Note: Intro -- Name Reactions in Heterocyclic Chemistry II -- Contents -- Foreword -- Preface -- Contributing Authors -- PART 1 THREE- AND FOUR-MEMBERED HETEROCYCLES -- Chapter 1 Aziridines and Epoxides -- 1.1 Blum Aziridine Synthesis -- 1.2 Gabriel-Heine Aziridine Isomerization -- 1.3 Shi Epoxidation -- PART 2 FIVE-MEMBERED HETEROCYCLES -- Chapter 2 Pyrroles and Pyrrolidines -- 2.1 Clauson-Kass Pyrrole Synthesis -- 2.2 Houben-Hoesch Acylation of Pyrroles -- 2.3 Overman Pyrrolidine Synthesis -- 2.4 Trofimov Synthesis of Pyrroles -- Chapter 3 Indoles -- 3.1 Bischler-Möhlau Indole Synthesis -- 3.2 Borsche-Drechsel Cyclization -- 3.3 Buchwald-Hartwig Indole Synthesis -- 3.4 Cadogan-Sundberg Indole Synthesis -- 3.5 Fukuyama Indole Synthesis -- 3.6 Gassman Oxindole Synthesis -- 3.7 Larock Indole Synthesis -- 3.8 Matinet Dioxindole Reaction -- 3.9 Mori-Ban Indole Synthesis -- 3.10 Sandmeyer Isatin Synthesis -- 3.11 Sommelet-Hauser Rearrangement -- 3.12 Stollé Oxindole Synthesis -- Chapter 4 Furans and Oxazoles -- 4.1 Nierenstein Reaction -- 4.2 Davidson Oxazole Synthesis -- 4.3 Fischer Oxazole Synthesis -- 4.4 Japp Oxazole Synthesis -- 4.5 Schöllkopf Oxazole Synthesis -- Chapter 5 Other Five-Membered Heterocycles -- 5.1 Bamberger Imidazole Cleavage -- 5.2 Dimroth Triazole Synthesis -- 5.3 Finnegan Tetrazole Synthesis -- 5.4 Hantzsch Thiazole Synthesis -- 5.5 Huisgen Tetrazole Rearrangement -- 5.6 Knorr Pyrazole Synthesis -- 5.7 Pechmann Pyrazole Synthesis -- PART 3 SIX-MEMBERED HETEROCYCLES -- Chapter 6 Pyridines -- 6.1 Baeyer Pyridine Synthesis -- 6.2 Katrizky Pyridine Synthesis -- Chapter 7 Quinolines and Isoquinolines -- 7.1 Betti Reaction -- 7.2 Bernthsen Acridine Synthesis -- 7.3 Lehmstedt- Tănăsescu Reaction -- 7.4 Niementowski Quinoline Synthesis -- 7.5 Povarov Reaction -- Chapter 8 Six-Membered Heterocycles -- 8.1 Balaban-Nenitzescu-Praill Reaction. , 8.2 Borsche Cinnoline Synthesis -- 8.3 Gutknecht Pyrazine Synthesis -- 8.4 Niementowski Quinazoline Synthesis -- 8.5 Pechmann Coumarin Synthesis -- 8.6 Robinson-Schöpf Condensation -- 8.7 Simonis Chromone Cyclization -- 8.8 Wesseley-Moser Rearrangement -- 8.9 Widman-Stoermer Cinnoline Synthesis -- 8.10 Wichterle Reaction -- Chapter 9 Miscellaneous Name Reactions -- 9.1 ANRORC Mechanism -- 9.2 Boulton-Katritzky Rearrangement -- 9.3 Chichibabin Amination Reaction -- 9.4 Dimroth Rearrangement -- 9.5 Hantzsch Synthesis -- 9.6 Ortoleva-King Reaction -- Appendixes -- Appendix 1, Table of Contents for Volume 1 : Name Reactions in Heterocyclic Chemistry -- Appendix 2, Table of Contents for Volume 2: Name Reactions for Functional Group Transformations -- Appendix 3, Table of Contents for Volume 3: Name Reactions for Homologations-I -- Appendix 4, Table of Contents for Volume 4: Name Reactions for Homologations-II -- Appendix 5, Table of Contents for Volume 5: Name Reactions for Ring Formations -- Subject Index.

Note: Cover -- I045116-FM -- I045116-01 -- I045116-02 -- I045116-03 -- I045116-04 -- I045116-05 -- I045116-06 -- I045116-07 -- I045116-08 -- I045116-09 -- I045116-10 -- I045116-11 -- I045116-12 -- I045116-13 -- I045116-14 -- I045116-Idx.

