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  • 1
    Electronic Resource
    Electronic Resource
    Review article: the pathogenesis of fibrosis in non-alcoholic steatohepatitis (2005)
    Oxford, UK : Blackwell Publishing Ltd
    Alimentary pharmacology & therapeutics 22 (2005), S. 0 
    Details
    ISSN: 1365-2036
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Non-alcoholic steatohepatitis has been recognized as a significant cause of end-stage liver disease and hepatic decompensation. Despite the growing interest in this condition, the molecular mechanisms underlying the development of fibrosis in this setting are only partially understood. In this article, the cellular and molecular basis of fibrosis in chronic liver disease are briefly outlined. In addition, mechanisms specifically operating in the context of fatty liver and steatohepatitis are examined, including: insulin resistance, oxidative stress, and inflammation. Finally, recent developments indicating the possible contribution of cytokines derived from adipose tissue (adipokines) to liver fibrosis is discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2036.2005.02595.x
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  • 2
    Electronic Resource
    Electronic Resource
    Effects of rhein on renal arachidonic acid metabolism and renal function in patients with congestive heart failure (1989)
    Springer
    European journal of clinical pharmacology 37 (1989), S. 1-5 
    Details
    ISSN: 1432-1041
    Keywords: congestive heart failure ; rhein ; non-steroidal antiinflammatory drugs (NSAIDs) ; renal prostaglandins ; renal function ; serum thromboxane ; side-effects
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary In a randomized double-blind cross-over study the effects of rhein (administered as diacetylrhein 50 mg b.d. for 5 days) and placebo on renal arachidonic acid metabolism and renal function have been compared in 12 elderly patients (mean age 75.2 years) with congestive heart failure, whose renal function was known to be dependent on the integrity of the renal prostaglandin system. Rhein like placebo, did not induce any change in the urinary excretion of prostaglandin (PG) E2, 6-keto-PGF1α and thromboxane (TX) B2, nor did it affect creatinine clearance, blood urea, urine output, natriuresis, body weight, plasma renin activity or plasma aldosterone concentration. Separate analysis of the results obtained in the 5 patients receiving diuretic treatment did not show any significant effect of rhein as compared with placebo on the parameters investigated. Serum TXB2 concentration during whole blood clotting, as an index of platelet arachidonic acid metabolism, also showed no significant difference when DAR and placebo were compared. It is concluded that in patients with congestive heart failure rhein does not inhibit renal or platelet eicosanoid metabolism, nor does it modify renal function, sodium excretion or the renal response to diuretics.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00609415
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  • 3
    Electronic Resource
    Electronic Resource
    The 1997 Umbria-Marche earthquakes (Italy): relation between the surface tectonic breaks and the area of deformation (2000)
    Springer
    Journal of seismology 4 (2000), S. 333-343 
    Details
    ISSN: 1573-157X
    Keywords: ground ruptures ; Italy ; seismotectonics ; Umbria-Marche earthquakes
    Source: Springer Online Journal Archives 1860-2000
    Topics: Geosciences , Physics
    Notes: Abstract We classified the most outstanding rupturesof the 1997 Umbria-Marche seismic sequence assecondary tectonic effects that occur within the zoneof deformation induced by the deep displacement on theseismogenic structure. The trend of the surfacedeformation is homogeneous within the entire area ofinterest and consistent with NE-oriented extensionevidenced by CMT focal solutions of the three mainshocks. We extrapolate the discontinuous sites ofbreak measurements and suggest that the localdeformation concentrates along four narrow bands.Location and direction of these bands are locallycontrolled by pre-existing structures. The comparisonbetween our data with the seismological data – such asmain rupture planes and spatial aftershockdistribution – highlights that three bands mark partof the boundaries of the NW-SE elongated aftershocksarea and the fourth occurs where this area is widest.Moreover, the analysis of the structural setting ofthe area suggests that N-S shear zones have stronglycontrolled the extension of the main rupture segmentsand the aftershock distribution. The surface rupturesare located within the area of coseismic deformationresulting from DInSAR data; we propose that theyrepresent the localized response to the verticalground deformation of the area. Finally, we discussthe contribution of the pattern of the 1997 surfacebreaks to the characterization of the seismogenicsource.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1026575219394
