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  • 1
    Online Resource
    Online Resource
    Berlin, Heidelberg : Springer Berlin Heidelberg
    Keywords: Medicine ; Hematology ; Nursing ; Oncology ; Pediatrics ; Medicine & Public Health ; Aufsatzsammlung ; Kind ; Onkologie ; Kind ; Onkologie
    Type of Medium: Online Resource
    Pages: Online-Ressource (XVI, 251 p, digital)
    ISBN: 9783540299769
    Series Statement: SpringerLink
    RVK:
    Language: English
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Annals of hematology 46 (1983), S. 117-124 
    ISSN: 1432-0584
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Springer
    Annals of hematology 48 (1984), S. 335-336 
    ISSN: 1432-0584
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Springer
    Annals of hematology 59 (1989), S. 109-110 
    ISSN: 1432-0584
    Keywords: Chronic ITP in children ; Immunoglobulin
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The treatment of childhood ITP with IVIG has been widely used in acute or in previously treatment-dependent, chronic forms of the disease. We discuss propositions of a prospective multicenter study to evaluate the efficacy of IVIG to prevent the development of chronic ITP in childhood. The problems of such a study, i.e. evaluation criteria, number (about 10% of patients with acute ITP will develop the chronic form) and related topics are discussed.
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    Springer
    Sozial- und Präventivmedizin 38 (1993), S. 196-201 
    ISSN: 1420-911X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Résumé Depuis 1980, la SPOG (Swiss paediatric oncology group) enregistre des cas de leucémie qui apparaissent en Suisse. Ce registre a été installé pour la recherche clinique. En plus, depuis 1985, la SPOG entreprend un grand effort pour compléter le registre par les cas de leucémie ne prenant pas part aux études cliniques. Les données de la SPOG des années 1976 à 1989 sont comparées aux données des registres du cancer et de la statistique de mortalité de l'Office fédéral de la statistique. Entre 1985 à 1988, la SPOG comptait 91% des cas enregistrés par les six registres cantonaux du cancer. Comparé à la statistique de mortalité, l'enregistrant était de 100% en 1989. C'est pourquoi les données de la SPOG peuvent être utilisées pour entreprendre des études épidemiologiques sur l'incidence et l'évolution des leucémies en Suisse.
    Abstract: Zusammenfassung Seit 1976 registriert die Schweizerische Pädiatrische Onkologie Gruppe in der Schweiz vorkommende Leukämien. Das Register wurde für klinische Forschung aufgebaut, seit 1985 aber laufen Bemühungen, auch Fälle ins Register aufzunehmen, die nicht an einer klinischen Studie teilnehmen. Die vorliegende Arbeit vergleicht Daten des SPOG Registers zwischen 1976 und 1989 mit Daten der Krebsregister und mit Daten der Mortalitätsstatistik des Bundesamtes für Statistik. Verglichen mit den sechs kantonalen Krebsregistern erreichte die Vollständigkeit der Daten in den SPOG Registern 91% zwischen 1985 und 1988 Verglichen mit den Mortalitätsdaten erreichte die Registrierung 100% im Jahre 1989. Die SPOG Datenbank kann deshalb als vollständig genug angesehen werden, um epidemiologische Studien über die Inzidenz von Leukämien in der Schweiz und den Verlauf dieser Inzidenzen durchzuführen.
    Notes: Summary Since 1976 the Swiss Paediatric Oncology Groups (SPOG) has registered leukaemia cases occurring in Switzerland. The registration was set up for clinical research; however, since 1985 efforts have been made to complete the registers with cases not taking part in a clinical trial. The data of the SPOG register between 1976 and 1989 are compared to data from cancer registers and the mortality statistics of the Federal Office of Statistics. Between 1985 and 1988 the SPOG register included 91% of the cases recorded by the six cantonal registries. Compared to mortality data, registration was 100% in 1989. The SPOG data file can therefore be assumed to be complete enough to be used for epidemiological studies on incidence of leukaemias and on time trends of leukaemias in Switzerland.
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    Springer
    Graefe's archive for clinical and experimental ophthalmology 231 (1993), S. 122-128 
    ISSN: 1435-702X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract To determine whether immunoglobulins of the IgG class diffus up to the corneal center after subconjunctival injection, rabbits were injected with fluoresceinisothiocyanate-labeled human IgG. The inoculum diffused from the entire periphery centrepetally towards the corneal center. The progression of the diffusion front slowed down as the distance to the limbus increased. The first increase of fluorescence in the corneal center was observed on day 6. The intensity increased during the following 10 days despite resorption in the corneal periphery due to the flow of IgG from paracentral toward central areas. The diffusion coefficient of 0.003–0.004 cm2/day was calculated by computer simulation using Fickian diffusion equations adapted for corneal geometry. We conclude that after subconjunctival application, IgG diffuses up to the corneal center with a delay of several days and that the penetration speed decreases as the distance to the limbus increases. This kinetics contributes to our understanding of the role of IgG in corneal pathology and may help to design therapeutic schedules for immunotherapy with IgG.
    Type of Medium: Electronic Resource
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