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  • 1
    Online Resource
    Online Resource
    Potassium Channels in Cardiovascular Biology. (2001)
    New York, NY :Springer,
    Details
    Keywords: Potassium channels. ; Electronic books.
    Type of Medium: Online Resource
    Pages: 1 online resource (919 pages)
    Edition: 1st ed.
    ISBN: 9781461513032
    URL: https://ebookcentral.proquest.com/lib/geomar/detail.action?docID=3079593
    DDC: 612/.1
    Language: English
    Note: Potassium Channels in Cardiovascular Biology -- Editor's page -- Copyright -- Contributors -- Preface -- Contents -- Abbreviations -- Part I Molecular Biology of Potassium Channels -- Chapter 1 Evolution of Potassium Channel Proteins -- Chapter 2 Three-Dimensional Structure of the K+ Channel Pore: Basis for Ion Selectivity and Permeability -- Chapter 3 Molecular Biology of Voltage-Gated K+ Channels -- Chapter 4 Molecular Biology of High-Conductance, Ca2+-Activated Potassium Channels -- Chapter 5 Molecular Biology of Inward Rectifier and ATP-Sensitive Potassium Channels -- Part II Potassium Channel Expression and Function -- Chapter 6 Design and Use of Antibodies for Mapping K+ Channel Expression in the Cardiovascular System -- Chapter 7 Molecular Methods for Evaluation of K+ Channel Expression and Distribution in the Heart -- Chapter 8 Concepts for Patch-Clamp Recording of Whole-Cell and Single-Channel K+ Currents in Cardiac and Vascular Myocytes -- Chapter 9 The Patch-Clamp Technique for Measurement of K+ Channels in Xenopus Oocytes and Mammalian Expression Systems -- Chapter 10 Heteromultimer Formation in Native K+ Channels -- Chapter 11 Use of Transgenic and Gene-Targeted Mice to Study K+ Channel Function in the Cardiovascular System -- Part III Pharmacology of Potassium Channels -- Chapter 12 Pharmacology of Voltage-Gated K+ Channels -- Chapter 13 Pharmacology of High-Conductance, Ca2+-Activated Potassium Channels -- Chapter 14 Pharmacology of Small-Conductance, Calcium-Activated K+ Channels -- Chapter 15 Molecular Pharmacology of ATP-Sensitive K+ Channels: How and Why? -- Part IV Potassium Channels in the Heart -- Chapter 16 Overview: Molecular Physiology of Cardiac Potassium Channels -- Chapter 17 Molecular Mechanisms Controlling Functional Voltage-Gated K+ Channel Diversity and Expression in the Mammalian Heart. , Chapter 18 Voltage-Gated Potassium Channels in the Myocardium -- Chapter 19 Inward Rectifying and ATP-Sensitive K+ Channels in the Ventricular Myocardium -- Chapter 20 Cholinergic and Adrenergic Modulation of Cardiac K+ Channels -- Chapter 21 Cardiac K+ Channel Expression and Function at Birth and in the Neonate -- Chapter 22 Overview: Physiological Role of K+ Channelsin the Regulation of Vascular Tone -- Chapter 23 Modulation of Vascular K+ Channels by Extracellular Messengers -- Chapter 24 Delayed Rectifier K+ Channels of Vascular Smooth Muscle: Characterization, Function, and Regulation by Phosphorylation -- Chapter 25 Potassium Channels in the Circulation of Skeletal Muscle -- Chapter 26 Regulation of Cerebral Artery Diameter by Potassium Channels -- Chapter 27 The Role of Potassium Channels in the Control of the Pulmonary Circulation -- Chapter 28 Potassium Channels in the Renal Circulation -- Chapter 29 Potassium Channels in the Coronary Circulation -- Chapter 30 Vascular K+ Channel Expression and Function at Birth and in the Neonate -- Part VI Potassium Channels in the Endothelium -- Chapter 31 Overview: Potassium Channels in Vascular Endothelial Cells -- Chapter 32 Single-Channel Properties of Ca2 +-Activated K+ Channels in the Vascular Endothelium -- Chapter 33 Endothelial Cell K+ Channels, Membrane Potential and the Release of Vasoactive Factorsfrom the Vascular Endothelium -- Chapter 34 Activation of Vascular Smooth Muscle K+ Channels by Endothelium-Derived Factors -- Part VII Potassium Channels in Cardiac Disease -- Chapter 36 The Molecular Basis of the Long QT Syndrome -- Chapter 37 Altered K+ Channel Expression in theHypertrophied and Failing Heart -- Chapter 38 Role of ATP-Sensitive K+ Channels in Cardiac Preconditioning -- Chapter 39 Therapeutic Potential of ATP-Sensitive K+ Channel Openers in Cardiac Ischemia. , Part VIII Potassium Channels in Vascular Disease -- Chapter 40 Altered Expression and Function of Kv Channels in Primary Pulmonary Hypertension -- Chapter 41 Anorectic Drugs and the Vasculature -- Chapter 42 Induction of Ca2+-Activated K+ Channel Expression during Systemic Hypertension: Protection against Pathological Vasoconstriction -- Chapter 43 Antisense Approaches and the Modulation of Potassium Channel Function in the Cardiovascular System -- Index.
