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1

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Advances in Protein Chemistry. (1991)

Anfinsen, C. B.

San Diego :Elsevier Science & Technology,

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Keywords: Metalloproteins -- Structure. ; Electronic books.

Type of Medium: Online Resource

Pages: 1 online resource (408 pages)

Edition: 1st ed.

ISBN: 9780080582153

Series Statement: Issn Series

URL: https://ebookcentral.proquest.com/lib/geomar/detail.action?docID=428483

DDC: 574.87

Language: English

Note: Front Cover -- Metalloproteins: Structural Aspects -- Copyright Page -- Contents -- Preface -- Chapter 1. Structural Aspects of Metal Liganding to Functional Groups in Proteins -- I. Metal-Binding Sites in Proteins -- II. Polarizabilities of Metals and Ligands -- III. Redox Behavior of Metal Ions -- IV. Number of Atoms Packed in First Coordination Sphere around Metal Ion -- V. Metal-Ligand Bond Distances -- VI. Asymmetry in Ionic Shape -- VII. Strengths of Bonds from Metal Ions to Ligands -- VIII. Selection of Metal Ions for Complexation -- IX. Metal Binding to Isolated Carboxylate Groups -- X. Metal Binding to Imidazole Groups -- XI. Metal Binding to Sulfur-Containing Groups. -- XII. Metal Binding to Main-Chain Carbonyl Groups -- XIII. Metal Binding to Two Groups -- XIV. Metals in Protein Crystal Structures -- XV. Electron Transfer in Metalloproteins -- XVI. Metal Competition and Replacement -- References -- Chapter 2. Calcium Binding Sites in Proteins: A Structural Perspective -- I. Introduction -- II. Functional and Structural Overview of Protein Ca2+-Binding Sites -- III. Regularities and Recurrent Themes in Ca2+-Binding Sites -- IV. Discussion and Summary -- References -- Chapter 3. Copper Protein Structures -- I. Introduction -- II. Cupredoxins: Proteins That Bind Only Type I Copper -- III. Proteins That Bind Only Type II Copper -- IV. Proteins That Bind Only Type III Copper -- V. Proteins That Bind More Than One Type of Copper -- VI. Summary and Conclusions -- References -- Chapter 4. Perspectives on Non-heme Iron Protein Chemistry -- I. Introduction -- II. Structures and Functions of Mononuclear Iron Proteins -- III. Structures and Mechanisms of Binuclear Octahedral Iron Proteins -- IV. Tetrahedral Iron: Fe:S Proteins -- V. Conclusions -- References -- Chapter 5. Structural Biology of Zinc -- I. Introduction. , II. Stereochemistry of Biological Zinc-Ligand Interactions -- III. Long-Range Protein-Metal Interactions -- IV. Examples of Zinc in Biological Catalysis and Regulation -- V. Protein Engineering of Zinc-Binding Sites -- VI. Summary -- References -- Author Index -- Subject Index.

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2

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Advances in Protein Chemistry. (1988)

Anfinsen, C. B.

San Diego :Elsevier Science & Technology,

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Keywords: Proteins. ; Electronic books.

Type of Medium: Online Resource

Pages: 1 online resource (273 pages)

Edition: 1st ed.

