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  • 1
    Electronic Resource
    Electronic Resource
    Potentiation of PGE2-mediated cAMP production during neuronal differentiation of human neuroblastoma SK-N-BE(2)C cells (2001)
    Oxford, UK : Blackwell Science Ltd
    Journal of neurochemistry 79 (2001), S. 0 
    Details
    ISSN: 1471-4159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: The prostaglandin-evoked cAMP production was studied in human neuroblastoma SK-N-BE(2)C cells during neuronal differentiation induced by all-trans retinoic acid. The incubation with 5 µm all-trans retinoic acid for 4–6 days promoted neurite outgrowth of cells. After differentiation, prostaglandin E2 (PGE2)-induced cAMP production was dramatically increased, whereas forskolin- and AlF〈inlineGraphic alt="inline image" href="urn:x-wiley:00223042:JNC577:JNC_577_mu1" location="equation/JNC_577_mu1.gif"/〉-induced cAMP productions were not changed. The increase reached maximum after 4-days of incubation with all-trans retinoic acid. The differentiation caused an increase in the maximal response and a decrease in the half-maximal effective concentration of the PGE2-induced cAMP production. In addition, the binding of [3H]PGE2 to membrane receptors was enhanced in differentiated cells. However, the order of potency of the various prostaglandins (PGE1 = PGE2 〉 PGD2 = PGF2α = PGI2) in cAMP production did not change during the differentiation, suggesting that mainly E-prostanoid (EP) receptors were involved. Butaprost, an EP2 receptor specific agonist, increased the cAMP level in a concentration dependent manner and had a similar potentiating effect on cAMP production as PGE2 upon differentiation. Northern blot analysis using the human cDNA probes shows that the EP2 mRNA level was about seven times higher in differentiated cells, while the dopamine β-hydroxylase (DBH) mRNA completely disappeared. Our results, thus, suggest that elevated gene expression of the prostanoid EP2 receptor results in an increase in the PGE2-evoked cAMP production in SK-N-BE(2)C cells during neuronal differentiation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1471-4159.2001.00577.x
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  • 2
    Electronic Resource
    Electronic Resource
    Suitable Glass-Ceramic Sealant for Planar Solid-Oxide Fuel Cells (2004)
    Westerville, Ohio : American Ceramics Society
    Journal of the American Ceramic Society 87 (2004), S. 0 
    Details
    ISSN: 1551-2916
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Physics
    Notes: Various glass-ceramics were prepared based on the BaO–Al2O3–B2O3–SiO2 system with the addition of La2O3, ZrO2, or NiO in an attempt to develop a suitable sealant for planar solid-oxide fuel cells operating at 800°C. To estimate the applicability of these glasses as suitable sealants, their thermal and chemical stabilities as well as the crystallization behavior and bonding characteristics of their parent glasses were investigated. The thermal properties and crystallization behavior of the parent glasses were dependent on the type of additive used, and the bonding characteristics were strongly influenced by the B2O3/SiO2 value in the glass composition. Observation of microstructural change and chemical reaction at the glass-ceramic/electrolyte interface confirmed that the prepared glass-ceramics possessed long-term stability during heat treatment at the operation temperature for up to 1000 h.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1551-2916.2004.00254.x
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  • 3
    Electronic Resource
    Electronic Resource
    SiO2 aerogel film as a novel intermetal dielectric (1997)
    [S.l.] : American Institute of Physics (AIP)
    Journal of Applied Physics 82 (1997), S. 1299-1304 
    Details
    ISSN: 1089-7550
    Source: AIP Digital Archive
    Topics: Physics
    Notes: A low dielectric constant material for an intermetal dielectric (IMD) is imperative to reduce power dissipation, cross talk, and interconnection delay in the deep submicron device regime. SiO2 aerogel is one of the possible candidate with an inherent low dielectric constant. This article reports on the results of the successful fabrication of a SiO2 aerogel film as well as its material properties and electrical properties. Fundamental physical, chemical, and electrical material properties were evaluated for a SiO2 aerogel film before and after thermal treatment. An inherent low dielectric constant of 2.0 was realized for about 70% porosity of the SiO2 aerogel film and the leakage current density held at a level of 10−7 A/cm2. Preliminary results of the SiO2 aerogel film investigated in our study represent a very positive prospective to IMD applications. © 1997 American Institute of Physics.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.365902
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  • 4
    Electronic Resource
    Electronic Resource
    Effect of iron state on crystallization and dissolution in Fe2O3-CaO-SiO2 glasses (2000)
    Springer
    Journal of materials science 11 (2000), S. 511-515 
    Details
    ISSN: 1573-4838
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine , Technology
    Notes: Abstract The possibility of iron-containing glasses as thermoseeds for hyperthermia of bone tumor was reported previously. There is, however, no report about the effect of iron state on the crystallization of magnetite and the resultant properties. The iron states were determined by Mo¨ssbauer spectroscopy in Fe2O3-CaO-SiO2 system. It was found that the higher CaO content interrupts the crystallization of magnetite crystallites as well as the oxidation of iron, that is, the transformation from Fe3+ to Fe2+. A sample containing large amounts of Fe2+ showed the faster increment of temperature when the alternating magnetic field was applied. In order to use the thermoseed for a hyperthermia, we can say that the composition with low CaO content is most useful.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1008913909247
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