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  • 1
    Electronic Resource
    Electronic Resource
    Cimetidine inhibits the pentagastrin-induced release of calcitonin in normocalcaemic man
    Amsterdam : Elsevier
    Regulatory Peptides 2 (1981), S. 175-180 
    Details
    ISSN: 0167-0115
    Keywords: C-cells ; calcitonin ; cimetidine ; normocalcaemic man ; pentagastrin ; thyroid
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0167-0115(81)90011-2
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  • 2
    Electronic Resource
    Electronic Resource
    Peroperative studies of s-calcitonin in thyroid and peripheral venous samples from patients with normal C-cells, C-cell hyperplasia, and medullary carcinoma on the thyroid (1983)
    Springer
    Research in experimental medicine 182 (1983), S. 139-147 
    Details
    ISSN: 1433-8580
    Keywords: Calcitonin ; Intra-arterial ; Pentagastrin ; Thyroid vein ; Peripheral vein ; Medullary carcinoma of the thyroid ; C-cell hyperplasia
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The calcitonin (Ct) secretion was studied during surgery in 11 patients with benign thyroid and/or parathyroid disorders and in six patients with familial medullary carcinoma of the thyroid (MCT) and C-cell hyperplasia (CCH). The preoperative diagnosis of MCT and CCH was established by S-Ct determinations before and after pentagastrin provocation. During surgery blood samples were collected from thyroid and peripheral veins before and after injection of 0.6µg pentagastrin · kg−1 in the inferior thyroid artery. In the control group the thyroid venous concentration of S-Ct increased from 395 ± 42 pmol · 1−1 to 2,692 ± 462 pmol · 1−1 after intra-arterial (i.a) pentagastrin. The basal value for S-Ct in thyroid venous samples from patients with MCT and CCH was distinctly elevated in five of six patients. After pentagastrin stimulation a very prompt and striking S-Ct peak in thyroid venous samples was demonstrated (range 11,500–2,700,000 pmol · 1−1), which in all cases widely exceeded that in the control group. Varying responses were registered in peripheral vein samples. S-Ct values obtained in the present investigation constitute valuable information for the interpretation of S-Ct values obtained in thyroid venous catheterization studies.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01851119
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  • 3
    Electronic Resource
    Electronic Resource
    Selective mesenteric phlebography in patients with carcinoid tumors (1979)
    Springer
    Abdominal imaging 4 (1979), S. 179-189 
    Details
    ISSN: 1432-0509
    Keywords: Abdominal angiography, indications ; Intestine, neoplasm ; Carcinoid tumors, diagnosis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Seventeen patients were investigated to localize carcinoid tumor growth in the small intestine and liver. Portography, selective phlebography of the intestinal veins, arteriography, and hormone assay (Serotonin, substance P) after simultaneous catheterization of the celiac artery and portal and caval veins were performed. Most of the patients have been operated on and findings at surgery have been compared with the preoperative localization methods. In 3 cases with small bowel carcinoids and typical fibroplastic changes of the mesentery, phlebography as well as arteriography demonstrated well the degree of mesenteric involvement. None of the methods demonstrated the primary tumors. Arteriography was superior in demonstration of liver metastasis. The hormone assay was a useful complement to angiographic techniques in the diagnosis and localization of tumor growth.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01887521
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  • 4
    Electronic Resource
    Electronic Resource
    Detection of theH-RAS oncogene in human thyroid anaplastic carcinomas (1989)
    Springer
    Cellular and molecular life sciences 45 (1989), S. 372-376 
    Details
    ISSN: 1420-9071
    Keywords: Anaplastic carcinoma ; thyroid ; H-RAS oncogene ; transfection
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary We have transfected high-molecular-weight DNA from human thyroid carcinomas into murine 3T3 cells. As a result we identified several foci of morphologically distinct transformed cells in each of the tumour DNA transfected cultures. After a total of three rounds of transfection, the transformed cells were shown to form tumours in nude mice. Southern blot analysis of DNA prepared from third-round transfectants demonstrated the presence of human Alu repetitive sequences and, after hybridization with probes for known oncogenes, indicated the presence of the humanH-RAS oncogene in 3T3 cells transfected with three out of four anaplastic carcinoma DNA samples. It appears therefore that activation ofRAS genes may be an important event in the development of the anaplastic thyroid tumours.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01957483
