Note: Intro -- Contents -- 1 Fritz Lipmann 1899-1986 -- Life with Fritz -- A Long Life in Times of Great Upheaval -- Fritz Lipmann: In Memoriam -- Lipmann's Remarkably Fulfilled Life as a Researcher -- Fritz Lipmann: June 12, 1899-July 24, 1986 -- Fritz Lipmann Molding the Design of Molecular Bioenergetics -- Recollections of Fritz Lipmann, 1941-1945 -- In Celebration of the Scientific Genius of Fritz Lipmann -- Lipmann and "Not Strictly Biochemistry" -- Communication in Metabolic Control. Intuition and Method in Biochemistry: Four Years each with Krebs and Lipmann -- Fritz Lipmann: Squiggle to Protein Sulfation -- Fritz Lipmann (1899-1986), Honorary Member of the Leopoldina Academy -- Dahlem in the Late Nineteen Twenties -- Our Apprenticeship -- The Kaiser-Wilhelm-Institutes in Berlin-Dahlem in the Late 1930ies and Early 1940ies: Reminiscences of a Student of Biochemistry -- On the Origin of the Squiggle (~) -- 2 Biochemistry Comes of Age -- The History of Metabolites Isolated from Urine -- The Pentose Phosphate Pathway -- Glycolysis and the Dawn of Modern Biochemistry -- Energy-Rich Bonds and Enzymatic Peptide Synthesis -- A Nostalgic View of the TCA Cycle in Bacteria -- The Role of Vitamins and their Carrier Proteins in Citrate Fermentation -- Lipmann's Influence on Firefly Luminescence -- Sulfur in Biomimetic Peptide Syntheses -- The Function of Teichoic Acids in Walls and Membranes of Bacteria -- The Amidotransferases: Origins of the Concept of Affinity Labeling of Enzymes -- Intracellular Protein Degradation: Past, Present and Future -- Lipmann's Squiggle and the Unification of Cellular Structure and Function -- The Historical Intermingling of Biochemistry and Cell Biology -- Regulation of Function of Membrane Proteins by Phosphorylation and Dephosphorylation -- Molecular Biology of Brain Peptides and their Cognate Receptors. , The Biological Activity of Tuftsin, Thr-Lys-Pro-Arg -- Biosynthesis of Linear Gramicidin, Pentadeca Peptide, is Tight Linked to Serine Metabolism and to Membranous Phosphoglyceride -- From Phosphoenolpyruvate Carboxykinase to Sporulation: Personal Reflections on Dr. F. Lipmann -- Research on Nonribosomal Systems: Biosynthesis of Peptide Antibiotics -- Metabolism of Carnosine and Related Peptides -- 3 Molecular Biology Sharpens its Tools -- DNA Repair in Human Cells: Molecular Cloning of cDNAs Coding for Enzymes Related to Repair -- Acyl~ Phosphate Intermediates in Oxidative DNA Sugar Damage by Antibiotics -- Rts1: A Multiphenotypic, Unusual Temperature Sensitive Drug Resistance Factor -- Human Prostatic Growth Factor on Steroid Hormones in Stimulating Thymidine Incorporation into DNA -- Developmentally Regulated Gene Amplification in Rhynchosciara -- Fritz Lipmann, a Few Personal Memories, and: What Else Came Out of the High-Energy Phosphate Bond? -- Regulation of Gene Expression by Posttranslational Modification of Transcription Factors -- How Does the Arginine Repressor Regulate the Synthesis of Arginine Biosynthetic Enzymes? -- The Biochemistry and Molecular Biology of the Terminal Reactions of Methionine Biosynthesis in Escherichia coli -- The Wheat Embryo, Then and Now -- Mechanism of Cytotoxic Action and Structures of Thiadiazolo-pyrimidines -- Architecture of Ribosomal Particles as Investigated by Image Reconstruction and X-Ray Crystallographic Studies -- Initiation of Protein Synthesis: Early Participation and Recent Revisit -- Structure of Ribosomal RNA Genes of Eukaryotes: Some Solved and Unsolved Questions -- Energetics and Dynamics of the Protein-Synthesizing Machinery -- Expression -- Punctuation in