Keywords:
Cancer -- Treatment -- Complications.
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Electronic books.
Description / Table of Contents:
Fertility preservation is one of the most important issues facing young cancer survivors. This gold-standard publication is the first comprehensive textbook for this emerging specialty. The full range of techniques involved is described in detail. The author team includes many of the world's leading experts in the field.
Type of Medium:
Online Resource
Pages:
1 online resource (569 pages)
Edition:
1st ed.
ISBN:
9780511989216
URL:
https://ebookcentral.proquest.com/lib/geomar/detail.action?docID=647378
DDC:
612.622
Language:
English
Note:
Cover -- Half-title -- Title -- Copyright -- Dedication -- Contents -- Contributors -- Foreword -- Foreword -- Preface -- Acknowledgements -- Section 1: Introduction -- Chapter 1 The evolution of ART -- References -- Chapter 2 The effect of chemotherapy and radiotherapy on the human reproductive system -- Normal ovarian development and follicular depletion -- Clinical detection of chemotherapy-induced ovarian damage -- Chemotherapy and the ovary -- Radiation and the hypothalamic-pituitary-ovarian axis -- Radiation and the uterus -- Testicular function -- Chemotherapy and the testis -- Radiotherapy to the testis -- Chemoprotection -- Summary -- References -- Chapter 3 Fertility preservation in non-cancer patients -- Introduction -- Ovarian damage and decreased activity -- Age -- Chemotherapy -- Radiotherapy -- Surgery -- Treatment for rheumatic diseases -- Disease modifying anti-rheumatic drugs -- Non-steroidal anti-inflammatory drugs -- Fertility preservation procedures -- Oocyte vitrification -- Embryo cryopreservation -- Ovarian tissue cryopreservation -- Gonadal medical protection -- Gonadotropin-releasing hormone agonists -- Imatinib -- In-vitro maturation -- Transposition of ovaries -- Indications for fertility preservation in non-oncological patients -- Autoimmune diseases -- Postponement of childbearing (age) -- Recurrent ovarian surgery (endometriosis) -- Bone marrow transplantation -- Chromosomal abnormalities that can lead to premature ovarian failure: Turner's syndrome -- Ovarian borderline tumors -- Other routine gynecological situations -- Ethical concerns about embryo freezing -- Conclusions -- References -- Section 2: Cancer biology, epidemiology and treatment -- Chapter 4 Basic cancer biology and immunology -- Introduction -- The origin of cancer -- Transformation of normal cells -- Oncogenes and tumor suppressor genes.
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Stepwise accumulation of mutations -- The "cancer stem cell" theory of cancer -- Molecular pathogenesis of cancer -- Anomalous growth factor and growth factor receptor signaling -- Abnormalities in signal transduction molecules -- Cell cycle and checkpoint abnormalities -- Defective cell death -- Aberrant differentiation -- Failure of DNA damage repair systems -- Hallmarks of cancer -- Self-sufficiency in growth signaling -- Insensitivity to anti-growth signals -- Limitless replicative potential -- Evasion of apoptosis -- Sustained angiogenesis -- Invasion and metastasis -- Genomic instability -- Basic immunology -- Tumor immunology -- Immunotherapy -- Concluding remarks -- References -- Chapter 5 Breast cancer and fertility preservation: A view from oncology -- Introduction and scope of the problem -- Risk of recurrence and reduction with adjuvant therapy -- Amenorrhea and survival -- Newer adjuvant treatments and additional benefits -- Standard regimens and how they might be altered to help preserve fertility -- Women with ER+ tumors (Figure 5.1) -- Women with ER- tumors (Figure 5.2) -- Chances that treatment will induce amenorrhea or loss of fertility -- Pregnancy following a breast cancer diagnosis and risk of relapse -- Barriers to fertility preservation for premenopausal women with breast cancer -- Cost of fertility preservation procedures -- Fertility preservation and adjuvant therapy delay -- COS, hormone levels and risk of recurrence -- Options other than COS and oocyte retrieval -- COS and high-risk women -- Logistics and summary -- References -- Chapter 6 Breast cancer therapy and reproduction -- Breast cancer in young women -- Pregnancy-associated breast cancer -- Effects of breast cancer treatment on reproductive function -- Ovarian function following chemotherapy for breast cancer -- Endocrine therapy and reproductive function.
