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  • 1
    Electronic Resource
    Electronic Resource
    Amsterdam : Elsevier
    Phytochemistry 35 (1994), S. 1215-1219 
    ISSN: 0031-9422
    Keywords: Bupleurum falcatum ; Cell suspension culture ; Lonicera japonica ; Polygonum tinctorium ; Solidago altissima ; biotransformation ; eudesmane ; germacrone ; guaiane ; sesquiterpene
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Amsterdam : Elsevier
    Phytochemistry 35 (1994), S. 1215-1219 
    ISSN: 0031-9422
    Keywords: Bupleurum falcatum ; Cell suspension culture ; Lonicera japonica ; Polygonum tinctorium ; Solidago altissima ; biotransformation ; eudesmane ; germacrone ; guaiane ; sesquiterpene
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Amsterdam : Elsevier
    Comparative Biochemistry and Physiology -- Part B: Biochemistry and 83 (1986), S. 45-49 
    ISSN: 0305-0491
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Springer
    Mineralogy and petrology 44 (1991), S. 213-234 
    ISSN: 1438-1168
    Source: Springer Online Journal Archives 1860-2000
    Topics: Geosciences
    Description / Table of Contents: Zusammenfassung Der Shiribeshi Seamount liegt östlich des Okushiri Rückens im nordöstlichen Japanischen Meer. Gesamtgesteins K-Ar Alter von Olivin-Augit-Andesiten von diesem Seamount ergeben Werte von 0,9 ± 0,2 Ma (Tsuchiya et al., 1989), und weisen darauf hin, daß Shiribeshi ein quartärer Vulkan im back-arc Bereich nahe dem Kreuzungspunkt des nordostjapanischen und des Kurilen-Inselbogens ist. Er besteht aus Gesteinen, deren Zusammensetzung von Basalt bis Rhyolit reicht. Petrographische Daten von 25 Proben, die von vier submarinen Lokationen durch Dredging aufgesammelt wurden, weisen auf eine typische kalk-alkalische Inselbogenzusammensetzung hin. Die Verbreitung von inkompatiblen Elementen, die unter anderem K, Rb, Sr, Nb, P, Ti, Y und Zr umfassen, in 16 representativen Proben wird zusammen mit denen von quartären vulkanischen Gesteinen aus dem nordöstlichen Japanischen und den Kurilen-Inselbogen diskutiert; dabei wird Variationen der Zusammensetzung über die Bögen hinweg besondere Beachtung geschenkt. Die so ermittelte Zusammensetzung des primären Magmas des Shiribeshi Vulkans wird durch höhere inkompatible Elementgehalte und höhere Zr/Y Verhältnisse charakterisiert, wenn man sie mit primären Magmen an der vulkanischen Stirn des Inselbogens vergleicht. HFS Element-Konzentrationen lassen erkennen, daß der Grad teilweiser Aufschmelzung für drei primäre Magmen von Oshima-Oshima, Shiribeshi und Rishiri im nordöstlichen Japanischen Meer graduell mit zunehmender Entfernung von der vulkanischen Stirm abnimmt. Die Gehalte an LIL Elementen und besonders an K und Rb sind in dem primären Magma des Rishiri Vulkans, der weit von der vulkanischen Front entfernt liegt, höher als in den zwei anderen primären Magmen. Dies weist darauf hin, daß LIL/HFS Verhältnisse (oder der Beitrag von LIL Elementen, die aus subduzierter ozeanischer Kruste stammen) am Rishiri Vulkan ein Minimum erreichen. Ein Basalt und drei Andesite von Shiribeshi zeigen87Sr/86Sr Verhältnisse von 0,70297 bis 0,70300; dies läßt erkennen, daß die Quelle des Magmas für Shiribeshi etwas mehr an87Sr angereichert war, als dieN-Typ Quelle.
    Notes: Summary Shiribeshi Seamount is located to the east of the Okushiri Ridge, in the northeast Japan Sea. Whole rock K-Ar age of olivine-augite andesite dredged from the Seamount was determined to be 0.9 ± 0.2 Ma (Tsuchiya et al., 1989), indicating that Shiribeshi Seamount is a Quaternary volcano in the back-arc region off the junction of the Northeast Japan and Kurile arcs. Shiribeshi volcano is composed of basalt to rhyolite, which show a typical island arc calc-alkaline nature on the basis of petrographical characteristics of 95 samples dredged from four sites. Abundances of incompatible elements including K, Rb, Sr, Nb, P, Ti, Y and Zr in 16 representative rocks are discussed, together with those in the Quaternary volcanic rocks from the NE Japan and Kurile arcs in terms of compositional variation across the arcs. The estimated composition of the primary magma of Shiribeshi volcano is characterized by higher incompatible element contents and a higher Zr/Y ratio than primary magmas in the volcanic front side. Based on HFS element concentrations the degree of partial melting for three primary magmas of Oshima-Oshima, Shiribeshi and Rishiri volcanoes in the northeast Japan Sea may decrease gradually with increasing distance from the volcanic front. However, LIL element contents, especially K and Rb are lower in the primary magma of Rishiri volcano located far from the volcanic front than in the remaining two primary magmas, which would imply that LIL/HFS ratios (or degree of contribution of LIL elements originating from the subducted oceanic crust) become minimal at Rishiri volcano. One basalt and three andesites from Shiribeshi volcano have the restricted range of low87Sr/86Sr ratios of 0.70297–0.70300, which indicates that the magma source for Shiribeshi volcano may be slightly more enriched in Sr isotopic compositions than theN-type MORB source.
