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  • 1
    Electronic Resource
    Electronic Resource
    Acral erythema and intrahepatic 5-fluorouracil infusion (1997)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of the European Academy of Dermatology and Venereology 8 (1997), S. 0 
    Details
    ISSN: 1468-3083
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1468-3083.1997.tb00494.x
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    Paper (German National Licenses)
    Fulltext
  • 2
    Electronic Resource
    Electronic Resource
    Chromosome doubling in Tripsacum: the production of artificial, sexual tetraploid plants (1995)
    Oxford, UK : Blackwell Publishing Ltd
    Plant breeding 114 (1995), S. 0 
    Details
    ISSN: 1439-0523
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition
    Notes: A collection of embryogenic diploid calli of Tripsacum was established and treated with colchicine to induce chromosome doubling. Sections containing duplicated cells in calli were identified using flow cytometry and ploidy level was determined in the regenerated plantlets. Tetraploid plants from several origins were obtained. In contrast to wild polyploid plants, which show apomictic development, the regenerated tetraploid plants reproduced sexually. By hybridizing these plants with wild tetraploid apomicts, various populations were established; these will allow a study of the inheritance of apomixis in Tripsacum.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1439-0523.1995.tb00798.x
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Microbial Populations and Malolactic Fermentation of Apple Cider using Traditional and Modified Methods (1994)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of food science 59 (1994), S. 0 
    Details
    ISSN: 1750-3841
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition , Process Engineering, Biotechnology, Nutrition Technology
    Notes: The evolution of yeasts and lactic acid bacteria was examined during two methods of cider making: the traditional employed unwashed apples of different varieties and the modified used a sole washed acidic apple variety with temperature control during the cider making process. The alcoholic fermentation was carried out mainly by Kloeckera apiculata and Sacharomyces cerevisiae species, and their distributions were similar in the two methods. In the traditional, the malolactic fermentation proceeded at the same time as alcoholic fermentation and the “piqure lactique” occurred. In the modified method, no malolactic fermentation took place. In all musts, a fundamentally heterofermentative lactic flora was found, with Lactobacillus species most abundant in the traditional process.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2621.1994.tb08190.x
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Gonadal steroids and astroglial plasticity (1996)
    Springer
    Cellular and molecular neurobiology 16 (1996), S. 225-237 
    Details
    ISSN: 1573-6830
    Keywords: estradiol ; progesterone ; testosterone ; neurosteroids ; pregnenolone ; dehydroepiandrosterone ; glial fibrillary acidic protein ; reactive astroglia ; synaptic plasticity ; neural cell adhesion molecule ; insulin-like growth factor I
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Summary 1. Recent evidence indicates that astroglia participate in the metabolism of gonadal hormones, in the synthesis of neurosteroids, and in the plastic responses of neurons to gonadal steroids. The role of astroglia on plastic responses of neural tissue to gonadal hormones and neurosteroids is examined in this review. 2. Gonadal steroids and neurosteroids promote astroglia plasticity in several areas of the central nervous system, including the hypothalamus, the striatum, and the hippocampus. 3. Gonadal steroids and neurosteroids modulate astroglia proliferation and the formation of reactive astroglia after brain injury. 4. Astroglia is a source of trophic factors that may mediate effects of gonadal steroids on neural tissue. 5. Astroglia is involved in the promotion of synaptic plastic changes by gonadal hormones. 6. The effect of gonadal hormones on astroglial plasticity is dependent on specific membrane interactions with neurons and on the expression of the embryonic highly polysialylated isoform of the neural cell adhesion molecule on neuronal membranes. 7. In conclusion, coordinated responses of neurons and astroglia appear to be involved in the modulation of neural function and response to injury by gonadal hormones and neurosteroids.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02088178
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  • 5
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    Nationwide cross-sectional study of the impact of chronic pain on an individuals employment: relationship with the family and the social support (2016)
    BMJ Publishing
    In: BMJ Open
    Details
    Publication Date: 2016-12-25
    Description: Objectives To determine the prevalence and the factors related to sick leave and job loss among individuals suffering from chronic pain (CP), and to analyse specifically the effect of family and social support on the individual's employment. Design Observational cross-sectional study. Setting Data were collected using structured computer-assisted telephone interviews between February and June 2011. Participants A nationwide study of 1543 Spanish adults of working age (〈65), 213 of whom suffered from CP (pain suffered at least 4 or 5 days a week during the past 3 months, according to the criteria of the International Association for the Study of Pain (IASP)). Main outcome measure Information was collected regarding the individual's sociodemographic status, pain characteristics, healthcare use and satisfaction, limitations in daily activities, mood status, perception of the impact of pain on their families, and their satisfaction with the family and social support. To identify factors associated with sick leave and job loss among those suffering CP, 2 logistic regression models were generated. Results The prevalence of sick leave due to CP in the general Spanish population was 4.21% (95% CI 3.2% to 5.2%). Sick leave were more likely for individuals who considered their family were affected by their pain (OR=2.18), needed help to dressing and grooming (OR=2.98), taking medication (OR=2.18), had a shorter pain duration (OR=0.99) and higher educational level. The prevalence of job loss due to CP was 1.8% (95% CI 1.1% to 2.5%). It was related to feelings of sadness (OR=4.25), being unsatisfied with the care provided by health professionals (OR=2.60) and consulting a doctor more often due to CP (OR=1.09). Conclusions CP is negatively associated with an individual's employment. This detrimental effect could be ameliorated if the factors related to sick leave and job loss provoked by CP are identified, especially those related to the effect of CP on the family and social environment.
