Note: Supramolecular Systems in Biomedical Fields -- Contents -- Chapter 1 Introduction -- 1.1 Sensing/Diagnostics/Imaging -- 1.2 Interaction with Proteins and Nucleic Acids -- 1.3 Drug Protection, Release and Targeting, Gene Delivery -- References -- Chapter 2 Signalling Techniques in Supramolecular Systems -- 2.1 Introduction -- 2.1.1 Background -- 2.1.2 Signal Ampli cation in Nature -- 2.1.3 Biological Assays -- 2.1.4 Signalling Strategies in Synthetic Systems -- 2.2 DNA Detection -- 2.2.1 Catalysis -- 2.2.2 Multivalency -- 2.2.3 Catalysis and Multivalency -- 2.3 Small (bio)Molecule Detection -- 2.3.1 Catalysis -- 2.3.2 Multivalency -- 2.4 Protein Detection -- 2.4.1 Catalysis -- 2.4.2 Multivalency -- 2.5 Conclusions -- Acknowledgement -- References -- Chapter 3 Metal Ion Sensing for Biomedical Uses -- 3.1 Introduction -- 3.2 Sensing Mechanisms -- 3.2.1 Photoinduced Electron Transfer (PET) -- 3.2.2 The State-of-the-Art in Point-of-Care Technology -- 3.3 Alkali and Alkaline Earth Ion Chemosensors -- 3.3.1 Sodium (Na+) -- 3.3.2 Potassium (K+) -- 3.3.3 Calcium (Ca2+) -- 3.3.4 Magnesium (Mg2+) -- 3.3.5 Lithium (Li+) -- 3.4 Heavy Metal Ion Chemosensors -- 3.4.1 Iron (Fe3+) -- 3.4.2 Zinc (Zn2+) -- 3.4.3 Copper (Cu+ and Cu2+) -- 3.4.4 Mercury (Hg2+), Cadmium (Cd2+) and Lead (Pb2+) -- 3.5 Actinide and Lanthanide Ion Chemosensors -- 3.6 Strategies for Multi-Analyte Sensing -- 3.6.1 'Lab-on-a-Molecule' Systems -- 3.6.2 One Receptor for Multiple Analytes -- 3.7 Summary and Outlook -- Acknowledgements -- References -- Chapter 4 Complexation of Biomedically Important Organic Compounds -- 4.1 Introduction -- 4.2 Amines/Neurotransmitters/Catecholamines -- 4.3 Biologically Important Acids -- 4.3.1 Amino Acids -- 4.4 Peptides -- 4.5 Nucleotides -- 4.6 Ureas, Biotin and Barbiturates -- 4.7 Carbohydrates -- 4.8 Steroids, Bile Acids, Prostaglandins -- 4.9 Alkaloids. , 4.10 Antibiotics and Toxins -- Acknowledgement -- References -- Chapter 5 Cyclodextrins for Pharmaceutical and Biomedical Applications -- 5.1 Cyclodextrins: The Early Times -- 5.2 First and Second Generation Cyclodextrins in Pharmaceutical Formulations: Improving Drug Solubility and Bioavailability -- 5.3 Third-generation CDs: Molecular Shuttles for Site-speci c Drug Delivery -- 5.4 Cyclodextrin Polymers: Increasing the Drug Loading Capacity -- 5.5 Cyclodextrin-based Poly(pseudo)rotaxanes for Sustained Drug Release -- 5.6 Cyclodextrin-Based Hydrogels and Nanogels as Controlled Drug Release Systems -- 5.7 CD-based Coatings and Films for Surgical Applications -- 5.8 Cyclodextrin-Based Nanoparticulated Devices from Amphiphilic CDs: Nanospheres and Nanocapsules -- 5.9 Polycationic Cyclodextrins as Non-viral Gene Vectors -- 5.10 Cyclodextrin-Based Hybrid Nanosystems: Programmable Nanocontainers -- 5.11 Cyclodextrin-Based Therapeutics -- 5.11.1 Cyclodextrins as Regulators of Cholesterol Metabolism -- 5.11.2 Cyclodextrins as Anti-infective Agents -- 5.11.3 Cyclodextrins as Pharmacological Chaperones in the Prevention and Treatment of Folding Diseases -- 5.11.4 Multivalent Cyclodextrin Conjugates to Control Carbohydrate-Protein Interactions -- 5.11.5 Cyclodextrin-Based Antitoxins -- 5.11.6 Cyclodextrin-Based Antagonists of Neuromuscular Blocking Drugs -- 5.11.7 Cyclodextrin-Based Sensitizers in Photodynamic Therapy -- 5.12 Cyclodextrin-Based Sensing Devices -- 5.12.1 Cyclodextrin-Based Pathogen and Allergen Sensors -- 5.12.2 Cyclodextrin-Based Nucleotide Sequencers -- 5.13 Conclusion and Perspectives -- Acknowledgements -- References -- Chapter 6 Interactions