Note: Mit franz. Zsfassung , Literaturverz. S. 136 - 148

Note: Cover -- Front Matter -- Contents -- Preface -- Innate Immunity -- The Else Kröner-Fresenius-Stiftung -- Introduction -- Innate Immunity's Resurrection: How It Perceives Infection -- Innate Immunity's Vibrancy: How Does It Promote Diseases? -- Innate Immunity and the Gut: How It Impacts Gut Microbiota Homeostasis -- Concluding Remarks -- Chapter 1: Innate Immunity and Inflammation -- Innate Immunity, Inflammation and Colorectal Cancer -- Abstract -- Results -- Discussion -- References -- Immunobiology of C-Type Lectin Receptors -- Abstract -- Danger Recognition by C-Type Lectin Receptors -- C-Type Lectin Receptor Effector Pathways -- Conclusions -- References -- Mechanisms of IL-1beta Maturation in Neutrophils -- Abstract -- Neutrophils at the Interface of an Inflammatory Response -- Synthesis and Maturation of IL-1beta -- The Inflammasomes -- Caspase 1-Independent Release of IL-1 -- Mechanism of Secretion of IL-1beta by Neutrophils -- Conclusion -- Acknowledgements -- References -- Chapter 2: Innate Immunity and Transplantation -- The Innate Immune System: Its Rediscovery before Toll Was Described -- Abstract -- References -- Innate-Adaptive Immune Responses in Organ Ischemia/Reperfusion Injury -- Abstract -- Introduction -- Toll-Like Receptor System in Ischemia/Reperfusion-Triggered Innate Immune Activation -- Non-Toll-Like Receptors in Ischemia/Reperfusion-Mediated Innate Immune Activation -- IL-10 in Ischemia/Reperfusion Innate Immune Signaling -- T Cells in Ischemia/Reperfusion Innate Immune Activation -- Conclusion -- References -- Tolerogenic Dendritic Cells in Transplantation: From Preclinical to Clinical Application -- Abstract -- Tolerogenic Dendritic Cells in Animal Models -- Tolerogenic Dendritic Cells in Humans -- From Bench to Bedside -- Conclusion -- Acknowledgements -- References. , Chapter 3: Innate Immunity and Intestinal Microbiota -- Microbiota's Influence on Immunity -- Abstract -- Gut Clostridia Affect the Immune System -- Regulatory T Cells in the Gut -- Clostridia-Mediated Treg Cell Induction -- Conclusion -- References -- Inflammasomes and Mucosal Immune Response -- Abstract -- Inflammasome Activation and Function -- Inflammasomes and the Intestinal Mucosal Immune Response -- The Inflammasome and Carcinogenesis -- Inflammasomes as Regulators of Metabolic Disorders -- References -- Microbial Endocrinology: An Evolution-Based Shared Mechanism Determining Microbiota's Influence on Health and Disease -- Abstract -- Discussion -- Conclusions -- Acknowledgements -- References -- Chapter 4: Innate Immunity and Disease Promotion -- Standing Guard: Innate Lymphoid Cells Promote Immunity and Tissue Homeostasis at Barrier Surfaces -- Abstract -- Identification of Group 2 Innate Lymphoid Cells -- Identification of Innate Lymphoid Cells in the Lungs of Mice and Humans -- Group 2 Innate Lymphoid Cells Regulate Airway Inflammation -- Innate Lymphoid Cells Promote Airway Epithelial Repair -- A Role for Lung Innate Lymphoid Cells in Anti-Helminth Immunity? -- Implications for Targeting Group 2 Innate Lymphoid Cells in Human Disease -- Identification of Group 3 Innate Lymphoid Cells -- ROR gammat+ Innate Lymphoid Cells Promote Protective Immunity against Enteric Pathogens -- Group 3 Innate Lymphoid Cells Promote Extraintestinal Tissue Regeneration -- Innate Lymphoid Cells Regulate Containment of Commensal Bacteria to Maintain Homeostasis -- Targeting Group 3 Innate Lymphoid Cells in Human Disease -- Conclusions -- Acknowledgements -- References -- Note Added in Proof -- miRNAs That Shape the Innate Immune System: Regulation through Toll-Like Receptor Signaling -- Abstract -- Results -- Conclusions -- References. , Type 2 Diabetes and Islet Inflammation -- Abstract -- Evidence for an Islet Inflammatory Process inbeta-Cell Failure during Type 2 Diabetes -- Regulation of IL-1beta Expression by Nutrients in Human Islets -- The Inflammasome as a Sensor of Metabolic Stress -- IL-1 Is a Master Regulator of Tissue and Islet Inflammation in Type 2 Diabetes -- Role of Insulitis in Obesity and Type 2 Diabetes: From Islet Adaptation to Failure -- Clinical Validation and Therapeutic Consequences -- References -- The Innate Immune System in Alzheimer's Disease -- Abstract -- Misfolded Proteins in Alzheimer's Disease and Other Neurodegenerative Diseases -- Microglia and IL-1beta in Alzheimer's Disease -- Misfolded Proteins as Activators of the Inflammasome -- Conclusions -- References -- Role of Inflammasomes in Obesity -- Abstract -- References -- Gut-Brain Communication in the Regulation of System Metabolism -- Abstract -- Ghrelin -- Insulin -- Amylin -- Cholecystokinin -- Cleavage Products of Proglucagon -- References -- Chapter 5: Drosophila and Immunity -- Metabolism and Innate Immunity: FOXO Regulation of Antimicrobial Peptides in Drosophila -- Abstract -- The Innate Immune System -- Antimicrobial Peptides -- The Drosophila Immune Pathways -- Local and Systemic Immune Defense -- Insulin Signaling and the FOXO Transcription Factor -- FOXO-Dependent Regulation of Antimicrobial Peptides -- Drosophila Innate Immunity and the Gut Microflora Community -- Receptors for Antimicrobial Peptides in the Brain of Drosophila? -- Acknowledgements -- References -- Chapter 6: Innate Signaling and Adaptive Immunity -- Dendritic Cells Orchestrate Innate Immunity against Bacterial Kidney Infection -- Abstract -- Results -- Conclusions -- Acknowledgments -- References -- Chapter 7: Speakers at the Symposium -- Speakers at the Symposium -- David Artis, PhD -- Bruce Beutler, MD. , Maria Cristina Cuturi, MD -- Vishva Dixit, MD -- Vishwa Deep Dixit, DVM, PhD -- Marc Y. Donath, MD -- Richard Flavell, PhD -- Anne Halle, MD -- Michael Hoch, PhD -- Kenya Honda, MD, PhD -- Veit Hornung, MD -- Michael Karin, PhD -- Daniel Kastner, MD, PhD -- Jerzy Kupiec-Weglinski, MD, PhD -- Christian Kurts, MD -- Walter G. Land, MD -- Eike Latz, MD -- Mark Lyte, PhD -- Luke O'Neill, PhD -- Eyal Raz, MD -- Jürgen Ruland, MD -- Matthias Tschöp, MD -- Harald von Boehmer, MD, PhD -- Editors -- Hermann Wagner, MD, PhD -- Gunther Hartmann, MD, PhD -- Author Index -- Subject Index -- Cover.