GLORIA

GEOMAR Library Ocean Research Information Access

feed icon rss

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
  • 1
    Online Resource
    Online Resource
    San Diego :Elsevier Science & Technology,
    Keywords: Machine-to-machine communications. ; Internet of things. ; Electronic books.
    Type of Medium: Online Resource
    Pages: 1 online resource (352 pages)
    Edition: 1st ed.
    ISBN: 9780080994017
    DDC: 004
    Language: English
    Note: Front Cover -- From Machine-to-Machine to the Internet of Things -- Copyright Page -- Contents -- Foreword -- Foreword -- Acknowledgements -- Author Biographies -- Part I: The Vision for Moving from M2M to IoT -- 1 Introduction and Book Structure -- 1.1 Introduction -- 1.2 Structure of the book -- Part I: The Internet of Things global context -- Chapter 2: M2M to IoT - the vision -- Chapter 3: M2M to IoT - a market perspective -- Chapter 4: M2M to IoT - an architectural overview -- Part II: Nuts and bolts of M2M and IoT -- Chapter 5: M2M and IoT technology fundamentals -- Chapters 6, 7 & -- 8: IoT architecture -- Chapter 9: Real-world design constraints -- Part III: Implementation examples -- Chapter 10: Asset management -- Chapter 11: Industrial automation -- Chapter 12: The smart grid -- Chapter 13: Commercial building automation -- Chapter 14: Smart cities -- Chapter 15: Participatory sensing -- Chapter 16: Conclusion and looking ahead -- Part IV: Appendices -- 2 M2M to IoT - The Vision -- 2.1 Introduction -- 2.2 From M2M to IoT -- 2.2.1 A brief background -- 2.2.2 M2M communication -- 2.2.2.1 A typical M2M solution overview -- 2.2.2.2 Key application areas -- 2.2.3 IoT -- 2.3 M2M towards IoT - the global context -- 2.3.1 Game changers -- 2.3.2 General technology and scientific trends -- 2.3.3 Trends in information and communications technologies -- 2.3.3.1 Capabilities -- 2.3.4 Implications for IoT -- 2.3.5 Barriers and concerns -- 2.4 A use case example -- 2.5 Differing characteristics -- 3 M2M to IoT - A Market Perspective -- 3.1 Introduction -- 3.1.1 Information marketplaces -- 3.2 Some definitions -- 3.2.1 Global value chains -- 3.2.2 Ecosystems vs. value chains -- 3.2.3 Industrial structure -- 3.3 M2M value chains -- 3.4 IoT value chains -- 3.5 An emerging industrial structure for IoT -- 3.5.1 The information-driven global value chain. , 3.5.1.1 Inputs to the information-driven global commodity chain -- 3.5.1.1.1 Sensors and radio frequency identification -- 3.5.1.1.2 End-users -- 3.5.1.2 Production processes of the information-driven global value chain -- 3.5.1.2.1 Data factories -- 3.5.1.2.2 Service providers/data wholesalers -- 3.5.1.2.3 Intermediaries -- 3.5.1.2.4 Resellers -- 3.6 The international-driven global value chain and global information monopolies -- 3.7 Conclusions -- 4 M2M to IoT - An Architectural Overview -- 4.1 Building an architecture -- 4.2 Main design principles and needed capabilities -- 4.3 An IoT architecture outline -- 4.4 Standards considerations -- Part II: IoT Technologies and Architectures -- 5 M2M and IoT Technology Fundamentals -- 5.1 Devices and gateways -- 5.1.1 Introduction -- 5.1.1.1 Device types -- 5.1.1.2 Deployment scenarios for devices -- 5.1.2 Basic devices -- 5.1.3 Gateways -- 5.1.3.1 Data management -- 5.1.3.2 Local applications -- 5.1.3.3 Device management -- 5.1.4 Advanced devices -- 5.1.5 Summary and vision -- 5.2 Local and wide area networking -- 5.2.1 The need for networking -- 5.2.2 Wide area networking -- 5.2.2.1 3rd generation partnership project technologies and machine type communications -- 5.2.3 Local area networking -- 5.2.3.1 Deployment considerations -- 