ISBN: 9780080582122

Series Statement: Issn Series

URL: https://ebookcentral.proquest.com/lib/geomar/detail.action?docID=403589

DDC: 574.87

Language: English

Note: Front Cover -- Advances in Protein Chemistry, Volume 39 -- Copyright page -- CONTENTS -- PREFACE -- Chapter 1. Basement Membrane Proteins: Molecular Structure and Function -- I. Introduction -- II. Morphology and Ultrastructure -- III. Components -- IV. Self-Assembly and Interaction between Components -- V. Biological Aspects -- References -- Chapter 2. Design of Peptides and Proteins -- I. Introduction -- II. Design of Small Peptides -- III. Design of Medium-Sized Peptides -- IV. Protein Design -- References -- Chapter 3. Weakly Polar Interactions in Proteins -- I. Introduction -- II. Electrostatic Interactions in Proteins -- III. Weakly Polar Interactions in Proteins -- IV. Interactions: A Summary -- V. Hydrophobic Interactions in Proteins -- VI. Discussion -- VII. Conclusion -- References -- Chapter 4. Stability of Protein Structure and Hydrophobic Interaction -- I. Introduction -- II. Calorimetric Studies of Protein Denaturation -- III Studies of Dissolution of Nonpolar Substances into Water -- IV. Hydration of Nonpolar Molecules -- V. Comparison of Results on Protein Denaturation and Hydrocarbon Dissolution in Water -- VI. Mechanism of Stabilization of Compact Protein Structures -- References -- Chapter 5. Abstract of a Review on Chemistry of Peanut Proteins -- Abstract -- References -- AUTHOR INEDX -- SUBJECT INDEX.

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3

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Advances in Protein Chemistry. (1991)

Anfinsen, C. B.

San Diego :Elsevier Science & Technology,

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Keywords: Proteins. ; Lysozyme. ; Electronic books.

Type of Medium: Online Resource

Pages: 1 online resource (353 pages)

Edition: 1st ed.

ISBN: 9780080582146

Series Statement: Issn Series

URL: https://ebookcentral.proquest.com/lib/geomar/detail.action?docID=349280

DDC: 574.87

Language: English

Note: Cover -- Contents -- Chapter 1. Physical Principles of Protein Crystallization -- I. Introduction -- II. Stages of Crystal Growth -- III. Driving Forces for Crystal Growth -- IV. Nucleation -- V. Crystal Growth Mechanisms -- VI. Competition between Nucleation and Growth -- VII. Cessation of Growth and Crystal Disorder -- VIII. Crystallization Methods -- IX. Protein Purity -- X. Searching for Crystallization Conditions -- XI. New Developments in Protein Crystallization -- XII. Summary Remarks -- References -- Chapter 2. Protein Hydration and Function -- I. Introduction -- II. Thermodynamics -- III. Dynamics -- IV. Structure -- V. Computer Simulation -- VI. Picture of Protein Hydration -- VII. Hydration and Function -- VIII. Conclusion -- Appendix: Percolation Theory -- References -- Chapter 3. Lysozyme and α-Lactalbumin: Structure, Function, and Interrelationships -- I. Introduction -- II. Early History -- III. Some Aspects of the Occurrence, Isolation, and Characterization of Lysozyme and α-Lactalbumin -- IV. Three-Dimensional Structure of Lysozyme -- V. Three-Dimensional Structure of α-Lactalbumin -- VI. Comparative Binding of Metal Ions in Lysozyme and α-Lactalbumin -- VII. Amino Acid Composition and Sequence Homologies in Lysozymeand α-Lactalbumin -- VIII. Galactosyltransferase and the Lactose Synthase System -- IX. Some Additional Physical, Chemical, and Biological Comparisons between Lysozyme and α-Lactalbumin -- X. Evolutionary Origins of Lysozyme and α-Lactalbumin -- XI. Conclusions and the Future -- References -- Note Added in Proof -- Author Index -- Index.

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4

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Advances in Protein Chemistry and Structural Biology. (2009)

Eisenberg, David S.

San Diego :Elsevier Science & Technology,

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Keywords: Proteins. ; Electronic books.

Type of Medium: Online Resource

Pages: 1 online resource (183 pages)

Edition: 1st ed.