    Keywords: Open access, Epidemiology, Occupational and environmental medicine
    Electronic ISSN: 2044-6055
    Topics: Medicine
    Published by BMJ Publishing
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  • 6
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    BMP4 Induces M2 Macrophage Polarization and Favors Tumor Progression in Bladder Cancer (2017)
    The American Association for Cancer Research (AACR)
    Details
    Publication Date: 2017-12-02
    Description: Purpose: Bladder cancer is a current clinical and social problem. At diagnosis, most patients present with nonmuscle-invasive tumors, characterized by a high recurrence rate, which could progress to muscle-invasive disease and metastasis. Bone morphogenetic protein (BMP)–dependent signaling arising from stromal bladder tissue mediates urothelial homeostasis by promoting urothelial cell differentiation. However, the possible role of BMP ligands in bladder cancer is still unclear. Experimental Design: Tumor and normal tissue from 68 patients with urothelial cancer were prospectively collected and analyzed for expression of BMP and macrophage markers. The mechanism of action was assessed in vitro by experiments with bladder cancer cell lines and peripheral blood monocyte–derived macrophages. Results: We observed BMP4 expression is associated and favored type II macrophage differentiation. In vitro experiments showed that both recombinant BMP4 and BMP4-containing conditioned media from bladder cancer cell lines favored monocyte/macrophage polarization toward M2 phenotype macrophages, as shown by the expression and secretion of IL10. Using a series of human bladder cancer patient samples, we also observed increased expression of BMP4 in advanced and undifferentiated tumors in close correlation with epithelial–mesenchymal transition (EMT). However, the p-Smad 1,5,8 staining in tumors showing EMT signs was reduced, due to the increased miR-21 expression leading to reduced BMPR2 expression. Conclusions: These findings suggest that BMP4 secretion by bladder cancer cells provides the M2 signal necessary for a protumoral immune environment. In addition, the repression of BMPR2 by miR-21 makes the tumor cells refractory to the prodifferentiating actions mediated by BMP ligands, favoring tumor growth. Clin Cancer Res; 23(23); 7388–99. ©2017 AACR .
    Print ISSN: 1078-0432
    Electronic ISSN: 1557-3265
    Topics: Medicine
    Published by The American Association for Cancer Research (AACR)
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  • 7
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    Spatial and temporal variation of the impact of an extreme Saharan dust event (2012)
    Wiley-Blackwell
    Details
    Publication Date: 2012-06-05
    Description: The impact on PM10, meteorology and visibility of the severe Saharan dust outbreak registered in Europe in October 2008 is evaluated in detail in mainland Spain and the Balearic Islands. Data from a large number of air quality stations (261), METAR observations at 39 airports, besides records from meteorological networks, were used. Information from dispersion models, satellite observations, synoptic charts and back-trajectory analysis, supported the interpretation. During the event, 89% of the monitoring stations exceeded the daily limit value. The highest daily averaged PM10 concentration across Spain ranged from 378 to 18 μg m−3, following a hyperbolic decay with increasing latitude. An opposite relationship between visibility and PM10 was found for data at 12 UTC. The strength of the episode may be related to strong subsidence at low levels over the Iberian Peninsula.
