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  • 1
    Digitale Medien
    Digitale Medien
    New York, NY [u.a.] : Wiley-Blackwell
    Developmental Dynamics 204 (1995), S. 432-445 
    ISSN: 1058-8388
    Schlagwort(e): Collagen XII ; Alternative splicing ; Mouse development ; Life and Medical Sciences ; Cell & Developmental Biology
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Medizin
    Notizen: Type XII collagen, a member of the FACIT group of extracellular matrix proteins, consists of molecules that are trimers of α1(XII) chains. The three chains in each molecule form a cross-shaped structure with a central globule from which a triple-helical tail and three finger-like regions (containing von Willebrand factor A-like domains and fibronectin type III repeats) extend. cDNA cloning/sequencing of chicken α1(XII) collagen and protein studies with mouse, bovine, and human material suggest that the α1(XII) collagen gene gives rise to two molecular variants, differing in the length of the finger-like regions, by alternative splicing of the primary transcript. To provide a basis for studies of the function of the two variants in an organism that can be genetically manipulated, we have isolated and sequenced mouse cDNAs encoding both splice variants. The sequence provides the first complete nucleotide and amino acid sequence of mammalian type XII collagen. From these cDNAs we have generated digoxigenin-labeled RNA probes for in situ hybridization of developing mouse embryos to find out whether the splicing mechanism responsible for generation of the two forms is developmentally regulated. The results, combined with Northern blot and RT-PCR analysis of RNA from embryos at various developmental stages, demonstrate that the long form of collagen XII, XIIA, is the predominant form at early stages (ED7 and 11); at later stages of development (ED15 and 17) the short form, XIIB, becomes the major form. As the short form becomes the major product, the long splice variant continues to be expressed in several tissues, even after birth. An exception is dermis, which is positive for the long form up to embryonic day 15, but negative at day 18, when only the short form RNA can be detected. © 1995 wiley-Liss, Inc.
    Zusätzliches Material: 10 Ill.
    Materialart: Digitale Medien
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 2
    Publikationsdatum: 2018-11-30
    Beschreibung: Author(s): Jens Kügel, Pin-Jui Hsu, Markus Böhme, Kathrin Schneider, Jacob Senkpiel, David Serrate, Matthias Bode, and Nicolás Lorente Scanning tunneling spectroscopy measurements of Mn phthalocyanine (MnPc) molecules adsorbed on ( 3 × 3 ) surface alloys show single inelastic steps at exclusively positive or negative bias strongly depending on the tip position. This is in contrast to conventional molecular excitation thresholds, which ... [Phys. Rev. Lett. 121, 226402] Published Thu Nov 29, 2018
    Schlagwort(e): Condensed Matter: Electronic Properties, etc.
    Print ISSN: 0031-9007
    Digitale ISSN: 1079-7114
    Thema: Physik
    Standort Signatur Einschränkungen Verfügbarkeit
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