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  • 5
    Electronic Resource
    Electronic Resource
    s.l. ; Stafa-Zurich, Switzerland
    Solid state phenomena Vol. 69-70 (Aug. 1999), p. 73-82 
    ISSN: 1662-9779
    Source: Scientific.Net: Materials Science & Technology / Trans Tech Publications Archiv 1984-2008
    Topics: Physics
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    Amsterdam : Elsevier
    Nuclear Inst. and Methods in Physics Research, B 80-81 (1993), S. 1380-1383 
    ISSN: 0168-583X
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Physics
    Type of Medium: Electronic Resource
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  • 7
    ISSN: 1437-7772
    Keywords: Key words Fadrozole ; Leuprorelin acetate ; Aromatase activity ; Cell proliferation ; SK-BR-3
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Background. In recent years, aromatase inhibitors have been used to treat hormone-dependent breast cancer in postmenopausal women. Although gonadotropin-releasing hormone (GnRH) agonists inhibit the growth of breast cancers by estrogen deprivation, it is not known whether GnRH agonists have a direct effect on breast cancer cells. In the present study, we examined the direct effect of a GnRH agonist (leuprorelin acetate) on aromatase activity in a human breast cancer cell line, SK-BR-3. We also studied the synergistic effect of fadrozole (an aromatase inhibitor) and leuprorelin acetate on aromatase activity and cell proliferation in SK-BR-3 cells. Methods. Aromatase activity was determined by measuring [3H] water released upon the conversion of [1β-3H] androstenedione to estrone. Cell proliferation was estimated by determining the incorporation of 5-bromo-2′-deoxyuridine in cellular DNA (cell proliferation assay system). Results. Aromatase activity in SK-BR-3 was inhibited by fadrozole. In addition, SK-BR-3 aromatase activity was inhibited by leuprorelin acetate. Stimulation of cell proliferation by estradiol (10 nM) and testosterone (20 nM) was almost completely inhibited by the addition of an estrogen receptor antagonist, ICI 182780 (10 nM), and fadrozole (1 nM). When both these compounds were added, the most potent inhibition of aromatase activity (fadrozole, 0.1 nM; leuprorelin acetate, 1 nM) and cell proliferation (fadrozole, 10 nM; leuprorelin acetate, 100 nM) was observed. Conclusions. These results lead us to the conclusion that combination therapy with an aromatase inhibitor and a GnRH agonist may provide a new treatment for both pre- and postmenopausal patients with hormone-dependent breast cancer.
    Type of Medium: Electronic Resource
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  • 8
    ISSN: 1432-0533
    Keywords: Amyotrophic lateral sclerosis ; Ophthalmoplegia ; Respirator ; Multisystem degeneration ; Basophilic inclusion body
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary We describe two patients with sporadic amyotrophic lateral sclerosis (ALS), who had developed progressive external ophthalmoplegia of a predominantly supranuclear type while they survived on respirators, and displayed histopathological abnormalities both typical and atypical of ALS. Patient 1 was a 43-year-old man with ALS of 5-year duration, who had initially exhibited fulminant ALS, and remained on a respirator for 4 years. Patient 2 was a 51-year-old man with ALS of 13-year duration, who remained on a respirator for 8 years. Both patients died in a “totally locked-in state”. Autopsy of both patients revealed not only histopathological abnormalities consistent with ALS, but also multisystem degeneration which involved the pontine tegmentum, substantia nigra, Clarke's dorsal nuclei and spinocerebellar tracts. In addition, Patient 2 displayed intracyto-plasmic neuronal basophilic inclusion bodies which exhibited marked immunoreactivity to anti-ubiquitin antibodies. Our case reports indicate that the longer survival which is possible through the use of respirators may make one subgroup of ALS patients prone to develop atypical clinical and neuropathological features which are not observed during the natural cours of ALS.
    Type of Medium: Electronic Resource
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  • 9
    Electronic Resource
    Electronic Resource
    Springer
    Immunogenetics 50 (1999), S. 363-365 
    ISSN: 1432-1211
    Keywords: Key words IKKα ; Polymorphism ; Okasitis ; Rheumatoid arthritis ; Systemic lupus erythematosus ; Crohn's disease
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Type of Medium: Electronic Resource
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  • 10
    ISSN: 1432-1211
    Keywords: Key words CD22 ; Polymorphism ; Systemic lupus erythematosus ; Rheumatoid arthritis ; Japanese
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract  CD22, a member of the immunoglobulin superfamily, is a B-cell transmembrane glycoprotein that acts as an accessory-signaling component of the B-cell antigen receptor (BCR). Recent evidence indicating the role of CD22 as a negative regulator of BCR signal transduction prompted us to test the possibility that genetic variations of human CD22 may be associated with autoimmune diseases. In this study, variation screening of the entire CD22 coding region was performed, and possible association with rheumatic diseases was tested, using the genomic DNA from 207 healthy Japanese individuals, 68 patients with systemic lupus erythematosus (SLE), and 119 patients with rheumatoid arthritis (RA). Through the variation screening, seven non-synonymous and four synonymous substitutions were identified. In addition, single base substitutions were found in two introns flanking exon-intron junctions. Among these variations, Q152E substitution within the second extracellular domain was observed with a marginally higher frequency in the patients with SLE (3/68, 4.4%) than that in healthy individuals (1/207, 0.5%) (P=0.048. SLE vs healthy individuals), although this difference was no longer significant after correction for the number of comparisons (Pc=0.62). No significant association was observed between any of the variations and RA. These findings indicate that a number of genetic variants are present in CD22, and suggest that CD22 could be considered a candidate for the susceptibility genes to autoimmune diseases.
    Type of Medium: Electronic Resource
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