Note: Förderkennzeichen BMBF 16KIS0130. - Verbund-Nummer 01152676 , Unterschiede zwischen dem gedruckten Dokument und der elektronischen Ressource können nicht ausgeschlossen werden

Note: Unterschiede zwischen dem gedruckten Dokument und der elektronischen Ressource können nicht ausgeschlossen werden , Förderkennzeichen BMBF 16BQ1014 [neu] - 01BQ1014 [alt]. - Verbund-Nr. 01080725. - Engl. Berichtsbl. u.d.T.: Final report on Quantum repeater platform by methods of quantum optics (QK_QuOReP), sub-project: Control and verification of quantum states in repeater components , Systemvoraussetzungen: Acrobat reader. , Zsfassungen in dt. u. engl. Sprache

Note: Cover -- Half title -- Title -- Copyright -- Contents -- Foreword -- Contributors -- Preface -- Part I Introduction -- 1 Quantum biology: introduction -- 1.1 Introduction -- 1.2 Excited states in biology -- 1.3 Light particles and tunnelling -- 1.4 Radical pairs -- 1.5 Questions for the present -- 1.6 Some wide-reaching questions -- 2 Open quantum system approaches to biological systems -- 2.1 Quantum mechanics concepts and notations -- 2.2 Open quantum systems: dynamical map approach -- 2.3 Open quantum systems: master equation approach -- 2.4 Formally exact QME -- 2.5 QME in the weak system-bath coupling limit -- 2.6 QME for weak coupling to a Markovian bath -- 2.7 QMEs beyond weak and Markovian limits -- 2.8 Second-order cumulant time-non-local equation and its hierarchical representation -- 2.9 A post-perturbative time convolution QME -- 2.10 QME in the polaron picture -- 2.11 Path integral techniques -- 2.12 DMRG based approaches -- 3 Generalized Förster resonance energy transfer -- 3.1 Introduction -- 3.2 Förster's rate expression: a complete derivation -- 3.3 Transition density cube method -- 3.4 Generalized Förster theories -- 3.5 Important computational issues in an actual application -- 3.6 Applications of MC-FRET -- 3.7 Summary -- 4 Principles of multi-dimensional electronic spectroscopy -- 4.1 Photo-induced dynamics of molecular systems -- 4.2 Non-linear response of multi-state systems -- 4.3 Cumulant expansion of a non-linear response -- 4.4 Selected non-linear spectroscopic methods -- 4.5 Conclusions -- Part II Quantum effects in bacterial photosynthetic energy transfer -- 5 Structure, function, and quantum dynamics of pigment-protein complexes -- 5.1 Introduction -- 5.2 Light-harvesting complexes from purple bacteria: structure, function and quantum dynamics -- 5.3 Optical transitions in pigment-protein complexes. , 5.4 Electron transfer in pigment-protein complexes -- 6 Direct observation of quantum coherence -- 6.1 Detecting quantum coherence -- 6.2 Observation of quantum coherence using 2D electronic spectroscopy -- 6.3 Identifying and characterizing quantum coherence signals -- 6.4 Quantum coherence in reaction centres using two colour electronic coherence photon echo spectroscopy -- 6.5 Observing quantum coherences at physiological temperatures -- 6.6 Outlook for future measurements of coherence -- 7 Environment-assisted quantum transport -- 7.1 Introduction -- 7.2 Master equations for quantum transport -- 7.3 Quantum transport in a two-chromophore system -- 7.4 The principles of noise-assisted quantum transport -- 7.5 Quantum transport in the Fenna-Matthews-Olson protein complex -- 7.6 Optimality and robustness of quantum transport -- 7.7 Conclusion -- Part III Quantum effects in higher organismsand applications -- 8 Excitation energy transfer and energy conversion in photosynthesis -- 8.1 Photosynthesis -- 8.2 Photosynthetic energy conversion: charge separation -- 8.3 Light-harvesting -- 9 Electron transfer in