ISBN: 9780080888712

Series Statement: Issn Series

URL: https://ebookcentral.proquest.com/lib/geomar/detail.action?docID=583435

DDC: 572.605

Language: English

Note: Cover -- ADVANCES IN PROTEIN CHEMISTRY AND STRUCTURAL BIOLOGY -- Copyright Page -- Contents -- Chapter 1 Engineered Tropoelastin and Elastin-Based Biomaterials -- ABSTRACT -- I. Introduction -- II. Hydrogels -- III. Electrospun Materials -- IV. Material Coating -- References -- Chapter 2 The Architecture of the Cornea and Structural Basis of Its Transparency -- ABSTRACT -- I. Introduction -- II. The Cornea - a Macroscopic Overview -- III. Collagen -- IV. Glycosaminoglycans and Proteoglycans -- V. The Structure of the Corneal Stroma -- VI. Corneal Transparency -- VII. Summary -- Acknowledgment -- References -- Chapter 3 Structural Biology of Periplasmic Chaperones -- ABSTRACT -- I. Introduction -- II. Chaperones Involved in Folding and Stabilization of Proteins in the Periplasm -- III. Carrier Chaperones -- IV. Conclusion -- References -- Chapter 4 Separate Roles of Structured and Unstructured Regionsof Y-Family DNA Polymerases -- ABSTRACT -- I. Historical Background -- II. Flexible Structures of Y-Family DNA Polymerases -- III. Functional Significance of Protein-Protein InteractionsInvolving TLS DNA Polymerases -- Acknowledgment -- References -- AUTHOR INDEX -- SUBJECT INDEX -- Color Plates.

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5

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Antigen Binding Molecules : Antibodies and T-Cell Receptors. (1996)

Richards, Frederic M.

San Diego :Elsevier Science & Technology,

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Keywords: Antigen-antibody reactions. ; T cells -- Receptors. ; Electronic books.

Type of Medium: Online Resource

Pages: 1 online resource (561 pages)

Edition: 1st ed.

ISBN: 9780080582221

Series Statement: Issn Series

URL: https://ebookcentral.proquest.com/lib/geomar/detail.action?docID=413830

Language: English

Note: Front Cover -- Antigen Binding Molecules: Antibodies and T-Cell Receptors -- Copyright Page -- Contents -- Preface -- Chapter 1. Antigen-Specific T-Cell Receptors and Their Reactions with Natural Complexes Formed by Peptides with Major Histocompatibility Complex Proteins -- I. Overview -- II. History and Background -- III. T-Cell Receptor Genes -- IV. T-Cell Receptor Proteins -- V. T-Cell Receptor Ligands: Peptide-MHC Complexes -- VI. T-Cell Responses to PepMHC -- VII. T-Cell Receptor Accessory Proteins -- VIII. Altered Peptide Ligands: Partial Agonists and Antagonists -- IX. MHC Restriction by Self and Nonself MHC: Paradox of Alloaggression -- X. Concluding Remarks -- References -- Chapter 2. X-Ray Crystallography of Antibodies -- I. Introduction -- II. X-Ray Crystallography of Whole Antibodies -- III. X-Ray Crystallography of Fc -- IV. X-Ray Crystallography of Antigen Binding Fragments -- V. X-Ray Crystallography of Complexes of Antibodies with Specific Ligand -- VI. Conclusions -- References -- Chapter 3. Insight into Antibody Combining Sites Using Nuclear Magnetic Resonance and Spin Label Haptens -- I. Introduction -- II. Antibodies ANOn -- III. Difference Spectra -- IV. Selective Deuteration -- V. NMR Signal Assignments -- VI. Diamagnetic Haptens -- VII. Distance Titrations -- VIII. Combining Site Dynamics and Reaction Kinetics -- IX. Crystal Structure of ANO2 -- X. Conformational Heterogeneity -- XI. Synopsis and Outlook -- References -- Chapter 4. Computational Biochemistry of Antibodies and T-cell Receptors -- I. Background -- II. Tools of Computer Analysis -- III. Structures, Sequences, and Superfamilies -- IV. Molecular Anatomy of Antibody Binding Site -- V. In Search of Effector Sites -- VI. Protocols for Three-Dimensional Modeling of Binding Sites -- VII. Binding Affinity and Specificity. , VIII. Molecular Basis of Protein Antigenicity -- IX. Antibody Engineering -- X. T-Cell Receptor Modeling and Engineering -- References -- Chapter 5. Catalytic Antibodies -- I. Introduction -- II. Immunological Evolution of Catalysis -- III. Structural Studies -- IV. Evolving Functions Not Yet Found in Nature -- V. Unnatural Cofactors -- VI. Difficult Chemical Transformations -- VII. Future Directions -- VIII. Conclusion -- References -- Chapter 6. The Nature of the Antigen -- I. Introduction -- II. Antigens, Antigenicity, Immunogenicity -- III. Molecular Criteria for Antigenicity -- IV. Role of Conformation in Antigenicity -- V. Antibody-Antigenic Epitope Interactions -- VI. Conformational Transitions Induced by Hapten Binding -- VII. T-Cell-Antigenic Epitope Interactions -- VIII. Thymus-Independent Antigens -- IX. Superantigens -- X. Tumor Antigens -- XI. Concluding Remarks -- References -- Chapter 7. Antibody Binding Sites -- I. Overview -- II. Protein Chemistry of Antibody Fragments and Antigen Binding Regions -- III. Engineered Antibody Binding Sites -- IV. Antibody Combining Site Structure: Antiarsonate and Antidigoxin Antibodies -- V. Enhancing Enzyme Selectivity with Substrate-Selective Antibodies -- References -- Chapter 8. Maturation of the Immune Response -- I. Introduction -- II. Genetic and Structural Diversity of Primary Repertoire -- III. Available Repertoire and Onset of Immune Response -- IV. Hypermutation -- V. Antigenic Selection -- VI. Structural and Evolutionary Implications -- References -- Author Index -- Subject Index.

