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  • 1
    Keywords: Geotechnical Engineering & Applied Earth Sciences ; Geotechnical engineering ; Hydrogeology ; Engineering geology ; Engineering—Geology ; Foundations ; Hydraulics ; Angewandte Hydrogeologie ; Tunnel ; Karst ; Karsthydrographie ; Wassereinbruch ; Kluftwasser ; Karstlandschaft ; Tunnelbau ; Hydrogeologie ; Wassereinbruch ; Kluftgrundwasserleiter ; Ingenieurgeologie
    Description / Table of Contents: Introduction -- Analysis of Environmental Factors Influencing the Karst Dynamics System of Tunnel in Typical Area -- Dynamic Characteristics of Groundwater and Hydrochemical Dynamics in Karst Tunnel -- Karst Morphology and Its Fractal Characteristics Revealed by Tunnel Excavation -- Experimental Study on the Dissolution Mechanism of Rock under the Condition of Tunnel Excavation -- Correlation between Fractal Characteristics of Karst Morphology and Hydrochemical Dynamics -- Hydrochemical Kinetics-Fractal Index Evaluation of Karst Development Degree
    Type of Medium: Online Resource
    Pages: 1 Online-Ressource (XXIII, 245 p. 127 illus., 41 illus. in color)
    Edition: 1st ed. 2020
    ISBN: 9789811399534
    Series Statement: Springer eBooks
    Language: English
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  • 2
    Online Resource
    Online Resource
    Singapore :Springer Singapore Pte. Limited,
    Keywords: Hydrology, Karst. ; Electronic books.
    Type of Medium: Online Resource
    Pages: 1 online resource (260 pages)
    Edition: 1st ed.
    ISBN: 9789811399534
    DDC: 551.49
    Language: English
    Note: Intro -- Foreword -- Preface -- Abstract -- Contents -- About the Authors -- 1 Introduction -- 1.1 Analysis on Research Status and Development Trends at Home and Abroad -- 1.1.1 Technical Status of the Control of Geological Disasters Such as Water Burst and Mud Burst in Karst Tunnels -- 1.1.2 Karst and Groundwater Forecast Technologies -- 1.1.3 Study on the Interaction Mechanism Between Karst and Groundwater -- 1.1.4 Research on Karst Forms -- 1.1.5 Analysis and Summary of Research Technology -- 1.2 Main Research Contents and Innovation of This Book -- 1.3 Analysis on Application Prospect -- 2 Analysis on Environmental Impact Factors of Tunnel Karst Dynamics System in Typical Areas -- 2.1 Overview of Karst Area Division in China -- 2.2 Statistics of Karst Tunnels and Karst Development in Different Regions -- 2.3 Division of Karst Dynamics Systems for Tunnels in Typical Areas -- 2.3.1 Overview of the Basic Theory of Karst Dynamics Systems -- 2.3.2 Division of Northern Karst Dynamics Systems -- 2.3.3 Division of Southern Karst Dynamics Systems -- 2.4 Geological Disasters in Karst Tunnel Construction in Typical Areas and Corresponding Environmental Impact Factors -- 3 Characteristics of Groundwater Dynamics and Hydrochemical Kinetics of Karst Tunnels -- 3.1 Dynamical Conditions of Groundwater for Karst Development and Vertical Profile Zoning of Karst -- 3.1.1 Dynamical Conditions of Groundwater for Karst Development -- 3.1.2 Karst Vertical Profile Zoning Under Dynamic Conditions of Karst Groundwater -- 3.2 Simplified Hydrogeochemical Model of Karst Groundwater -- 3.3 Variation Characteristics and Hydrochemical Kinetics Characteristics of Groundwater Chemical Composition of Karst Tunnels in Typical Areas -- 3.3.1 Variation Characteristics of Groundwater Chemical Composition of Karst Tunnels in Typical Areas. , 3.3.2 Hydrochemical Kinetics Characteristics of Karst Groundwater -- 4 Karst Forms and Fractal Characteristics Revealed by Tunnel Excavation -- 4.1 Karst Forms Revealed by Tunnel Surface and Inside Excavation -- 4.1.1 Tunnel Surface Karst Forms -- 4.1.2 Karst Forms Revealed by Tunnel Inside Excavation -- 4.1.3 Diversity of Karst Fillers -- 4.2 Feasibility of Applying Fractal Theory to Karst Research -- 4.3 The Dialectical Relationship