Note: Intro -- Name Reactions for Homologations: Part II -- Table of Contents -- Foreword -- Preface -- Contributing Authors -- Chapter 1. Rearrangements -- Section 1.1 Concerted rearrangement -- 1.1.1 Alder ene reaction -- 1.1.2 Claisen and related rearrangements -- 1.1.3 Cope and related rearrangements -- 1.1.4 Curtius rearrangement -- 1.1.5 Hofmann rearrangement -- 1.1.6 Lossen rearrangement -- 1.1.7 Overman rearrangement -- 1.1.8 [ 1,2]-Wittig rearrangement -- 1.1.9 [2,3]-Wittig rearrangement -- 1.1.10 Wolff rearrangement -- Section 1.2 Cationic rearrangement -- 1.2.1 Beckmann rearrangement -- 1.2.2 Demjanov rearrangement -- 1.2.3 Meyer-Schuster rearrangement -- 1.2.4 Pinacol rearrangement -- 1.2.5 Pummerer rearrangement -- 1.2.6 Schmidt rearrangement -- 1.2.7 Wagner-Meerwein rearrangement -- Section 1.3 Anionic rearrangement -- 1.3.1 Benzilic acid rearrangement -- 1.3.2 Brook rearrangement -- 1.3.3 Favorskii rearrangement -- 1.3.4 Grob fragmentation -- 1.3.5 Neber rearrangement -- 1.3.6 Payne rearrangement -- 1.3.7 Smiles rearrangement -- 1.3.8 Stevens rearrangement -- Chapter 2. Asymmetric C-C bond formation -- 2.1 Evans aldol reaction -- 2.2 Hajos-Wiechert reaction -- 2.3 Keck stereoselective allylation -- 2.4 Roush allylboronation -- Chapter 3. Miscellaneous homologation reactions -- 3.1 Bamford-Stevens reaction -- 3.2 Mannich reaction -- 3.3 Mitsunobu reaction -- 3.4 Parham cyclization -- 3.5 Passerini reaction -- 3.6 Ugi reaction -- Appendixes -- Appendix 1, Table of Contents for Volume 1 : Name Reactions in Heterocyclic Chemistry -- Appendix 2, Table of Contents for Volume 2: Name Reactions for Functional Group Transformations -- Appendix 3, Table of Contents for Volume 3: Name Reactions for Homologations-I -- Appendix 4, Table of Contents for Volume 5: Name Reactions for Ring Formations. , Appendix 5, Table of Contents for Volume 6: Name Reactions in Heterocyclic Chemistry-II -- Subject index.

Note: Intro -- Contents -- Foreword -- Abbreviations and Acronyms -- 1 Fundamental Techniques -- 1.1 Safety! -- 1.2 Useful Preparations -- 1.3 Chromatography -- 1.4 Crystallization -- 1.5 Residual Solvent Peaks in Nuclear Magnetic Resonance -- 2 Functional Group Manipulations -- 2.1 Alcohol Oxidation State -- 2.2 Ketone Oxidation State -- 2.3 Acid Oxidation State -- 3 Oxidation -- 3.1 Alcohol to Ketone Oxidation State -- 3.2 Alcohol to Acid Oxidation State -- 3.3 Olefin to Diol -- 3.4 Aldehyde to Acid Oxidation State -- 3.5 Heteroatom Oxidations -- 4 Reductions -- 4.1 Alcohols to Alkanes -- 4.2 Aldehydes, Amides, and Nitriles to Amines -- 4.3 Carboxylic Acids and Derivatives to Alcohols -- 4.4 Esters and Other Carboxylic Acid Derivatives to Aldehydes -- 4.5 Ketones or Aldehydes to Alcohols -- 4.6 Ketones to Alkanes or Alkenes -- 4.7 Reductive Dehalogenations -- 4.8 Carbon-Carbon Double and Triple Bond Reductions -- 4.9 Heteroatom-Heteroatom Reductions -- 5 Carbon-Carbon Bond Formation -- 5.1 Carbon-Carbon Forming Reactions (Single Bonds) -- 5.2 Carbon-Carbon Double Bonds (Olefin Formation) -- 5.3 Reactions that Form Multiple Carbon-Carbon Bonds -- 6 Protecting Groups -- 6.1 Alcohols and Phenols -- 6.2 Amines and Anilines -- 6.3 Aldehydes and Ketones -- Index -- A -- B -- C -- D -- E -- F -- G -- H -- I -- J -- K -- L -- M -- N -- O -- P -- Q -- R -- S -- T -- U -- V -- W -- Y -- Z.