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6

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Advances in Protein Chemistry. (1993)

Anfinsen, C. B.

San Diego :Elsevier Science & Technology,

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Keywords: Protein folding. ; Electronic books.

Type of Medium: Online Resource

Pages: 1 online resource (231 pages)

Edition: 1st ed.

ISBN: 9780080582177

Series Statement: Issn Series

URL: https://ebookcentral.proquest.com/lib/geomar/detail.action?docID=428657

DDC: 574.87

Language: English

Note: Front Cover -- Accessory Folding Proteins -- Copyright Page -- Contents -- Preface -- Chapter 1. Mechanism of Enzymatic and Nonenzymatic Prolylcis-trans lsomerization -- I. Introduction -- II. Nonenzymatic Prolyl Isomerization -- III. Enzymatic Prolyl Isomerization -- IV. Mechanism of Enzymatic Prolyl Isomerization: Catalysis by Distortion -- References -- Chapter 2. Prolyl lsomerases: Role in Protein Folding -- I. Introduction -- II. Prolyl Isomerization -- III. Prolyl Isomerases -- IV. RNase T1 as Model System to Probe Catalysis of Folding -- V. Catalysis of Folding in Absence of Disulfide Bonds -- VI. Catalysis of Prolyl Isomerization during Unfolding and Refolding -- VII. Simultaneous Action of Prolyl Isomerase and Protein Disulfide-Isomerase as Catalysts of Folding -- VIII. Role of Prolyl Isomerase for Cellular Folding -- IX. Conclusions -- References -- Note Added in Proof -- Chapter 3. Structure and Mechanism of 70-kDa Heat-Shock-Related Proteins -- I. Overview of Stress-70 Proteins -- II. Biochemical Activities of Stress-70 Proteins -- III. Structure of Stress-70 Proteins -- IV. Enzymatic Mechanism of Stress-70 Proteins -- V. Modulators of Stress-70 Protein Activity -- VI. Epilogue -- References -- Chapter 4. PapD and Superfamily of Periplasmic Immunoglobulin-like Pilus Chaperones -- I. General Perspective -- II. Introduction -- III. pap Gene Cluster -- IV. Postsecretional Assembly -- V. Summary -- References -- Note Added in Proof -- Chapter 5. Protein Disulfide-lsomerase: Role in Biosynthesis of Secretory Proteins -- I. Introduction -- II. Catalytic Properties of Protein Disulfide-Isomerase -- III. Cellular Properties of Protein Disulfide-Isomerase -- IV. Role of Protein Disulfide-Isomerase in Intracellular Protein Folding -- V. Multifunctionality of Protein Disulfide-Isomerase -- VI. Conclusions -- References. , Chapter 6. SecB: A Molecular Chaperone of Escherichia coli Protein Secretion Pathway -- I. Overview -- II. Introduction -- III. Precursor Conformation Governing Signal Peptide Function -- IV. SecB as Component of Secretion Machinery -- V. Properties of SecB -- VI. SecB and Its Ligands Forming Isolable Complexes -- VII. Nature of SecB Binding Sites -- VIII. Other Chaperones and Protein Secretion -- IX. Recapitulation and Speculation -- References -- Author Index -- Subject Index.