Between Macroscopic Law and Microscopic Law of Karst Form -- 4.4 Fractal Calculation Method of Karst Forms Revealed by Tunnel Excavation -- 4.4.1 Concept of Karst Unit -- 4.4.2 Calculation Method of Karst Fractal Dimension -- 4.4.3 Calculation Example of Karst Fractal Dimension -- 4.5 Fractal Index Assessment Method of Karst Development Degree -- 4.5.1 Fractal Assessment Index of Karst Development Degree -- 4.5.2 Fractal Index Assessment Method of Karst Development Degree -- 5 Experimental Study on Karst Dissolution Action Mechanism Under Tunnel Excavation Condition -- 5.1 Technical Status of Experimental Study on Dissolution -- 5.2 Schematic Design of Dissolution Experiment -- 5.2.1 Experiment Intentions, Contents, and Expected Objectives -- 5.2.2 Design of the Principle and Setup of the Experiment -- 5.2.3 Design of Method and Procedure of the Experiment -- 5.3 Implementation of Dissolution Experiments -- 5.3.1 Selection of Test Setup and Water Sample -- 5.3.2 Experimental Procedures -- 5.3.3 Statistics of Actual Workload -- 5.4 Preliminary Analysis and Discussion of the Experimental Results -- 5.4.1 Dissolution Amounts at Different pH Values, Temperatures, and Flow Regimes -- 5.4.2 Analysis of Microstructure at Different pH Values, Temperatures, and Flow Regimes -- 5.4.3 Hydrochemical Composition at Different pH Values, Temperatures, and Flow Regimes -- 5.4.4 Brief Summary of Experiment. , 6 Correlation Between Fractal Characteristics and Hydrochemical Kinetics Characteristics of Karst Forms -- 6.1 Study on Microscopic Karst Fractal Characteristics of Rock Grinding for Dissolved Rock Samples -- 6.1.1 Brief Description of Microscopic Analysis on Rock Grinding -- 6.1.2 Analysis on the Results of Electron Microscope Experiments -- 6.1.3 Analysis on the Results of Polarized Microscope Experiments -- 6.2 Hydrochemical Kinetics Parameters and Hydrochemical Fractal Characteristics of Karst Groundwater -- 6.2.1 Trilinear Diagram for Hydrochemistry of Dissolution Liquid -- 6.2.2 Characteristics of Hydrochemical Kinetics Parameters of Dissolution Liquid -- 6.2.3 Hydrochemical Fractal Characteristics of Dissolution Liquids -- 6.2.4 Hydrochemical Kinetics Parameters and Hydrochemical Fractal Characteristics of Karst Groundwater -- 6.3 Correlation Between Microscopic Karst Fractal Characteristics and Hydrochemical Fractal Characteristics -- 6.3.1 Correlation Between Hydrochemical Compositions and Characteristics of Hydrochemical Kinetics with the Degree of Karst Development -- 6.3.2 Correlation Between Hydrochemical Kinetics Parameters of Karst Water and Fractal Index of Karst Development Degree -- 6.3.3 Correlation Between Hydrochemical Fractal Index and Microscopic Karst Fractal Index -- 7 Hydrochemical Kinetics Fractal Index Assessment Technology for Karst Development Degree -- 7.1 Index System for Karst Development Degree Assessment -- 7.1.1 Concept of Karst Development Degree -- 7.1.2 Qualitative Indexes for the Assessment of Karst Development Degree -- 7.1.3 Quantitative Indexes for Karst Development Degree Assessment -- 7.1.4 Comprehensive Assessment Indexes for Karst Development Degree -- 7.2 Assessment Model for Karst Development Degree Based on Hydrochemical Kinetics-Fractal Index and Assessment Criteria. , 7.2.1 Assessment Model for Karst Development Degree Based on Hydrochemical Kinetics-Fractal Index -- 7.2.2 Assessment Criteria for Karst Development Based on Hydrochemical Kinetics-Fractal Index -- 7.3 Project Practices for Karst Development Degree Assessment Technology -- References.
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  • 3
    Publication Date: 2022-05-25
    Description: © The Author(s), 2018. This article is distributed under the terms of the Creative Commons Attribution License. The definitive version was published in Progress in Earth and Planetary Science 5 (2018): 19, doi:10.1186/s40645-018-0167-8.