5.2.3.2 Key technologies -- 5.3 Data management -- 5.3.1 Introduction -- 5.3.2 Managing M2M data -- 5.3.2.1 Data generation -- 5.3.2.2 Data acquisition -- 5.3.2.3 Data validation -- 5.3.2.4 Data storage -- 5.3.2.5 Data processing -- 5.3.2.6 Data remanence -- 5.3.2.7 Data analysis -- 5.3.3 Considerations for M2M data -- 5.3.4 Conclusions -- 5.4 Business processes in IoT -- 5.4.1 Introduction -- 5.4.2 IoT integration with enterprise systems -- 5.4.3 Distributed business processes in IoT -- 5.4.4 Considerations -- 5.4.5 Conclusions -- 5.5 Everything as a service (XaaS). , 5.6 M2M and IoT analytics -- 5.6.1 Introduction -- 5.6.2 Purposes and considerations -- 5.6.3 Analytics architecture -- 5.6.4 Methodology -- 5.6.4.1 Business understanding -- 5.6.4.1.1 Predictive maintenance example -- 5.6.4.2 Data understanding -- 5.6.4.2.1 Predictive maintenance example -- 5.6.4.3 Data preparation -- 5.6.4.3.1 Predictive maintenance example -- 5.6.4.4 Modeling -- 5.6.4.4.1 Predictive maintenance example -- 5.6.4.5 Evaluation -- 5.6.4.5.1 Predictive maintenance example -- 5.6.4.6 Deployment -- 5.6.4.6.1 Predictive maintenance example -- 5.7 Knowledge management -- 5.7.1 Data, information, and knowledge -- 5.7.2 A knowledge management reference architecture -- 5.7.2.1 Data sources -- 5.7.2.2 Data integration -- 5.7.2.3 Processed data -- 5.7.3 Retrieval layer -- 5.7.3.1 Information access tools -- 5.7.3.2 Knowledge discovery tools -- 6 IoT Architecture - State of the Art -- 6.1 Introduction -- 6.2 State of the art -- 6.2.1 European Telecommunications Standards Institute M2M/oneM2M -- 6.2.1.1 ETSI M2M high-level architecture -- 6.2.1.2 ETSI M2M service capabilities -- 6.2.1.3 ETSI M2M interfaces -- 6.2.1.4 ETSI M2M resource management -- 6.2.2 International Telecommunication Union - Telecommunication sector view -- 6.2.3 Internet Engineering Task Force architecture fragments -- 6.2.4 Open Geospatial Consortium architecture -- 7 Architecture Reference Model -- 7.1 Introduction -- 7.2 Reference model and architecture -- 7.3 IoT reference model -- 7.3.1 IoT domain model -- 7.3.1.1 Model notation and semantics -- 7.3.1.2 Main concepts -- 7.3.1.3 Further considerations -- 7.3.2 Information model -- 7.3.3 Functional model -- 7.3.3.1 Device functional group -- 7.3.3.2 Communication functional group -- 7.3.3.3 IoT Service functional group -- 7.3.3.4 Virtual Entity functional group -- 7.3.3.5 IoT Service Organization functional group. , 7.3.3.6 IoT Process Management functional group -- 7.3.3.7 Management functional group -- 7.3.3.8 Security functional group -- 7.3.3.9 Application functional group -- 7.3.3.10 Modular IoT functions -- 7.3.4 Communication model -- 7.3.5 Safety, privacy, trust, security model -- 7.3.5.1 Safety -- 7.3.5.2 Privacy -- 7.3.5.3 Trust -- 7.3.5.4 Security -- 8 IoT Reference Architecture -- 8.1 Introduction -- 8.2 Functional view -- 8.2.1 Device and Application functional group -- 8.2.2 Communication functional group -- 8.2.3 IoT Service functional group -- 8.2.4 Virtual Entity functional group -- 8.2.5 IoT process management functional group -- 8.2.6 Service Organization functional group -- 8.2.7 Security functional group -- 8.2.8 Management functional group -- 8.3 Information view -- 8.3.1 Information description -- 8.3.2 Information flow and lifecycle -- 8.3.3 Information handling -- 8.4 Deployment and operational view -- 8.5 Other relevant architectural views -- 9 Real-World Design Constraints -- 9.1 Introduction -- 9.2 Technical design constraints - hardware is popular again -- 9.2.1 Devices and networks -- 9.2.1.1 Functional requirements -- 9.2.1.2 Sensing and communications field -- 