Note: Intro -- Name Reactions for Carbocyclic Ring Formations -- Contents -- Foreword -- Preface -- Contributing Authors -- Chapter 1 Three-Membered Carbocycles -- 1.1 Freund Reaction -- 1.2 Kishner Cyclopropane Synthesis -- 1.3 Kulinovich Cyclopropanol Synthesis -- 1.4 Simmons-Smith Cyclopropanation -- Chapter 2 Four-Membered Carbocycles -- 2.1 Staudinger Ketene Cycloaddition -- Chapter 3 Five-Membered Carbocycles -- 3.1 Danheiser Annulation -- 3.2 Dieckmann Condensation -- 3.3 Favorskii Rearrangement -- 3.4 Nazarov Cyclization -- 3.5 Pauson-Khand Reaction -- 3.6 Weiss-Cook Reaction -- Chapter 4 Six-Membered Carbocycles -- 4.1 Bardhan-Sengupta Pheantherene Synthesis -- 4.2 Bergman Cyclization -- 4.3 Bogert-Cook Reaction -- 4.4 Bradsher Cycloaddition and Bradsher Reaction -- 4.5 Bradsher Reaction -- 4.6 Darzens Synthesis of Tetralin Derivatives -- 4.7 Diels-Alder Reaction -- 4.8 Dötz Benzannulation -- 4.9 Elbs Reaction -- 4.10 Fujimoto-Belleau Reaction -- 4.11 Haworth Reaction -- 4.12 Moore Cyclization -- 4.13 Myers-Saito Cyclization -- 4.14 Robinson Annulation -- 4.15 Scholl Reaction -- Chapter 5 Large-Ring Carbocycles -- 5.1 Buchner Reaction -- 5.2 de Mayo Reaction -- 5.3 Ring-closing Metathesis (RCM) -- 5.4 Thorpe-Ziegler Reaction -- Chapter 6 Transformations of Carbocycles -- 6.1 Blanc Chloromethylation Reaction -- 6.2 Asymmetric Friedel-Crafts Reactions: Past to Present -- 6.3 Houben-Hoesch Reaction -- 6.4 Kolbe-Schmitt Reaction -- 6.5 Vilsmeier-Haack Reaction -- 6.6 von Richter Reaction -- Appendices -- 1, Contents Volume 1: Name Reactions in Heterocyclic Chemistry -- 2, Contents Volume 2: Name Reactions for Functional Group Transformations -- 3, Contents Volume 3: Name Reactions for Homologations-Part I -- 4, Contents Volume 4: Name Reactions for Homologations-Part II -- 5, Contents Volume 6: Name Reactions in Heterocyclic Chemistry-Part II. , Subject Index.

Note: Intro -- Name Reactions for Functional Group Transformations -- Table of Contents -- Foreword -- Preface -- Contributing Authors -- Chapter 1 Asymmetric Synthesis -- 1.1 CBS reduction -- 1.2 Davis chiral oxaziridine reagents -- 1.3 Midland reduction -- 1.4 Noyori catalytic asymmetric hydrogenation -- 1.5 Sharpless asymmetric hydroxylation reactions -- Chapter 2 Reduction -- 2.1 Eschweiler-Clark reductive alkylation of amines -- 2.2 Gribble reduction of diaryl ketones -- 2.3 Luche reduction -- 2.4 Meerwein-Ponndorf-Verley reduction -- 2.5 Staudinger reaction -- 2.6 Wharton reaction -- Chapter 3 Oxidation -- 3.1 Baeyer-Villiger oxidation -- 3.2 Brown hydroboration reaction -- 3.3 Burgess dehydrating reagent -- 3.4 Corey-Kim oxidation -- 3.5 Dess-Martin periodinane oxidation -- 3.6 Tamao-Kumada-Fleming oxidation -- 3.7 Martin's sulfurane dehydrating reagent -- 3.8 Oppenauer oxidation -- 3.9 Prilezhaev reaction -- 3.10 Rubottom oxidation -- 3.11 Swern oxidation -- 3.12 Wacker-Tsuji oxidation -- 3.13 Woodward cis-dihydroxylation -- Chapter 4 Olefination -- 4.1 Chugaev elimination -- 4.2 Cope elimination reaction -- 4.3 Corey-Winter olefin synthesis -- 4.4 Perkin reaction (cinnamic acid synthesis) -- 4.5 Perkow vinyl phosphate synthesis -- 4.6 Ramberg-Bäcklund olefin synthesis -- 4.7 Shapiro