ISSN:
1432-1335
Keywords:
[dl-1,2-Bis(2-hydroxyphenyl)ethylenediamine]dichloroplatinum(II)
;
Ovarian cancer
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary The synthesis of diastereoisomeric [1,2-bis (2-hydroxyphenyl)ethylenediamine]dichloroplatinum(II) complexes,dl-3-PtCl2 andmeso-3-PtCl2, and their evaluation on the hormone-independent, human MDA-MB231 breast cancer cell line, on the cisplatin-sensitive and -resistant L1210 leukemia cell line, on the cisplatinresistant human NIH:OVCAR 3 ovarian cancer cell line, on the P-388 leukemia of the mouse and on the cisplatinsensitive and -resistant Ehrlich ascites tumor of the mouse are described. On all tumor modelsdl-3-PtCl2 produces a marked inhibitory effect. The diastereoisomermeso-3-PtCl2 is less active and more toxic. It is striking thatdl-3-PtCl2 leads to a pronounced inhibition of all cisplatin-resistant tumors. At non-toxic concentrationsdl-3-PtCl2 produces cytocidal effects on the NIH:OV-CAR 3 cell line. Thereforedl-3-PtCl2 is of interest for further evaluation for the therapy of ovarian cancer.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF01612897
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