9.2.1.3 Programming and embedded intelligence -- 9.2.1.4 Power -- 9.2.1.5 Gateway -- 9.2.1.6 Nonfunctional requirements -- 9.2.1.7 Financial cost -- 9.3 Data representation and visualization -- 9.4 Interaction and remote control -- Part III: IoT Use Cases -- 10 Asset Management -- 10.1 Introduction -- 10.2 Expected benefits -- 10.3 e-Maintenance in the M2M Era -- 10.4 Hazardous goods management in the M2M Era -- 10.5 Conclusions -- 11 Industrial Automation -- 11.1 Service-oriented architecture-based device integration -- 11.2 SOCRADES: realizing the enterprise integrated Web of Things -- 11.3 IMC-AESOP: from the Web of Things to the Cloud of Things -- 11.4 Conclusions. , 12 The Smart Grid -- 12.1 Introduction -- 12.2 Smart metering -- 12.3 Smart house -- 12.4 Smart energy city -- 12.5 Conclusions -- 13 Commercial Building Automation -- 13.1 Introduction -- 13.2 Case study: phase one - commercial building automation today -- 13.2.1 Background -- 13.2.2 Technology overview -- 13.2.3 Value chain -- 13.3 Case study: phase two - commercial building automation in the future -- 13.3.1 Evolution of commercial building automation -- 13.3.2 Background -- 13.3.3 Technology overview -- 13.3.4 Evolved value chain for commercial building automation -- 14 Smart Cities -- 14.1 Introduction -- 14.2 Smart cities-the need -- 14.3 Smart cities-a working definition -- 14.4 Smart cities-some examples -- 14.5 Roles, actors, engagement -- 14.6 Transport and logistics-an IoT perspective -- 14.6.1 Physical infrastructure for transport -- 14.6.2 Information marketplace for transport and logistics -- 14.7 Conclusions -- 15 Participatory Sensing -- 15.1 Introduction -- 15.2 Roles, actors, engagement -- 15.2.1 Collective design and investigation -- 15.2.2 Public contribution -- 15.2.3 Personal use and reflection -- 15.3 Participatory sensing process -- 15.4 Technology overview -- 15.5 An early scenario -- 15.6 Recent trends -- 15.6.1 Citizen journalism -- 15.6.2 Passive participation -- 15.7 A modern example -- 16 Conclusion and Looking Ahead -- Abbreviations -- References -- Index.
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
  • 2
    Electronic Resource
    Electronic Resource
    Oxford UK : Blackwell Science Ltd
    Molecular microbiology 24 (1997), S. 0 
    ISSN: 1365-2958
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology , Medicine
    Notes: In the absence of exogenous promoters, plasmid-mediated complementation of the temperature-sensitive ftsW201 allele requires the presence of the full coding sequence of ftsW plus upstream DNA encompassing the C-terminus of mraY and the full coding sequence of murD. We used molecular and genetic techniques to introduce an insertional inactivation into the chromosomal copy of ftsW, in the presence of the plasmid-borne wild-type ftsW gene under the control of PBAD. In the absence of arabinose, the ftsW-null strain is not viable, and a shift from arabinose- to glucose-containing liquid medium resulted in a block in division, followed by cell lysis. Immunofluorescence microscopy revealed that in ftsW-null filaments, the FtsZ ring is absent in 50–60% of filaments, whilst between one and three Z-rings per filament can be detected in the remainder of the population, with the majority of these containing only one Z-ring per filament. We also demonstrated that the expression of only ftsWS (the smaller of two ftsW open reading frames) from PBAD is sufficient for complementation of the ftsW-null allele. We conclude that FtsW is an essential cell-division protein in Escherichia coli, and that it plays a role in the stabilization of the FtsZ ring during cell division.
