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  • 1
    Publication Date: 2013-12-20
    Keywords: Platelets and Thrombopoiesis
    Print ISSN: 0006-4971
    Electronic ISSN: 1528-0020
    Topics: Biology , Medicine
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  • 2
    Publication Date: 2016-11-25
    Description: Introduction Cerebral venous thrombosis (CVT) is a rare cerebrovascular condition accounting for 〈1% of all stroke cases and mainly affects young adults. Its genetic aetiology is not clearly elucidated. Methods and analysis To better understand the genetic basis of CVT, we have established an international biobank of CVT cases, Biorepository to Establish the Aetiology of Sinovenous Thrombosis (BEAST) which aims to recruit highly phenotyped cases initially of European descent and later from other populations. To date we have recruited 745 CVT cases from 12 research centres. As an initial step, the consortium plans to undertake a genome-wide association analysis of CVT using the Illumina Infinium HumanCoreExome BeadChip to assess the association and impact of common and low-frequency genetic variants on CVT risk by using a case–control study design. Replication will be performed to confirm putative findings. Furthermore, we aim to identify interactions of genetic variants with several environmental and comorbidity factors which will likely contribute to improve the understanding of the biological mechanisms underlying this complex disease. Ethics and dissemination BEAST meets all ethical standards set by local institutional review boards for each of the participating sites. The research outcomes will be published in international peer-reviewed open-access journals with high impact and visibility. The results will be presented at national and international meetings to highlight the contributions into improving the understanding of the mechanisms underlying this uncommon but important disease. This international DNA repository will become an important resource for investigators in the field of haematological and vascular disorders.
    Keywords: Open access, Genetics and genomics, Neurology
    Electronic ISSN: 2044-6055
    Topics: Medicine
    Published by BMJ Publishing
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  • 3
    ISSN: 1600-0765
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Apoptosis provides a mechanism for clearance of unwanted cells in a variety of situations in which programmed or physiological cell death occurs; but the premature death of defensive cells could promote infection, inflammation and concomitant disease. We detected high values of apoptosis in polymorphonuclear cells (PMN) elicited from crevicular sulci of smokers affected by adult periodontitis. To learn more about the effects of nicotine on the periodontal environment, we studied its ability to modulate the apoptosis of two phagocytic lines, PMN and mononuclear cells, which are continuously recruited from gingival vessels to prevent or control plaque extension. Brief exposure of PMN to nicotine concentrations ranging from 0.01 to 0.3% shortened, in a dose-dependent relationship, the lag culture time required to observe at fluorescent microscopy the morphological traces of apoptosis. These observations were confirmed by specific tools of apoptosis: DNA fragmentation on gel electrophoresis and expression of the apoptosis-signaling receptor Fas/Apo-1. The apoptotic effect excited by nicotine on these first line defensive cells may be an important feature of the pathogenesis of periodontal disease. As for mononuclear leukocytes, nicotine was unable to induce apoptotic modifications on cells observed up to 72 h culture time, but the drug inhibited IL-1β release and procoagulant activity (PCA) expression. The conflicting role played by these lipopolysaccharide (LPS)-induced monocyte functions in the inflammatory process is a further intrigue in the mechanism by which nicotine compromises the oral health.
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    [s.l.] : Nature Publishing Group
    Nature 289 (1981), S. 282-285 
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Three representative sections from archaeological excavationsdemonstrate the principal characteristics of the entire eruptive sequence, assuming emplacement of pyroclastic flows, surges and lahars above the pumice bed, during the 30-h eruptive period. Data from more than 30 sections included in the ...