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  • 4
    Electronic Resource
    Electronic Resource
    Study of site effects in the area of Nocera Umbra (Central Italy) during the 1997 Umbria-Marche seismic sequence (2000)
    Springer
    Journal of seismology 4 (2000), S. 555-565 
    Details
    ISSN: 1573-157X
    Keywords: Nocera Umbra ; site effects ; weak motions
    Source: Springer Online Journal Archives 1860-2000
    Topics: Geosciences , Physics
    Notes: Abstract During the ML = 5.6 and 5.8 earthquakes occurredin central Italy on 26 September 1997 the historiccentre of Nocera Umbra, lying on top of a 120 m highhill, was diffusely damaged (VII-VIII degrees of MCSintensity). Some recently built houses in the modernpart of the town suffered an even higher level ofdamage. A temporary seismic array was deployed toinvestigate a possible correlation between localamplifications of ground motion in this area and theobserved pattern of damage. After a geologic andmacroseismic survey, eight sites were selected asrepresentative of different local conditions, such astopographic irregularities, sharp hard-to-softlithology transitions, alluvium-filled valleys, andboth undisturbed and deformed rocks.Horizontal-to-vertical spectral ratios for bothmicrotremor and earthquake recordings, as well asspectral ratios referred to undisturbed rock sites,were used to quantify local variations of groundmotion. In spite of the diffuse damage in the historiccentre of Nocera Umbra, a small amplification isobserved at the stations on the hill's top. Thissuggests that the higher vulnerability of the ancientbuildings mainly accounts for the diffuse damage inthat part of the town. In the frequency band ofengineering interest (1 to 10 Hz) the largestamplifications of ground motion are found at softsites: in the Topino river valley, where many episodesof severe structural damage occurred, spectralamplification is significant over a broad frequencyband ranging from 2 Hz to more than 20 Hz. Inparticular, in the central part of the valley highamplification (〉 4) is found from 3 to 10 Hz,reaching a maximum of 20 around 4 Hz. At the edge ofthe valley, close to the soil-to-rock transition,amplification is as large as 10 in a frequency bandranging from 4 to more than 20 Hz. A significantamplification (by a factor of 10 around 10 Hz) isobserved also at one of the rock sites, possibly dueto the presence of a cataclastic zone related to theactivity of a regional fault that altered themechanical properties of the rock.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1026510300469
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  • 5
    Electronic Resource
    Electronic Resource
    Large amplification of ground motion at rock sites within a fault zone in Nocera Umbra (central Italy) (2000)
    Springer
    Journal of seismology 4 (2000), S. 543-554 
    Details
    ISSN: 1573-157X
    Keywords: fault zone ; ground motion ; Nocera Umbra ; site effects
    Source: Springer Online Journal Archives 1860-2000
    Topics: Geosciences , Physics
    Notes: Abstract During the two mainshocks of September 26, 1997 inthe Umbria-Marche border a strong-motion accelerographrecorded peak ground accelerations as large as 0.6 g,approximately, in the town of Nocera Umbra, atdistances of 10 to 15 km from the epicentres. Thisvalue is significantly larger than expected on thebasis of the usual regressions with magnitude anddistance. A broad-band amplification up to a factor of10 was consistently estimated in previous papers,using both weak and strong motion data recorded at theaccelerograph site during local moderate earthquakes.To study the cause of this amplification we deployedsix seismologic stations across the tectonic contactbetween the Ceno-Mesozoic limestone and the Mesozoicmarly sandstone where the accelerograph is installed.Seismograms of 21 shallow aftershocks in the magnituderange from 2.2 to 4.0 and a subcrustal Mw = 5.3event are analysed. Regardless of epicentre location,waveforms show a large complexity in an approximately200 m wide band adjacent to the tectonic contact. Thisis interpreted as the effect of trapped waves in thehighly fractured, lower velocity materials within thefault zone.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1026559901378
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  • 6
    Electronic Resource
    Electronic Resource
    Observations of vertical ground accelerations exceeding gravity during the 1997 Umbria-Marche (central Italy) earthquakes (2000)
    Springer
    Journal of seismology 4 (2000), S. 517-523 
    Details
    ISSN: 1573-157X
    Keywords: Ground motion calculation ; stone fracturation ; vertical ground accelerations
    Source: Springer Online Journal Archives 1860-2000
    Topics: Geosciences , Physics
