GLORIA

GEOMAR Library Ocean Research Information Access

X
feed icon rss

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
  • 1
    Online Resource
    Online Resource
    Nicotinic Receptors in the Nervous System. (2001)
    Milton :Taylor & Francis Group,
    Details
    Keywords: Nicotinic receptors -- Research -- Methodology. ; Electronic books.
    Description / Table of Contents: Featuring a unique approach, Nicotinic Receptors in the Nervous System provides integrated coverage of research on neuronal nicotinic systems relevant to smoking addiction and cognitive dysfunction. By bringing together molecular and neurochemical applications, the book provides the key to understanding function and dysfunction of nicotinic systems and how they are significant for disease, addiction, and the development of novel drug treatments. The book presents readers with the basic mechanistic background for these treatments as well as the functional assessment necessary to determine therapeutic effects.
    Type of Medium: Online Resource
    Pages: 1 online resource (310 pages)
    Edition: 1st ed.
    ISBN: 9781420038521
    Series Statement: Frontiers in Neuroscience Series
    URL: https://ebookcentral.proquest.com/lib/geomar/detail.action?docID=264015
    Language: English
    Note: Front cover -- Dedication -- Methods & -- New Frontiers in Neuroscience -- Preface -- The Editor -- Contributors -- Table of Contents -- Section 1 -- Chapter 1. Some Methods for Studies of Nicotinic Acetylcholine Receptor Pharmacology -- Chapter 2. Presynaptic Nicotinic Acetylcholine Receptors: Subtypes Mediating Neurotransmitter Release -- Chapter 3. Effects of Nicotine on Dopaminergic Neurotransmission -- Chapter 4. Nicotinic Receptors in the Periphery -- Section 2 -- Chapter 5. Nicotinic Cholinergic Receptors as Targets in Pain Control -- Chapter 6. Mouse Models to Evaluate Genetic Influences on Responses to Nicotine -- Chapter 7. Nicotinic Involvement in Cognitive Function of Rats -- Chapter 8. Nicotine and Cognition in Young and Aged Nonhuman Primates -- Chapter 9. Neuroscience Research with Nicotine Self-Administration -- Section 3 -- Chapter 10. Evaluation of Pharmacologic Treatments for Smoking Cessation -- Chapter 11. Nicotine and Schizophrenia -- Chapter 12. Nicotinic Medications and Tourette's Disorder -- Chapter 13. Nicotine Effects on Attention Deficit Hyperactivity Disorder -- Chapter 14. Clinical Methodologies in the Examination of Nicotinic Effects on Cognition -- Section 4 -- Chapter 15. Nicotinic Systems: An Integrated Approach -- Index -- Back cover.
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    GEOMAR EBL
  • 2
    Online Resource
    Online Resource
    Neurotransmitter Interactions and Cognitive Function. (2006)
    Basel :Springer Basel AG,
    Details
    Keywords: Cognitive neuroscience. ; Electronic books.
    Type of Medium: Online Resource
    Pages: 1 online resource (288 pages)
    Edition: 1st ed.
    ISBN: 9783764377724
    Series Statement: Experientia Supplementum Series ; v.98
    URL: https://ebookcentral.proquest.com/lib/geomar/detail.action?docID=324159
    DDC: 612.8/2
    Language: English
    Note: Intro -- CONTENTS -- List of contributors -- The rationale for studying transmitter interactions to understand the neural bases of cognitive function -- Neurotransmitters and cognition -- Interactions between CRF and acetylcholine in the modulation of cognitive behaviour -- Forebrain dopaminergic-cholinergic interactions, attentional effort, psychostimulant addiction and schizophrenia -- Intraseptal cholinergic infusions alter memory in the rat: method and mechanism -- Modulation of visual perception and action by forebrain structures and their interactions in amphibians -- Neuromodulators of LTP and NCAMs in the amygdala and hippocampus in response to stress -- Central histaminergic system interactions and cognition -- Cholinergic, histaminergic, and noradrenergic regulation of LTP stability and induction threshold: cognitive implications -- Nicotinic-antipsychotic drug interactions and cognitive function -- Function and dysfunction of monoamine interactions in children and adolescents with AD/HD -- Prepulse inhibition mechanisms and cognitive processes: a review and model -- Index.
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    GEOMAR EBL
  • 3
    facet.materialart.