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7

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Advances in Protein Chemistry. (1995)

Anfinsen, C. B.

San Diego :Elsevier Science & Technology,

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Keywords: Biochemistry. ; Electronic books.

Type of Medium: Online Resource

Pages: 1 online resource (473 pages)

Edition: 1st ed.

ISBN: 9780080582207

Series Statement: Issn Series

URL: https://ebookcentral.proquest.com/lib/geomar/detail.action?docID=403592

DDC: 574.87

Language: English

Note: Front Cover -- Advances in Protein Chemistry, Volume 47 -- Copyright Page -- Contents -- Contributors -- Preface -- Chapter 1. Hemocyanins -- Prologue -- I. Oxygen Transport Proteins: An Overview -- II. Three-Dimensional Structures of Hemocyanin Molecules -- III. The Oxygen-Binding Site -- IV. Oxygen-Binding Equilibria -- V. Synthesis of Hemocyanins -- VI. Evolution of Hemocyanins -- References -- Chapter 2. Molten Globule and Protein Folding -- I. Introduction -- II. Equilibrium Molten Globule State -- III. Phase Transitions -- IV. Kinetics of Protein Folding -- V. Mechanism of Protein Folding -- VI. Physiological Role of Molten Globule -- VII. Conclusion -- References -- Chapter 3. Enthalpic Contribution to Protein Stability: Insights from Atom-Based Calculations and Statistical Mechanics -- I. Introduction -- II. Models for Protein Stability -- III. Enthalpy of Protein Folding -- IV. van der Waals Interactions in Proteins and Model Systems -- V. Electrostatic Interactions in Proteins: Hydrogen Bond Contribution -- Vl. Enthalpy of Solvation of Polar Groups: Breakdown of Surface Area Proportionality Assumption -- VII. Concluding Discussion -- Appendix: Computational Details -- References -- Epilogue -- Chapter 4. Energetics of Protein Structure -- List of Symbols -- I. Introduction -- II. Structural Characteristics of Analyzed Proteins -- III. Thermodynamic Characteristics of Analyzed Proteins -- IV. Net Hydration Effects of Protein Groups -- V. Hydration Effects on Protein Unfolding -- VI. Entropy of Protein Unfolding in Vacuum -- VII. Enthalpy of Protein Unfolding in Vacuum -- VIII. lnteractions in Proteins -- IX. Protein Unfolding in Aqueous Media -- X. Contribution of Hydrogen Bonding in Stabilizing Protein Structure in Water -- XI. Hydrophobic Interactions in Proteins -- XII. Role of Packing of Groups in Protein Interior. , XIII. Molten Globule State -- XIV. Balance of Forces Stabilizing and Destabilizing Protein Structure -- XV. Concluding Remarks -- References -- Epilogue -- Author Index -- Subject Index.

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8

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Lipoproteins, Apolipoproteins, and Lipases. (1994)

Anfinsen, C. B.

San Diego :Elsevier Science & Technology,

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Keywords: Proteins. ; Lipoproteins. ; Electronic books.

Type of Medium: Online Resource

Pages: 1 online resource (489 pages)

Edition: 1st ed.

