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  • 1
    Keywords: Forschungsbericht ; Melanom ; DNA-Impfstoff ; Individualisierte Medizin ; Immuntherapie
    Type of Medium: Online Resource
    Pages: 1 Online-Ressource (18 Seiten, 859,36 KB) , Diagramme
    Language: German
    Note: Förderkennzeichen BMBF 131A004A. - Verbund-Nummer 01119325 , Projektleiter und -wissenschaftler sind laut Berichtsblatt Autor , Vollständiger Name des Zuwendungsempfängers im Kopf der Titelseite: "TRON, Translationale Onkologie an der Universitätsmedizin der Johannes Gutenberg-Universität Mainz gemeinnützige GmbH" , Unterschiede zwischen dem gedruckten Dokument und der elektronischen Ressource können nicht ausgeschlossen werden , Mit deutscher und englischer Zusammenfassung
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  • 2
    Keywords: Forschungsbericht ; Krebs ; Impfstoff ; Immuntherapie ; Biomarker ; Immunreaktion ; Mucine ; Eins
    Type of Medium: Online Resource
    Pages: 1 Online-Ressource (23 Seiten, 1,22 MB) , Illustrationen, Diagramme
    Language: German
    Note: Förderkennzeichen BMBF 131A003B. - Verbund-Nummer 01121225 , "Autor(en): Dr. Valesca Bukur, Dr. David Weber, Dr. Goran Marti´c" - Berichtsblatt , Unterschiede zwischen dem gedruckten Dokument und der elektronischen Ressource können nicht ausgeschlossen werden , Sprache der Zusammenfassung: Deutsch, Englisch
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  • 3
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Science Ltd
    Molecular microbiology 56 (2005), S. 0 
    ISSN: 1365-2958
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology , Medicine
    Notes: In Escherichia coli the β-lactam mecillinam specifically inhibits penicillin-binding protein 2 (PBP2), a peptidoglycan transpeptidase essential for maintaining rod shape. We have previously shown that PBP2 inactivation  results  in  a  cell  division  block  and  that an increased concentration of the nucleotide ppGpp, effector of the RelA-dependent stringent response, confers mecillinam resistance and allows cells to divide as spheres in the absence of PBP2 activity. In this study we have characterized an insertion mutation which confers mecillinam resistance in wild-type and ΔrelA strains but not in ΔrelAΔspoT strains, devoid of ppGpp. The mutant has an insertion in the fes gene, coding for enterochelin esterase. This cytoplasmic enzyme hydrolyses enterochelin–Fe3+ complexes, making the scavenged iron available to the cells. We show that inactivation of the fes gene causes iron limitation on rich medium plates and a parallel SpoT-dependent increase of the ppGpp pool, as judged by the induction of the iron-regulated fiu::lacZ fusion and the repression of the stringently controlled P1rrnB::lacZ fusion respectively. We further show, by direct ppGpp assays, that iron starvation in liquid medium produces a SpoT-dependent increase of the ppGpp pool, strongly suggesting a role for iron in the balance of the two activities of SpoT, synthesis and hydrolysis of (p)ppGpp. Finally, we present evidence that ppGpp exerts direct or indirect positive control on iron uptake, suggesting a simple homeostatic regulatory circuit: iron limitation leads to an increased ppGpp pool, which increases the expression of iron uptake genes, thereby alleviating the limitation.
    Type of Medium: Electronic Resource
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  • 4
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    PANGAEA
    In:  Supplement to: Lattuada, Matteo; Albrecht, Christian; Wilke, Thomas (2019): Differential impact of anthropogenic pressures on Caspian Sea ecoregions. Marine Pollution Bulletin, 142, 274-281, https://doi.org/10.1016/j.marpolbul.2019.03.046
    Publication Date: 2023-01-30
    Description: Over the past decades, overall ecological conditions in the Caspian Sea have deteriorated. However, a comprehensive understanding of lake-wide spatial differences in anthropogenic pressures is lacking and the biological consequences of human impacts are poorly understood. This paper therefore aims at assessing the individual and combined effects of critical anthropogenic pressures on the Caspian Sea ecoregions. First, cumulative pressure scores were calculated with a cumulative environmental assessment (CEA) analysis. Then, the individual contribution of anthropogenic pressures was quantified. Finally, ecoregion-specific differences were assessed. The analyses show that both cumulative and individual pressure scores are unevenly distributed across the Caspian Sea. The most important individual pressures are invasive species, chemical pollution and poaching. This uneven distribution of pressure scores across Caspian Sea ecoregions creates new challenges for future conservation strategies, as different ecoregions usually require different conservation measures.
