Keywords:
Dentistry.
;
Electronic books.
Type of Medium:
Online Resource
Pages:
1 online resource (281 pages)
Edition:
1st ed.
ISBN:
9783319223452
Series Statement:
Advances in Experimental Medicine and Biology Series ; v.881
URL:
https://ebookcentral.proquest.com/lib/geomar/detail.action?docID=4086750
DDC:
610.28
Language:
English
Note:
Intro -- Preface: Engineering Mineralized and Load-Bearing Tissues: Progress and Challenges -- Engineering Mineralized and Load Bearing Tissues -- Contents -- Part I: Fabrication Methods and Techniques -- 1: 3D Printing and Biofabrication for Load Bearing Tissue Engineering -- 1.1 Introduction -- 1.2 Biofabrication and Bioprinting of Load Bearing Tissue Engineering -- 1.2.1 Bone -- 1.2.2 Cartilage and Osteochondral Regions -- 1.2.3 Dental Tissue Engineering -- 1.3 Summary and Conclusions -- References -- 2: Microfabrication of Cell-Laden Hydrogels for Engineering Mineralized and Load Bearing Tissues -- 2.1 Introduction -- 2.2 Hydrogels: Artificial Extracellular Matrices -- 2.3 Microfabrication Techniques to Engineer Cell-Laden Hydrogels -- 2.3.1 Photolithography -- 2.3.2 Soft Lithography -- 2.3.3 Bioprinting -- 2.4 Applications of Microfabrication Technology in Regenerative Dentistry -- 2.4.1 Regeneration of a Bioengineered Tooth -- 2.4.2 Regeneration of Dental Pulpal Tissues -- 2.4.3 Regeneration of Periodontium -- 2.5 Applications of Microfabrication Technology in Bone Regeneration -- 2.6 Applications of Microfabrication Technology in Cartilage Regeneration -- 2.7 Conclusion and Future Perspectives -- References -- 3: Electrospinning of Bioinspired Polymer Scaffolds -- 3.1 Introduction -- 3.2 Polymers -- 3.3 Composites and Hybrid Materials -- 3.3.1 Electrospun Fibre Reinforcement with Bioactive Substances -- 3.3.2 Surface Mineralisation of Electrospun Nanofibres -- 3.4 Ceramics -- 3.5 Designs for 3D Structure Generation -- 3.6 Load-Bearing Structures -- 3.7 Electrospinning and Tissue Engineering -- 3.7.1 Bone -- 3.7.2 Osteochondral -- 3.7.3 Tooth -- 3.8 Drug Delivery Systems -- 3.9 Future Perspectives -- References -- Part II: Applied Strategies for Tissue Engineering: Bone and Cartilage.
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4: Bone Tissue Engineering Challenges in Oral & -- Maxillofacial Surgery -- 4.1 Introduction -- 4.2 Challenges for Bone Tissue Engineering in the Craniofacial Complex -- 4.3 Current Methods of Maxillofacial Reconstruction -- 4.4 Mandible Reconstruction -- 4.5 Maxillary Reconstruction -- 4.6 The "Ideal" Material for Craniofacial Reconstructions -- 4.7 Scaffold Materials -- 4.7.1 Calcium/Phosphate-Based Bioactive Ceramics -- 4.7.2 Polymer-Based Scaffolds -- 4.8 Bioactive Factors -- 4.8.1 Bone Morphogenetic Protein (BMP) -- 4.8.2 Platelet Derived Growth Factor (PDGF) -- 4.8.3 Transforming Growth Factor-Beta (TGF-β) -- 4.8.4 Fibroblast Growth Factor (FGF) -- 4.8.5 Insulin-Like Growth Factor (IGF) -- 4.9 Gene Delivery -- 4.10 Mesenchymal and Adipose Derived Stem Cells -- 4.11 Future Challenges for Craniofacial Tissue Engineering -- References -- 5: Engineering Pre-vascularized Scaffolds for Bone Regeneration -- 5.1 Introduction -- 5.2 Vasculogenesis and Angiogenesis -- 5.3 Cellular Approaches to Engineer Vascular Networks -- 5.3.1 Growth Factor Delivery -- 5.3.1.1 Physical Entrapment of Growth Factors -- 5.3.1.2 Chemically Immobilized Growth Factors -- 5.3.2 On-Chip Vascularization Studies -- 5.4 Biofabrication Approaches to Engineer Pre-vascularized Scaffolds -- 5.4.1 Lithography and Microfabrication -- 5.4.2 3D Printing -- 5.5 Final Remarks -- References -- 6: Morphogenic Peptides in Regeneration of Load Bearing Tissues -- 6.1 Introduction -- 6.2 Peptides Derived from Bone Morphogenic Proteins and Soluble Proteins of Bone Matrix -- 6.3 Integrin Binding Peptides -- 6.4 Peptides Derived from Vasculogenic and Neurogenic Proteins -- 6.5 Osteoinductivity of Peptides Versus Proteins -- 6.6 Dose Dependence of Osteoinductivity of Morphogenic Peptides -- 6.7 Osteoinductive Peptide Delivery Strategies.
