Keywords:
Molecular neurobiology.
;
Neurochemistry.
;
Electronic books.
Description / Table of Contents:
Solomon Snyder has been instrumental in the establishment of modern psychopharmacology. Science and Psychiatry is a collection of some of his best scientific papers from the past forty years, representing important advances in psychopharmacology and molecular biology.
Type of Medium:
Online Resource
Pages:
1 online resource (514 pages)
Edition:
1st ed.
ISBN:
9781585628827
URL:
https://ebookcentral.proquest.com/lib/geomar/detail.action?docID=5515025
DDC:
573.8/4
Language:
English
Note:
Cover -- Contents -- About the Author -- Foreword: Sol Snyder: Audacious Scientist, Leader of the Scientifice Community, and Remarkable Human Being! -- Introduction -- Part I: DISCOVERY AND CHARACTERIZATION OF THE OPIATE RECEPTOR -- Commentary: Radioligand Binding Methodologies: New Inventions, New Directions -- 1 Opiate Receptor: Demonstration in Nervous Tissue -- 2 Opiate Agonists and Antagonists Discriminated by Receptor Binding in Brain -- 3 Historical Review: Opioid Receptors -- Part II: CHARACTERIZATION OF THE ENKEPHALINS -- Commentary: The Discovery of Endogenous Opiates and Their Receptors: A Snyderian Saga of Skill and Judgment -- 4 Opiate Receptor in Normal and Drug Altered Brain Function -- 5 Morphine-Like Peptides in Mammalian Brain: Isolation, Structure Elucidation, and Interactions With the Opiate Receptor -- 6 Opioid Peptide Enkephalin: Immunohistochemical Mapping in Rat Central Nervous System -- Part III: DOPAMINE RECEPTORS AND INFLUENCES OF NEUROLEPTICS -- Commentary: Dopamine Receptor Binding and Its Therapeutics -- 7 Dopamine Receptor Binding Predicts Clinical and Pharmacological Potencies of Antischizophrenic Drugs -- 8 Antischizophrenic Drugs: Chronic Treatment Elevates Dopamine Receptor Binding in Brain -- 9 Dopamine Receptors, Neuroleptics, and Schizophrenia -- Part IV: DRUG EFFECTS EXPLAINED AS ACTIONS ON NEUROTRANSMITTER RECEPTORS -- Commentary: Perspectives on Simplicity and Discovery -- 10 Antischizophrenic Drugs and Brain Cholinergic Receptors: Affinity for Muscarinic Sites Predicts Extrapyramidal Effects -- 11 Tricyclic Antidepressants: Therapeutic Properties and Affinity for α-Noradrenergic Receptor Binding Sites in the Brain -- Part V: DRUG ACTIONS AND SEROTONIN RECEPTOR SUBTYPES.
,
Commentary: Clinical Data Stimulation of Basic Research: The Far-Reaching Clinical Significance of Serotonin Receptor Subtype Identification -- 12 Long-Term Antidepressant Treatment Decreases Spiroperidol-Labeled Serotonin Receptor Binding -- 13 Two Distinct Central Serotonin Receptors With Different Physiological Functions -- Part VI: INOSITOL PHOSPHATES AND ACTIONS OF LITHIUM -- Commentary: Lithium, Second Messengers, and Downstream Effects -- 14 Lithium Blocks a Phosphoinositide-Mediated Cholinergic Response in Hippocampal Slices -- 15 Solubilization, Purification, and Characterization of an Inositol Trisphosphate Receptor -- 16 Second Messenger Systems and Psychoactive Drug Action: Focus on the Phosphoinositide System and Lithium -- 17 Purified Inositol 1,4,5-Trisphosphate Receptor Mediates Calcium Flux in Reconstituted Lipid Vesicles -- Part VII: NITRIC OXIDE AS A NEUROTRANSMITTER -- Commentary: Just Say "Yes": Snyder's Approach to the Difficult Problem of NO -- 18 Nitric Oxide Mediates Glutamate-Linked Enhancement of cGMP Levels in the Cerebellum -- 19 Cloned and Expressed Nitric Oxide Synthase Structurally Resembles Cytochrome P-450 Reductase -- 20 Behavioral Abnormalities in Male Mice Lacking Neuronal Nitric Oxide Synthase -- Part VIII: D-AMINO ACIDS AS NEUROTRANSMITTERS -- Commentary: Disruptive Science: Incongruent Findings Lead to Novel Insights Into How the Brain Works -- 21 D-Aspartate Localizations Imply Neuronal and Neuroendocrine Roles -- 22 Serine Racemase: A Glial Enzyme Synthesizing D-Serine to Regulate Glutamate-N-Methyl-D-Aspartate Neurotransmission -- 23 Serine Racemase: Activation by Glutamate Neurotransmission via Glutamate Receptor Interacting Protein and Mediation of Neuronal Migration -- Part IX: NEURAL MESSENGERS OF CELL LIFE AND DEATH -- Commentary: Beyond Neurotransmitters.
,
24 Cytochrome c Binds to Inositol 1,4,5-Trisphosphate Receptors, Amplifying Calcium-Dependent Apoptosis -- 25 Bilirubin Benefits: Cellular Protection by a Biliverdin Reductase Antioxidant Cycle -- 26 S-Nitrosylated GAPDH Initiates Apoptotic Cell Death by Nuclear Translocation Following Siah1 Binding -- Part X: WHAT MAKES FOR CREATIVE DISCOVERY IN SCIENCE? -- Commentary: What Creates Creative Science and Scientists? -- 27 The Audacity Principle in Science -- Index -- A -- B -- C -- D -- E -- F -- G -- H -- I -- J -- K -- L -- M -- N -- O -- P -- Q -- R -- S -- T -- U -- V -- W -- Y -- Z.
Permalink