    Description: The Quaternary hemipelagic sediments of the Japan Sea are characterized by centimeter- to decimeter-scale alternation of dark and light clay to silty clay, which are bio-siliceous and/or bio-calcareous to a various degree. Each of the dark and light layers are considered as deposited synchronously throughout the deeper (〉 500 m) part of the sea. However, attempts for correlation and age estimation of individual layers are limited to the upper few tens of meters. In addition, the exact timing of the depositional onset of these dark and light layers and its synchronicity throughout the deeper part of the sea have not been explored previously, although the onset timing was roughly estimated as ~ 1.5 Ma based on the result of Ocean Drilling Program legs 127/128. Consequently, it is not certain exactly when their deposition started, whether deposition of dark and light layers was synchronous and whether they are correlatable also in the earlier part of their depositional history. The Quaternary hemipelagic sediments of the Japan Sea were drilled at seven sites during Integrated Ocean Drilling Program Expedition 346 in 2013. Alternation of dark and light layers was recovered at six sites whose water depths are 〉 ~ 900 m, and continuous composite columns were constructed at each site. Here, we report our effort to correlate individual dark layers and estimate their ages based on a newly constructed age model at Site U1424 using the best available paleomagnetic datum and marker tephras. The age model is further tuned to LR04 δ18O curve using gamma ray attenuation density (GRA) since it reflects diatom contents that are higher during interglacial high-stands. The constructed age model for Site U1424 is projected to other sites using correlation of dark layers to form a high-resolution and high-precision paleo-observatory network that allows to reconstruct changes in material fluxes with high spatio-temporal resolutions.
    Description: This work was supported by a grant from IODP Exp. 346 After Cruise Research Program, JAMSTEC, awarded to TR, IK, Irino T, Itaki T, ST, KY, SS, and KA and from JSPS KAKENHI grant number 16H01765 awarded to TR.
    Keywords: Quaternary sediments ; Japan Sea ; Inter-site correlation ; High-resolution age model ; IODP ; Expedition 346 ; U1424 ; U1425 ; U1426 ; U1430
    Repository Name: Woods Hole Open Access Server
    Type: Article
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  • 4
    Publication Date: 2012-01-13
    Description: The Journal of Physical Chemistry B DOI: 10.1021/jp209699g
    Electronic ISSN: 1520-5207
    Topics: Chemistry and Pharmacology , Physics
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  • 5
    Publication Date: 2015-01-30
    Description: Background: Community-based health education programs may be helpful in improving health outcomes in patients with chronic illnesses. This study aimed to evaluate community-based health education strategies in the management of hypertensive patients with low socioeconomic status in Dongguan City, China. Methods: This was a randomized, non-blinded trial involving 360 hypertensive patients enrolled in the community health service centre of Liaobu Town, Dongguan City, China. Participants were randomized to receive one of the three community-based health education programs over 2 years: self-learning reading (Group 1), monthly regular didactic lecture (Group 2), monthly interactive education workshop (Group 3). Outcomes included the changes in the proportion of subjects with normalized blood pressure (BP), hypertension-related knowledge score, adherence to antihypertensive treatment, lifestyle, body mass index and serum lipids. Results: After the 2-y intervention, the proportion of subjects with normalized BP increased significantly in Group 2 (from 41.2% to 63.2%, p
    Electronic ISSN: 1471-2458
    Topics: Medicine
    Published by BioMed Central
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  • 6
    Publication Date: 2015-01-14
    Description: We describe a one-step, deterministic and scalable scheme for creating macroscopic arbitrary entangled coherent states (ECSs) of separate nitrogen-vacancy center ensembles (NVEs) that couple to a superconducting flux qubit. We discuss how to generate the entangled states between the flux qubit and two NVEs by the resonant driving. Then the ECSs of the NVEs can be obtained by projecting the flux qubit, and the entanglement detection can be realized by transferring the quantum state from the NVEs to the flux qubit. Our numerical simulation shows that even under current experimental parameters the concurrence of the ECSs can approach unity. We emphasize that this method is straightforwardly extendable to the case of many NVEs. Scientific Reports 5 doi: 10.1038/srep07755
    Electronic ISSN: 2045-2322
    Topics: Natural Sciences in General
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  • 7
    Publication Date: 2015-03-07
    Description: Purpose To assess whether urea-based cream (UBC) has prophylactic benefits on sorafenib-induced hand-foot skin reaction (HFSR) in patients with advanced hepatocellular carcinoma (HCC). Patients and Methods In this randomized, open-label trial, 871 patients with advanced HCC throughout China were treated with 10% UBC three times per day plus best supportive care (BSC; n = 439) or BSC alone excluding all creams (n = 432), starting on day 1 of sorafenib treatment, for up to 12 weeks. HFSR was assessed every 2 weeks and at 14 weeks for patients completing the study. Once HFSR occurred, patients were allowed any cream, including a UBC. Results The 12-week incidence of any grade HFSR was significantly lower in the UBC group versus the BSC-alone group (56.0% v 73.6%, respectively; odds ratio [OR], 0.457; 95% CI, 0.344 to 0.608; P 〈 .001), as was the incidence of grade ≥ 2 HFSR (20.7% v 29.2%, respectively; OR, 0.635; 95% CI, 0.466 to 0.866; P = .004). Median time to first occurrence of HFSR was significantly longer in the UBC group than the BSC-alone group (84 v 34 days, respectively; hazard ratio, 0.658; 95% CI, 0.541 to 0.799; P 〈 .001). Elevated AST was associated with increased risk of HFSR but did not alter the treatment effect of UBC. UBC plus BSC, compared with BSC alone, did not affect the sorafenib dose reduction or interruption rate (9.1% v 11.8%, respectively; P = .1937), response rate (11.1% v 10.1%, respectively; P = .6674), or disease control rate (98.8% v 98.2%, respectively; P = .5350) at week 12. Conclusion UBC prophylaxis in patients with advanced HCC starting sorafenib reduced HFSR rates, extended the time to first occurrence of HFSR, and improved patient quality of life compared with BSC. Blinded, randomized, placebo-controlled trials to determine the role of UBC on the incidence and severity of HFSR are warranted.
