conversion of dihydrorhodamine 123 into fluorescent rhodamine 123 was used for oxidative burst measurements. Expression of complement receptors CD 11b and CD35 was investigated using fluorescein-isothiocyanate labeled antibodies. Results: Incubation with gelatine significantly increased expression of complement receptors and oxidative burst. Dextranes and HES had no influence on neutrophil function. Human albumin reduced the oxidative burst, whereas CD 35 expression was increased. Conclusion: The physiological significance of these changes in a range of 10% has to be clarified in further investigations.
    Notes: Zusammenfassung Fragestellung: Der Einfluss kolloidaler Volumenersatzmittel auf die Immunfunktion ist unzureichend belegt. In dieser Studie wurden die Auswirkungen von Gelatinelösungen, Hydroxyäthylstärke (HAES), Humanalbumin und Dextranen auf Expression von Oberflächenrezeptoren und Funktion polymorphkerniger neutrophiler Granulozyten durchflusszytometrisch untersucht. Methodik: Vollblut von gesunden Probanden wurde 30 min mit folgenden Volumenersatzmitteln inkubiert: HAES (6% und 10%), Dextran 40, Dextran 60, Gelatinelösung (3%), Humanalbumin 20%. Die Phagozytoseleistung wurde mittels Fluoreszeinisothiozyanat-markierten Bakterien ermittelt. Der Oxidative Burst wurde anhand der Umwandlung von Dihydrorhodamin 123 in grün-fluoreszierendes Rhodamin 123 bestimmt. Die Expression der Komplementrezeptoren CD11b und CD 35 wurde mit Fluoreszeinisothiozyanat-markierten Antikörpern untersucht. Ergebnisse: Nach Inkubation mit Gelatinelösung waren Expression von Komplementrezeptoren und Oxidativer Burst signifikant erhöht. Der Median der Fluoreszenzintensität stieg für CD35 von 531±42 auf 565±51, für CD 11b von 416±24 auf 446±19 und für den Oxidativen Burst von 490±52 auf 516±51. HAES und Dextrane beeinflussten die Granulozytenfunktion nicht. Humanalbumin 20% steigerte die Expression von CD 35, reduzierte jedoch den Oxidativen Burst. Schlussfolgerung: Die klinische Bedeutung dieser in vitro-Veränderungen in einer Größenordnung von maximal 10% des Ausgangswerts sollte in in vivo-Studien näher untersucht werden.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001010050814
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  • 3
    Electronic Resource
    Electronic Resource
    Postoperative nausea and vomiting after Faden operation (2000)
    Springer
    Graefe's archive for clinical and experimental ophthalmology 238 (2000), S. 59-63 
    Details
    ISSN: 1435-702X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  · Objective: The purpose of this study was to evaluate the antiemetic effect of prophylactic dimenhydrinate application prior to Faden operation and to compare the incidence of PONV between bimedial Faden operation (BMF) and horizontal recess-resect procedure (R&R). · Methods: Ninety-nine children (4–10 years) scheduled for BMF were included in this prospective double-blind study. Midazolam (0.5 mg/kg body weight, BW) was administered orally for premedication 30 min before induction of anesthesia. Additionally, children weighing ≥23 kg received either dimenhydrinate suppositories or placebo. The placebo group was compared with 148 children who underwent R&R surgery without antiemetic prophylaxis during the same period. Anesthesia was induced with thiopentone (5–10 mg/kg BW) and vecuronium (0.1 mg/kg BW) bromide and maintained with halothane (1–2 vol%) in N2O/O2 (65/35 vol%). Age, height, weight, and incidence of oculocardiac reflex were documented. PONV was classified into ”no vomiting”, ”vomiting without therapy”, and ”vomiting requiring rescue medication”. In the latter case dimenhydrinate was given again. The chi-square test was used for statistical analysis.  · Results: Forty-eight patients received placebo, while 51 received dimenhydrinate. No differences between any groups were observed concerning age, height, weight, and incidence of oculocardiac reflex. Compared to R&R surgery, PONV requiring rescue medication occurred significantly more frequently after BMF (45% vs 23% after R&R). PONV after BMF was significantly less severe in the dimenhydrinate group than in the placebo group. The total incidence of PONV after BMF, however, was not significantly reduced. · Conclusion: The high incidence of PONV after BMF can be explained by the greater invasiveness of BMF than R&R surgery. PONV requiring antiemetic rescue medication can be reduced by preoperative administration of dimenhydrinate suppositories.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004170050010
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