proteins -- 9.1 Introduction -- 9.2 The rate for a single-step electron transfer reaction mediated by elastic through-bridge tunnelling -- 9.3 Dependence of tunnelling on protein structure: tunnelling pathways and their interferences -- 9.4 Tunnelling matrix element fluctuations in deep-tunnelling ET reactions -- 9.5 Vibrational quantum effects and inelastic tunnelling -- 9.6 Biological ET chains with tunnelling and hopping steps through the protein medium -- 9.7 Conclusions -- 9.8 Acknowledgements -- 10 A chemical compass for bird navigation -- 10.1 Introduction -- 10.2 Theoretical basis for a chemical compass -- 10.3 In vitro magnetic field effects on radical pair reactions -- 10.4 Evidence for a radical pair mechanism in birds. , 10.5 Conclusion -- 11 Quantum biology of retinal -- 11.1 Introduction -- 11.2 Retinal in rhodopsin and bacteriorhodopsin -- 11.3 Quantum physics of excited state dynamics -- 11.4 Regulation of photochemical processes for biological function -- 11.5 Potential energy crossing and conical intersection -- 11.6 Electronic structure of protonated Schiff base retinal -- 11.7 Mechanism of spectral tuning in rhodopsins -- 11.8 Photoisomerization of retinal in rhodopsins -- 11.9 Summary and outlook -- 11.10 Acknowledgement -- 12 Quantum vibrational effects on sense of smell -- 12.1 Phonon assisted tunnelling in olfaction -- 12.2 Important processes and timescales -- 12.3 Quantum rate equations -- 12.4 Putting in numbers -- 12.5 Can we make predictions? -- 12.6 Extensions of the theory for enantiomers -- 13 A perspective on possible manifestations of entanglement in biological systems -- 13.1 Introduction -- 13.2 Entanglement -- 13.3 Non-local correlations -- 13.4 Entanglement in biology -- 13.5 Open driven systems and entanglement -- 13.6 Conclusions -- 14 Design and applications of bio-inspired quantum materials -- 14.1 Potential applications of bio-inspired quantum materials -- 14.2 Progress in designing biomimetic quantum materials -- 15 Coherent excitons in carbon nanotubes -- 15.1 Structure -- 15.2 Electronic properties in 1D systems -- 15.3 Exciton-exciton interactions -- 15.4 Non-linear optical response of excitons -- 15.5 Simulations of intensity-dependent 3PEPS -- 15.6 Discussion and conclusions -- 15.7 Acknowledgement -- References -- Index.

Note: Molecular Simulations and Biomembranes -- Contents -- Chapter 1 Methods and Parameters for Membrane Simulations -- 1.1 Introduction -- 1.2 Force Fields/Descriptions of Interactions -- 1.2.1 Current Atomistic Force Fields -- 1.2.2 Development of Force Field Parameters -- 1.2.3 Issues with Combining Force Fields -- 1.3 Starting Structures -- 1.3.1 Bilayers -- 1.3.2 Membrane Proteins -- 1.3.3 Embedding Proteins in Bilayers -- 1.4 Sampling -- 1.4.1 Improving Sampling -- 1.4.2 Coarse Graining -- 1.5 Pressure Coupling -- 1.6 Electrostatics -- 1.7 Periodicity -- 1.8 Future Developments -- Acknowledgements -- References -- Chapter 2 Lateral Pressure Profiles in Lipid Membranes: Dependence on Molecular Composition -- 2.1 Introduction -- 2.2 Theoretical Concepts -- 2.2.1 Lateral Pressure Profile -- 2.2.2 Calculation of Lateral Pressure Profile from Simulation -- 2.2.3 Elastic Properties -- 2.2.4 Interplay of Pressure Profile and Membrane Protein Activation -- 2.3 Gauging Pressure Profile -- 2.4 Dependence of Pressure Profiles on Molecular Composition -- 2.4.1 Dependence on Unsaturation Level -- 2.4.2 Effects of Different Sterols in Two-component Membranes -- 2.4.3 Pressure Profiles in Three-component Bilayers -- 2.4.4 Implications of Anesthetics on Pressure Profile -- 2.4.5 Elastic Properties Calculated from Lateral