Note: Front Cover -- Cell Surface Carbohydrate Chemistry -- Copyright Page -- Table of Contents -- Dedication -- List of Contributors -- Preface -- Chapter 1. The Involvement of Membranes in the Biosynthesis of Glycoproteins -- INTRODUCTION -- PEPTIDES AND "ACTIVATED PEPTIDES" IN CELLS -- ORIGIN OF THE PEPTIDES AND "ACTIVATED PEPTIDES -- ACTIVATED PEPTIDES AS A PRECURSOR OF PROTEINS -- OTHER EVIDENCE -- DEFICIENCIES OF THE ORTHODOX CONCEPT OF PROTEIN BIOSYNTHESIS -- CONCLUSIONS -- REFERENCES -- Chapter 2. Surface Membranes of Tumor Cells -- INTRODUCTION -- GLYCOPEPTIDE ALTERATIONS IN TUMOR AND VIRUS TRANSFORMED CELLS -- COMPARISON OF LOOSELY ASSOCIATED AND INTRINSIC GLYCOPEPTIDES -- PURIFICATION OF THE MEMBRANE GLYCOPEPTIDES -- SEQUENCING OF GLYCOPEPTIDE V -- TENTATIVE STRUCTURE FOR GLYCOPEPTIDE V -- IMPLICATIONS OF THE SEQUENCING -- ACKNOWLEDGMENTS -- REFERENCES -- Chapter 3. The Role of the Golgi Apparatus in the Synthesis of Glycoproteins and Glycolipids -- INTRODUCTION -- SUBCELLULAR LOCALIZATION OF SOME PROTEIN GLYCOSYLTRANSFERASES -- SUBCELLULAR LOCALIZATION OF SOME GLYCOLIPID GLYCOSYLTRANSFERASES -- SYNTHESIS OF SULFATIDES IN VIVO -- CONCLUSIONS -- NOTATION -- ACKNOWLEDGMENTS -- REFERENCES -- Chapter 4. Structural Studies on the Major Glycoproteins of the TA3-HA Ascites Tumor Cell -- INTRODUCTION -- OCCURRENCE AND ISOLATION OF EPIGLYCANIN -- COMPOSITION OF THE CARBOHYDRATE MOIETIES IN EPIGLYCANIN -- GLYCOPEPTIDE LINKAGES AND THE TYPES OF CARBOHYDRATE CHAINS -- IMMUNOCHEMICAL STUDIES -- PARTIAL CHARACTERIZATION OF THE CARBOHYDRATE CHAINS IN EPIGLYCANIN BY CHEMICAL METHODS -- ISOLATION AND PARTIAL CHARACTERIZATION OF CARBOHYDRATE CHAINS -- FINE STRUCTURES OF THE CARBOHYDRATE CHAINS -- CONCLUSIONS -- ACKNOWLEDGMENTS -- REFERENCES -- Chapter 5. Cell Surface Galactosyltransferase in Mitosis, Differentiation, Neoplastic Transformation, and Metastases. , INTRODUCTION -- GLYCOSYLTRANSFERASES OF THE UNDIFFERENTIATED INTESTINAL CRYPT CELL AND FETAL INTESTINE -- LECTIN BINDING SITES, AGGLUTINATION, AND CELL MEMBRANE GLYCOSYLTRANSFERASE ACTIVITIES -- ANIMAL TUMOR MODELS AND THE RELEASE OF AN ELECTROPHORETICALLY DISTINCT GALACTOSYLTRANSFERASE -- CONCLUSIONS -- REFERENCES -- Chapter 6. Pertinence of Surface Membrane Changes in Spontaneously and Virally Transformed Cells to the Balance between Tumorigenicity and Immune Rejection -- ORIGIN AND BIOLOGIC PROPERTIES OF THE VARIOUS CELL LINES -- LABELING AND PREPARATION OF CELL SURFACE MEMBRANES -- ANALYSIS OF THE CELL MEMBRANE PREPARATIONS FROM THE VARIOUS CELL LINES -- ANTIGENIC DIFFERENCES ON THE CELL SURFACE SOLUBILIZATION AND PURIFICATION OF THE SV40 SPECIFIC ANTIGENS -- INTERPRETATION OF THE BIOLOGIC, IMMUNOCHEMICAL, AND BIOCHEMICAL RESULTS -- REFERENCES -- Chapter 7. Membrane Glycolipids and Their Relationship to the Structure and Function of Cell Surface Receptors for Glycoprotein Hormones, Bacterial Toxins, and Interferon -- INTRODUCTION -- THE ROLE OF GANGLIOSIDE OR GANGLIOSIDE-LIKE COMPOUNDS IN THE STRUCTURE AND FUNCTION OF THE THYROTROPIN RECEPTOR -- THE ROLE OF GANGLIOSIDE OR GANGLIOSIDE-LIKE COMPOUNDS IN THE STRUCTURE AND FUNCTION OF RECEPTORS FOR OTHER GLYCOPROTEIN HORMONES -- SIMILARITIES IN THE STRUCTURE AND FUNCTION OF RECEPTORS FOR CHOLERA TOXIN AND THE GLYCOPROTEIN HORMONES EXTEND TO INTERFERON -- SIMILARITIES IN THE STRUCTURE AND FUNCTION OF RECEPTORS FOR CHOLERA TOXIN AND THE GLYCOPROTEIN HORMONES CANNOT ONLY BE EXTENDED TO OTHER BACTERIAL TOXINS BUT THIS RELATIONSHIP HAS POTENTIAL PATHOPHYSIOLOGICAL SIGNIFICANCE -- THE MECHANISM BY WHICH GLYCOPROTEIN HORMONES, INTERFERON, AND THE BACTERIAL TOXINS EFFECT CELL CHANGES -- ACKNOWLEDGMENTS -- REFERENCES -- Chapter 8. Structural Studies on Lectins and Lectin-Saccharide Interactions. , INTRODUCTION -- STRUCTURE OF CON A -- DEMETALLIZED CON A -- CON A-SACCHARIDE COMPLEX -- CHEMICAL DERIVATIVES ON CON A -- CONCLUSIONS -- ACKNOWLEDGMENTS -- REFERENCES -- Chapter 9. Alterations of Surface Glycoconjugates and Cell Morphology Induced by Butyric Acid -- INTRODUCTION -- EFFECT OF BUTYRATE ON CELL MORPHOLOGY -- EFFECT OF BUTYRATE ON GANGLIOSIDE METABOLISM IN HELA -- EFFECT OF BUTYRATE ON ENZYME ACTIVITIES -- INDUCTION OF SIALYLTRANSFERASE I ACTIVITY -- A ROLE FOR CYCLIC AMP? -- CORRELATION BETWEEN INDUCTION OF GM3 SYNTHESIS AND MORPHOLOGICAL DIFFERENTIATION BY BUTYRATE -- OTHER BIOCHEMICAL CHANGES INDUCED IN HELA CELLS BY BUTYRATE -- ROLE OF GM3 IN MORPHOLOGICAL DIFFERENTIATION -- CONCLUSIONS -- REFERENCES -- Chapter 10. Sugar Composition of Mammalian Cell Surface Membrane: A Function of Carbon Source -- INTRODUCTION -- METHODS AND MATERIALS -- RESULTS -- NUCLEOTIDE SUGAR METABOLISM -- SUGAR COMPOSITION OF MEMBRANES -- DISCUSSION -- REFERENCES -- Chapter 11. Initial Studies on the Mechanism of Substrate Adhesion of Normal and Virus-Transformed Cells -- INTRODUCTION -- IDENTIFICATION OF SUBSTRATE-ATTACHED MATERIAL (SAM) -- TOPOGRAPHICAL DISTRIBUTION -- BIOCHEMICAL COMPOSITION -- SCANNING ELECTRON MICROSCOPIC STUDY -- CONCLUSIONS -- ACKNOWLEDGMENTS -- REFERENCES -- Chapter 12. Surface Glycoproteins of Normal and Abnormal Platelets -- INTRODUCTION -- PLATELET SURFACE ULTRASTRUCTURE -- PLATELET CHARGE -- GLYCOPROTEINS OF THE PLATELET SURFACE -- SURFACE GLYCOPROTEIN OF ABNORMAL PLATELETS -- CONCLUSION -- REFERENCES -- Chapter 13. Major Glycosphingolipids of Bovine-Erythrocyte Membranes -- INTRODUCTION -- EXPERIMENTAL PROCEDURE -- RESULTS -- GANGLIOSIDES IN BOVINE ERYTHROCYTES -- DISCUSSION -- REFERENCES -- Chapter 14. Transferrin Receptor from Rabbit Reticulocyte Membranes -- INTRODUCTION -- MATERIALS & -- METHODS -- RESULTS -- DISCUSSION. , SUMMARY -- ACKNOWLEDGMENTS -- REFERENCES -- Chapter 15. Molecular Probes for the Mechanism of D-Glucose Transport across Cellular Membranes -- INTRODUCTION -- BINDING REQUIREMENTS OF ACTIVE SUGAR TRANSPORT IN HAMSTER INTESTINE -- BINDING REQUIREMENTS FOR THE TRANSPORT OF D-GLUCOSE ACROSS THE HUMAN ERYTHROCYTE MEMBRANE -- THE CYTOCHALASINS AS TRANSPORT PROBES -- ACKNOWLEDGMENTS -- REFERENCES -- Chapter 16. Control of Cell Growth by Nucleoside Efflux through the Membrane -- INTRODUCTION -- THE PATHWAYS FOR INCORPORATION OF CYTOSINE AND THYMINE INTO DNA -- THE CARRIER-MEDIATED TRANSPORT SYSTEM FOR dThd and dUrd -- THE EFFLUX OF NUCLEOSIDES AND CELL GROWTH -- RATIONALE FOR THE USE OF BrdUrd-OPO2Me -- INHIBITION OF DEOXYRIBONUCLEOSIDE INFLUX WITH BrdUrd-OPO2Me -- SUMMARY -- ACKNOWLEDGMENTS -- REFERENCES -- Chapter 17. Cell Surface as a Target for Chemotherapy: Potential Inhibitors of Biosynthesis of the Protein-Carbohydrate Linkage in Glycoproteins -- ACKNOWLEDGMENTS -- REFERENCES -- Index.