    Type of Medium: Electronic Resource
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
  • 3
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] IL-2 is an immunoregulatory, T-cell-derived molecule which is required for the clonal expansion of antigen-activated T cells7. A recombinant vaccinia virus expressing murine IL-2 was constructed to study the lymphokine's effect on virus growth and immunogenicity. As shown schematically in Fig. 2a, ...
    Type of Medium: Electronic Resource
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
  • 4
    Electronic Resource
    Electronic Resource
    Springer
    Virus genes 6 (1992), S. 281-290 
    ISSN: 1572-994X
    Keywords: vaccinia virus ; fowlpox virus ; promoters ; cowpox virus ; β-galactosidase
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract A comparison was undertaken of poxvirus promoters in vaccinia and fowlpox virus (FPV) recombinants using the level of β-galactosidase expressed from theLacZ gene as a measure of promoter function. In this study a comparison was made of the vaccinia virus promoters, P 7.5 and P L11, the major late promoter of cowpox virus, P CPX (expressing the abundant inclusion body protein), and the FPV promoters, P E/L and P L. In vaccinia virus recombinants the FPV P E/L promoter expressed one-third to one-half the level of β-galactosidase expressed by the P L11 promoter. In comparison with the P 7.5 promoter, the FPV P E/L promoter expressed four to five times the level of β-galactosidase. In FPV recombinants β-galactosidase activity expressed was equal for the P E/L and P CPX promoters. Levels expressed by P L11 and P L were one-half and one-fifth that level, respectively. The temporal regulation of the promoters was maintained in both vaccinia virus and FPV recombinants. The P E/L promoter of FPV has the TAAATG sequence characteristic of late poxvirus promoters at the transcription initiation site. In an attempt to enhance the utility of this promoter for the expression of foreign genes in FPV and vaccinia virus recombinants, the effect upon promoter function of changing the G of the ATG to A, T, or C was determined using transient expression assays with vaccinia virus. Substitution of A, T, or C for the G abolished promoter function. Because of its early/late function, the level of expression and the presence of the oppositely oriented late P L promoter, the FPV P E/L promoter will be valuable for the expression of foreign genes in poxvirus recombinants.
    Type of Medium: Electronic Resource
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
  • 5
    Publication Date: 2018-06-08
    Description: Identification of breeding sites remains a critical step in species conservation, particularly in procellariiform seabirds whose threat status is of global concern. We designed and conducted an integrative radiotelemetry approach to uncover the breeding grounds of the critically endangered New Zealand Storm Petrel Fregetta maoriana (NZSP), a species considered extinct before its rediscovery in 2003. Solar-powered automated radio receivers and hand-held telemetry were used to detect the presence of birds on three island groups in the Hauraki Gulf near Auckland, New Zealand. At least 11 NZSP captured and radiotagged at sea were detected at night near Te Hauturu-o-Toi/Little Barrier Island with the detection of an incubating bird leading to the discovery of the first known breeding site for this species. In total, four NZSP breeding burrows were detected under mature forest canopy and three adult NZSP and two NZSP chicks were ringed. Telemetry data indicated NZSP showed strong moonlight avoidance behaviour over the breeding site, had incubation shifts of approximately 5 days and had a breeding season extending from February to June/July, a different season from other Procellariiformes in the region. Radiotelemetry, in combination with rigorously collected field data on species distribution, offers a valuable technique for locating breeding grounds of procellariiform seabirds and gaining insights into breeding biology while minimizing disturbance to sensitive species or damage to fragile habitat. Our study suggests an avenue for other breeding ground searches in one of the most threatened avian Orders, and highlights the general need for information on the location of breeding sites and understanding the breeding biology in data-deficient birds.