Pressure Profile -- 2.4.6 Free Energy of Protein Activation and Lateral Pressure Profile -- 2.5 Concluding Remarks -- 2.6 Abbreviations -- Acknowledgements -- References -- Chapter 3 Coarse-grained Molecular Dynamics Simulations of Membrane Proteins -- 3.1 Introduction -- 3.2 Coarse-grained Simulations: Methodology -- 3.2.1 CG-MD and Lipid Bilayers -- 3.2.2 CG-MD and Membrane Peptides and Proteins -- 3.3 Evaluation of CG-MD: Model Membrane Peptides -- 3.4 Simulation Studies of Membrane Peptide Oligomerization -- 3.4.1 Glycophorin A. , 3.4.2 Influenza M2 Channels -- 3.5 Coarse-grained MD: Larger Systems -- 3.5.1 Vesicle Simulations -- 3.5.2 More Complex Membrane Proteins -- 3.6 Concluding Remarks and Future Directions -- Acknowledgements -- References -- Chapter 4 Passive Permeation Across Lipid Bilayers: a Literature Review -- 4.1 Introduction -- 4.2 Experimental Methods -- 4.2.1 Water and Small Organic Molecules -- 4.2.2 Drugs -- 4.3 The Solubility-Diffusion Model -- 4.3.1 The z-Constraint Method -- 4.4 Small Molecules -- 4.5 Drugs -- 4.6 Fullerene -- 4.7 Discussion -- 4.8 Conclusions -- References -- Chapter 5 Implicit Membrane Models For Peptide Folding and Insertion Studies -- 5.1 Introduction -- 5.2 Implicit Membrane Models -- 5.2.1 Overview -- 5.2.2 Implicit Membrane Models for Studying Membrane Protein Folding -- 5.2.3 The Generalized Born Model -- 5.2.4 Non-polar Interactions -- 5.2.5 Accuracy and Partitioning Properties -- 5.2.6 Transmembrane and Surface-bound Helices, Insertion Energy Landscape -- 5.2.7 Thermodynamic Analysis -- 5.3 Simulating Peptide Folding and Partitioning -- 5.3.1 Summary -- 5.3.2 Transbilayer Peptide Folding -- 5.3.3 Peptide Adsorption, Insertion and Folding -- 5.3.4 Comparison with Explicit Methods -- 5.3.5 Sampling Performance -- 5.3.6 Conclusions -- Acknowledgements -- References -- Chapter 6 Multi-scale Simulations of Membrane Sculpting by N-BAR Domains -- 6.1 Introduction -- 6.2 Methods -- 6.3 All-atom Simulations -- 6.4 Residue-based Coarse-grained Simulations -- 6.5 Shape-based Coarse-grained Simulations -- 6.6 Continuum Elastic Membrane Model -- 6.7 Results and Discussion -- 6.8 Simulations of a Single N-BAR Domain -- 6.9 Comparison of RBCG and SBCG Simulations for Systems with Six N-BAR Domains -- 6.10 Effect of Different N-BAR Domain Lattices on Membrane Curvatures -- 6.11 Comparing All-atom and SBCG Simulations of an N-BAR Domain Lattice. , 6.12 Complete Membrane Tubulation by Lattices of BAR Domains -- 6.13 Elastic Membrane Computations -- 6.14 Conclusion -- Acknowledgements -- References -- Chapter 7 Continuum Electrostatics and Modeling of K+ Channels -- 7.1 Introduction -- 7.2 Theory and Methods -- 7.2.1 The Poisson-Boltzmann (PB) Equation -- 7.2.2 Calculation of Electrostatic Free Energies and Decomposition -- 7.2.3 The Modified PB Equation for Treatment of Transmembrane Voltage -- 7.3 Applications -- 7.3.1 Electrostatics in the Intracellular Vestibule of K+ Channels -- 7.3.2 Long-pore Electrostatics in K+ Channels -- 7.3.3 K+ Channels and the Transmembrane Potential -- 7.4 Conclusion -- References -- Chapter 8 Computational Approaches to Ionotropic Glutamate Receptors -- 8.1 Introduction -- 8.2 The Amino-terminal Domain -- 8.3 The Ligand-binding Domain (LBD) -- 8.3.1 Selectivity and Modulation -- 8.3.2 Dynamics -- 8.4 The Transmembrane Domain -- 8.5 Conclusion -- Acknowledgements -- References -- Chapter 9 Molecular Dynamics Studies of Outer Membrane Proteins: a Story of Barrels -- 9.1 Introduction -- 9.2 Outer Membrane Proteins -- 9.3 Simple Barrels -- 9.3.1 OmpA and Its Homologues -- 9.3.2 Simple OMPs in Diverse Environments -- 9.4 