    Unknown
    Liver genomic responses to ciguatoxin: evidence for activation of Phase I and Phase II detoxification pathways following an acute hypothermic response in mice (2021)
    In:  Fran.VanDolah@noaa.gov | http://aquaticcommons.org/id/eprint/14902 | 403 | 2014-03-11 17:21:58 | 14902 | United States National Ocean Service
    Details
    Publication Date: 2021-06-28
    Description: Ciguatoxins (CTX) are polyether neurotoxins that target voltage-gated sodium channels and are responsible for ciguatera, the most common fish-borne food poisoning in humans. This study characterizes the global transcriptional response of mouse liver to a symptomatic dose (0.26 ng/g) of the highly potent Pacific ciguatoxin-1 (P-CTX-1). At 1 h post-exposure 2.4% of features on a 44K whole genome array were differentially expressed (p ≤ 0.0001), increasing to 5.2% at 4 h and decreasing to 1.4% by 24 h post-CTX exposure. Data were filtered (|fold change| ≥ 1.5 and p ≤ 0.0001 in at least one time point) and a trend set of 1550 genes were used for further analysis. Early gene expression was likely influenced prominently by an acute 4°C decline in core body temperature by 1 h, which resolved by 8 h following exposure. An initial downregulation of 32 different solute carriers, many involved in sodium transport, was observed. Differential gene expression in pathways involving eicosanoid biosynthesis and cholesterol homeostasis was also noted. Cytochrome P450s (Cyps) were of particular interest due to their role in xenobiotic metabolism. Twenty-seven genes, mostly members of Cyp2 and Cyp4 families, showed significant changes in expression. Many Cyps underwent an initial downregulation at 1 h but were quickly and strongly upregulated at 4 and 24 h post-exposure. In addition to Cyps, increases in several glutathione S-transferases were observed, an indication that both phase I and phase II metabolic reactions are involved in the hepatic response to CTX in mice.
    Keywords: Chemistry ; Health
    Repository Name: AquaDocs
    Type: article , TRUE
    Format: application/pdf
    Format: application/pdf
    Format: 298-310
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    PAPER (OA)
  • 4
    Electronic Resource
    Electronic Resource
    Combined Administration of Agonist-Antagonist as a Method of Regulating Receptor Activation (1995)
    Oxford, UK : Blackwell Publishing Ltd
    Annals of the New York Academy of Sciences 757 (1995), S. 0 
    Details
    ISSN: 1749-6632
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Natural Sciences in General
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1749-6632.1995.tb17478.x
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 5
    Electronic Resource
    Electronic Resource
    Acute and Chronic Nicotinic Interactions with Dopamine Systems and Working Memory Performance (1995)
    Oxford, UK : Blackwell Publishing Ltd
    Annals of the New York Academy of Sciences 757 (1995), S. 0 
    Details
    ISSN: 1749-6632
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Natural Sciences in General
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1749-6632.1995.tb17481.x
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 6
    Electronic Resource
    Electronic Resource
    Radial-arm maze performance in rats is impaired by a combination of nicotinic-cholinergic and D2 dopaminergic antagonist drugs (1989)
    Springer
    Psychopharmacology 99 (1989), S. 371-373 
    Details
    ISSN: 1432-2072
    Keywords: Radial-arm maze ; Nicotinic ; D1 dopamine receptors ; D2 dopamine receptors ; SCH 23390 ; Raclopride ; Mecamylamine
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Performance on the radial-arm maze depends on the integrity of both cholinergic and dopaminergic systems. We have previously found that administration of either the nicotinic-cholinergic antagonist, mecamylamine, or the muscarinic-cholinergic antagonist, scopolamine, impairs choice accuracy in the radial-arm maze. Co-administration of the dopaminergic antagonist, haloperidol, ameliorated the performance deficit caused by scopolamine but exacerbated the deficit caused by mecamylamine. Furthermore, antagonism of the effect of scopolamine is due specifically to blockade of D1 receptors. In the present experiment behaviorally subthreshold doses of mecamylamine and the D2 antagonist raclopride impaired maze performance when administered together. No interactive effects were observed between mecamylamine and the D1 antagonist SCH 23390. Although several of the drug treatments studied significantly increased choice latency, an index of motor behavior, there was no perfect relationship between choice accuracy and choice latency. These data indicate that nicotinic-cholinergic and muscarinic-cholinergic systems interact selectively and differentially with D1 and D2 dopaminergic systems.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00445560
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 7
    Electronic Resource
    Electronic Resource
    Chronic neuroleptic effects on spatial reversal learning in monkeys (1989)
    Springer
    Psychopharmacology 97 (1989), S. 496-500 
    Details
    ISSN: 1432-2072
    Keywords: Fluphenazine ; Learning ; Monkeys