the Genetic Code: A Plausible Basis for the Degeneracy of the Code to Initiate Translation. , Reconstruction of Translation: Role of EF-P in Regulation of Peptide Bond Formation -- On the Role of Spermine in Protein Synthesis -- 4 Functional Dynamics -- 4.1 The Squiggle-Symbol of Bioenergetics -- Energy-Rich Compounds and Work -- Squiggle Phosphate of Inorganic Pyrophosphate and Polyphosphates -- Enzymology of 3ʹ-Squiggled Nucleotides -- Pyridine Nucleotides as Group Transfering Coenzymes -- The Nature of Squiggle in Oxidative Phosphorylation -- Motional Dynamics of Fatty Acids: Advantages of 15N and Deuterium Substituted Fatty Acid Spin Labels for Studies of Lipid-Protein Interactions and Motion in Membrane Bilayers -- Thyroid Hormones and Oxidative Phosphorylation -- Structure-Activity Relationships of Natural and Synthetic. E-β-Methoxyacrylates of the Strobilurin and Oudemansin Series -- The Intracellular Mechanism of Insulin Action -- Unity and Diversity in Biological Redox Catalysis: Comparative Enzymology of Some Microbial Oxidoreductases Showing Variation in Cofactor Identity -- Ammonia-Forming, Dissimilatory Nitrite Reductases as a Homologous Group of Hexaheme C-Type Cytochromes in Metabolically Diverse Bacteria -- Halorhodopsin -- Control of Futile Transmembrane Potassium Cycling in Escherichia coli -- Bioenergetics of Protein Transport into Mitochondria: Role of Δψ and of Nucleoside Triphosphates -- Some Recent Functional and Structural Contributions to the Molecular Mechanism of Photosynthesis -- Salt Toxicity and Mineral Deficiency in Plants: Cytoplasmic Ion Homeostasis, a Necessity for Growth and Survival Under Stress -- 4.2 Molecular Recognition and Communication -- Dawn of Ca Research: Regulation of Muscle Contraction -- Comparative Aspects of the Mechanisms of Energy Transduction in Sarcoplasmic Reticulum Between Rabbit and Frog Skeletal Muscle -- Caltrin: A Versatile Regulator of Calcium Transport in Spermatozoa. , Protein Kinase C, the Structural Heterogeneity and Differential Expression in Rat Brain -- Regulation of Erythrocyte Membrane Cytoskeletal Protein Interactions by Phosphorylation -- A Kinase Splitting Membranal Proteinase: Use in the Study of Receptors Involved in the Cellular Response to Hormones -- Fritz Lipmann, Phosphoproteins and Regulation of Aromatic Amino Acid Hydroxylase Activity -- The Regulation of Hepatic Phenylalanine Hydroxylase by Phosphorylation-Dephosphorylation -- Catabolite Inactivation and Adenylate Cyclase in Yeast -- Protein Modification by Tyrosine-Sulfation: Possible Functional Implications -- Proteoglycans and Connective Tissue Pathobiochemistry -- Acylation of Myelin Proteolipid Protein: A Link to the Past -- The Unusual Regulation of the Adenylyl Cyclase of Amphibian Oocytes by Progesterone. - A Review -- Sterol Synergism, A Tool for Studies on Sterol Function -- Chemical Modification of Benzodiazepine Receptors of Cortical P2 Membranes -- Dual Pathways for the Catabolism of γ-Hydroxy-butyrate: Cytosolic and Mitochondrial Mechanisms -- 5 Evolution -- Prebiotic Syntheses and the Mechanism of Early Chemical Evolution -- Prebiotic Roots of Informed Protein Synthesis: Nature of the Lipmann Connection -- A Case for an Additional RNA Base Pair in Early Evolution -- Inorganic Pyrophosphate in Cellular Energetics and Evolution -- Selforganization in Biosystems -- List of Contributors -- Acknowledgements -- Lipmann's Coworkers at Massachusetts General Hospital, Boston, and the Rockefeller University, New York -- Bibliography 1924-1985 -- Index.

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