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  • 1
    Electronic Resource
    Electronic Resource
    Action of the active metabolites of tiazofurin and ribavirin on purified IMP dehydrogenase (1988)
    s.l. : American Chemical Society
    Biochemistry 27 (1988), S. 2193-2196 
    Details
    ISSN: 1520-4995
    Source: ACS Legacy Archives
    Topics: Biology , Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/bi00406a057
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  • 2
    Electronic Resource
    Electronic Resource
    Bacteriocins Applied to Food Packaging Materials to Inhibit Listeria monocytogenes on Meats (1997)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of food science 62 (1997), S. 0 
    Details
    ISSN: 1750-3841
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition , Process Engineering, Biotechnology, Nutrition Technology
    Notes: Bacteriocins in powders were produced from milk-based media and applied to food packaging films. Nisin and pediocin “powders” were retained in casings during dialysis. Antilisterial casings were prepared by internal coating with pediocin. Antilisterial activity applied in powdered form was retained during processing and retained on contact food packaging surfaces. Pediocin powder was applied to plastic packaging bags at 7.75 μg/cm2. Meats and poultry samples were inoculated with Listeria monocytogenes. The bags coated with pediocin powder completely inhibited growth of inoculated L. monocytogenes through 12 wk storage at 4°C. Applying bacteriocins to food packaging films is an effective approach to reduce L. monocytogenes contamination in meats and poultry.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2621.1997.tb04015.x
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  • 3
    Electronic Resource
    Electronic Resource
    IMP dehydrogenase, an enzyme linked with proliferation and malignancy (1975)
    [s.l.] : Nature Publishing Group
    Nature 256 (1975), S. 331-333 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Briefly, in tumours, three classes of behaviour of enzymes and pathways were distinguished. Enzymes or pathways of the first group show a positive or negative correlation with tumour growth rate; these alterations seem to indicate a linking with the degree of expression of malignancy. Parameters of ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/256331a0
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  • 4
    Electronic Resource
    Electronic Resource
    Increased UDP kinase activity in rat and human hepatomas (1975)
    [s.l.] : Nature Publishing Group
    Nature 253 (1975), S. 567-569 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Our investigations on the UTP-synthesising enzyme, UDP kinase (nucleosidediphosphate kinase; ATP:UDP phospho-transferase, EC 2.7.4.6) were undertaken because in the hepa-tomas of different growth rates the capacity of certain key enzymes involved in the biosynthesis of UDP increased in parallel ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/253567a0
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  • 5
    Electronic Resource
    Electronic Resource
    Increased CTP synthetase activity in cancer cells (1978)
    [s.l.] : Nature Publishing Group
    Nature 271 (1978), S. 71-73 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Our studies on CTP synthetase, the enzyme that catalyses the synthesis of CTP from UTP, were undertaken because the activity of UDP kinase, an enzyme that produces UTP, was elevated in all hepatomas examined15. In rapidly growing hepatoma 3924A, however, the concentration of UTP was unaltered, but ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/271071a0
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  • 6
    Electronic Resource
    Electronic Resource
    Carbohydrate metabolism in cancer cells and the molecular correlation concept (1968)
    Springer
    Naturwissenschaften 55 (1968), S. 418-429 
    Details
    ISSN: 1432-1904
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology , Natural Sciences in General
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00602650
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  • 7
    Electronic Resource
    Electronic Resource
    Schedule-dependent synergistic action of tiazofurin and dipyridamole on hepatoma 3924A cells (1992)
    Springer
    Cancer chemotherapy and pharmacology 31 (1992), S. 93-96 
    Details
    ISSN: 1432-0843
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Tiazofurin is an oncolytic nucleoside analog that has shown therapeutic activity in end-stage acute non-lymphocytic leukemia and in chronic granulocytic leukemia in blast crisis. Tiazofurin is anabolized to the active metabolite, TAD, which inhibits IMP dehydrogenase activity, leading to a reduction in guanylate pools and to the cessation of neoplastic cell proliferation. The drug exhibits potent cytostatic and cytotoxic activity against hepatoma 3924A cells in culture. In growth-inhibition and clonogenic assays, the 50% inhibitory concentration of tiazofurin was 3.8 and 4.2 μm, respectively. Dipyridamole, an inhibitor of nucleoside transport, curtails the salvage of nucleosides and bases for nucleotide biosynthesis. Dipyridamole exhibited cytotoxicity against hepatoma 3924A cells, with an LC50 of 24 μm and an IC50 of 29 μm being recorded. A combination of tiazofurin and dipyridamole provided synergistic cytotoxicity in hepatoma 3924A cells in culture. This synergistic activity was dependent on the order of addition of the drugs. Simultaneous addition of the two drugs produced antagonism, whereas preincubation of cells with tiazofurin or dipyridamole followed by addition of the second drug resulted in synergy. TAD concentrations were significantly higher (129% and 135%) in cells that had been pretreated with tiazofurin or dipyridamole before the addition of the second agent as compared with cells that had been treated simultaneously (113%). These studies indicate the importance of the order of the addition of drugs to obtain a synergistic response in combination chemotherapy and suggest the need for a careful selection of drug modulation in clinical trials of tiazofurin and dipyridamole.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00685093