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Cebus apella monkeys were chronically administered the antipsychotic drug fluphenazine decanoate for periods ranging from 3.5 to 5.5 years. In the present study, four of these monkeys and two controls were tested for cognitive abilities on a spatial learning task, which consisted of an original discrimination and four reversals of that discrimination. No effect of fluphenazine administration was seen in the rate of learning the original discrimination, but the carryover of learning across discrimination reversals was significantly reduced by fluphenazine. After overtraining on the original discrimination, the controls showed the normal difficulty in learning the first reversal. The fluphenazine-treated monkeys showed no such disruption. On subsequent reversals, the controls showed continually improving performance, so that on the third and fourth reversals they had near-perfect scores. On the other hand, the fluphenazine-treated monkeys showed no change over the four reversals. Unlike normal monkeys, their learning did not improve with practice. Although simple forms of learning seem to be relatively unaffected by chronic fluphenazine administration, more complex learning is disrupted.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00439554
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 8
    Electronic Resource
    Electronic Resource
    Nicotinic systems and cognitive function (1992)
    Springer
    Psychopharmacology 108 (1992), S. 417-431 
    Details
    ISSN: 1432-2072
    Keywords: Acetylcholine ; Nicotinic ; Memory ; Nicotine ; Mecamylamine
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Nicotinic acetylcholine receptors have been found to be important for maintaining optimal performance on a variety of cognitive tasks. In humans, nicotine-induced improvement of rapid information processing is particularly well documented. In experimental animals nicotine has been found to improve learning and memory on a variety of tasks, while the nicotinic antagonist mecamylamine has been found to impair memory performance. Nicotine has been found to be effective in attenuating memory deficits resulting from lesions of the septohippocampal pathway or aging in experimental animals. Nicotinic receptors are decreased in the cortex of patients with Alzheimer's disease. Preliminary studies have found that some aspects of the cognitive deficit in Alzheimer's disease can be attenuated by nicotine. Nicotine may prove to be useful therapeutic treatment for this and other types of dementia.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02247415
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 9
    Electronic Resource
    Electronic Resource
    d-Amphetamine-induced “Floating limb” syndrome in young rhesus monkeys (1990)
    Springer
    Psychopharmacology 101 (1990), S. 112-117 
    Details
    ISSN: 1432-2072
    Keywords: Rhesus ; Monkeys ; Amphetamine ; Dyskinesia ; Athetosis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Acuted-amphetamine administration to young rhesus monkeys (N=10) caused a motor syndrome of hypoactivity and chorea-like postures and motor movements which we have termed “floating limb”. Frequently after subcutaneous injections of 0.3 or 0.6 mg/kgd-amphetamine, an affected monkey raised one or both legs or arms and held the limb(s) motionless in the air. Affected limbs were usually returned to a normal position if they appeared to enter the animal's visual field. In other cases, the monkey assumed bizarre and contorted postures which were held for prolonged periods. Such postures were often accompanied by gentle repetitive brushing of the ears and facial hair with extremities of the affected limbs. Quantification of the frequency of these movements showed that they occurred regularly for 90–150 min afterd-amphetamine. Hydroxyamphetamine, a peripherally-acting amphetamine analog, did not induce floating limb, indicating that the behavior was probably mediated by central actions ofd-amphetamine. A similar disorder has been reported occasionally in other studies with monkeys and cats. It may be related to the chorea that is seen in humans after the use of amphetamine and other stimulants.d-Amphetamine treatment in young monkeys may provide a viable model of human choreoathetoid disorders induced by disease or drug use.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02253727
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 10
    Electronic Resource
    Electronic Resource
    Delayed spatial alternation deficits resulting from perinatal PCB exposure in monkeys (1988)
    Springer
    Archives of toxicology 62 (1988), S. 267-273 
    Details
    ISSN: 1432-0738
    Keywords: PCBs ; Polychlorinated biphenyls ; Monkeys ; Attention ; Delayed spatial alternation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Monkeys exposed to low, chronic levels of polychlorinated biphenyls (PCBs) in utero and during nursing until 4 months after birth were tested at 4–6 years of age on delayed spatial alternation (DSA), a spatial learning and memory task. Deficits in performance accuracy were detected in two cohorts of monkeys whose mothers had been fed 2.5 ppm of the PCB mixture, Aroclor 1248, in their diet for an 18-month period ending at least 12 months prior to pregnancy. The deficit was most apparent at the shorter delays, suggesting that it was not due to memory impairment, but may have been due to impairments in associational or attentional processes. There may also have been a deficit in a group of monkeys whose mothers were fed 1.0 ppm of the PCB mixture, Aroclor 1016. However, the deficit in this group was less pronounced than in the other groups. The appearance of a PCB-induced cognitive deficit more than 3 years after the end of exposure indicated the existence of very long-term adverse consequences of low-level perinatal PCB exposure.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00332486
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...