    Print ISSN: 0148-0227
    Topics: Geosciences , Physics
    Published by Wiley-Blackwell on behalf of American Geophysical Union (AGU).
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  • 8
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    A Novel Tumor suppressor network in squamous malignancies (2012)
    Nature Publishing Group (NPG)
    Details
    Publication Date: 2012-11-10
    Description: The specific ablation of Rb1 gene in stratified epithelia (RbF/F;K14cre) promotes proliferation and altered differentiation but is insufficient to produce spontaneous tumors. The pRb relative, p107, compensates some of the functions of pRb in these tissues; however, RbF/F;K14cre;p107−/− mice die postnatally. Here we show, using an inducible mouse model (RbF/F;K14creERTM), that p107 exerts specific tumor suppressor functions in the absence of pRb in stratified epithelia. The simultaneous absence of pRb and p107 produces impaired p53 transcriptional functions and reduction of Pten expression, allowing spontaneous squamous carcinoma development. These tumors display significant overlap with human squamous carcinomas, supporting that RbF/F;K14creERTM;p107−/− mice might constitute a new model for these malignancies. Remarkably tumor development in vivo is partially alleviated by mTOR inhibition. These data demonstrate the existence of a previously unreported functional connection between pRb, Pten and p53 tumor suppressors, through p107, of a particular relevance in squamous tumor development. Scientific Reports 2 doi: 10.1038/srep00828
    Electronic ISSN: 2045-2322
    Topics: Natural Sciences in General
    Published by Nature Publishing Group (NPG)
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  • 9
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    Breakup and neutron-transfer effects on ^{6}He+^{206}Pb elastic scattering below the Coulomb barrier (2013)
    American Physical Society (APS)
    Details
    Publication Date: 2013-06-05
    Description: Author(s): Ł. Standyło, L. Acosta, C. Angulo, R. Berjillos, J. A. Duenas, M. S. Golovkov, N. Keeley, T. Keutgen, I. Martel, M. Mazzocco, F. Perez-Bernal, A. M. Sánchez-Benítez, C. Signorini, M. Romoli, K. Rusek, and R. Wolski The elastic scattering and inclusive α -particle yield for the 6 He+ 206 Pb system at an incident energy of 18 MeV, just below the nominal Coulomb barrier, have been measured. The α -particle yield at forward angles is also reported. The data are analyzed by means of continuum-discretized coupled-channel... [Phys. Rev. C 87, 064603] Published Tue Jun 04, 2013
    Keywords: Nuclear Reactions
    Print ISSN: 0556-2813
    Electronic ISSN: 1089-490X
    Topics: Physics
    Published by American Physical Society (APS)
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  • 10
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    Disruption of Rb-E2F-Ezh2 Loop in Bladder Cancer (2014)
    The American Association for Cancer Research (AACR)
    Details
    Publication Date: 2014-11-15
    Description: Bladder cancer is a highly prevalent human disease in which retinoblastoma (Rb) pathway inactivation and epigenetic alterations are common events. However, the connection between these two processes is still poorly understood. Here, we show that the in vivo inactivation of all Rb family genes in the mouse urothelium is sufficient to initiate bladder cancer development. The characterization of the mouse tumors revealed multiple molecular features of human bladder cancer, including the activation of E2F transcription factor and subsequent Ezh2 expression and the activation of several signaling pathways previously identified as highly relevant in urothelial tumors. These mice represent a genetically defined model for human high-grade superficial bladder cancer. Whole transcriptional characterizations of mouse and human bladder tumors revealed a significant overlap and confirmed the predominant role for Ezh2 in the downregulation of gene expression programs. Importantly, the increased tumor recurrence and progression in human patients with superficial bladder cancer is associated with increased E2F and Ezh2 expression and Ezh2-mediated gene expression repression. Collectively, our studies provide a genetically defined model for human high-grade superficial bladder cancer and demonstrate the existence of an Rb–E2F–Ezh2 axis in bladder whose disruption can promote tumor development. Cancer Res; 74(22); 6565–77. ©2014 AACR.
    Print ISSN: 0008-5472
    Electronic ISSN: 1538-7445
    Topics: Medicine
    Published by The American Association for Cancer Research (AACR)
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