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  • 8
    Electronic Resource
    Electronic Resource
    Histone acetyltransferase activity in rat hepatomas (1989)
    Springer
    Journal of cancer research and clinical oncology 115 (1989), S. 435-438 
    Details
    ISSN: 1432-1335
    Keywords: Histone acetyltransferase ; rat hepatomas ; rat liver
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary In view of various reports describing differences in histone acetylation between normal rat liver and hepatomas, the behaviour of histone acetyltransferase (EC 2.3.1.48) activity was elucidated in normal rat liver and in a spectrum of well-characterized rat hepatomas of slow, intermediate and rapid growth rates. In all tumours the acetyltransferase specific activity, expressed as nmol h-1 mg total protein-1, was higher than in the corresponding normal livers and the rise correlated positively with the proliferation rates of the tumors. No difference is observed if acetyltransferase activity is expressed per milligram of histone. This is explained by elevated ratios of histones and of DNA to total protein in the hepatomas compared to the ratios in normal liver. Electrophoretic analysis of [3H]acetate-labeled histones revealed similar patterns in hepatoma and normal liver. The extent of histone H4 acetylation, as indicated by the frequency distribution of non-, mono-, di-, tri-, and tetraacetylated H4-species, was found to be identical in hepatomas and normal liver. The histone protein and acetate labeling patterns were near normal in the slowly growing hepatomas.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00393332
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  • 9
    Electronic Resource
    Electronic Resource
    Expression of key enzymes of purine and pyrimidine metabolism in a hepatocyte-derived cell line at different phases of the growth cycle (1990)
    Springer
    Journal of cancer research and clinical oncology 116 (1990), S. 251-258 
    Details
    ISSN: 1432-1335
    Keywords: Purine and pyrimidine metabolism ; Enzyme expression ; Growth phase ; Liver cell line
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The effect of growth phase on enzymatic activities of the de novo and salvage pathways for purine and pyrimidine nucleotide synthesis was studied in a hepatocyte-derived cell line from the rat. The cells were in lag phase after plating for 36 h; log phase started at 48 h and persisted up to 120 h of culture. Then the cells stopped growing and entered into plateau phase (144 h). In non-proliferating cells (144 h of culture) the basal activities of the enzymes of purine de novo biosynthesis were 1.7- to 6.8-fold higher than in normal rat liver, those of pyrimidine de novo synthesis showed 0.6- to 30-fold increase in activity. The purine salvage enzymes were unchanged, and the pyrimidine salvage enzymes were 3.1- to 7.4-fold higher compared to normal liver. During the growth cycle all enzymes except the purine salvage enzymes, which did not change, showed a peak in activity at 72 h of culture (log phase). The increase in activity in log phase compared to plateau phase was 1.3- to 2.4-fold for purine de novo synthetic enzymes, 1.1- to 2.4-fold for pyrimidine de novo enzymes, and 1.4- to 4.7-fold for pyrimidine salvage enzymes. The specific activities of the enzymes in exponentially growing cells were comparable either to that in 24-h regenerating liver, or to that in hepatomas of low or medium growth rate. It was concluded that the enzymatic pattern and metabolic state of the cells shared some features with regenerating liver, others with tumors, although they were not tumorigenic after transplantation into athymic nude mice.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01612899
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  • 10
    Electronic Resource
    Electronic Resource
    Role of differentiation induction in action of purine antimetabolites (1994)
    Springer
    Pharmacy world & science 16 (1994), S. 77-83 
    Details
    ISSN: 1573-739X
    Keywords: Differentiation ; Drug synergism ; Gemcitabine ; Hypoxanthine-guanine phosphoribosyltransferase ; IMP dehydrogenase ; Leukemia, myeloid, chronic ; Oncogenes ; Ribavirin ; Tiazofurin
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract In cancer cells, particularly in leukaemic cells, guanylate biosynthesis is up-regulated as shown by the increased activities of IMP dehydrogenase, the rate-limiting enzyme ofde novo GTP biosynthesis, and of the salvage enzyme, hypoxanthine-guanine phosphoribosyltransferase (HGPRT). In enzyme pattern-targeted chemotherapy, tiazofurin inhibits IMP dehydrogenase activity in cancer cells and allopurinol-induced high serum hypoxanthine levels inhibit. HGPRT activity. A triad of responses was observed in the blast cells of patients treated with tiazofurin infusions: chemotherapy, induced differentiation, and down-regulation of c-Ki-ras andc-myc oncogenes. Tiazofurin was synergistic in cytotoxicity and in causing differentiation with ribavirin, retinoic acid, and difluorodeoxycytidine. Induced differentiation plays an important role in the overall impact of antipurine agents.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01880659
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