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  • 1
    Electronic Resource
    Electronic Resource
    Phase behavior of polystyrene in methyl acetate: a static light scattering study (1993)
    s.l. : American Chemical Society
    Macromolecules 26 (1993), S. 5088-5095 
    Details
    ISSN: 1520-5835
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology , Physics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/ma00071a017
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Palaeomagnetic Evidence for Rotation of Sardinia during the Early Miocene (1973)
    [s.l.] : Nature Publishing Group
    Nature 243 (1973), S. 281-283 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Fig. 1 Map of the Castelsardo area with sampling sites indicated. The volcanic rocks of northern Sardinia consist of andesites, trachytes and liparites. Tuffs, tuffites and sediments are intercalated. The exposures are discontinuous, the sediments show Tapid facies transitions, and block faulting ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/243281a0
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    The relationship between leisure time, physical activities and musculoskeletal symptoms and disability in worker populations (2000)
    Springer
    International archives of occupational and environmental health 73 (2000), S. 507-518 
    Details
    ISSN: 1432-1246
    Keywords: Key words Leisure time physical activity ; Physical activity ; Sports participation ; Sick leave ; Physical work load
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Objectives: To assess the association between leisure time physical activity and musculoskeletal morbidity, as well as possible interactions with physical activity at work. Methods: A literature search was performed to collect all studies on musculoskeletal disorders in which physical activity was involved as a variable. Next, an analysis was made of questionnaire data on a group of 2,030 workers in various occupations, on self-reported physical activity in leisure time and at work, musculoskeletal symptoms (from low back, neck-shoulder and lower extremity) and sick leave due to these symptoms. A logistic regression analysis was carried out to estimate the association between musculoskeletal morbidity and four physical-activity indices (participation in sports and sedentary activities, active life style, sedentary life style), adjusted for age, gender, education and work load. Interaction of leisure activities with age and work load was tested too. Results: Available literature data (39 studies) showed inconsistent results. Most studies did not show any effects. Some studies indicated favourable effects of physical activity, both on low back and neck pain. Participation in some vigorous sports seemed associated with unfavourable effects. The empirical data showed no association between participation in sports and/or other physical activities in leisure time and musculoskeletal symptoms. Sedentary activity in leisure time was associated with higher prevalence rates of low back symptoms and sick leave due to low back symptoms. Conclusions: Stimulation of leisure time physical activity may constitute one of the means of reducing musculoskeletal morbidity in the working population, in particular in sedentary workers.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004200000167
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Recent changes in occupational medicine in The Netherlands (1999)
    Springer
    International archives of occupational and environmental health 72 (1999), S. 285-291 
    Details
    ISSN: 1432-1246
    Keywords: Key words Occupational health services ; Occupational physician ; Occupational health research ; Education ; Occupational medicine
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  In some respects, the Dutch seem to be forerunners in Europe. Occupational health care for all workers can be considered as a substantial progress. Nonetheless, The Netherlands has taken the lead in Europe regarding high work pressure, sickness absence and disability for work. The resulting focus on sickness absence management in many companies is associated with changes in the tasks and position of the occupational physician. Quality of occupational health care is not always as high as it should be, partly as a result of the commercial approach occupational health services have to adopt nowadays. However, the post-academic education programme, with special attention for training of skills, is increasingly adapted to occupational physicians working in a commercial environment. Moreover, a basis has been laid for a better infrastructure and occupational physicians show an increase in professional enthusiasm. Furthermore, co-operation between different professionals has become increasingly common, resulting in a more comprehensive support for companies. Efforts are being made for better co-operation with general practitioners and medical specialists. Finally, the priorities for future research have been clearly outlined by a programming study. Experts are in demand for studies regarding implementation and evaluation of interventions, especially cost-benefit analysis. Furthermore, work stress and musculoskeletal disorders remain on the research agenda.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004200050376
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  • 5
    Electronic Resource
    Electronic Resource
    Questionnaire surveys on health and working conditions: development of an instrument for risk assessment in companies (2000)