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6.8 Aggregation of Osteoinductive Peptides -- 6.9 Future Work -- References -- 7: Osseointegration of Plateau Root Form Implants: Unique Healing Pathway Leading to Haversian-Like Long-Term Morphology -- 7.1 Introduction -- 7.2 Early Osseointegration Pathway: Interfacial Remodeling, Intramembranous-Like Healing (Healing Chambers), and Hybrid Healing -- 7.2.1 Interfacial Remodeling Healing Pathway -- 7.2.2 Intramembranous-Like Healing Pathway (Healing Chamber Osseointegration) -- 7.2.3 Current Trend: Hybrid Healing Pathway: Integrating Interfacial Remodeling and Intramembranous-Like Bone Healing Modes -- 7.3 Long-Term Osseointegration: Healing Pathway Effect on Osseointegration, Bone Morphology, and Bone Mechanical Property Evolution -- 7.3.1 Long-Term Morphology of Implants That Undergo Interfacial Remodeling -- 7.3.2 Long-Term Morphology, Bone Mechanical Property, and Temporal Osseointegration of Implants That Undergo Intramembranous-Like Healing -- 7.4 Hastening the Osseointegration Process -- 7.5 Final Remarks -- References -- 8: Dentin Matrix Proteins in Bone Tissue Engineering -- 8.1 Introduction -- 8.2 Expression and Localization of DMPs in Bone -- 8.2.1 DMP1 -- 8.2.2 DPP or DMP2 -- 8.2.3 DSP -- 8.2.4 DMP4/FAM20C -- 8.3 Functions of DMPs -- 8.3.1 DMP1 -- 8.3.1.1 Biomineralization Function of DMP1 -- 8.3.1.2 DMP1 and Stem Cell Differentiation -- 8.3.2 DPP -- 8.3.2.1 DPP Mediated Hydroxyapatite Nucleation -- 8.3.2.2 Signaling Roles of DPP -- 8.3.3 DSP -- 8.3.4 DMP4/Fam20C -- 8.3.4.1 Calcium-Binding Property of DMP4/Fam20c -- 8.3.4.2 Fam20C/DMP4 and Osteoblast Differentiation -- 8.4 Tissue Engineering Strategies Using DMPs -- 8.4.1 DMP1 -- 8.4.2 DPP -- 8.4.3 DSP -- 8.4.4 DMP4/Fam20C -- 8.5 Conclusion -- References -- 9: Multiphasic, Multistructured and Hierarchical Strategies for Cartilage Regeneration.