    Notes: Abstract We found extensive evidence that the vertical ground accelerations produced during the largest shock (M = 6.0) of the 1997 Umbria-Marche earthquake sequence exceeded 1g in two areas close to the heavily-damaged villages of Annifo and Colle Croce. This evidence comes from the striking observation of thousands of freshly fractured and broken rocks and stones in these areas. Some of the broken stones lie isolated on soft detritic soil while others had been previously piled up, probably a long time agoto clear the fields for farming. The freshness of the cuts and fractures and the consistency of the observations for thousands of rocks and stones in these areas indicate that these rocks were thrown upwards during the earthquake, with breakage occurring at the time of impact. Ground motion calculations consistent with the static deformation inferred from GPS and interferometry data, show that the broken stones and rocks are found in the zone where the strongest shaking took place during the earthquake and that most of the shaking there was vertical.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1026579908823
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  • 7
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    The mitogen-activated protein kinase ERK5 regulates the development and growth of hepatocellular carcinoma (2015)
    BMJ Publishing Group
    In: Gut
    Details
    Publication Date: 2015-08-09
    Description: Objective The extracellular signal-regulated kinase 5 (ERK5 or BMK1) is involved in tumour development. The ERK5 gene may be amplified in hepatocellular carcinoma (HCC), but its biological role has not been clarified. In this study, we explored the role of ERK5 expression and activity in HCC in vitro and in vivo. Design ERK5 expression was evaluated in human liver tissue. Cultured HepG2 and Huh-7 were studied after ERK5 knockdown by siRNA or in the presence of the specific pharmacological inhibitor, XMD8-92. The role of ERK5 in vivo was assessed using mouse Huh-7 xenografts. Results In tissue specimens from patients with HCC, a higher percentage of cells with nuclear ERK5 expression was found both in HCC and in the surrounding cirrhotic tissue compared with normal liver tissue. Inhibition of ERK5 decreased HCC cell proliferation and increased the proportion of cells in G0/G1 phase. These effects were associated with increased expression of p27 and p15 and decreased CCND1. Treatment with XMD8-92 or ERK5 silencing prevented cell migration induced by epidermal growth factor or hypoxia and caused cytoskeletal remodelling. In mouse xenografts, the rate of tumour appearance and the size of tumours were significantly lower when Huh-7 was silenced for ERK5. Moreover, systemic treatment with XMD8-92 of mice with established HCC xenografts markedly reduced tumour growth and decreased the expression of the proto-oncogene c-Rel. Conclusions ERK5 regulates the biology of HCC cells and modulates tumour development and growth in vivo. This pathway should be investigated as a possible therapeutic target in HCC.
    Keywords: Hepatic cancer
    Print ISSN: 0017-5749
    Electronic ISSN: 1468-3288
    Topics: Medicine
    Published by BMJ Publishing Group
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  • 8
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    Population-Based Study of the Increased Incidence of Skin and Soft Tissue Infections and Associated Antimicrobial Use [Clinical Therapeutics] (2012)
    The American Society for Microbiology (ASM)
    Details
    Publication Date: 2012-11-13
    Description: Community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) has spread rapidly throughout the world in the last decade. We sought to demonstrate the impact of the emergence of CA-MRSA in Western Canada on physician visits, incision-and-drainage procedures, and antibiotic prescribing for skin and soft tissue infections (SSTI). We used the provincial physician billing system to determine the rate of physician visits (per 1,000 population per year) of SSTI and incision-and-drainage procedures. A database capturing all outpatient prescriptions in the province was anonymously linked to associated physician billing codes to quantify prescriptions associated with SSTI. Antibiotic prescriptions (overall and class specific) were expressed as their defined daily dose (DDD) per 1,000 inhabitants per day. Between 1996 and 2008, the rate of visits for all SSTI increased by 15%, and the majority of visits did not include an incision-and-drainage procedure. The rate of antibiotic prescribing for SSTI increased by 49%. The majority of this increase was attributable to the higher rates of use of clindamycin (627%), trimethoprim-sulfamethoxazole (380%), cephalosporins (160%), and amoxicillin-clavulanate (627%). Health care utilization and antibiotic prescribing rates for SSTI, but not incision-and-drainage procedures, have increased in association with the CA-MRSA epidemic. While much of the increase in antibiotic use reflects an appropriate change to trimethoprim-sulfamethoxazole, there is room for education regarding the limitations of cephalosporins and clindamycin, given current susceptibility profiles.