reaction -- 4.8 Zaitsev elimination -- Chapter 5 Amine Synthesis -- 5.1 Fukuyama amine synthesis -- 5.2 Gabriel synthesis -- 5.3 Leuckart-Wallach reaction -- Chapter 6 Carboxylic Acid Derivatives Synthesis -- 6.1 Fischer-Speier esterification -- 6.2 Mukaiyama esterification -- 6.3 Ritter reaction -- 6.4 Strecker amino acid synthesis -- 6.5 Yamada coupling reagent -- 6.6 Yamaguchi esterification -- Chapter7 Miscellaneous Functional Group Manipulations -- 7.1 Balz-Schiemann reaction -- 7.2 Buchwald-Hartwig reactions -- 7.3 Haloform reaction. , 7.4 Hunsdiecker reaction -- 7.5 Japp-Klingemann hydrazone synthesis -- 7.6 Krapcho decarboxylation -- 7.7 Nef reaction -- 7.8 Prins reaction -- 7.9 Regitz diazo synthesis -- 7.10 Sommelet reaction -- Appendixes -- Appendix 1. Table of Contents for Volume 1: Name Reactions in Heterocyclic Chemistry -- Appendix 2. Table of Contents for Volume 3: Name Reactions for Chain Extension -- Appendix 3. Table of Contents for Volume 4: Name Reactions for Ring Formation -- Appendix 4. Table of Contents for Volume 5 Name Reactions in Heterocyclic Chemistry-2 -- Subject Index.

Note: Name Reactions in Heterocyclic Chemistry -- Table of Contents -- Foreword -- Preface -- Acronyms and abbreviations -- PART 1 THREE- AND FOUR-MEMBERED HETEROCYCLES -- Chapter 1 Epoxides and Aziridines -- 1.1 Corey-Chaykovsky reaction -- 1.2 Darzens glycidic ester condensation -- 1.3 Hoch-Campbell aziridine synthesis -- 1.4 Jacobsen-Katsuki epoxidation -- 1.5 Paterno-Buchi reaction -- 1.6 Sharpless-Katsuki epoxidation -- 1.7 Wenker aziridine synthesis -- PART 2 FIVE-MEMBERED HETEROCYCLES -- Chapter 2 Pyrroles and Pyrrolidines -- 2.1 Barton-Zard reaction -- 2.2 Knorr and Paal-Knorr pyrrole syntheses -- 2.3 Hofmann-Loffler-Freytag reaction -- Chapter 3 Indoles -- 3.1 Bartoli indole synthesis -- 3.2 Batcho-Leimgruber indole synthesis -- 3.3 Bucherer carbazole synthesis -- 3.4 Fischer indole synthesis -- 3.5 Gassman indole synthesis -- 3.6 Graebe-Ullman carbazole synthesis -- 3.7 Hegedus indole synthesis -- 3.8 Madelung indole synthesis -- 3.9 Nenitzescu indole synthesis -- 3.10 Reissert indole synthesis -- Chapter 4 Furans -- 4.1 Feist-Benary furan synthesis -- 4.2 Paal-Knorr furan synthesis -- Chapter 5 Thiophenes -- 5.1 Fiesselmann thiophene synthesis -- 5.2 Gewald aminothiophene synthesis -- 5.3 Hinsberg synthesis of thiophene derivatives -- 5.4 Paal thiophene synthesis -- Chapter 6 Oxazoles and Isoxazoles -- 6.1 Claisen isoxazole synthesis -- 6.2 Cornforth rearrangement -- 6.3 Erlenmeyer-Plochl azlactone synthesis -- 6.4 Fischer oxazole synthesis -- 6.5 Meyers oxazoline method -- 6.6 Robinson-Gabriel synthesis -- 6.7 van Leusen oxazole Synthesis -- Chapter 7 Other Five-Membered Heterocycles -- 7.1 Auwers flavone synthesis -- 7.2 Bucherer-Bergs reaction -- 7.3 Cook-Heilbron 5-amino-thiazole synthesis -- 7.4 Hurd-Mori 1,2,3-thiadiazole synthesis -- 7.5 Knorr pyrazole synthesis -- PART 3 SIX-MEMBERED HETEROCYCLES -- Chapter 8 Pyridines. , 8.1 Preparation via condensation reactions -- 8.1.1 Hantzsch (dihydro)-pyridine synthesis -- 8.1.1.1 Description -- 8.1.1.2 Historical perspective -- 8.1.1.3 Mechanism -- 8.1.1.4 Variations -- 8.1.1.4.1 Guareschi-Thorpe pyridine