ISSN:
1432-1971
Keywords:
Chromosomal abnormalities
;
Complex congenital heart disease
;
First trimester abortions
;
Monosomy X
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract The incidence of congenital heart disease appears to be about 1 per 100 liveborn infants. In infants who die before term, however, there is a much higher incidence of congenital heart disease, with a tendency for an excess of complex lesions. Some but not all of these lesions are associated with gross chromosomal abnormalities, which occur frequently in first-trimester abortions. Most of these chromosomal abnormalities are associated with such maldevelopment of many organ systems that fetal death occurs in utero. Monosomy X (45, XO), has a high association with congenital heart disease. Most fetuses with this abnormality die in utero, but because the abnormality is not inevitably lethal a small increase in survival of these fetuses would cause a large increase in the total incidence of congenital heart disease.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00794186
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