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  • 2
    Book
    Book
    Dimethyl Sulphide Biogeochemistry within a Coccolithophore Bloom (DISCO) (2002)
    Oxford [u.a.] : Pergamon
    Details Availability
    Keywords: Aufsatzsammlung
    Type of Medium: Book
    Pages: IV S., S. 2863-3101 , graph. Darst., Kt
    Series Statement: Deep sea research 49,15
    Language: English
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  • 3
    Electronic Resource
    Electronic Resource
    Duration of effects of isradipine during twice daily therapy in angina pectoris (1994)
    Springer
    Cardiovascular drugs and therapy 8 (1994), S. 199-210 
    Details
    ISSN: 1573-7241
    Keywords: isradipine ; calcium channel antagonist ; angina pectoris ; exercise ; myocardial ischemia ; plasma concentrations
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Isradipine, a 1,4 dihydropyridine calcium channel antagonist, is a potent coronary artery dilator that increases coronary blood flow with little effect on cardiac contractility. Isradipine is an approved antihypertensive agent, but its anti-anginal effects have not been well documented. In this placebo-controlled, double-blind, parallel-group design study we evaluated the duration of effects and safety of isradipine 10 mg bid in male patients with chronic stable angina pectoris. Seventy-two patients experiencing moderately severe angina between 3 and 7.5 minutes during a standard Bruce exercise test received placebo in a single-blind manner for 8–14 days. Sixty-one of these patients had reproducible treadmill exercise test results on three consecutive occasions and underwent further exercise tests at 3, 8, and 12 hours after a placebo period. Patients were then randomized (double blind) to either placebo or isradipine 10 mg bid for 2 weeks. Symptom-limited exercise tests were repeated predose and at 3, 8, and 12 hours after the 0800 hour dose dosing. Exercise duration increased significantly from baseline (last qualifying test during the single-blind placebo therapy, i.e., 0800 hours predose at visit 4) in the isradipine group compared to the placebo group prior to the administration of the 0800 hour dose (i.e., 12 hours after the 2000 hour dose) by 51 vs. 18 seconds, p=0.04; and after the administration of the 0800 hour dose at 3 hours by 78 vs. 29 seconds, p=0.005; and at 8 hours by 54 vs. 18 seconds, p=0.04. Similarly, statistical significance was achieved when exercise data were analyzed using visit 4 (single-blind placebo therapy) corresponding time points as baseline. At 12 hours after the 0800 hour dose, exercise tolerance did not increase significantly after isradipine compared to placebo. Time to 1-mm ST-segment depression increased significantly after isradipine at 3 hours post 0800 hour dose compared to placebo (87 vs. 7 seconds, p〈0.01) but not at the 0, 8, or 12-hour postdose time points, regardless of which baseline was used. Isradipine therapy did not affect the rate-pressure double product. A significant correlation between the mean increase in total exercise time and mean plasma isradipine concentration was also present (p=0.0295). During double-blind treatment, drug-related adverse events were experienced by four patients in the isradipine group and two patients in the placebo group. None of the patients experienced ischemic complications during the study. In male patients with chronic stable angina, monotherapy with isradipine 10 mg twice a day significantly increased exercise duration for 8 hours after the 0800 hour dose. Of interest is the observation that isradipine significantly increased exercise duration at 12 hours post 2000 hour dose but not after post 0800 hour dose. These findings would suggest that three-time rather than twice-daily dosing with the standard formulation of isradipine, which has been recommended for the treatment of hypertension, may be required for optimal anti-anginal therapy.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00877328
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Craniofacial Electromyogram Activation Response: Another Indicator of Anesthetic Depth (1998)
    Springer
    Journal of clinical monitoring and computing 14 (1998), S. 5-17 