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9.1 Introduction -- 9.2 The Hierarchical Composition of Articular Cartilage -- 9.3 Research Progress on Cartilage Regeneration Strategies -- 9.3.1 Multiphasic Strategies -- 9.3.2 Multiscale Strategies -- 9.3.3 Multilayered Strategies -- 9.3.4 Hierarchical Strategies -- 9.4 Summary and Future Directions -- References -- 10: Anterior Cruciate Ligament: Structure, Injuries and Regenerative Treatments -- 10.1 Introduction -- 10.2 Anterior Cruciate Ligament -- 10.3 ACL Replacements -- 10.3.1 Autograft -- 10.3.2 Allograft -- 10.3.3 Xenograft -- 10.3.4 Synthetic Ligament Implants -- 10.4 Graft Fixation -- 10.5 Tissue Engineering of Ligaments -- 10.5.1 Cell Sources -- 10.5.2 Growth Factors -- 10.5.3 Scaffolds -- 10.5.3.1 Collagenous Structures -- 10.5.3.2 Silk Based Scaffolds -- 10.5.3.3 Seri-ACL™ -- 10.5.3.4 Sugar-Based Scaffolds -- 10.5.3.5 Synthetic Structures -- 10.5.3.6 Interface Tissue Engineering -- 10.5.4 Bioreactors -- 10.5.5 Animal Models -- 10.6 Conclusions -- References -- 11: Hard-Soft Tissue Interface Engineering -- 11.1 Introduction -- 11.2 Structure of Natural Interface Tissues -- 11.2.1 Ligament and Tendon Insertions -- 11.2.2 The Osteochondral Interface -- 11.2.3 Mechanical Properties of Interface Tissues -- 11.3 Engineering of Tissue Interfaces -- 11.3.1 Scaffolds -- 11.3.1.1 Scaffold Properties -- 11.3.1.2 Scaffold Manufacturing Techniques -- 11.3.2 External Factors -- 11.3.3 Cells -- 11.4 Conclusions -- References -- Part III: Applied Strategies for Tissue Engineering: Dentin, Enamel, Cementum and PDL -- 12: Cementum and Periodontal Ligament Regeneration -- 12.1 Introduction -- 12.2 The Periodontal Complex -- 12.2.1 Cementum -- 12.2.2 Periodontal Ligament (PDL) -- 12.2.3 Alveolar Bone -- 12.2.4 The Oral Mucosa -- 12.3 Dental Disease -- 12.3.1 Periodontitis.
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12.3.2 Periodontal Wound Healing -- 12.4 Current Treatment Approaches -- 12.4.1 Bone Grafts -- 12.4.2 Guided Tissue Regeneration -- 12.4.3 Delivery of Bioactive Materials -- 12.5 Cell-Based Tissue Engineering -- 12.5.1 Challenges and Limitations Associated with Tissue Engineering Based Approaches to Periodontal Therapy -- 12.5.2 Use of Biomaterials in Regeneration of Dental Tissues -- 12.6 Mesenchymal Stem Cells -- 12.6.1 Utilisation and Efficacy of Bone Marrow Derived MSC (BMSC) in Regeneration of Dental Tissues -- 12.6.2 Utilisation and Efficacy of Dental Pulp Derived MSC (DPSC) in Regeneration of Dental Tissues -- 12.6.3 Utilisation and Efficacy of Periodontal Ligament Derived MSC (PDLSC) in Regeneration of Dental Tissues -- 12.6.4 Utilisation and Efficacy of Stem Cells Derived from Human Exfoliated Deciduous Teeth (SHED) in Regeneration of Dental Tissues -- 12.6.5 Utilisation and Efficacy of Stem Cells from Apical Papilla (SCAP) in Regeneration of Dental Tissues -- 12.6.6 Utilisation and Efficacy of Dental Follicle Derived Stem Cells (DFC) in Regeneration of Dental Tissues -- 12.6.7 Utilisation and Efficacy of Induced Pluripotent Stem (iPS) Cells in Regeneration of Dental Tissues -- 12.7 Future Prospects for Stem Cells Based Therapies in Periodontal Tissue Regeneration -- 12.8 Conclusion -- References -- 13: Amelogenin in Enamel Tissue Engineering -- 13.1 Introduction -- 13.2 The Structure and Composition of Mature Enamel -- 13.3 The Basic Model of Amelogenesis and a Question Mark Over It -- 13.4 The Role of Proteases or How Amelogenin Needs to Disappear in Order for Apatite to Appear -- 13.5 Attempts to Probe the Higher Orders of the Structure of Amelogenin -- 13.6 Combining Protein Assembly, Crystal Growth and Proteolysis in Experiments Attempting to Engineer the Artificial Enamel.
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13.7 The Role of Other Protein Species, Fluoride, pH, Water and Dentin.
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