    Type: Article , PeerReviewed
    Format: text
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
  • 6
    Publication Date: 2015-08-02
    Description: Background: Loss of heterozygosity (LOH) is a common genetic event in cancer development, and is known to be involved in the somatic loss of wild-type alleles in many inherited cancer syndromes. The wider involvement of LOH in cancer is assumed to relate to unmasking a somatically mutated tumour suppressor gene through loss of the wild type allele. Methods: We analysed 86 ovarian carcinomas for mutations in 980 genes selected on the basis of their location in common regions of LOH. Results: We identified 36 significantly mutated genes, but these could only partly account for the quanta of LOH in the samples. Using our own and TCGA data we then evaluated five possible models to explain the selection for non-random accumulation of LOH in ovarian cancer genomes: 1. Classic two-hit hypothesis: high frequency biallelic genetic inactivation of tumour suppressor genes. 2. Epigenetic two-hit hypothesis: biallelic inactivation through methylation and LOH. 3. Multiple alternate-gene biallelic inactivation: low frequency gene disruption. 4. Haplo-insufficiency: Single copy gene disruption. 5. Modified two-hit hypothesis: reduction to homozygosity of low penetrance germline predisposition alleles. We determined that while high-frequency biallelic gene inactivation under model 1 is rare, regions of LOH (particularly copy-number neutral LOH) are enriched for deleterious mutations and increased promoter methylation, while copy-number loss LOH regions are likely to contain under-expressed genes suggestive of haploinsufficiency. Reduction to homozygosity of cancer predisposition SNPs may also play a minor role. Conclusion: It is likely that selection for regions of LOH depends on its effect on multiple genes. Selection for copy number neutral LOH may better fit the classic two-hit model whereas selection for copy number loss may be attributed to its effect on multi-gene haploinsufficiency. LOH mapping alone is unlikely to be successful in identifying novel tumour suppressor genes; a combined approach may be more effective.
    Electronic ISSN: 1755-8794
    Topics: Medicine
    Published by BioMed Central
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
  • 7
    Publication Date: 2016-06-14
    Description: We report on the existence of a smooth transition from field emission to a self-sustained plasma in microscale electrode geometries at atmospheric pressure. This behavior, which is not found at macroscopic scales or low pressures, arises from the unique combination of large electric fields that are created in microscale dimensions to produce field-emitted electrons and the high pressures that lead to collisional ionization of the gas. Using a tip-to-plane electrode geometry, currents less than 10  μ A are measured at onset voltages of ∼200 V for gaps less than 5  μ m, and analysis of the current–voltage ( I-V ) relationship is found to follow Fowler–Nordheim behavior, confirming field emission. As the applied voltage is increased, gas breakdown occurs smoothly, initially resulting in the formation of a weak, partial-like glow and then a self-sustained glow discharge. Remarkably, this transition is essentially reversible, as no significant hysteresis is observed during forward and reverse voltage sweeps. In contrast, at larger electrode gaps, no field emission current is measured and gas breakdown occurs abruptly at higher voltages of ∼400 V, absent of any smooth transition from the pre-breakdown condition and is characterized only by glow discharge formation.