synthesis -- 8.1.1.4.2 Chichibabin (Tschitschibabin) pyridine synthesis -- 8.1.1.4.3 Bohlmann-Rahtz pyridine synthesis -- 8.1.1.4.4 Krohnke pyridine synthesis -- 8.1.1.4.5 Petrenko-Kritschenko piperidone synthesis -- 8.1.1.5 Improvements or modifications -- 8.1.1.6 Experimental -- 8.1.1.6.1 Three-component coupling -- 8.1.1.6.2 Two-component coupling -- 8.1.1.7 References -- 8.2 Preparation via cycloaddition reactions -- 8.2.1 Boger reaction -- 8.3 Preparation via rearrangement reactions -- 8.3.1 Boekelheide reaction -- 8.3.2 Ciamician-Dennstedt rearrangement -- 8.4 Zincke reaction -- Chapter 9 Quinolines and Isoquinolines -- 9.1 Bischler-Napieralski reaction -- 9.2 Camps quinoline synthesis -- 9.3 Combes quinoline synthesis -- 9.4 Conrad-Limpach reaction -- 9.5 Doebner quinoline synthesis -- 9.6 Friedlander synthesis -- 9.7 Gabriel-Colman rearrangement -- 9.8 Gould-Jacobs reaction -- 9.9 Knorr quinoline synthesis -- 9.10 Meth-Cohn quinoline synthesis -- 9.11 Pfitzinger quinoline synthesis -- 9.12 Pictet-Gams isoquinoline synthesis -- 9.13 Pictet-Hubert reaction -- 9.14 Pictet-Spengler isoquinoline synthesis -- 9.15 Pomeranz-Fritsch reaction -- 9.16 Riehm quinoline synthesis -- 9.17 Skraup/Doebner-von Miller reaction -- Chapter 10 Other Six-Membered Heterocycles -- 10.1 Algar-Flynn-Oyamada reaction -- 10.2 Beirut reaction -- 10.3 Biginelli reaction -- 10.4 Kostanecki-Robinson reaction -- 10.5 Pinner pyrimidine synthesis -- 10.6 von Richter cinnoline reaction -- Subject Index.

Note: Front cover -- Palladium in Heterocyclic Chemistry -- Copyright page -- Preface to the second edition -- Preface to the first edition -- Abbreviations -- Contents -- Chapter 1 An introduction to palladium catalysis -- 1.1 Oxidative coupling/cyclization -- 1.2 Cross-coupling reactions with organometallic reagents -- 1.3 The Sonogashira reaction -- 1.4 The Heck, intramolecular Heck, and heteroaryl Heck reactions -- 1.5 Carbonylation reactions -- 1.6 The Pd-catalyzed C-P bond formation -- 1.7 Palladium-catalyzed C-N bond and C-O bond-forming reactions -- 1.8 The Tsuji-Trost reaction -- 1.9 The Wacker-type reactions -- 1.10 Mori-Ban, Hegedus, and Larock indole syntheses -- 1.11 References -- Chapter 2 Pyrroles -- 2.1 Synthesis of pyrrolyl halides -- 2.2 Oxidative coupling/cyclization -- 2.3 Coupling reactions with organometallic reagents -- 2.4 Sonogashira reaction -- 2.5 Heck and intramolecular Heck reactions -- 2.6 Carbonylation -- 2.7 C-N bond formation reactions -- 2.8 Miscellaneous -- 2.9 References -- Chapter 3 Indoles -- 3.1 Synthesis of indolyl halides -- 3.2 Oxidative coupling/cyclization -- 3.3 Coupling reactions with organometallic reagents -- 3.4 The Sonogashira coupling -- 3.5 Heck couplings -- 3.6 Carbonylation -- 3.7 C-N bond formation reactions -- 3.8 Miscellaneous -- 3.9 References -- Chapter 4 Pyridines -- 4.1 Synthesis of halopyridines -- 4.2 Coupling reactions with organometallic reagents -- 4.3 Sonogashira reaction -- 4.4 Heck and intramolecular Heck reactions -- 4.5 Buchwald-Hartwig aminations(C-N bond formation) -- 4.6 Direct C-C bond formation -- 4.7 Summary -- 4.8 References -- Chapter 5 Thiophenes and benzo[b]thiophenes -- 5.1 Preparation of halothiophenes