Note: Title Page -- Preface -- Contents -- Historical Review of Irreversible Electroporation in Medicine -- Introduction -- The 18^{th} and 19^{th} Centuries -- First Half of the 20^{th} Century -- 1950 to 1970 -- 1970 to 1990 -- 1990 to 2000 -- 2000 to 2008 -- References -- Tissue Electroporation as a Bioelectric Phenomenon: Basic Concepts -- Introduction -- Overview of Basic Electricity Concepts -- Cells and Tissues in Electrical Terms -- Electroporation Threshold -- Time Course of Currents and Electric Fields during Electroporation Pulses -- Conductivity Changes Induced by Electroporation -- Effect of Electroporation on Other Bioelectric Phenomena -- References -- Experimental Studies on Irreversible Electroporation of Cells -- Introduction -- Pore Formation -- Resealing Process -- Factors That Affect the Uptake, Efficiency and Viability of the Cells -- Changes in the Cell Caused by Electroporation -- Irreversible Electroporation Studies in Mammalian Cells -- Discussion -- References -- Mechanism of Irreversible Electroporation in Cells: Insight from the Models -- Introduction -- Background: IRE in Planar Membranes -- Experimental Observations -- Theory of Electroporation in Planar Membranes: Pore Energy -- Mechanism of Membrane Rupture -- Revised Effect of the Transmembrane Potential on Pore Energy -- Dynamics of Membrane Rupture -- IRE in Cells under Voltage-Clamp Conditions -- IRE in Cells in External Electric Field -- Transmembrane Potential and Pore Creation -- Cell Deformation by the Field -- Effect of Pores on Membrane Tension -- Postshock Pore Shrinkage and Coarsening -- Membrane Tension-Induced Leakage through Pores -- Change in Ionic Concentrations and Colloidal-Osmotic Swelling -- Other Processes Affecting Irreversibility of Electroporation -- Possible Mechanisms of Cell Death during IRE -- Parameters of the Model. , References -- Thermal Aspects of Irreversible Electroporation -- Introduction -- Effects of Electroporation Fields -- Transmembrane Potential -- Electric Field Threshold -- Properties Change during Electroporation -- Joule Heating -- Thermal Regimes -- Determining the Temperature Distribution -- Derivation of Heat Diffusion Equation from 1^{st} Principles -- Bioheat Equation -- Bioheat Equation Transformation -- Non-dimensionalized Form of the Bioheat Equation -- Modeling for Treatment Planning -- Models -- Accuracy of 2D versus 3D -- Boundary Conditions -- Cell Constants -- Heat Dissipation -- Geometrical Considerations -- Special Considerations When Modeling Tissues -- Tissue Heterogeneity -- Temperature Dependent Properties -- Assessing Thermal Effects -- Damage Equation -- Analytical Model -- Analytical Results -- Equivalent Thermal Dose Equation -- Conclusion -- References -- Experimental Studies on Non-thermal Irreversible Electroporation in Tissue -- Introduction -- NTIRE of the Liver -- NTIRE of the Prostate -- NTIRE of the Heart and the Cardiovascular System -- NTIRE in the Treatment of Tumors -- Summary of Experimental Studies -- References -- Finite Element Modeling of in Vivo Electroporation -- Introduction -- Which Modeling Method to Use? -- Finite Element Method -- Geometrical Considerations -- Physical Considerations -- Biological Tissues -- Model Verification and Validation -- Summary -- References -- Optimization and Numerical Modeling in Irreversible Electroporation Treatment Planning -- Introduction -- A Brief Overview of Irreversible Electroporation Basics -- Radiation Therapy vs. Irreversible Electroporation Procedure -- Medical Imaging -- Delineation of Clinical Volumes and Definition of Dose Constraints -- Tissue Properties -- Dose Calculation Algorithms. , Multiphysics (Applicable to Irreversible Electroporation Only) -- Forward and Inverse Treatment Planning Procedure -- Tumor Ablation with Irreversible Electroporation Treatment Planning Examples -- Conclusions -- References -- The Place of the Electroporation-Based Antitumor Therapies in the Electrical Armamentarium against Cancer -- Introduction: Reversible and Irreversible « Electroporation » -- Antitumor Treatments Based on the Delivery of Electricity -- Worldwide Current Technologies -- Technologies Used in the Clinical Practice in Various Parts of the World -- Experimental Approaches -- Electrochemotherapy -- The Electrochemotherapy Concept -- ases of the Electrochemotherapy -- Electrochemotherapy in the Clinics -- The Complementarities of Electrochemotherapy and IRE Approaches -- Conclusion -- References -- Irreversible Electroporation: First Patient Experience Focal Therapy of Prostate Cancer -- Introduction -- Methods -- Results -- Discussion -- References -- Human Experience with Irreversible Electroporation -- Illustrations -- Irreversible Electroporation Systems for Clinical Use -- Introduction -- General Safety Remarks -- General Device Structure -- Design Issues -- Pulse Generation -- Pulse Transformer -- High Voltage Generator -- Speed Issue -- Variable Load -- Size Issue -- Software Architecture -- The Graphical User Interface -- Power Unit Control -- Regulation and Standards -- Conclusions -- References -- The Use of Irreversible Electroporation in Food Preservation -- The Need for Food Preservation -- Major Preservation Technologies -- Safety and Quality Loss -- Modern Need and Customer Demand -- Introduction to Irreversible Electroporation Theory and Applications -- Applications of Irreversible Electroporation in Food Industry -- Technology -- Process Factors. , Influence of a Kind of Microbial Contamination -- Product Parameters -- Hurdle Technology Implementation of IRE in Food Treatment -- IRE and Temperature Combination -- Combination of IRE and Microbial Agents -- Combination of IRE and High Pressure CO_{2} -- IRE and High Hydrostatic Pressure (HHP) -- Ultrasound and IRE Combination -- Ultraviolet Irradiation and IRE Combination -- Examples of Product Treatment -- Water -- Beer and Wine -- Grape Juice -- Apple Juice -- Orange Juice -- Tomato Juice -- Milk -- Yakju (Rice Wine) -- Egg Processing -- Green Tea -- Green Pea Soup -- Sour Cherry Juice, Peach and Apricot Nectars -- Future Research Needs -- References -- Author Index.