ISBN: 9780080582184

Series Statement: Issn Series

URL: https://ebookcentral.proquest.com/lib/geomar/detail.action?docID=403591

Language: English

Note: Front Cover -- Advances in Protein Chemistry, Volume 45 -- Copyright Page -- Contents -- Contributors -- Preface -- Chapter 1. Structure and Function of Lipases -- I. Introduction -- II. Lipases: Crystallographic Database -- III. Molecular Basis of Liquid Degradation by Lipases -- IV. Evolutionary Relationships -- V. Lipases with Unknown Three-Dimensional Structures -- VI. Conclusions -- References -- Chapter 2. Structure and Catalytic Mechanism of Secretory Phospholipases A2 -- I. Introduction -- II. Primary Structure and Classification -- III. Secondary and Tertiary Structure -- IV. Chemistry of Catalysis of Secretory Phospholipases A2 -- V. Interfacial Catalysis -- References -- Chapter 3. Lipid-Binding Proteins: A Family of Fatty Acid and Retinoid Transport Proteins -- I. Introduction -- II. General Structural Features -- III. Conformational Similarity among Intracellular Lipid-Binding Proteins -- IV. Intracellular Lipid-Binding Protein Cavity -- V. Apo- versus Holo-iLBP Structure -- VI. Gap between βD and βE -- VII. Binding Affinity and Specificity Based on Biochemical Studies -- VIII. Binding Affinity and Specificity Based on Crystallographic Studies -- IX. Members of iLBP Family with Known Crystal Structure -- X. Members of eLBP Family with Known Crystal Structure -- XI. Factors Involved in Lipid Binding in iLBPs -- XII. Concluding Remarks -- References -- Chapter 4. Structure of Serum Albumin -- I. Introduction -- II. Albumin Structure -- III. Nature of Ligand Binding -- IV. Evolution of Albumin Structure -- V. Summary and Future Directions -- References -- Chapter 5. Apolipoprotein B and Low-Density Lipoprotein Structure: Implications for Biosynthesis of Triglyceride-Rich Lipoproteins -- I. Introduction -- II. Apolipoprotein B Structure -- III. Low-Density Lipoprotein Structure. , IV. Structural Studies of Apolipoprotein B on Low-Density Lipoprotein Surfaces -- V. Lipoprotein Assembly -- VI. Summary -- References -- Chapter 6. Apolipoprotein E: Structure-Function Relationships -- I. Introduction -- II. Apolipoprotein -- III. Function -- IV. Impact of Structure on Function -- V. Three-Dimensional Structure of Apolipoprotein E 22-kDa Fragments -- VI. Lipid Binding -- VII. Future Directions -- References -- Chapter 7. The Amphipathic α Helix: A Multifunctional Structural Motif in Plasma Apolipoproteins -- I. Plasma Lipoproteins and Apolipoproteins -- II. The Amphipathic α Helix -- III. Conclusions -- References -- Chapter 8. Lipophorin: The Structure of an Insect Lipoprotein and Its Role in Lipid Transport in Insects -- I. Introduction -- II. Lipid and Apolipoprotein Composition of Lipophorins -- III. Size, Molecular Weight, Heterogeneity, and Shape of Lipophorins -- IV. Organization of Lipids and Proteins in Lipophorins -- V. Metabolism -- VI. Metabolic Implications of Lipophorin Structure -- VII. Concluding Remarks and Future Directions -- References -- Author Index -- Subject Index.

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9

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Cytokines. (1998)

Richards, Frederic M.

San Diego :Elsevier Science & Technology,

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Keywords: Cytokines. ; Electronic books.

Type of Medium: Online Resource

Pages: 1 online resource (329 pages)

Edition: 1st ed.