    Details
    ISSN: 1573-2614
    Keywords: Anesthesia: general, depth, isoflurane, computer simulation ; Arousal ; Monitoring: anesthetic depth, electromyogram, EMG ; Memory: awareness
    Source: Springer Online Journal Archives 1860-2000
    Topics: Computer Science , Medicine
    Notes: Abstract Objective. After finding that craniofacial EMG preceding a stimulus was a poor predictor of movement response to that stimulus, we evaluated an alternative relation between EMG and movement: the difference in anesthetic depth between the endpoint of EMG responsiveness to a stimulus and endpoint of movement responsiveness to that stimulus. We expressed this relation as the increment of isoflurane between the two endpoints. Methods. We measured EMG over the frontalis muscle, over the corrugator muscle, and between the Fp2 and the mastoid process as patients emerged from general anesthesia during suture closing of the surgical incision. Anesthesia was decreased by controlled washout of isoflurane while maintaining 70% N2O, and brain isoflurane concentrations (CisoBrain) were calculated. We studied a control group of 10 patients who received only surgical stimulation, and 30 experimental patients who intermittently received test stimuli in addition to the surgical stimulation. Patients were observed for movement responses and EMG records were evaluated for EMG activation responses. We defined an EMG activation response to be a rapid voltage increase of at least 1.0 µV RMS above baseline, with a duration of at least 30 s, in at least one of the three EMG channels. Patient responses to stimuli were classified as either an EMG activation response without a move response (EMG+, a move response without an EMG activation response (MV+), both an EMG activation response and a move response (EMG+MV+), or no response. We defined the EMG+ endpoint to be the threshold between EMG+ response and nonresponse to a stimulus, and estimatedC isoBrain at this endpoint. We similarly defined the move endpoint and estimated the move endpointC isoBrain. We then calculated the increment ofC isoBrain at the EMG+ endpoint relative to the move endpoint. Main results. For the 30 experimental patients, the initial response to a test stimulus was an EMG+ in 14 patients (47%), an EMG+MV+ in 12 patients (40%), and a MV+ in 1 patient (3%); no response occurred by the time surgery was completed in 3 patients (10%). No response occurred in 7 of the control patients (70%). Of the 14 patients with an initial EMG+ response to a test stimulus, 9 patients later had a move response. For these 9 patients, the increment of CisoBrain between the EMG+ endpoint and move endpoint was 0.11 ± 0.04 vol% (mean ± SD). Conclusions. Our results suggest that, given the circumstances of our study, an EMG activation response by a nonmoving patient indicates that the patient is at an anesthetic level close to that at which movement could occur. However, because the first EMG activation response may occur simultaneously with movement, the EMG activation response cannot be relied upon to always herald a move response before it occurs. Our results also suggest that EMG responsiveness to a test stimulus may be used to estimate the anesthetic depth of an individual patient.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1007489321321
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  • 5
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    Physical exchanges at the air–sea interface : UK–SOLAS field measurements (2010)
    American Meteorological Society
    Details
    Publication Date: 2022-05-25
    Description: Author Posting. © American Meteorological Society, 2009. This article is posted here by permission of The UK–SOLAS projects were funded by the Natural Environment Research Council Grants NE/C001826/1 (HiWASE), NE/C001842/1 (SEASAW), NE/C001702/1 (DOGEE), and NE/E011489/1 (DMS Fluxes); and by NSF Grants ATM05-26341 (Hawaii), OCE-0623450 (Miami), and NSF-OCE 0549887/0834340/0550000 (APL-UW). for personal use, not for redistribution. The definitive version was published in Bulletin of the American Meteorological Society 90 (2009): 629-644, doi:10.1175/2008BAMS2578.1.
