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  • 1
    Publication Date: 2020-12-02
    Description: We present a new surface-atmospheric dataset for driving ocean–sea-ice models based on Japanese 55-year atmospheric reanalysis (JRA-55), referred to here as JRA55-do. The JRA55-do dataset aims to replace the CORE interannual forcing version 2 (hereafter called the CORE dataset), which is currently used in the framework of the Coordinated Ocean-ice Reference Experiments (COREs) and the Ocean Model Intercomparison Project (OMIP). A major improvement in JRA55-do is the refined horizontal grid spacing (∼ 55 km) and temporal interval (3 hr). The data production method for JRA55-do essentially follows that of the CORE dataset, whereby the surface fields from an atmospheric reanalysis are adjusted relative to reference datasets. To improve the adjustment method, we use high-quality products derived from satellites and from several other atmospheric reanalysis projects, as well as feedback on the CORE dataset from the ocean modelling community. Notably, the surface air temperature and specific humidity are adjusted using multi-reanalysis ensemble means. In JRA55-do, the downwelling radiative fluxes and precipitation, which are affected by an ambiguous cloud parameterisation employed in the atmospheric model used for the reanalysis, are based on the reanalysis products. This approach represents a notable change from the CORE dataset, which imported independent observational products. Consequently, the JRA55-do dataset is more self-contained than the CORE dataset, and thus can be continually updated in near real-time. The JRA55-do dataset extends from 1958 to the present, with updates expected at least annually. This paper details the adjustments to the original JRA-55 fields, the scientific rationale for these adjustments, and the evaluation of JRA55-do. The adjustments successfully corrected the biases in the original JRA-55 fields. The globally averaged features are similar between the JRA55-do and CORE datasets, implying that JRA55-do can suitably replace the CORE dataset for use in driving global ocean–sea-ice models.
    Description: Published
    Description: 79-139
    Description: 4A. Oceanografia e clima
    Description: JCR Journal
    Repository Name: Istituto Nazionale di Geofisica e Vulcanologia (INGV)
    Type: article
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  • 2
    Publication Date: 2019-03-29
    Description: This report outlines the structure of and summarizes the recommendations made at the 5th International Conference on Reanalysis (ICR5)1, attended by 259 participants from 37 countries, in Rome (Italy), on 13-17 November 2017. It first summarizes the conference structure. Then, the key recommendations of ICR5 are given for the five main conference topics: production; observations (data rescue and preparation); data assimilation methods; quality assurance of reanalysis; and applications in science, services, and policymaking. Lastly, five high-level recommendations are proposed to managing agencies on how best to advance the field of reanalyses, which serves tens of thousands of users, via enhanced research, development, and operations.
    Description: Published
    Description: ES139-ES144
    Description: 4A. Oceanografia e clima
    Description: JCR Journal
    Repository Name: Istituto Nazionale di Geofisica e Vulcanologia (INGV)
    Type: article
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  • 3
    Electronic Resource
    Electronic Resource
    Melbourne, Australia : Blackwell Science Pty
    International journal of urology 12 (2005), S. 0 
    ISSN: 1442-2042
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Abstract Background:  Female urethral cancer with a diverticular form is assumed to originate from the para-urethral  duct,  which  is  embryologically  homologous  to  the  male  prostate  gland.  The  purpose  of the present paper was to investigate the female para-urethral adenocarcinomas histologically and immunohistochemically.Methods:  Surgical specimens obtained from six female patients with para-urethral adenocarcinomas were examined histologically, and an immunohistochemical study using antibodies against carcinoembryonic antigen (CEA), prostate specific antigen (PSA), and chromogranin A was performed.Results:  On histologic examination, the female para-urethral cancers were divided into five cases of mucin-producing-type adenocarcinoma and one case of clear cell-type adenocarcinoma. All five mucin-producing-type adenocarcinomas were positive with anti-CEA, and two of them showed neuroendicrine differentiation. One of them showed a focally positive area with anti-PSA. The clear cell-type adenocarcinoma had no positive reactions to these antibodies.Conclusions:  On the basis of histologic structure, positive CEA staining, and the presence of focal neuroendocrine differentiation, mucin-producing-type adenocarcinomas may arise from the proximal part of the para-urethral duct.
