Publication Date:
2013-03-21
Description:
The EMBO Journal 32, 816 (2013). doi:10.1038/emboj.2013.28 Authors: Alessandra Mancino, Mohamed Habbeddine, Ella Johnson, Lionel Luron, Magali Bebien, Sylvie Memet, Carol Fong, Marc Bajenoff, Xuefeng Wu, Michael Karin, Jorge Caamano, Hongbo Chi, Michael Seed & Toby Lawrence Dendritic cells (DC) are required for priming antigen-specific T cells and acquired immunity to many important human pathogens, including Mycobacteriuim tuberculosis (TB) and influenza. However, inappropriate priming of auto-reactive T cells is linked with autoimmune disease. Understanding the molecular mechanisms that regulate the priming
Keywords:
dendritic cellsI kappa B Kinase alphainterferon regulatory factor 3T-cell priming
Print ISSN:
0261-4189
Electronic ISSN:
1460-2075
Topics:
Biology
,
Medicine
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