    Description: As part of the U.K. contribution to the international Surface Ocean–Lower Atmosphere Study, a series of three related projects—DOGEE, SEASAW, and HiWASE—undertook experimental studies of the processes controlling the physical exchange of gases and sea spray aerosol at the sea surface. The studies share a common goal: to reduce the high degree of uncertainty in current parameterization schemes. The wide variety of measurements made during the studies, which incorporated tracer and surfactant release experiments, included direct eddy correlation fluxes, detailed wave spectra, wind history, photographic retrievals of whitecap fraction, aerosol-size spectra and composition, surfactant concentration, and bubble populations in the ocean mixed layer. Measurements were made during three cruises in the northeast Atlantic on the RRS Discovery during 2006 and 2007; a fourth campaign has been making continuous measurements on the Norwegian weather ship Polarfront since September 2006. This paper provides an overview of the three projects and some of the highlights of the measurement campaigns.
    Description: As part of the U.K. contribution to the international Surface Ocean–Lower Atmosphere Study, a series of three related projects—DOGEE, SEASAW, and HiWASE—undertook experimental studies of the processes controlling the physical exchange of gases and sea spray aerosol at the sea surface. The studies share a common goal: to reduce the high degree of uncertainty in current parameterization schemes. The wide variety of measurements made during the studies, which incorporated tracer and surfactant release experiments, included direct eddy correlation fluxes, detailed wave spectra, wind history, photographic retrievals of whitecap fraction, aerosol-size spectra and composition, surfactant concentration, and bubble populations in the ocean mixed layer. Measurements were made during three cruises in the northeast Atlantic on the RRS Discovery during 2006 and 2007; a fourth campaign has been making continuous measurements on the Norwegian weather ship Polarfront since September 2006. This paper provides an overview of the three projects and some of the highlights of the measurement campaigns.
    Repository Name: Woods Hole Open Access Server
    Type: Article
    Format: application/pdf
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  • 6
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    Modelling the coupled mercury-halogen-ozone cycle in the central Arctic during spring (2023)
    University of California Press
    In:  EPIC3Elementa: Science of the Anthropocene, University of California Press, 11(1), pp. 6237-6271, ISSN: 2785-4558
    Details
    Publication Date: 2023-09-15
    Description: Near-surface mercury and ozone depletion events occur in the lowest part of the atmosphere during Arctic spring. Mercury depletion is the first step in a process that transforms long-lived elemental mercury to more reactive forms within the Arctic that are deposited to the cryosphere, ocean, and other surfaces, which can ultimately get integrated into the Arctic food web. Depletion of both mercury and ozone occur due to the presence of reactive halogen radicals that are released from snow, ice, and aerosols. In this work, we added a detailed description of the Arctic atmospheric mercury cycle to our recently published version of the Weather Research and Forecasting model coupled with Chemistry (WRF-Chem 4.3.3) that includes Arctic bromine and chlorine chemistry and activation/recycling on snow and aerosols. The major advantage of our modelling approach is the online calculation of bromine concentrations and emission/recycling that is required to simulate the hourly and daily variability of Arctic mercury depletion. We used this model to study coupling between reactive cycling of mercury, ozone, and bromine during the Multidisciplinary drifting Observatory for the Study of Arctic Climate (MOSAiC) spring season in 2020 and evaluated results compared to land-based, ship-based, and remote sensing observations. The model predicts that elemental mercury oxidation is driven largely by bromine chemistry and that particulate mercury is the major form of oxidized mercury. The model predicts that the majority (74%) of oxidized mercury deposited to land-based snow is re-emitted to the atmosphere as gaseous elemental mercury, while a minor fraction (4%) of oxidized mercury that is deposited to sea ice is re-emitted during spring. Our work demonstrates that hourly differences in bromine/ozone chemistry in the atmosphere must be considered to capture the springtime Arctic mercury cycle, including its integration into the cryosphere and ocean.