of Calix[n]arenes and Other Organic Supramolecular Systems with Proteins -- 6.0 Introduction -- 6.1 Soluble Proteins -- 6.1.1 Albumins -- 6.1.2 Enzymes -- 6.1.3 Blood Coagulation Cascade Proteins. , 6.1.4 Insulin -- 6.1.5 Signal Proteins-Histones -- 6.1.6 Proteins Associated with Neurodegenerative Diseases -- 6.1.7 Prostate-speci c Antigen (PSA) -- 6.2 Membrane Proteins -- 6.2.1 Transport Proteins -- 6.2.2 Peripheral Proteins -- 6.2.3 C-type Lectin Family -- 6.3 Conclusion -- References -- Chapter 7 Cucurbiturils in Drug Delivery And For Biomedical Applications -- 7.1 Introduction -- 7.2 Factors Governing the Formation, Stability, and Properties of CucurbiturilGuest Complexes -- 7.3 Design of Cucurbituril Derivatives and Analogues with Improved Properties -- 7.4 Investigated Drug Molecules with Cucurbiturils as Macrocyclic Hosts -- 7.4.1 Anti-pathogenic Agents -- 7.4.2 Anti-neoplastic Agents -- 7.4.3 Antagonist Agents -- 7.4.4 Enzyme Inhibitors -- 7.4.5 Ocular Drugs -- 7.4.6 Vitamins and Hormones -- 7.4.7 Anti-tuberculosis Agents -- 7.4.8 Neurotransmitters and Neuromuscular Blockers -- 7.4.9 Local Anaesthetics -- 7.4.10 Other Investigated Drug Molecules -- 7.5 Release of Drug Molecules from the Cavity of Cucurbiturils and Related Microheterogeneous Systems -- 7.5.1 Drug Release from Cucurbiturils -- 7.5.2 Drug Release from Cucurbituril-Based Microheterogeneous Systems -- 7.6 Cucurbituril-Based Assemblies as Targeted Drug Delivery Systems -- 7.7 Studies of Cucurbiturils and their Drug Complexes in Vitro and in vivo -- 7.7.1 Penetration of Cucurbiturils and their Complexes into Cells -- 7.7.2 Cytotoxicity and Toxicity of Cucurbiturils and their Functionalized Forms -- 7.7.3 Activities of CBDrug Complexes in Vitro -- 7.7.4 Activities of CBDrug Complexes in Vivo -- 7.7.5 Other in Vivo Rami cations of Cucurbiturils -- 7.8 Pharmaceutical Formulation -- 7.9 Other Biologically Relevant Applications Based on Cucurbiturils -- 7.9.1 Cucurbituril-Based Recognition of Biologically Important Species. , 7.9.2 Application of Cucurbituril Host-Guest Complexes for Analytical and Diagnostic Bioassays -- 7.9.3 Cucurbiturils for Bio-related Applications -- 7.10 Conclusions -- Acknowledgements -- References -- Chapter 8 Nucleic Acids as Supramolecular Targets -- 8.1 Introduction -- 8.2 General Binding Modes with Nucleic Acids -- 8.2.1 Groove Binding -- 8.2.2 Intercalation -- 8.2.3 Bis-intercalation -- 8.2.4 Quadruplexes -- 8.3 Biogenic Polyamine Interactions with DNA/RNA -- 8.4 Synthetic Linear Polyamines -- 8.5 Polyamine-Aryl Conjugates -- 8.6 Interactions of Polyamine and Polyamine- Conjugates with DNA G-Quadruplexes -- 8.7 Selection between DNA and RNA Grooves/ Cyclophanes Interacting with DNA and RNA/ Unfolding of Double Strands -- 8.8 Interaction of Polyamine Calixarenes with DNA/RNA -- 8.9 Supramolecular Gene Delivery Systems -- 8.9.1 Dendron-Based Polyamine Structures -- 8.10 DNA Cleavage by Metal-free Polyamines -- 8.11 Binding Modulation by pH, Metal Ions and Other Effectors -- 8.12 Selective DNA/RNA Cleavage with Metal Complexes -- 8.12.1 Complexes of First-row Transition Metal Ions and Zinc(II) -- 8.12.2 Lanthanide Complexes -- 8.13 DNA Bionanotechnology -- Acknowledgements -- References -- Chapter 9 Biomolecular Interactions of Platinum Complexes -- 9.1 Introduction -- 9.2 cis-Diamminedichloro Platinum(II)-Cisplatin -- 9.3 Cisplatin Derivatives -- 9.3.1 Initially Proposed Structure-Activity Relationships -- 9.4 Types of DNA Binding Interactions -- 9.4.1 Irreversible Covalent/Coordinative Binding -- 9.4.2 