and halobenzothiophenes -- 5.2 Oxidative and reductive coupling reactions -- 5.3 Cross-coupling with organometallic reagents -- 5.4 Sonogashira reaction. , 5.5 Heck and intramolecular Heck reactions -- 5.6 Carbonylation reactions -- 5.7 Buchwald-Hartwig aminations -- 5.8 Miscellaneous -- 5.9 References -- Chapter 6 Furans and benzo[b]furans -- 6.1 Synthesis of halofurans and halobenzo[b]furans -- 6.2 Oxidative coupling/cyclization -- 6.3 Coupling reactions with organometallic reagents -- 6.4 Sonogashira reaction -- 6.5 Heck, intramolecular Heck, and heteroaryl Heck reactions -- 6.6 Heteroannulation -- 6.7 Carbonylation and C-N and C-O bond formation -- 6.8 References -- Chapter 7 Thiazoles and benzothiazoles -- 7.1 Synthesis of halothiazoles -- 7.2 Coupling reactions with organometallic reagents -- 7.3 Sonogashira reaction -- 7.4 Heck and heteroaryl Heck reactions -- 7.5 Carbonylation -- 7.6 C-N bond formation -- 7.7 Site selective coupling reactions -- 7.8 References -- Chapter 8 Oxazoles and benzoxazoles -- 8.1 Introduction -- 8.2 Synthesis of halooxazoles and halobenzoxazoles -- 8.3 Coupling reactions with organometallic reagents -- 8.4 Heck and heteroaryl Heck reactions -- 8.5 Carbonylation -- 8.6 Palladium-catalyzed amination -- 8.7 Carbopalladation of nitriles -- 8.8 Quaterfuran and Quinquifuran -- 8.9 Summary -- 8.10 References -- Chapter 9 Imidazoles -- 9.1 Synthesis of haloimidazoles -- 9.2 Homocoupling reaction -- 9.3 Coupling reactions with organometallic reagents -- 9.4 Sonogashira reaction -- 9.5 Heck and heteroaryl Heck reactions -- 9.6 Tsuji-Trost reaction -- 9.7 Phosphonylation -- 9.8 References -- Chapter 10 Pyrazines and quinoxalines -- 10.1 Pyrazines -- 10.2 Coupling reactions with organometallic reagents -- 10.3 Palladium-catalyzed amination -- 10.4 Heck reaction -- 10.5 Carbonylation reactions -- 10.6 Cyanation of pyrazines -- 10.7 Deoxygenation of heteroamine-N-oxide -- 10.8 Quinoxalines -- 10.9 References -- Chapter 11 Pyrimidines. , 11.1 Synthesis of pyrimidinyl halides and triflates -- 11.2 Coupling reactions with organometallic reagents -- 11.3 Sonogashira reaction -- 11.4 Heck reaction -- 11.5 The carbonylation reaction -- 11.6 Heteroannulation -- 11.7 References -- Chapter 12 Quinolines -- 12.1 Synthesis of quinoline electrophiles -- 12.2 Synthesis of quinoline nucleophiles -- 12.3 Cross-coupling reactions with organometallic reagents -- 12.4 Sonogashira reaction -- 12.5 Heck reaction -- 12.6 Miscellaneous reactions mediated by palladium -- 12.7 References -- Chapter 13 Pyridazines -- 13.1 Synthesis of (pseudo)halopyridazines and (pseudo)halopyridazin-3(2H)-ones -- 13.2 Coupling reactions with organometallic reagents -- 13.3 Sonogashira reaction -- 13.4 Heck and intramolecular Heck reactions -- 13.5 Carbonylation reactions -- 13.6 C-N bond formation -- 13.7 References -- Chapter 14 Industrial scale palladium chemistry -- 14.1 Introduction -- 14.2 Pharmaceutical products -- 14.3 Cosmaceuticals -- 14.4 Agrochemical products -- 14.5 Material sciences -- 14.6 Polymer chemistry -- 14.7 New catalyst developments in fine chemical synthesis -- 14.8 Amination -- 14.9 Carbonylation -- 14.10 Amidocarbonylation -- 14.11 References -- Index.