    Repository Name: EPIC Alfred Wegener Institut
    Type: Article , peerRev
    Format: application/pdf
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  • 7
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    Coccolithophore counts from polarized microscopy birefringence measurements of samples collected in the Northwest Atlantic during R/V Endeavor cruise EN616 in July 2018 (2023)
    Biological and Chemical Oceanography Data Management Office (BCO-DMO). Contact: bco-dmo-data@whoi.edu
    Details
    Publication Date: 2023-03-08
    Description: Dataset: Coccolithophore birefringence from polarized microscopy
    Description: This dataset presents polarized microscopy-derived concentration data for coccolithophores and detached coccoliths in samples collected from stations in the Northwest Atlantic during R/V Endeavor cruise EN616 in July 2018. Counts are based on image analysis of dark-field, cross-polarized views of filtered particulate matter. These counts take advantage of the birefringence property of calcium carbonate (particulate inorganic carbon) that it rotates the plane of linearly polarized incident light by 90 degrees. Incident light directed upwards, towards the microscope slide, is polarized 90 degrees with a linear polarizer. Particles are viewed from above the slide, through a second, linear polarizer filter held between the microscope stage and the camera which only accepts light that is polarized orthogonal to the lower polarizer. Calcium carbonate particles in the beam appear as bright dots of light. Image analysis software then analyzes the pattern of birefringence and enumerates only those particles with size and shape of coccolithophores or detached coccoliths. For a complete list of measurements, refer to the full dataset description in the supplemental file 'Dataset_description.pdf'. The most current version of this dataset is available at: https://www.bco-dmo.org/dataset/887863
    Description: NSF Division of Ocean Sciences (NSF OCE) OCE-1635748
    Keywords: Coccolithophore ; birefringence ; polarized microscopy ; phytoplankton enumeration ; coccoliths
    Repository Name: Woods Hole Open Access Server
    Type: Dataset
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  • 8
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    Hydrography and environmental conditions measured with CTD at nine stations during R/V Endeavor cruise EN616 in July 2018 (2023)
    Biological and Chemical Oceanography Data Management Office (BCO-DMO). Contact: bco-dmo-data@whoi.edu
    Details
    Publication Date: 2023-03-09
    Description: Dataset: EN616 CTD hydrography
    Description: Hydrography and environmental conditions were measured with CTD at nine stations during R/V Endeavor cruise EN616 in July 2018. The stations ranged from the New England Continental Shelf, New England Continental Slope, to the Sargasso Sea ocean regions. For a complete list of measurements, refer to the full dataset description in the supplemental file 'Dataset_description.pdf'. The most current version of this dataset is available at: https://www.bco-dmo.org/dataset/887800
    Description: NSF Division of Ocean Sciences (NSF OCE) OCE-1635748
    Keywords: CTD ; beam attenuation ; chlorophyll fluorescence ; dissolved oxygen
    Repository Name: Woods Hole Open Access Server
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  • 9
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    Ambient concentrations of acetate, glycerol, and mannitol measured from samples collected during R/V Endeavor cruise EN616 in the northwest Atlantic in July 2018 (2023)
    Biological and Chemical Oceanography Data Management Office (BCO-DMO). Contact: bco-dmo-data@whoi.edu
    Details
    Publication Date: 2023-03-09
    Description: Dataset: Data for ambient concentrations of three DOC compounds (acetate, glycerol, mannitol)
    Description: This data set provides ambient concentrations of three dissolved organic compound (acetate, glycerol and mannitol) measured from water samples taken during R/V Endeavor cruise EN616 in the northwest Atlantic in July 2018. These concentrations were derived using new analytical methods described in the below-referenced Science Advances manuscript by Balch et al. For a complete list of measurements, refer to the full dataset description in the supplemental file 'Dataset_description.pdf'. The most current version of this dataset is available at: https://www.bco-dmo.org/dataset/887851
    Description: NSF Division of Ocean Sciences (NSF OCE) OCE-1635748
    Keywords: glycerol ; mannitol ; acetate ; DOC uptake ; Dissolved Organic Carbon
    Repository Name: Woods Hole Open Access Server
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  • 10
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    FlowCAM enumeration of phytoplankton classes from samples taken during R/V Endeavor cruise EN616 in July 2018 (2023)
    Biological and Chemical Oceanography Data Management Office (BCO-DMO). Contact: bco-dmo-data@whoi.edu
    Details
    Publication Date: 2023-03-09
    Description: Dataset: FlowCAM imaging cytometer data from EN616 cruise
    Description: This dataset presents imaging cytometer data from water samples collected during R/V Endeavor cruise EN616. Niskin bottle samples were taken at nine stations and eight depths in the northwest Atlantic in July 2018. A Yokogawa FlowCAM imaging cytometer was used to enumerate the major microalgal classes, and the particle size distribution function was estimated. For a complete list of measurements, refer to the full dataset description in the supplemental file 'Dataset_description.pdf'. The most current version of this dataset is available at: https://www.bco-dmo.org/dataset/887787
    Description: NSF Division of Ocean Sciences (NSF OCE) OCE-1635748
    Keywords: phytoplankton enumeration ; FlowCAM ; phytoplankton biomass ; particle size distribution function
    Repository Name: Woods Hole Open Access Server
    Type: Dataset
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