ISBN: 9780080582252

Series Statement: Issn Series

URL: https://ebookcentral.proquest.com/lib/geomar/detail.action?docID=403594

DDC: 612/.01575

Language: English

Note: Front Cover -- Advances in Protein Chemistry, Volume 52 -- Copyright Page -- Contents -- Preface -- Chapter 1. General Classes and Functions of Four-Helix Bundle Cytokines -- I. Overview -- II. Long-Chain Cytokines Using Homodimeric Type I Cytokine Receptors for Signaling -- III. Short-Chain Cytokines Using Homodimeric Tyrosine Kinase Receptors for Signaling: Macrophage Colony-Stimulating Factor, Stem Cell Factor, and FLK2/FLT3 Ligand -- IV. Long-Chain Cytokines Using Leukemia Inhibitory Factor Receptors and/or gp130 for Signaling: Pleiotropic Cytokines: Interleukin-6, Interleukin-11, Leukemia Inhibitory Factor, Oncostatin M, Ciliary Neurotrophic Factor, and Cardiotrophin-1 -- V. Short-Chain Cytokines Using βc for Signaling: Hemopoietic Cytokines: Granulocyte-Macrophage Colony-Stimulating Factor, Interleukin-3, and Interleukin-5 -- VI. Cytokines Using Class II Cytokine Receptors for Signaling: Viral Resistance Cytokines: Interferons, Interleukin-10, and Interleukin-12 -- VII. Short-Chain Cytokines Using γc or Interleukin-4 Receptor for Signaling: Acquired Immunity Cytokines: Interleukins-2, -4, -7, -9, -13, and -15 -- VIII. Concluding Comments -- References -- Chapter 2. Structural Basis for Cytokine Hormone-Receptor Recognition and Receptor Activation -- I. Introduction -- II. Class 1 of the Superfamily -- III. Class 2 of the Superfamily -- IV. Comparison of Class 1 and Class 2 Receptors -- References -- Chapter 3. General Mechanisms of Cytokine Receptor Signaling -- I. Introduction -- II. Multicomponent Receptors for the Interleukin 6/Ciliary Neurotrophic Factor Cytokine Family: Shared Signal Transducing Receptor Components -- III. Cytokine Binding Drives Receptor Complex Assembly -- IV. Homo- or Heterodimerization of Signal Transducing Components is Required for Signaling: JAK Kinases are Preassociated with Signal Transducers. , V. Shared Principles of Receptor Activation by Different Cytokine Families and Receptor Tyrosine Kinases -- VI. STATs and Other Substrates Activated by Cytokine Receptors -- VII. Choice of STATs and Other Substrates Specified by Modular Tyrosine-Based Motifs in Cytokine Receptors -- VIII. Phosphatases and Other Regulators of Cytokine Receptor Signaling -- IX. Therapeutic Approaches for Modulating Cytokine Signaling -- References -- Chapter 4. Cytokines in Hematopoiesis: Specificity and Redundancy in Receptor Function -- I. Introduction -- II. Structure and Regulation of Hematopoietic Compartment -- III. Historical Perspective -- IV. Experimental Models to Study Cytokine Receptors -- V. Inductive versus Stochastic Models of Hematopoiesis -- VI. Cytokine Receptor Signaling -- VII. Pathological Effects of Aberrant Cytokine Receptor Function -- VIII. Summary and Future Perspectives -- References -- Chapter 5. Cytokines in Endocrine Function -- I. Introduction -- II. Growth Hormone Signal Transduction -- III. Growth Hormone Receptor Dimerization and Antagonists -- IV. Impact of Molecular Defects of the Receptor -- V. Tissue Dictating Growth Hormone Receptor Requirements -- VI. Pulsatile Growth Hormone -- VII. Clinical Relevance of Growth Hormone Receptor/ Therapeutic Implications -- VIII. Conclusion -- References -- Chapter 6. Cytokines in Brain Development and Function -- I. Introduction -- II. Role of Cytokines in Regulation of Neurogenesis -- III. Cytokine Subgroups: Specific Roles and Regulation of Expression in Nervous System -- IV. Cytokine Regulation of Neurogenesis: Patterns of Expression of Hemopoietins, Receptors, and Signaling Molecules -- V. Summary and Future Directions -- References -- Author Index -- Subject Index.

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Linkage Thermodynamics of Macromolecular Interactions. (1998)

Richards, Frederic M.

San Diego :Elsevier Science & Technology,

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Keywords: Proteins. ; Electronic books.

Type of Medium: Online Resource

Pages: 1 online resource (485 pages)

Edition: 1st ed.