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    [s.l.] : Nature Publishing Group
    Nature 344 (1990), S. 142-144 
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    Springer
    Contributions to mineralogy and petrology 120 (1995), S. 159-169 
    ISSN: 1432-0967
    Source: Springer Online Journal Archives 1860-2000
    Topics: Geosciences
    Notes: Abstract  Glass inclusions in olivine and diopside phenocrysts from pyroclasts of various eruptions of Vesuvius are representative of the magmas that supplied the volcano in the last 4–5000 years. During this interval the volcano alternated between open conduit activity (e.g. 1944 and 1906 eruptions) with long pauses interrupted by Plinian and sub-Plinian eruptions (e.g. 3360 B.P. ”Avellino”, A.D. 79 ”Pompei”, A.D. 472 ”Pollena”). The eruptive behaviour was conditioned in all cases by the presence of shallow reservoirs: two cases are distinguished: (1) small and very shallow, 1906-type; (2) large and deeper Plinian – sub-Plinian magma chamber. Lapilli of 1906 lava fountains contain olivine (Fo89.5–90.4) including Cr-spinel [Cr/(Cr+Al)] (Cr#〉75) and volatile-K-rich tephritic glasses, which represent the first recognized Vesuvius primary magmas. Mg-poorer olivine (Fo83–89) also occurs in 1906 and 1944 products; it formed within the shallow reservoir, together with pyroxene and leucite, between 1200 and 1130° C, from K-tephritic melts (MgO=6–8 wt%). The Plinian and sub-Plinian pumices contain diopside, phlogopite and minor olivine (Fo85–87) representing adcumulates wrenched from the chamber walls. Glass inclusions in diopside (and some olivine) range from K-basalt to K-tephrite (MgO=6–8 wt%), with homogenization temperature of 1130–1170° C. They have been regarded as representative of the magmas supplying the Plinian-sub-Plinian chamber(s). The Avellino glass inclusions have K-basaltic compositions, contrasting with the mostly K-tephritic Pompei and Pollena inclusions. They display lower Cl and P contents with respect to the younger tephritic melts, and these variations should reflect primary features of the mantle-derived magmas. The primary and the near-primary Vesuvius magmas, as illustrated by melt inclusions, emphasize high K, P and volatile (H2O, Cl, F, S) contents, with high K2O/H2O (2–2.5), Cl/F (2.5) and Cl/S (2–3) ratios, consistent with a metasomatized mantle source, and distinguishing the Vesuvius potassic primary magmas from those of the northern part of the Roman Province.
    Type of Medium: Electronic Resource
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  • 7
    Electronic Resource
    Electronic Resource
    Springer
    Contributions to mineralogy and petrology 120 (1995), S. 159-169 
    ISSN: 1432-0967
    Source: Springer Online Journal Archives 1860-2000
    Topics: Geosciences
    Notes: Abstract Glass inclusions in olivine and diopside phenocrysts from pyroclasts of various eruptions of Vesuvius are representative of the magmas that supplied the volcano in the last 4–5000 years. During this interval the volcano alternated between open conduit activity (e.g. 1944 and 1906 eruptions) with long pauses interupted by Plinian and sub-Plinian eruptions (e.g. 3360 B.P. “Avellino”, A.D. 79 “Pompei”, A.D. 472 “Pollena”). The eruptive behaviour was conditioned in all cases by the presence of shallow reservoirs: two cases are distinguished: (1) small and very shallow, 1906-type; (2) large and deeper Plinian-sub-Plinian magma chamber. Lapilli of 1906 lava fountains contain olivine (Fo89.5–90.4) including Cr-spinel [Cr/(Cr+Al)] (Cr#〉75) and volatile-K-rich tephritic glasses, which represent the first recognized Vesuvius primary magmas. Mg-poorer olivine (Fo83–89) also occurs in 1906 and 1944 products; it formed within the shallow reservoir, together with pyroxene and leucite, between 1200 and 1130°C, from K-tephritic melts (MgO=6–8 wt%). The Plinian and sub-Plinian pumices contain diopside, phlogopite and minor olivine (Fo85–87) representing adcumulates wrenched from the chamber walls. Glass inclusions in diopside (and some olivine) range from K-basalt to K-tephrite (MgO=6–8 wt%), with homogenization temperature of 1130–1170°C. They have been regarded as representative of the magmas supplying the Plinian-sub-Plinian chamber(s). The Avellino glass inclusions have K-basaltic compositions, contrasting with the mostly K-tephritic Pompei and Pollena inclusions. They display lower C1 and P contents with respect to the younger tephritic melts, and these variations should reflect primary features of the mantle-derived magmas. The primary and the near-primary Vesuvius magmas, as illustrated by melt inclusions, emphasize high K, P and volatile (H2O, Cl, F, S) contents, with high K2O/H2O (2–2.5), Cl/F (2.5) and Cl/S (2–3) ratios, consistent with a metasomatized mantle source, and distinguishing the Vesuvius potassic primary magmas from those of the northern part of the Roman Province.