    Print ISSN: 0021-8979
    Electronic ISSN: 1089-7550
    Topics: Physics
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
  • 8
    Publication Date: 2016-10-25
    Description: The serine/threonine kinases ROCK1 and ROCK2 are central mediators of actomyosin contractile force generation that act downstream of the RhoA small GTP-binding protein. As a result, they have key roles in regulating cell morphology and proliferation, and have been implicated in numerous pathological conditions and diseases including hypertension and cancer. Here we describe the generation of a gene-targeted mouse line that enables CRE-inducible expression of a conditionally-active fusion between the ROCK2 kinase domain and the hormone-binding domain of a mutated estrogen receptor (ROCK2:ER). This two-stage system of regulation allows for tissue-selective expression of the ROCK2:ER fusion protein, which then requires administration of estrogen analogues such as tamoxifen or 4-hydroxytamoxifen to elicit kinase activity. This conditional gain-of-function system was validated in multiple tissues by crossing with mice expressing CRE recombinase under the transcriptional control of cytokeratin14 ( K14 ), murine mammary tumor virus ( MMTV ) or cytochrome P450 Cyp1A1 ( Ah ) promoters, driving appropriate expression in the epidermis, mammary or intestinal epithelia respectively. Given the interest in ROCK signaling in normal physiology and disease, this mouse line will facilitate research into the consequences of ROCK activation that could be used to complement conditional knockout models. This article is protected by copyright. All rights reserved.
    Topics: Biology , Medicine
    Published by Wiley-Blackwell
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
  • 9
    Publication Date: 2014-04-24
    Description: Background: We tested the hypothesis that harm avoidance, a trait associated with behavioral inhibition, is associated with the rate of change in parkinsonism in older adults. Methods: At baseline harm avoidance was assessed with a standard self-report instrument in 969 older people without dementia participating in the Rush Memory and Aging Project, a longitudinal community-based cohort study. Parkinsonism was assessed annually with a modified version of the motor section of the Unified Parkinson's Disease Rating Scale (mUPDRS). Results: Average follow-up was 5 years. A linear mixed-effects model controlling for age, sex and education showed that for an average participant (female, 80 years old at baseline, with 14 years of education and a harm avoidance score of 10), the overall severity of parkinsonism increased by about 0.05 unit/ year (Estimate, 0.054, S.E., 0.007, p
    Electronic ISSN: 1471-2318
    Topics: Medicine
    Published by BioMed Central
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
  • 10
    Publication Date: 2016-07-07
    Description: Aims Recurrent EWSR1 gene rearrangements characterise a select group of bone and soft tissue tumours. In our routine diagnostic practice with fluorescence in situ hybridisation (FISH), we have occasionally observed EWSR1 gene rearrangements in tumours not classically associated with EWSR1 translocations. This study aimed to review our institutional experience of this phenomenon and also to highlight the occurrence of unusual EWSR1 FISH signals (i.e. 5′ centromeric region or 3′ telomeric region signals) that do not fulfill the published diagnostic criteria for rearrangements. Methods and Results Using an EWSR1 break-apart probe, we performed FISH assays on formalin-fixed paraffin embedded tissue sections from 135 bone and soft tissue specimens as part of their routine diagnostic workup. EWSR1 gene rearrangements were identified in 51% of cases, 56% of which also showed an abnormal FISH signal pattern (in addition to classically rearranged signals). However, atypical FISH signals were present in 45% of the non-rearranged cases. In addition, we observed tumours unrelated to those classically described as EWSR1- associated were technically EWSR1 rearranged in 6% of cases. Borderline levels of rearrangement (affecting 10-30% of lesional cells) were present in an additional 17% of these cases. Conclusions While our study confirmed that FISH is a sensitive and specific tool in the diagnosis of EWSR1 -associated tumours, atypical FISH signals and classical rearrangement in entities other than EWSR1-associated tumours can occur. Therefore, it is essential that the FISH result not be used as an isolated test, but must be evaluated in the context of clinical features, imaging, pathological and immunohistochemical findings. This article is protected by copyright. All rights reserved.
    Print ISSN: 0309-0167
    Electronic ISSN: 1365-2559
    Topics: Medicine
    Published by Wiley-Blackwell
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...