Leaking Barrels -- 9.5 Transporting Barrels -- 9.5.1 TonB-dependent Transporters -- 9.5.2 Autotransporters -- 9.5.3 TolC -- 9.6 Reacting Barrels -- 9.7 Technological Barrels -- 9.8 Conclusion -- Acknowledgements -- References -- Chapter 10 Molecular Mechanisms of Active Transport Across the Cellular Membrane -- 10.1 Introduction -- 10.2 Computational Methodology -- 10.2.1 Electrostatic Potential Calculation -- 10.2.2 Net Charge Density Distribution Calculation -- 10.3 ATP-driven Transport in ABC Transporters -- 10.4 Ion-driven Neurotransmitter Uptake by the Glutamate Transporter. , 10.5 Substrate Binding and Selectivity in Glycerol-3-Phosphate Transporter -- 10.6 Membrane Potential-driven Nucleotide Exchange in ADP/ATP Carrier -- 10.7 Mechanically Driven Transport Across the Outer Membrane -- 10.8 Conclusion -- Acknowledgements -- References -- Chapter 11 Molecular Dynamics Studies of the Interactions Between Carbon Nanotubes and Biomembranes -- 11.1 Introduction -- 11.1.1 Carbon Nanotube Structure -- 11.1.2 Experimental Techniques for Studying CNTs in a Biological Environment -- 11.2 Molecular Dynamics Simulations -- 11.2.1 Methodology -- 11.2.2 Parameterization of CNT Models -- 11.3 CNT Interactions with Lipids and Related Molecules -- 11.4 Interaction of CNTs with Lipid Bilayers -- 11.5 CNTs as Nanopores -- 11.5.1 Transport of Water and Ions Through CNT Nanopores -- 11.5.2 Nanopores as Nanosyringes -- 11.6 Conclusion -- References -- Subject Index.

Note: Intro -- 978-3-540-36397-2_BookFrontmatter_OnlinePDF -- 978-3-540-36397-2_1_OnlinePDF -- 978-3-540-36397-2_2_OnlinePDF -- 978-3-540-36397-2_3_OnlinePDF -- 978-3-540-36397-2_4_OnlinePDF -- 978-3-540-36397-2_5_OnlinePDF -- 978-3-540-36397-2_6_OnlinePDF -- 978-3-540-36397-2_7_OnlinePDF -- 978-3-540-36397-2_8_OnlinePDF -- 978-3-540-36397-2_9_OnlinePDF -- 978-3-540-36397-2_10_OnlinePDF -- 978-3-540-36397-2_11_OnlinePDF.

Note: Front Cover -- Membrane Receptors -- Copyright Page -- Contents -- Contributors -- Preface -- Yale Membrane Transport Processes Volumes -- Contents of Previous Volumes -- PART I: ADENYLATE CYCLASE-RELATED RECEPTORS -- Chapter 1. Hormone Receptors and the Adenylate Cyclase System: Historical Overview -- Text -- References -- Chapter 2. The Elucidation of Some Aspects of Receptor Function by the Use of a Kinetic Approach -- I. Introduction -- II. Signal-Response Coupling and Receptor Theory -- III. Applying Kinetic Theory to Data Generated by Turkey Erythrocyte Adenylate Cyclase -- IV. Conclusions -- References -- Chapter 3. The ß-Adrenergic Receptor: Ligand Binding Studies Illuminate the Mechanism of Receptor-Adenylate Cyclase Coupling -- I. Introduction -- II. Development of Radioligands Specific for Adrenergic Receptors -- III. Study of Adrenergic Receptors in Membranes -- IV. Characterization of Detergent-Solubilized Adrenergic Receptors -- References -- Chapter 4. Receptor-Mediated Stimulation and Inhibition of Adenylate Cyclase -- I. Introduction -- II. Stimulation of Adenylate Cyclase -- III. GTP-Dependent Inhibition of Adenylate Cyclase -- IV. Bimodally Regulated Adenylate Cyclase Systems -- V. Receptor Binding of Inhibitory Ligands -- VI. The Role of GTP Hydrolysis in Inhibition of Adenylate Cyclase -- VII. The Relationship between Ns and Ni -- VIII. Structural Studies on Dually Regulated Adenylate Cyclase Systems -- IX. Future Directions -- X. Conclusion -- References -- Chapter 5. Desensitization of the Response of Adenylate Cyclase to Catecholamines -- I. Introduction -- II. Scope of the Review -- III. Catecholamine-Induced Desensitization of Intact Cells -- IV. Catecholamine-Induced Changes in