    Type of Medium: Electronic Resource
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  • 4
    ISSN: 1442-2042
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: We successfully treated three patients using the flexible video cystoscope (CYF-240A, Olympus, Japan) for superficial bladder cancer under local anesthesia and/or spinal anesthesia. The major advantage of this new technique is that surgeons can use digital pictures and high frequency cauterization. This new system provides good quality of life for bladder cancer patients experiencing frequent recurrences.
    Type of Medium: Electronic Resource
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  • 5
    ISSN: 1442-2042
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: We report our investigation of urinary incontinence in 51 male paraplegics with radical transurethral resection of the prostate. Pre-operatively, 28 cases (55.9%) had moderate or severe incontinence, which persisted post-operatively only in 21 cases (41.2%) and was less severe. Post-operatively, bladder compliance was improved from 22.1 22.6 ml/cmH2O to 36.4 38.5 ml/cmH2O, and the maximum pressure of uninhibited detrusor contraction was reduced from 40.2 21.5 cmHzO to 18.3 19.0 cmH2O. These significant improvements are thought to contribute to the relief of urinary incontinence, regardless of the reduction in maximum urethral closure pressure.
    Type of Medium: Electronic Resource
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  • 6
    ISSN: 1442-2042
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: To inveslgate the possible involvement of endogenous endothelin (ET) in cyclosporin A (CsA) nephrotoxicity, we examined the renal effects of the selective [125I]ET-1 binding to porcine aortic membrane (ETA) receptor antagonist, BQ-123 (BQ), on CsA-treated rats. An osmotic minipump filled with BQ or its vehicle (saline), was subcutaneously implanted and animals were treated with CsA (50mg/kg/d, i.p.) for 4 d. In both BQ-and its vehicle-treated rats, the 24-hour urine volume, urinary N-acetyl-D-glucosaminidase (NAG) excretion, urinaryCa/creatinine (Cr) and urinaryNAG/Cr ratios were significantly increased compared with those before administration of CsA. In contrast, after administration of CsA, urinary Cr excretion was significantly decreased in both rat groups. Although urinary NAG excretion and the NAG/Cr ratio in the rats treated with BQ were significantly increased compared with those treated with saline, the serum Cr levels in BQ-treated rats were significantly lower than those in saline-treated rats. Urinary immunoreactive ET-1 (irET-1) excretion in all animals was significantly increased after administration of CsA. There were no significant differences in urinary irET-1 excretion in both BQ-treated and saline-treated rats with and without CsA. Expression of irET-1 was seen in the cytoplasm of renal tubules, but the degree of expression was similar in the BQ-treated and saline-treated rats on CsA. In the BQ-treated rats, small round areas with high grain densities over the glomeruli in the cortex and vesa recta bundles in the outer medulla were masked by the antagonist action of BQ. On microscopic examination of autoradiograms, the numbers of autoradiographic grains were clearly decreased in the glomeruli and vessels, which confirmed the presence of ETA. It was concluded that: (1) BQ had no effect on the products and release of ET-1; (2) BQ could not entirely prevent CsA nephrotoxicity in rats; (3) BQ increased the tubular damage caused by CsA.
    Type of Medium: Electronic Resource
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  • 7
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Science Pty
    International journal of urology 9 (2002), S. 0 
    ISSN: 1442-2042
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Background: A study was conducted to evaluate our experience of ileal-conduit formation in tetraplegic patients with special reference to late complications due to upper urinary tract stones and pyocystis. Methods: Ileal-conduit formation was performed in 16 patients with tetraplegia to improve urinary management. The mean age at operation was 46 years (range 19–70) and the mean follow-up period was 8.7 years (range 2–17). We evaluated the results retrospectively from patients’ medical records. Results: Two patients died 2 years after the procedure and one patient died 8 years after the ileal-conduit formation. Five patients suffered from repeated renal or ureteral stone. In three of these cases, serious urinary tract infections developed whenever the stone caused an obstruction. Three patients received a cystectomy at the time of the ileal-conduit formation. Eight patients suffered from empyema of the bladder and in two of these cases a subsequent cystectomy was required. Conclusions: Ileal-conduit formation should be cautiously considered as an option in the urinary management of tetraplegic patients, particularly when more conservative management strategies have proved unsuccessful. However, an antirefluxing mechanism for the ileal conduit may be necessary, and a simultaneous cystectomy may improve the results.