    Keywords: Chemotherapy, Quality of Life, Supportive Care
    Print ISSN: 0732-183X
    Electronic ISSN: 1527-7755
    Topics: Medicine
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  • 8
    Publication Date: 2015-03-06
    Description: In this work, an LCL-type resonant dc/dc converter with a capacitive output filter is modeled in two stages. In the first high-frequency ac stage, all ac signals are decomposed into two orthogonal vectors in a synchronous rotating d–q frame using multi-frequency modeling. In the dc stage, all dc quantities are represented by their average values with average state-space modeling. A nonlinear two-stage model is then created by means of a non-linear link. By aligning the transformer voltage on the d-axis, the nonlinear link can be eliminated, and the whole converter can be modeled by a single set of linear state-space equations. Furthermore, a feedback control scheme can be formed according to the steady-state solutions. Simulation and experimental results have proven that the resulted model is good for fast simulation and state variable estimation.
    Electronic ISSN: 1996-1073
    Topics: Energy, Environment Protection, Nuclear Power Engineering
    Published by MDPI Publishing
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  • 9
    Publication Date: 2016-10-14
    Description: Purpose This analysis of the FIRST trial in patients with newly diagnosed multiple myeloma (MM) ineligible for stem-cell transplantation examined updated outcomes and impact of patient age. Patients and Methods Patients with untreated symptomatic MM were randomly assigned at a one-to-one-to-one ratio to lenalidomide plus low-dose dexamethasone until disease progression (Rd continuous), Rd for 72 weeks (18 cycles; Rd18), or melphalan, prednisone, and thalidomide (MPT; 72 weeks), stratified by age (≤ 75 v 〉 75 years), disease stage (International Staging System stage I/II v III), and country. The primary end point was progression-free survival. Rd continuous and MPT were primary comparators. Results Between August 21, 2008, and March 7, 2011, 1,623 patients were enrolled (Rd continuous, n = 535; Rd18, n = 541; MPT, n = 547), including 567 (35%) age older than 75 years. Higher rates of advanced-stage disease and renal impairment were observed in patients older than 75 versus 75 years of age or younger. Rd continuous reduced the risk of progression or death compared with MPT by 31% (hazard ratio [HR], 0.69; 95% CI, 0.59 to 0.80; P 〈 .001) overall, 36% (HR, 0.64; 95% CI, 0.53 to 0.77; P 〈 .001) in patients age 75 years or younger, and 20% (HR, 0.80; 95% CI, 0.62 to 1.03; P = .084) in those age older than 75 years. Median overall survival was longer with Rd continuous than with MPT, including a 14-month difference in patients age older than 75 years. Progression-free survival with Rd18 was similar to that with MPT, and overall survival with Rd18 was marginally inferior to that with Rd continuous. Rates of grade 3 to 4 treatment-emergent adverse events were similar for Rd continuous–treated patients age 75 years or older and those age older than 75 years; however, older patients had more frequent lenalidomide dose reductions. Conclusion Results support Rd continuous treatment as a new standard of care for stem-cell transplantation–ineligible patients with newly diagnosed MM of all ages.
    Keywords: Chemotherapy, Biology & Immunology, Rapid Communications
    Print ISSN: 0732-183X
    Electronic ISSN: 1527-7755
    Topics: Medicine
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  • 10
    Publication Date: 2016-04-08
    Description: Rectovaginal fistula (RVF) refers to a pathological passage between the rectum and vagina, which is a public health challenge. This study was aimed to explore the clinical value of endoluminal biplane ultrason...
    Electronic ISSN: 1471-2342
    Topics: Biology
    Published by BioMed Central
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