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  • 1
    Electronic Resource
    Electronic Resource
    Immunohistochemical localization of bone morphogenetic protein (BMP) in calcifying fibrous epulis (1993)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of oral pathology & medicine 22 (1993), S. 0 
    Details
    ISSN: 1600-0714
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Immunohistochemical detection of bone morphogenetic protein (BMP) in calcifying fibrous epulis was performed to elucidate the biological process of ossification and cemento-ossification. In a total 25 cases, 15 (60%) showed positive BMP staining in bone forming areas. Histopathological features of developing hard tissues were varied, consisting of structures such as woven bone and cemento-osseous formations. BMP immunostaining was limited to osteoblasts and fibrous connective tissue surrounding the bone matrix. BMP was concentrated in the periodontal fibres and in dense fibrous structures in the cemento-osseous masses. On the basis of histopathological and immunohistochemical features, the histogenesis of ossifying and cemento-ossifying processes appear to be of two possible origins; the excessive proliferation of periodontal ligament and a meta-plastic process occurring in the connective tissue fibres (non-periodontal in origin), with the former being more common.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1600-0714.1993.tb00131.x
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  • 2
    Electronic Resource
    Electronic Resource
    A SNP in the ABCC11 gene is the determinant of human earwax type (2006)
    [s.l.] : Nature Publishing Group
    Nature genetics 38 (2006), S. 324-330 
    Details
    ISSN: 1546-1718
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Medicine
    Notes: [Auszug] Human earwax consists of wet and dry types. Dry earwax is frequent in East Asians, whereas wet earwax is common in other populations. Here we show that a SNP, 538G → A (rs17822931), in the ABCC11 gene is responsible for determination of earwax type. The AA genotype corresponds to dry earwax, ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/ng1733
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  • 3
    Electronic Resource
    Electronic Resource
    Carcinoma in gastric hyperplastic polyps (1996)
    Springer
    Digestive diseases and sciences 41 (1996), S. 377-386 
    Details
    ISSN: 1573-2568
    Keywords: hyperplastic polyps ; malignant changes ; cancer foci ; dysplasia ; adenocarcinoma ; intestinal metaplasia
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract One-hundred twelve hyperplastic polyps were analyzed. The aim was to study their malignant transformation. Among them, four hyperplastic polyps harbored adenocarcinoma; two were from our own institution (1.8%). The majority were pedunculated and located in the antrum with an average of 14.5 mm in diameter. The four polyps bore well-differentiated adenocarcinoma. Dysplasia and intestinal metaplasia were detected in two and three polyps, respectively. The cancer and dysplastic foci shared the same type of neutral and acid mucosubstances. p53 oncoprotein was positive in three cancer foci and in the dysplastic areas, and nucleolar organizer region counts were higher in the cancer foci. In conclusion, hyperplastic polyps have malignant potential. Such possibility increases in polyps larger than 14.5 mm. In our cases, the carcinoma foci may have arisen from dysplastic areas. Once the neoplastic changes occur, the cancer cells proliferate and behave as other adenocarcinomas of the stomach.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02093832
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  • 4
    Electronic Resource
    Electronic Resource
    Significance of Angiogenic Factors in Liver Metastatic Tumors Originating from Colorectal Cancers (1998)
    Springer
    Digestive diseases and sciences 43 (1998), S. 2634-2640 
    Details
    ISSN: 1573-2568
    Keywords: VASCULAR ENDOTHELIAL GROWTH FACTOR ; CD34 ; LIVER METASTASIS ; COLORECTAL CARCINOMAS
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract We examined the expression of vascularendothelial growth factor (VEGF) and microvessel countsexpressed by CD34 staining in 39 patients with primaryand 44 patients with metastatic liver tumors ofmetastatic colorectal carcinoma, and 29 patients withnonmetastatic colorectal carcinoma as control in orderto determine their value in the evaluation of prognosisand recurrence after hepatectomy. Microvessel counts in primary colorectal carcinomas of themetastatic group were significantly higher than those incontrol (P 〈 0.05). Neither factor correlated withany clinicopathological feature of primary or metastatic liver carcinomas. Higher microvessel counts inmetastatic liver tumors tended to be associated with ashorter disease-free interval to second recurrence inthe remaining liver (P = 0.069) and were significantly associated with poor prognosis afterhepatectomy (P 〈 0.05). We conclude that microvesselcount is an important marker of liver metastatasis andprognosis in patients with colorectal carcinoma treated with hepatectomy.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1026643009152
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  • 5
    Electronic Resource
    Electronic Resource
    Dextran Sulfate Sodium-Induced Colitis in Immunodeficient Rats (2000)
    Springer
    Digestive diseases and sciences 45 (2000), S. 2320-2326 
    Details
    ISSN: 1573-2568
    Keywords: ulcerative colitis ; dextran sulfate sodium ; immunodeficiency ; spontaneously hypertensive rats
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract To examine the morphology of colitis and study the role of the immune system in colitis, we compared colitis in immunocompetent Wistar-Kyoto rats with that in spontaneously hypertensive rats, known to have T-cell dysfunction. Rats were treated with 3% dextran sulfate in drinking water for periods ranging from 3 to 60 days. Diarrhea developed earlier and was associated with a more severe weight loss in Wistar-Kyoto rats than spontaneously hypertensive rats. The morphologic findings (flattening of the gland epithelium, gland dropout and ulceration) in spontaneously hypertensive rats were milder than in Wistar-Kyoto rats. Only spontaneously hypertensive rats survived 60 days of treatment; the findings included ulceration, crypt distortion, and inflammatory pseudopolyp formation. Immunostaining for B-cell, T-cell, and macrophage markers showed no difference in the distribution of these cells in the mucosa of Wistar-Kyoto rats and spontaneously hypertensive rats. Spontaneously hypertensive rats with T-cell dysfunction develop dextran sulfate sodium-induced colitis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1005678606273
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  • 6
    Electronic Resource
    Electronic Resource
    Autopsy case of colocalized tumors of hepatocellular carcinoma and malignant lymphoma (1996)
    Springer
    Journal of gastroenterology 31 (1996), S. 129-132 
    Details
    ISSN: 1435-5922
    Keywords: double cancer ; hepatocellular carcinoma ; malignant lymphoma
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract We present a rare case of colocalized tumors of hepatocellular carcinoma (HCC) and malignant lymphoma in the liver and bone marrow. A 64-year-old man with hepatitis B virus (HBV)-induced cirrhosis was admitted after detection of elevated serum α-fetoprotein level. He was diagnosed as having HCC and treated with chemotherapy and radiotherapy, but the size of the tumors did not diminish. After 11 months' hospitalization, he died due to rupture of esophageal varices. Autopsy revealed two heterogenic malignant tumors, HCC and malignant lymphoma (B cell type), in the liver. These tumors showed colocalization in the liver and bone marrow. The carcinogenetic process of colocalized tumors of HCC and lymphoma was not clarified, but the possibility that persistent HBV infection play a role in promoting hepatocarcinogenic and hematopoietic tumor growths in the reticuloendothelial organs could not be excluded.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01211200
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