Note: Intro -- THE ART OF DRUG SYNTHESIS -- CONTENTS -- Foreword -- Preface -- Contributors -- 1 THE ROLE OF MEDICINAL CHEMISTRY IN DRUG DISCOVERY -- 1.1 Introduction -- 1.2 Hurdles in the Drug Discovery Process -- 1.3 The Tools of Medicinal Chemistry -- 1.3.1 In Silico Modeling -- 1.3.2 Structure-Based Drug Design (SBDD) -- 1.4 The Role of Synthetic Chemistry in Drug Discovery -- References -- 2 PROCESS RESEARCH: HOW MUCH? HOW SOON? -- 2.1 Introduction -- 2.2 Considerations for Successful Scale-up to Tox Batches and Phase I Material -- 2.3 Considerations for Phase 2 Material and Beyond -- 2.3.1 Reagent Selection -- 2.3.2 Solvent Selection -- 2.3.3 Unit Operations -- 2.3.4 Developing Simple, Effective, Efficient Work-ups and Isolations -- 2.3.5 The Importance of Physical States -- 2.3.6 Route Design and Process Optimization to Minimize COG -- 2.4 Summary -- References -- I CANCER AND INFECTIOUS DISEASES -- 3 AROMATASE INHIBITORS FOR BREAST CANCER: EXEMESTANE (AROMASIN®), ANASTROZOLE (ARIMIDEX®), AND LETROZOLE (FEMARA®) -- 3.1 Introduction -- 3.2 Synthesis of Exemestane -- 3.3 Synthesis of Anastrozole -- 3.4 Synthesis of Letrozole -- References -- 4 QUINOLONE ANTIBIOTICS: LEVOFLOXACIN (LEVAQUIN®), MOXIFLOXACIN (AVELOX®), GEMIFLOXACIN (FACTIVE®), AND GARENOXACIN (T-3811) -- 4.1 Introduction -- 4.1.1 Mechanism of Action -- 4.1.2 Modes of Resistance -- 4.1.3 Structure-Activity Relationship (SAR) and Structure-Toxicity Relationship (STR) -- 4.1.4 Pharmacokinetics -- 4.1.5 Synthetic Approaches -- 4.2 Levofloxacin -- 4.3 Moxifloxacin -- 4.4 Gemifloxacin -- 4.5 Garenoxacin (T-3811): A Promising Clinical Candidate -- References -- 5 TRIAZOLE ANTIFUNGALS: ITRACONAZOLE (SPORANOX®), FLUCONAZOLE (DIFLUCAN®), VORICONAZOLE (VFEND®), AND FOSFLUCONAZOLE (PRODIF®) -- 5.1 Introduction -- 5.2 Synthesis of Itraconazole -- 5.3 Synthesis of Fluconazole. , 5.4 Synthesis of Voriconazole -- 5.5 Synthesis of Fosfluconazole -- References -- 6 NON-NUCLEOSIDE HIV REVERSE TRANSCRIPTASE INHIBITORS -- 6.1 Introduction -- 6.2 Synthesis of Nevirapine -- 6.3 Synthesis of Efavirenz -- 6.4 Synthesis of Delavirdine Mesylate -- References -- 7 NEURAMINIDASE INHIBITORS FOR INFLUENZA: OSELTAMIVIR PHOSPHATE (TAMIFLU®) AND ZANAMIVIR (RELENZA®) -- 7.1 Introduction -- 7.1.1 Relenza -- 7.1.2 Tamiflu -- 7.2 Synthesis of Oseltamivir Phosphate (Tamiflu®) -- 7.3 Synthesis of Zanamivir (Relenza®) -- References -- II CARDIOVASCULAR AND METABOLIC DISEASES -- 8 PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR (PPAR) AGONISTS FOR TYPE 2 DIABETES -- 8.1 Introduction -- 8.1.1 Insulin -- 8.1.2 Sulfonylurea Drugs -- 8.1.3 Meglitinides -- 8.1.4 Biguanides -- 8.1.5 Alpha-Glucosidase Inhibitors -- 8.1.6 Thiazolidinediones -- 8.2 Synthesis of Rosiglitazone -- 8.3 Synthesis of Pioglitazone -- 8.4 Synthesis of Muraglitazar -- References -- 9 ANGIOTENSIN AT(1) ANTAGONISTS FOR HYPERTENSION -- 9.1 Introduction -- 9.2 Losartan Potassium -- 9.2.1 Introduction to Losartan Potassium -- 9.2.2 Synthesis of Losartan Potassium -- 9.3 Valsartan -- 9.3.1 Introduction to Valsartan -- 9.3.2 Synthesis of Valsartan -- 9.4 Irbesartan -- 9.4.1 Introduction to Irbesartan -- 9.4.2 Synthesis of Irbesartan -- 9.5 Candesartan Cilexetil -- 