ISBN: 9780080582245

Series Statement: Issn Series

URL: https://ebookcentral.proquest.com/lib/geomar/detail.action?docID=403593

DDC: 574.29

Language: English

Note: Front Cover -- Advances in Protein Chemistry, Volume 51 -- Copyright Page -- Contents -- Introduction -- Chapter 1. Electrostatic Contributions to Molecular Free Energies in Solution -- I. Introduction -- II. Theory and Calculational Methods -- III. Applications -- IV. Outlook -- References -- Chapter 2. Site-Specific Analysis of Mutational Effects in Proteins -- I. Introduction -- II. The Reference Cycle -- III. Structural Mapping of Energetics -- IV. Site-Specific Analysis of Mutational Effects in Proteins -- V. Site-Specific Dissection of Thrombin Specificity -- VI. Concluding Remarks -- References -- Chapter 3. Allosteric Transitions of the Acetylcholine Receptor -- I. Introduction -- II. Mechanistic Models -- III. Recovery from Desensitization -- IV. Kinetic Basis of Dose-Response Curves -- V. Multiple Phenotypes -- VI. Deductions from Single-Channel Measurements -- VII. Allosteric Effectors and Coincidence Detection -- VIII. General Considerations -- References -- Chapter 4. Deciphering the Molecular Code of Hemoglobin Allostery -- I. Introduction -- II. Overview -- III. Binding Curves and Stoichiometric Information -- IV. Site-Specific Aspects of Oxygen Binding -- V. Experimental Determination of Site-Specific Cooperativity Terms -- VI. How the Molecular Code Was Deciphered -- VII. Concluding Remarks -- References -- Chapter 5. Statistical Thermodynamic Linkage between Conformational and Binding Equilibria -- I. Introduction -- II. The Most Probable Distribution -- III. Coupling of Statistical Weights to Ligands -- IV. Modulation of Distribution of States by Specific Ligands -- V. Modulation of Distribution of States by Denaturants -- VI. Ligand-Induced Conformational Changes -- VII. The Distribution of Conformational States According to Their Gibbs Energy -- VIII. Is the Unfolded State the State with the Highest Gibbs Energy?. , IX. The Gibbs Energy Scale of Conformational States -- X. Statistical Descriptors of the Conformational Ensemble -- XI. Conclusions -- References -- Chapter 6. Analysis of Effects of Salts and Uncharged Solutes on Protein and Nucleic Acid Equilibria and Processes: A Practical Guide to Recognizing and Interpreting Polyelectrolyte Effects, Hofmeister Effects, and Osmotic Effects of Salts -- I. Introduction -- II. Overview of Concentration-Dependent Effects of Perturbing Solutes on Processes Involving Biopolymers -- III. Preferential Interaction Coefficients as Fundamental Measures of Thermodynamic Effects due to Solute-Biopolymer Interactions -- IV. Preferential Interactions of Nonelectrolyte Molecules with an Uncharged Biopolymer -- V. Preferential Interactions of Electrolyte Ions with a Charged Biopolymer -- VI. Use of Three-Component Preferential Interaction Coefficients to Analyze Effects of Solute Concentration on Equilibrium Constants, Transition Temperatures, or Free Energy Changes of Biopolymer Processes -- VII. Two-Domain Predictions of Functional Forms of Effects of Nonelectrolyte Concentration on Equilibria (Kobs) and Transition Temperatures ( Tm ) of Uncharged Biopolymers in Aqueous Solution -- VIII. Polyelectrolyte and Two-Domain Predictions of Functional Forms of Effects of Salt Concentration on Equilibria (Kobs) and Transition Temperatures ( Tm ) of Charged Biopolymers in Aqueous Solution -- IX. Conclusions and Future Directions -- References -- Chapter 7. Control of Protein Stability and Reactions by Weakly Interacting Cosolvents: The Simplicity of the Complicated -- I. Introduction -- II. Preferential Interactions -- III. Wyman Linkages in Preferential Interactions -- IV. Linkage Control of Protein Stability -- V. Linkage Control of Protein Reactions -- VI. Sources of Exclusion -- VII. Osmolytes -- VIII. Conclusion -- References. , Author Index -- Subject Index.

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