    Type of Medium: Electronic Resource
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  • 8
    Electronic Resource
    Electronic Resource
    Melbourne, Australia : Blackwell Science Pty
    International journal of urology 12 (2005), S. 0 
    ISSN: 1442-2042
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Abstract  Background: We examined so-called Müllerian duct cysts both histologically and immunohistochemically with anatomical observation to investigate the etiology of the ‘Müllerian duct cyst’.Methods: Five cystic lesions located in the prostatic midline were obtained from surgical specimens. A communication between the cystic lesion and the urethra via the utricular orifice was looked for and the specimens were subjected to histological and immunohistochemical testing.Results: A communication between the cyst and the urethra was confirmed in four cases, but not in one case. Histological and immunohistochemical examinations of the epithelium lining indicated that its characteristics were identical to those of the prostatic utricle in all cases.Conclusions: The so-called Müllerian duct cyst exhibits features comparable to those previously described in the prostatic utricle. There is no evidence that these cystic lesions originate from the Müllerian duct remnant, at least in the epithelial lining. We suggest that they should be termed a prostatic utricular cyst or cystic dilation of the prostatic utricle, depending on whether an outlet to the urethra is absent or present, respectively.
    Type of Medium: Electronic Resource
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  • 9
    Electronic Resource
    Electronic Resource
    Melbourne, Australia : Blackwell Science Pty
    International journal of urology 10 (2003), S. 0 
    ISSN: 1442-2042
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Backgroud:  The therapeutic role of α-blockers in the treatment of voiding disorders due to benign prostatic hyperplasia has been extensively examined. To investigate a possible effect of α1-blocker on urodynamic voiding parameters in patients with neurogenic bladder, we conducted a clinical trial using tamsulosin.Methods:  Twenty-four patients (14 men and 10 women) ranging from 24 to 82 years of age (mean age 61 years) with neurogenic bladder were analyzed. Urodynamic studies were performed before and after treatment with 0.4 mg tamsulosin daily for 4 weeks.Results:  On uroflowmetry, the average flow rate (from 4.6 ± 3.3 to 6.7 ± 3.0 mL/s, P = 0.04), maximum flow rate (from 9.4 ± 6.8 to 14.1 ± 7.0 mL/s, P = 0.016) and residual urine rate (from 46 ± 29 to 32 ± 21%, P = 0.02) improved significantly. In patients with detrusor contraction during voiding, detrusor opening pressure and detrusor pressure at maximum flow decreased significantly from 69.0 ± 36.2 to 49.2 ± 26.4 cmH2O (P = 0.046) and from 66.7 ± 34.6 to 53.6 ± 26.5 cmH2O (P = 0.007), respectively. On the other hand, in patients with detrusor areflexia, vesical opening pressure (from 78.2 ± 23.4 to 61.6 ± 25.2 cmH2O), or vesical pressure at maximum flow (from 68.6 ± 23.2 to 62.9 ± 25.2 cmH2O) did not change significantly after treatment.Conclusion:  Tamsulosin reduces functional urethral resistance during voiding and improves flow rate in patients with neurogenic bladder. It has more beneficial urodynamic effects in patients with detrusor contraction during voiding than in patients with detrusor areflexia.
    Type of Medium: Electronic Resource
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  • 10
    Electronic Resource
    Electronic Resource
    Melbourne, Australia : Blackwell Science Pty
    International journal of urology 8 (2001), S. 0 
    ISSN: 1442-2042
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Abstract A case is presented of prostatic cancer with marked neuroendocrine differentiation. Double-labeled immunohistochemical staining was performed with prostate-specific antigen and Chromogranin A. Both antibodies were localized to some of the cancer cells with Paneth cell-like features. Furthermore, most of the cancer cells were positively stained with luminal cell marker CAM 5.2, suggesting that neuroendocrine cells originated from the prostatic luminal cells.
    Type of Medium: Electronic Resource
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