Adenylate Cyclase and in βAR Binding Properties -- V. Separation of Native and Desensitized βAR. , VI. Receptor Endocytosis as a Mechanism for Agonist-Induced Desensitization -- VII. A Kinetic Model for Agonist-Induced Desensitization -- VIII. Differential Expression of βAR during Growth of 1321N1 Cells -- IX. Down-Regulation of βAR and the Recovery of Lost Receptors -- X. Isoproterenol-Induced Changes in Agonist Binding Properties of Intact 1321N1 Cells -- XI. Conclusions -- References -- Chapter 6. Hormone-Sensitive Adenylate Cyclase: Identity, Function, and Regulation of the Protein Components -- I. Overview -- II. Protein Components of Hormone-Sensitive Adenylate Cyclase -- III. Protein-Protein Interactions and the Regulation of Adenylate Cyclase -- IV. Assessment of Progress -- References -- Chapter 7. The Regulation of Adenylate Cyclase by Glycoprotein Hormones -- I. Introduction -- II. Nature of the Hormones -- III. Nature of the Receptors -- IV. Involvement of Cyclic AMP in Hormone Action -- V. Important Features of the Hormone Receptor-Adenylate Cyclase System -- VI. Desensitization and Down-Regulation by Homologous Hormone -- References -- Chapter 8. The Activity of Adenylate Cyclase Is Regulated by the Nature of Its Lipid Environment -- I. Structure of Biological Membranes -- II. Structural Aspects of Hormone Receptor-Adenylate Cyclase Interaction -- III. Membrane Fluidity as a Regulator of Adenylate Cyclase Activity -- IV. Selective Modulation of Adenylate Cyclase by Asymmetric Perturbations of the Membrane Bilayer -- V. Phospholipid Headgroup Composition and Adenylate Cyclase Activity -- VI. Disease States -- References -- Chapter 9. The Analysis of Interactions between Hormone Receptors and Adenylate Cyclase by Target Size Determinations Using Irradiation Inactivation -- I. Irradiation Inactivation: General Considerations -- II. Practical Considerations in Irradiation Inactivation Studies on Membranes -- III. Analysis of Data. , IV. The Application of Target Size Analysis to Rat Liver Plasma Membrane Adenylate Cyclase -- V. Model of Hormone Action -- VI. Effects of Fluoride -- VII. Evaluation of the Model in Relation to the Results of Other Approaches -- References -- PART II: RECEPTORS NOT INVOLVING ADENYLATE CYCLASE -- Chapter 10. Vasopressin Isoreceptors in Mammals: Relation to Cyclic AMP-Dependent and Cyclic AMP-Independent Transduction Mechanisms -- I. Introduction -- II. Methodological Basis for the Characterization of Vasopressin Isoreceptors -- III. Kinetics of Hormone Binding to Vasopressin Receptors -- IV. Transduction Mechanisms Triggered by Vasopressin Receptors -- V. Effects of Nucleotides and Other Putative Effectors on Vasopressin Receptors -- VI. Physicochemical Characteristics of Solubilized Vasopressin Receptors -- VII. Recognition Patterns of Vasopressin Isoreceptors -- VIII. Summary and Conclusions -- References -- Chapter 11. Induction of Hormone Receptors and Responsiveness during Cellular Differentiation -- I. Introduction -- II. Model Systems -- III. Conclusion -- References -- Chapter 12. Receptors for Lysosomal Enzymes and Glycoproteins -- I. Introduction -- II. The Phosphomannosyl Recognition Pathway -- III. Role of Oligosaccharide Moiety in Recognition of Extracellular Lysosomal Enzymes and Glycoproteins -- IV. Lysosomal Enzymes and the Mannosyl Recognition System -- V. Receptor-Mediated Endocytosis of Glycoconjugates -- VI. Conclusion -- References -- Chapter 13. The Insulin-Sensitive Hexose Transport System in Adipocytes -- I. Summary of the Present Status -- II. Historical Background -- III. Critical Steps in the Methodology -- IV. Kinetic