9.5.1 Introduction to Candesartan Cilexetil -- 9.5.2 Synthesis of Candesartan Cilexetil -- 9.6 Olmesartan Medoxomil -- 9.6.1 Introduction to Olmesartan Medoxomil -- 9.6.2 Synthesis of Olmesartan Medoxomil -- 9.7 Eprosartan Mesylate -- 9.7.1 Introduction to Eprosartan Mesylate -- 9.7.2 Synthesis of Eprosartan Mesylate -- 9.8 Telmisartan -- 9.8.1 Introduction to Telmisartan -- 9.8.2 Synthesis of Telmisartan -- References -- 10 LEADING ACE INHIBITORS FOR HYPERTENSION -- 10.1 Introduction -- 10.2 Synthesis of Enalapril Maleate. , 10.3 Synthesis of Lisinopril -- 10.4 Synthesis of Quinapril -- 10.5 Synthesis of Benazepril -- 10.6 Synthesis of Ramipril -- 10.7 Synthesis of Fosinopril Sodium -- References -- 11 DIHYDROPYRIDINE CALCIUM CHANNEL BLOCKERS FOR HYPERTENSION -- 11.1 Introduction -- 11.2 Synthesis of Nifedipine (Adalat®) -- 11.3 Synthesis of Felodepine (Plendil®) -- 11.4 Synthesis of Amlodipine Besylate (Norvasc®) -- 11.5 Synthesis of Azelnidipine (Calblock®) -- References -- 12 SECOND-GENERATION HMG-CoA REDUCTASE INHIBITORS -- 12.1 Introduction -- 12.2 Synthesis of Fluvastatin (Lescol®) -- 12.3 Synthesis of Rosuvastatin (Crestor®) -- 12.4 Synthesis of Pitavastatin (Livalo®) -- References -- 13 CHOLESTEROL ABSORPTION INHIBITORS: EZETIMIBE (ZETIA®) -- 13.1 Introduction -- 13.2 Discovery Path to Ezetimibe -- 13.3 Synthesis of Ezetimibe (Zetia®) -- References -- III CENTRAL NERVOUS SYSTEM DISEASES -- 14 DUAL SELECTIVE SEROTONIN AND NOREPINEPHRINE REUPTAKE INHIBITORS (SSNRIs) FOR DEPRESSION -- 14.1 Introduction -- 14.2 Synthesis of Venlafaxine -- 14.3 Synthesis of Milnacipran -- 14.4 Synthesis of Duloxetine -- References -- 15 GABA(A) RECEPTOR AGONISTS FOR INSOMNIA: ZOLPIDEM (AMBIEN®), ZALEPLON (SONATA®), ESZOPICLONE (ESTORRA®, LUNESTA®), AND INDIPLON -- 15.1 Introduction -- 15.2 Synthesis of Zolpidem -- 15.3 Synthesis of Zaleplon -- 15.4 Synthesis of Eszopiclone -- 15.5 Synthesis of Indiplon -- References -- 16 α(2)δ LIGANDS: NEURONTIN® (GABAPENTIN) AND LYRICA® (PREGABALIN) -- 16.1 Introduction -- 16.2 Synthesis of Gabapentin -- 16.3 Synthesis of Pregabalin -- References -- 17 APPROVED TREATMENTS FOR ATTENTION DEFICIT HYPERACTIVITY DISORDER: AMPHETAMINE (ADDERALL®), METHYLPHENIDATE (RITALIN®), AND ATOMOXETINE (STRATERRA®) -- 17.1 Introduction -- 17.1.1 Stimulant versus Nonstimulants -- 17.2 Synthesis of Amphetamine. , 17.2.1 Pharmacokinetic Properties of d- and l-Amphetamine -- 17.2.2 Chiral Synthesis of Amphetamine -- 17.3 Synthesis of Methylphenidate -- 17.3.1 Methylphenidate Formulations -- 17.3.2 Chiral Synthesis of Methylphenidate -- 17.4 Synthesis of Atomoxetine -- References -- Index.

Note: Front Cover -- Contents -- Preface -- Editor -- Contributors -- Chapter 1: Introduction -- Chapter 2: Radical-Mediated C―H Bond Activation -- Chapter 3: Pd-Catalyzed C―H Functionalization -- Chapter 4: Rhodium-Catalyzed C―H Activation -- Chapter 5: Nickel-Catalyzed C―H Activation -- Chapter 6: Iron-Catalyzed C―H Activation -- Chapter 7: Copper-Mediated C―H Activation -- Chapter 8: Cobalt-Catalyzed C―H Activation -- Chapter 9: Fluorination and Trifluoromethylation of Arenes and Heteroarenes via C―H Activation -- Chapter 10: C―H Activation of Heteroaromatics -- Back Cover.