    Type of Medium: Electronic Resource
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  • 8
    ISSN: 1432-0819
    Source: Springer Online Journal Archives 1860-2000
    Topics: Geosciences
    Notes: Abstract Subsurface geothermal exploration has considerably added to our knowledge of the Latera volcanic complex. A syenitic body is located about 2 km below the present-day surface; K-Ar data point a 0.9 Ma age. The primary magma was a silica-saturated trachyte; undersaturated, hauyne-bearing products are found near the carbonatic wall-rocks and have been interpreted as reaction products. Subsurface data from deep drilling and geophysical surveys suggest that the Latera caldera resulted from three main successive collapse phases: (i) formation of an old caldera, now buried, related to the eruption of ignimbrites from the syenitic magma chamber; (ii) sinking of the eastern sector as a consequence of the formation of the nearby Bolsena caldera (∼0.3 Ma); (iii) multistage formation of the present Latera caldera (∼0.16 Ma).
    Type of Medium: Electronic Resource
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  • 9
    Electronic Resource
    Electronic Resource
    Springer
    Bulletin of volcanology 47 (1984), S. 359-370 
    ISSN: 1432-0819
    Source: Springer Online Journal Archives 1860-2000
    Topics: Geosciences
    Notes: Abstract Phenomena occurring since 1982 in the Phlegraean Fields, interpreted as precursors of a potential renewal of volcanic activity, have forced us to anticipate some conclusions of a volcanic-hazard study based on the reconstruction of past eruptions in the area, to serve as basis for civil defense preparedness plans. The eruptive history of the Phlegraean Fields suggests a progressive decrease with time in the strength of eruptive phenomena paralleling a migration of vents towards the center of the Phlegraean caldera. Studies concerning the volcanic risk zonation were therefore concentrated on activities during the last 4,500 years and two eruptions (Monte Nuovo and Agnano Monte Spina), that occurred in 1538 and 4,400 years B.P., respectively were selected as the «reference eruptions» from which possible eruption scenarios were drawn.
    Type of Medium: Electronic Resource
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  • 10
    Publication Date: 2017-04-04
    Description: We present here some criticism to the scientific content of the paper of Milia et al. [2007. The dark nature of Somma-Vesuvius volcano: evidence from the 3.5 ka B.P. Avellino eruption. Quaternary International, 173–174, 57–66] published in Quaternary International. Milia et al. (2007) interpreted seismic lines in the Gulf of Naples (southern Italy), and inferred the presence of deposits from a large debris avalanche which occurred just before the Avellino eruption of Somma-Vesuvius volcano. The authors supported their seismic profile interpretation with on-land stratigraphies and logs. However, we present here different on-land data that demonstrate the inconsistency of the occurrence of any debris avalanche before or after the Avellino eruption, and we provide also an alternative interpretation for the observed seismic facies offshore of Somma-Vesuvius.
    Description: Published
    Description: 102–109
    Description: 3.5. Geologia e storia dei sistemi vulcanici
    Description: JCR Journal
    Description: open
    Keywords: Somma-Vesuvius volcano ; Avellino eruption ; 04. Solid Earth::04.04. Geology::04.04.99. General or miscellaneous ; 04. Solid Earth::04.04. Geology::04.04.08. Sediments: dating, processes, transport ; 04. Solid Earth::04.04. Geology::04.04.10. Stratigraphy ; 04. Solid Earth::04.08. Volcanology::04.08.99. General or miscellaneous
    Repository Name: Istituto Nazionale di Geofisica e Vulcanologia (INGV)
    Type: article
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