    Springer
    International archives of occupational and environmental health 73 (2000), S. 47-55 
    Details
    ISSN: 1432-1246
    Keywords: Key words Questionnaire survey ; Health survey ; Instrument development ; Reference data ; OHS service
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Periodic Occupational Health Surveys (POHS) are frequently used by occupational health and safety services in the Netherlands as a risk assessment instrument. These surveys include a questionnaire on work and health. Systematic attention is paid in this questionnaire to a broad range of working conditions and health complaints. In this article a method is presented to identify and evaluate work risks and health problems in groups of workers. Working conditions and health in any given company or department are assessed by comparing questionnaire data from its worker populations with data from one or more reference populations. Significant differences are interpreted as signals for both adverse working conditions and health problems. Considerations and choices with regard to the technical, operational and strategic quality of the method are elucidated. Probabilities of α- and β-errors, choice of significance levels, and selection of reference populations are dealt with. Finally, a way of presentation of the results is shown. The method is considered to be part of a broader approach toward risk assessment. We recommend the combined use of questionnaire results and other available information, such as workplace surveys and sickness absence data. Questionnaires about work and health can be seen as one step in a multi-phase design: like in many diagnostic processes, the latter phases can enhance the precision of previous results. Recommendations are made for validating and evaluating this instrument.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/PL00007937
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    Paper (German National Licenses)
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  • 6
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    Cohort Profile: LifeLines, a three-generation cohort study and biobank (2015)
    Oxford University Press
    Details
    Publication Date: 2015-10-01
    Description: The LifeLines Cohort Study is a large population-based cohort study and biobank that was established as a resource for research on complex interactions between environmental, phenotypic and genomic factors in the development of chronic diseases and healthy ageing. Between 2006 and 2013, inhabitants of the northern part of The Netherlands and their families were invited to participate, thereby contributing to a three-generation design. Participants visited one of the LifeLines research sites for a physical examination, including lung function, ECG and cognition tests, and completed extensive questionnaires. Baseline data were collected for 167 729 participants, aged from 6 months to 93 years. Follow-up visits are scheduled every 5 years, and in between participants receive follow-up questionnaires. Linkage is being established with medical registries and environmental data. LifeLines contains information on biochemistry, medical history, psychosocial characteristics, lifestyle and more. Genomic data are available including genome-wide genetic data of 15 638 participants. Fasting blood and 24-h urine samples are processed on the day of collection and stored at -80 °C in a fully automated storage facility. The aim of LifeLines is to be a resource for the national and international scientific community. Requests for data and biomaterials can be submitted to the LifeLines Research Office [ LLscience@umcg.nl ].
    Print ISSN: 0300-5771
    Electronic ISSN: 1464-3685
    Topics: Medicine
    Published by Oxford University Press
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  • 7
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    Reconstructing Quaternary Rhine–Meuse dynamics in the southern North Sea: architecture, seismo-lithofacies associations and malacological biozonation (2013)
    Wiley-Blackwell
    Details
    Publication Date: 2013-06-15
    Description: ABSTRACT Mapping the Middle to Upper Pleistocene Rhine–Meuse sequence in the southern North Sea based on new core and seismic data has allowed a detailed palaeoenvironmental re-assessment. An integrated seismo-lithostratigraphic and malacological biostratigraphic framework is correlated with the optically stimulated luminescence-dated Rhine–Meuse sequence onshore. The data point to a dynamic interplay of fluvial and marine systems in the southern part of the North Sea driven by longer-term (〉100 ka) tectonic and epeirogenic processes and shorter-term (〈10 ka) climatic processes. The final permanent breaching of the Cretaceous chalk at the Strait of Dover during the Saalian (Marine Isotope Stage 6, MIS 6) ice age led to the formation of the ‘Eurogeul’ belt, a gravelly sand belt that represents the largest concentration of gravelly fluvial sediments in the southern North Sea. The formation and preservation of the Rhine–Meuse sequence is related to long-term (〉100 ka) uplift of the Wealden–Artois synclinorium and compaction-driven subsidence of Tertiary shales within the Voorne Trough. The dominant erosive sedimentary signatures within the Rhine–Meuse sequence resulted through shorter-term (〈10 ka) interplay of Pleistocene transgressions, glaciations and the permanent breaching of the Cretaceous chalk at the Strait of Dover by the Palaeo-Channel river during the Saalian (MIS 6).