    Print ISSN: 0066-4804
    Electronic ISSN: 1098-6596
    Topics: Biology , Medicine
    Published by The American Society for Microbiology (ASM)
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  • 9
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    Ground Motions Recorded in Rome during the April 2009 L'Aquila Seismic Sequence: Site Response and Comparison with Ground-Motion Predictions Based on a Global Dataset (2013)
    Seismological Society of America (SSA)
    Details
    Publication Date: 2013-06-08
    Description: The mainshock and moderate-magnitude aftershocks of the 6 April 2009 M  6.3 L’Aquila seismic sequence, about 90 km northeast of Rome, provided the first earthquake ground-motion recordings in the urban area of Rome. Before those recordings were obtained, the assessments of the seismic hazard in Rome were based on intensity observations and theoretical considerations. The L’Aquila recordings offer an unprecedented opportunity to calibrate the city response to central Apennine earthquakes—earthquakes that have been responsible for the largest damage to Rome in historical times. Using the data recorded in Rome in April 2009, we show that (1) published theoretical predictions of a 1 s resonance in the Tiber valley are confirmed by observations showing a significant amplitude increase in response spectra at that period, (2) the empirical soil-transfer functions inferred from spectral ratios are satisfactorily fit through 1D models using the available geological, geophysical, and laboratory data, but local variability can be large for individual events, (3) response spectra for the motions recorded in Rome from the L’Aquila earthquakes are significantly amplified in the radial component at periods near 1 s, even at a firm site on volcanic rocks, and (4) short-period response spectra are smaller than expected when compared to ground-motion predictions from equations based on a global dataset, whereas the observed response spectra are higher than expected for periods near 1 s. Online Material: Velocity models used in computing theoretical site response.
    Print ISSN: 0037-1106
    Electronic ISSN: 1943-3573
    Topics: Geosciences , Physics
    Published by Seismological Society of America (SSA)
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  • 10
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    Geochemical fingerprints of volcanic materials: Identification of a pumice trade route from Pompeii to Rome (2013)
    Geological Society of America (GSA)
    Details
    Publication Date: 2013-02-28
    Description: Geochemical investigations on samples of pumice and lava extracted from the mortars and concretes of the Forum of Caesar and the Forum and Markets of Trajan are presented and integrated with previous analyses of lava samples from Rome and Pompeii, and of pumices from the Colosseum and the Dioclethian’s Bath, with the aim to identify the lithological provenance of these materials. Discrimination diagrams based on ratios of selected trace elements (i.e., Zr/Y, Nb/Y, Th/Ta, Nb/Zr) allow us to recognize the geochemical signature of the different volcanic regions of central Italy. These diagrams indicate that in the mortars of the Forum of Caesar and Forum of Trajan, the Roman builders integrated the scanty pumices from deposits of the Monti Sabatini Volcanic District near Rome with others coming from the Vesuvius and Phlegrean Fields. Some of the pumices employed in the vaulted ceilings of these monuments display a peculiar geochemistry that has a unique correspondence with a pyroclastic deposit recovered in a borehole drilled on the southern flanks of Vesuvius. Similarly, lava flows from this borehole display a different trace-element signature with respect to that of other coeval lava flows of the northern flanks of Vesuvius, and it has a closer correspondence to that of the archaeological lava samples. These observations, integrated with historical and archaeological data, indicate that the Roman builders had a profound empirical knowledge of the physical properties of the volcanic rocks from different regions, and suggest that a systematic cultivation of lightweight volcanic material occurred in the area of Pompeii for exportation to Rome and, likely, to other regions of the Mediterranean.
    Print ISSN: 0016-7606
    Electronic ISSN: 1943-2674
    Topics: Geosciences
    Published by Geological Society of America (GSA)
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