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  • 5
    Electronic Resource
    Electronic Resource
    Formaldehyde-ozone-induced fluorescence in isolated gastrin granules (1975)
    Springer
    Histochemistry and cell biology 44 (1975), S. 197-200 
    Details
    ISSN: 1432-119X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary In several mammals the antral gastrin cells display characteristic formaldehydeozone-induced fluorescence (375/500-520 nm). Such fluorescence is also given by gastrinoma cells. Gastrin granules, isolated from gastrinomas and identified by immunofluorescence and electron microscopy, were found to show intense formaldehyde-ozone-induced fluorescence.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00494082
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  • 6
    Electronic Resource
    Electronic Resource
    Substance P and 5-HT in granules isolated from an intestinal argentaffin carcinoid (1977)
    Springer
    Histochemistry and cell biology 52 (1977), S. 217-222 
    Details
    ISSN: 1432-119X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Intestinal argentaffin carcinoids, thought to originate from enterochromaffin cells, occasionally contain large amounts of substance P-like immunoreactivity in addition to 5-HT. The cytoplasmic granules of one such tumour were isolated. The granules, which in the electron microscope were shown to be argentaffin, contained both substance P-like immunoreactivity and 5-HT. The results support the view that substance P is localized in a population of enterochromaffin cells where it is stored in the cytoplasmic granules together with 5-HT.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00495858
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  • 7
    Electronic Resource
    Electronic Resource
    Tumours of the testis (1976)
    Springer
    International urology and nephrology 8 (1976), S. 295-307 
    Details
    ISSN: 1573-2584
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The records of 128 patients treated between 1960 and 1971 at the University Hospital, Lund, because of tumour of the testis were analysed in respect of age at onset of the tumour, symptoms, histology, diagnosis, treatment and survival rate. Teratoma occurred in 67 cases, in the majority at the age of 20–30 years. Treatment consisted in orchiectomy, lymphadenectomy, administration of cytostatics and radiation alone or combined, depending upon the histology and spread of the tumour. The 5-year survival rate was 40%. Sixty-one patients had seminoma, most of which appeared between 30 and 40 years of age. The patients were treated with orchiectomy and radiation. The 5-year survival rate was 82%.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02082094
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  • 8
    Electronic Resource
    Electronic Resource
    Organization of the sympathetic innervation in liver tissue from monkey and man (1978)
    Springer
    Cell & tissue research 195 (1978), S. 371-380 
    Details
    ISSN: 1432-0878
    Keywords: Liver (man, monkey) ; Sympathetic innervation ; Catecholamine fluorescence ; Adrenergic mechanisms
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary The sympathetic innervation of the liver of monkey and man has been investigated in a combined fluorescence histochemical, chemical and electron microscopical study. By means of the Falck-Hillarp fluorescence method a dense network of monoamine-containing nerve fibers was visualized in liver tissue of monkey and man. The nerve fibers ran in close contact to both hepatocytes and blood vessels. Chemical quantitations showed high concentrations of noradrenaline in both human and monkey liver. Microspectrofluorometry of the intraneuronal monoamine resulted in spectra characteristic of a catecholamine. For the electron microscopical study the dopamine analogue, 5-hydroxydopamine, was used to “label” the catecholamine terminals in both human and monkey liver. The nerve profiles, identified as catecholamine-containing, were demonstrated in a perivascular location and in close contact to hepatocytes. No synaptic membrane specializations were present between nerve fibers and hepatocytes. The general ultramorphology and intralobular distribution pattern of nerves in the liver of monkey and man were similar. The present results prove the existence of a sympathetic innervation of hepatocytes and blood vessels in the liver of man and monkey.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00233883
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