    Print ISSN: 0267-8179
    Electronic ISSN: 1099-1417
    Topics: Geography , Geosciences
    Published by Wiley-Blackwell
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  • 8
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    A search strategy to identify studies on the prognosis of work disability: a diagnostic test framework (2015)
    BMJ Publishing
    In: BMJ Open
    Details
    Publication Date: 2015-05-21
    Description: Objective Searching the medical literature for evidence on prognosis is an important aspect of evidence-based disability evaluation. To facilitate this, we aimed to develop and evaluate a comprehensive and efficient search strategy in PubMed, to be used by either researchers or practitioners and that will identify articles on the prognosis of work disability. Methods We used a diagnostic test analytic framework. First, we created a reference set of 225 articles on the prognosis of work disability by screening a total of 65 692 titles and abstracts from10 journals in the period 2000–2009. Included studies had a minimum follow-up of 6 months, participants in the age of 18–64 with a minimum sick leave of 4 weeks or longer or having serious activity limitations in 50% of the cases and outcome measures that reflect impairments, activity limitations or participation restrictions. Using text mining methods, we extracted search terms from the reference set and, according to sensitivity and relative frequency, we combined these into search strings. Results Both the research and the practice search filter outperformed existing filters in occupational health, all combined with the Yale-prognostic filter. The Work Disability Prognosis filter for Research showed a comprehensiveness of 90% (95% CI 86 to 94) and efficiency expressed more user-friendly as Number Needed to Read=20 (95% CI 17 to 34). Conclusions The Work Disability Prognosis filter will help practitioners and researchers who want to find prognostic evidence in the area of work disability evaluation. However, further refining of this filter is possible and needed, especially for the practitioner for whom efficiency is especially important.
    Keywords: Open access, Epidemiology, Evidence based practice, Occupational and environmental medicine, Public health
    Electronic ISSN: 2044-6055
    Topics: Medicine
    Published by BMJ Publishing
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  • 9
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    Who knows the risk? Challenge to improve education and knowledge infrastructure for workers and companies (2015)
    BMJ Publishing Group
    Details
    Publication Date: 2015-07-17
    Description: The large-scale study of Dragano, et al 1 informs us about the knowledge of workers about health and safety risks at their job, a subject often taken for granted. The topic is related to the responsibility of employers to provide health and safety instructions to their employees, reinforced by legal obligations as specified in the European Framework Directive on Safety and Health (1989). Surprisingly, there is not much valid information on this subject, and evaluation studies are scarce. In this study, the knowledge of employees in 27 European Union (EU) countries has been evaluated, using the European Working Conditions Survey in 2010 and a few other sources. The central question of the study was "Regarding the health and safety risks related to performance of your job, how well informed would you say you are". About 10% of the workers reported that they were ‘not very well’ or ‘not...
    Print ISSN: 1351-0711
    Electronic ISSN: 1470-7926
    Topics: Medicine
    Published by BMJ Publishing Group
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  • 10
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    Beneficial Outcome of Losartan Therapy Depends on Type of FBN1 Mutation in Marfan Syndrome [Original Articles] (2015)
    American Heart Association (AHA)
    Details
    Publication Date: 2015-04-22
    Description: Background— It has been shown that losartan reduces aortic dilatation in patients with Marfan syndrome. However, treatment response is highly variable. This study investigates losartan effectiveness in genetically classified subgroups. Methods and Results— In this predefined substudy of COMPARE, Marfan patients were randomized to daily receive losartan 100 mg or no losartan. Aortic root dimensions were measured by MRI at baseline and after 3 years. FBN1 mutations were classified based on fibrillin-1 protein effect into (1) haploinsufficiency, decreased amount of normal fibrillin-1, or (2) dominant negative, normal fibrillin-1 abundance with mutant fibrillin-1 incorporated in the matrix. A pathogenic FBN1 mutation was found in 117 patients, of whom 79 patients were positive for a dominant negative mutation (67.5%) and 38 for a mutation causing haploinsufficiency (32.5%). Baseline characteristics between treatment groups were similar. Overall, losartan significantly reduced aortic root dilatation rate (no losartan, 1.3±1.5 mm/3 years, n=59 versus losartan, 0.8±1.4 mm/3 years, n=58; P =0.009). However, losartan reduced only aortic root dilatation rate in haploinsufficient patients (no losartan, 1.8±1.5 mm/3 years, n=21 versus losartan 0.5±0.8 mm/3 years, n=17; P =0.001) and not in dominant negative patients (no losartan, 1.2±1.7 mm/3 years, n=38 versus losartan 0.8±1.3 mm/3 years, n=41; P =0.197). Conclusions— Marfan patients with haploinsufficient FBN1 mutations seem to be more responsive to losartan therapy for inhibition of aortic root dilatation rate compared with dominant negative patients. Additional treatment strategies are needed in Marfan patients with dominant negative FBN1 mutations. Clinical Trial Registration— http://www.trialregister.nl/trialreg/index.asp ; Unique Identifier: NTR1423.
    Keywords: Clinical genetics, ACE/Angiotension receptors, Valvular heart disease, Pediatric and congenital heart disease, including cardiovascular surgery
    Print ISSN: 1942-325X
    Electronic ISSN: 1942-3268
    Topics: Medicine
    Published by American Heart Association (AHA)
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