Reversible Intermolecular Associations -- 9.4.3 Groove Binders -- 9.4.4 Intercalation -- 9.5 Multinuclear Platinum(II) Compounds -- 9.6 Terpyridineplatinum(II)-Based Intercalators -- 9.6.1 Monointercalators -- 9.6.2 Ligand Substitution and Attached Groups -- 9.7 Platinum(II) Metallointercalators -- 9.8 Platinum(IV) Compounds -- 9.9 Other Metals. , 9.9.1 Ruthenium, Iridium, Osmium, Rhodium and Iron complexes -- 9.9.2 Copper Complexes -- 9.9.3 Titanium and Vanadium Complexes -- 9.9.4 Gold Complexes -- 9.9.5 Metal Mediated Base Pair Formation -- 9.10 Conclusion -- Acknowledgements -- References -- Chapter 10 Supramolecular Metal Complexes for Imaging and Radiotherapy -- 10.1 Introduction -- 10.2 Supramolecular Chemistry in Imaging -- 10.2.1 Magnetic Resonance Imaging -- 10.2.2 Optical Imaging -- 10.3 Supramolecular Chemistry in Radioimaging and Radiotherapy -- 10.3.1 Technetium -- 10.3.2 Gallium -- 10.3.3 Other Metal Ions -- References -- Chapter 11 Supramolecular Gels for Pharmaceutical and Biomedical Applications -- 11.1 Supramolecular Gel: De nition and Properties -- 11.2 Supramolecular Gels for Pharmaceutical and Biomedical Applications -- 11.2.1 Emerging Therapeutic Properties of Supramolecular Gels -- 11.2.2 Supramolecular Gels in Cell Culture and Tissue Engineering -- 11.2.3 Supramolecular Gels for Drug Delivery and Controlled Release -- 11.2.4 Other Biomedical Applications -- 11.3 Final Remarks -- References -- Chapter 12 Supramolecular Enzyme Assays -- 12.1 Introduction -- 12.2 Chemosensors -- 12.3 Membrane Transport -- 12.3.1 Transport Assays and Sensing Concepts -- 12.3.2 Synthetic Multifunctional Pores -- 12.3.3 Membrane-Active Polymers -- 12.4 Supramolecular Tandem Assays -- 12.4.1 Conceptual Approach -- 12.4.2 Substrate-Selective Tandem Assays -- 12.4.3 Kinetics, Progress Curves and Inhibition Constants -- 12.5 Extended Applications and Concepts -- 12.5.1 Coupled Enzyme Assays -- 12.5.2 Reactive Ampli ers -- 12.5.3 Biosensing and Chiral Discrimination -- 12.6 Summary and Conclusions -- References -- Chapter 13 Constitutional Dynamic Chemistry for Bioactive Compounds -- 13.1 Introduction -- 13.2 Applications of CDC for Bioactive Compounds. , 13.2.1 CDC with Reversible Disul de Reactions.

Note: Front Cover -- Contents -- Foreword -- Contributors -- Chapter 1: Introduction and Overview -- Chapter 2: Inorganic Analytes and Sensors -- Chapter 3: Organic and Biological Analytes -- Chapter 4: Potentiometric Ion Sensors : Host-Guest Supramolecular Chemistry in Ionophore-Based Ion-Selective Membranes -- Chapter 5: Supramolecular Self-Assembly Governed Molecularly Imprinted Polymers for Selective Chemical Sensing -- Chapter 6: Supramolecular Chromatography -- Chapter 7: Industrial and Environmental Applications : Separation and Purification -- Chapter 8: Chemomechanical Materials -- Chapter 9: Supramolecular Structures in Organic Electronics -- Chapter 10: Molecular Tectonics : An Approach to Crystal Engineering -- Chapter 11: Supramolecular Complex Design and Function for Photodynamic Therapy and Solar Energy Conversion via Hydrogen Production : Common Requirements for Molecular Architectures for Varied Light-Activated Processes -- Chapter 12: Supramolecular Polymers -- Chapter 13: Supramolecular Hydrogels for Soft Nanotechnology -- Chapter 14: Supramolecular Drug-Delivery Systems -- Chapter 15: Protein and Nucleic Acid Targeting -- Chapter 16: Gadolinium(III) Complexes-Based Supramolecular Aggregates as MRI Contrast Agents -- Chapter 17: Applications in the Food and Textile Industries -- Back Cover.