Approaches to the Study of Hexose Transport -- V. Transport of Nonmetabolizable Sugars and Sugar Analogs in the Adipocyte -- VI. The Requirements for D-Glucose Binding to the Adipocyte Hexose Transport System. , VII. Nontransported Competitive Inhibitors of Transport -- VIII. Sugars Which Are Both Transported and Phosphorylated-Rate-Limiting Steps -- IX. Modulation of the Transport System by Glucose Metabolites -- X. Mechanism of Insulin's Ability to Increase Vmax -- XI. Human Adipocytes -- XII. The Transport System in Obesity and Diabetes -- XIII. Reconstitution of the Hexose Transporter -- XIV. Concluding Remarks -- References -- Chapter 14. Epidermal Growth Factor Receptor and Mechanisms for Animal Cell Division -- I. Introduction -- II. Properties of EGF -- III. The EGF Receptor -- IV. The Pathway to Nuclear DNA Replication -- V. A Family of EGF-like Polypeptides and Their Role in Animal Development and Growth -- References -- Chapter 15. The Linkage between Ligand Occupation and Response of the Nicotinic Acetylcholine Receptor -- I. Introduction -- II. Structure of the Isolated Receptor -- III. Biophysical Properties of the Receptor Channel -- IV. The Behavior of Partial Agonists, Antagonists, and Anesthetics in Relation to Channel Activation -- V. Desensitization of the Receptor -- VI. Ligand Occupation and Transitions in Receptor State -- VII. Other Ligands Affecting Receptor Function -- VIII. Analysis of Receptor Activation -- IX. Toward the Understanding of Coupling between Occupation of the Receptor and the Permeability Response -- X. Occupation and Activation by Agonists -- XI. Association of Antagonists with the Receptor and Functional Antagonism -- XII. Quantitation of Antagonist Occupation and Functional Antagonism -- XIII. Structural Implications and Arrangement of Subunits -- XIV. Analysis of the Bound Ligand States -- References -- Chapter 16. The Interaction of Cholera Toxin with Gangliosides and the Cell Membrane -- I. Structure and Action of Cholera Toxin -- II. The Role of Ganglioside GM1 as a Cell-Surface Receptor. , III. The Nature of the Reaction between Ganglioside and Toxin -- IV. Transport of Cholera Toxin across the Cell Membrane and the Role of Binding to Ganglioside -- V. Other Compounds That Bind to Gangliosides -- References -- Index.

Note: Intro -- Editor's Preface -- Contents -- Author and Editor -- Introduction -- The Philosophically Interested Colleagues Among Heisenberg's Circle of Physicists -- On the Origin of the Philosophical Manuscript "Reality and Its Order" -- Notes on the Contents of the Essay and Conclusions -- References -- Reality and Its Order -- I -- 1. The Diverse Areas of Reality -- 2. Language -- 3. Order -- II -- 1. The Domain of Reality in Goethe's View -- 2. (Classical) Physics -- (a) Mechanics -- (b) Electricity and Magnetism -- (c) The Infinite -- 3. Chemistry -- (a) Heat -- (b) The Laws of Chemistry -- (c) The Boundaries of the Domains -- (d) Chance -- 4. Organic Life -- (a) The Relation Between Biological and Physical-Chemical Laws of Nature -- (b) The Structure of the Biological Domain -- (c) The Unique Position of the Human Being -- 5. Consciousness -- (a) Consciousness and Biology -- (b) Consciousness and Reality -- 6. Symbol and Gestalt -- (a) The Means of Communication -- (b) Art -- (c) Science -- (d) The Symbols of the Human Communities -- 7. The Creative Forces -- (a) Religion -- (b) Illumination -- (c) The Great Parable -- III -- Commentary on Werner Heisenberg's "Reality and Its Order" -- Preamble to the Commentary -- The Comments -- References.

Note: Literaturangaben

Note: Los Angeles, Ca., Univ., Diss. 1974. -