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Fertility preservation in breast cancer patients -- Embryo cryopreservation -- Oocyte preservation -- Ovarian tissue cryopreservation -- Donor eggs and surrogacy -- Attempts to preserve fertility during chemotherapy: suppression of ovarian function -- Contraception following breast cancer -- Pregnancy following breast cancer -- Lactation following breast cancer -- Summary and conclusions -- References -- Chapter 7 Pediatric cancer therapy and fertility -- Background -- Effects of chemotherapy and radiation on ovaries -- Normal physiology and potential for fertility -- Effects of chemotherapy -- Effects of radiation -- Effects of chemotherapy and radiation on testes -- Normal physiology and potential for fertility -- Effects of chemotherapy -- Effects of radiation -- Risk of infertility after treatment -- Preservation of fertility -- Preventive strategies for females before treatment -- Preservation of fertility during treatment for females -- Preventive strategies for males before treatment -- Preservation of fertility in males during treatment -- Emerging data on fertility after cancer treatment -- Role of physician -- References -- Chapter 8 Cancer epidemiology and environmental factors in children, adolescents and young adults -- Introduction -- Descriptive epidemiology -- Childhood cancer -- Cancer in adolescents and young adults -- Survival -- Risk factors: childhood cancer -- Ionizing radiation -- Intrauterine and postnatal exposure -- Preconception exposure -- Extremely low-frequency electromagnetic fields -- Parental occupational exposure -- Infections -- Lifestyle factors -- Diet and breastfeeding -- Parental tobacco smoking -- Parental alcohol consumption -- Recreational drugs -- Risk factors for the most frequent cancers in adolescents and young adults -- Melanoma -- Testicular cancer -- Cervical cancer -- Thyroid cancer -- Conclusions.
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References -- Section 3: Reproductive biology and cryobiology -- Chapter 9 Life and death in the germ line: Apoptosis and the origins of DNA damage in human spermatozoa -- Introduction: apoptosis and DNA damage in human spermatozoa -- DNA damage in spermatozoa, assisted reproductive technology and embryonic development -- Age, DNA damage and disease in the progeny -- Smoking, DNA damage and disease in the progeny -- Is DNA damage related to apoptosis in the germ line? -- Nature of the DNA damage -- Ability of the germ line to undergo apoptosis -- Significance of spermiogenesis in the etiology of DNA damage -- Importance of chromatin remodeling and oxidative stress -- Importance of apoptosis in spermatozoa -- Lives in the balance: apoptosis and pro-survival factors -- Conclusions -- References -- Chapter 10 Molecular aspects of follicular development -- Introduction -- The follicle develops in stages -- From the formation of primordial follicles to the pre-antral phase of follicular development -- Pre-antral to antral phase transition -- Antral phase and resumption of meiosis -- Ovulation and subsequent luteinization of the follicle -- Concluding remarks -- References -- Chapter 11 Fundamental cryobiology of reproductive cells and tissues: Concepts and misconceptions -- Introduction -- Classical cryopreservation -- Equilibrium and non-equilibrium slow freezing -- Toxicity and osmotic effects of cryoprotectants -- Vitrification -- Equilibrium and non-equilibrium vitrification methods -- Preservation of reproductive cells and tissues -- Cryobiology of spermatozoa -- Cryobiology of oocytes -- Mature human oocytes -- Immature human oocytes -- Ovarian tissue -- Cryobiology of embryos -- Conclusion -- References -- Chapter 12 Fundamental aspects of vitrification as a method of reproductive cell, tissue and organ cryopreservation -- Introduction.
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Historical origins of vitrification as a means of cryopreservation -- Physical aspects of vitrification -- Ice nucleation and growth -- The necessity of the vitreous state -- The concentration dependence of vitrification and devitrification -- Kinetic aspects of ice avoidance -- Thermo-mechanical instability in vitreous materials and the problem of glass fracturing -- Vitreous state storage below Tg -- Vitrification solutions and vitrification solution toxicity -- Good VSs require bad glass-forming agents -- Consider employing cryoprotectant toxicity neutralization -- Include extracellular agents in moderation -- Consider special additives -- Choose your carrier solution carefully -- Define your needs -- Eliminate osmotic effects -- Summary -- Acknowledgements -- References -- Section 4: Fertility preservation strategies in the male -- Chapter 13 Hormonal suppression for fertility preservation in the male -- Introduction -- History and hypotheses -- Effect of cytotoxic agents on testicular function -- Hormone suppression studies in animal models -- Clinical trials -- Analysis of interspecies differences -- Acknowledgements -- References -- Chapter 14 Cryopreservation of spermatozoa: Old routine and new perspectives -- Introduction -- Vitrification: a promising new direction -- How does vitrification work in principle? -- Spermatozoa vitrification techniques -- Is vitrification suitable for IVF, ICSI and insemination? -- Future perspectives on the long-term storage of male gametes -- Conclusions -- References -- Chapter 15 Transplantation of cryopreserved spermatogonia -- Background -- Development of spermatogonial transplantation -- Morphological identification of spermatogonial stem cells -- Isolation, purification and culture of murine spermatogonial stem cells -- Culture of human spermatogonial stem cells.
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Cryopreservation of spermatogonial stem cells.
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