    Keywords: Anthropogenic impact; Caspian_Sea; Caspian Sea; Cumulative environmental assessment; Ecoregions; Endemic species; File format; File name; File size; Uniform resource locator/link to file
    Type: Dataset
    Format: text/tab-separated-values, 36 data points
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  • 5
    Publication Date: 2024-03-02
    Description: The Caspian Sea is renowned for its endemic mollusk biodiversity. However, over the past decades, increasing anthropogenic pressures have caused decreases in abundances and even extinction of species. Both key pressures and endemic taxa are distributed spatially unevenly across the Caspian Sea, suggesting that ecologically different taxa such as gastropods and bivalves are also affected differentially. In addition, hotspot and non-hotspot areas for these taxa might differ quantitatively in pressure scores and qualitatively in key individual anthropogenic pressures. To test this working hypothesis, hotspot areas for endemic bivalve and gastropod species were identified using stacked species ranges. Cumulative and individual pressure scores were estimated for hotspot and non-hotspot areas of bivalves and gastropods. Differences in cumulative and individual pressure scores were tested for significance using non-parametric MANOVA and Wilcoxon rank sum tests, respectively. We identified various mollusk biodiversity hotspots across locations and depths, which are differentially affected both in terms of cumulative pressure scores and in the composition of the contributing individual pressures. Similarly, hotspot and non-hotspot areas for both bivalves and gastropods are differentially affected by anthropogenic pressures. By defining endemic hotspot areas and the respective anthropogenic pressures, this study provides an important baseline for mollusk-specific conservation strategies.
    Keywords: Anthropogenic pressures; Aquatic invertebrates; Caspian_Sea; Caspian Sea; Endemism; Environmental degradation; File format; File size; Hotspots; Spatial data analysis; Species; Uniform resource locator/link to file
    Type: Dataset
    Format: text/tab-separated-values, 284 data points
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  • 6
    Publication Date: 2015-01-18
    Description: A new 1 km global IIASA-IFPRI cropland percentage map for the baseline year 2005 has been developed which integrates a number of individual cropland maps at global to regional to national scales. The individual map products include existing global land cover maps such as GlobCover 2005 and MODIS v.5, regional maps such as AFRICOVER and national maps from mapping agencies and other organizations. The different products are ranked at the national level using crowdsourced data from Geo-Wiki to create a map that reflects the likelihood of cropland. Calibration with national and subnational crop statistics was then undertaken to distribute the cropland within each country and subnational unit. The new IIASA-IFPRI cropland product has been validated using very high-resolution satellite imagery via Geo-Wiki and has an overall accuracy of 82.4%. It has also been compared with the EarthStat cropland product and shows a lower root mean square error on an independent data set collected from Geo-Wiki. The first ever global field size map was produced at the same resolution as the IIASA-IFPRI cropland map based on interpolation of field size data collected via a Geo-Wiki crowdsourcing campaign. A validation exercise of the global field size map revealed satisfactory agreement with control data, particularly given the relatively modest size of the field size data set used to create the map. Both are critical inputs to global agricultural monitoring in the frame of GEOGLAM and will serve the global land modelling and integrated assessment community, in particular for improving land use models that require baseline cropland information. These products are freely available for downloading from the http://cropland.geo-wiki.org website.
    Print ISSN: 1354-1013
    Electronic ISSN: 1365-2486
    Topics: Biology , Energy, Environment Protection, Nuclear Power Engineering , Geography
    Published by Wiley-Blackwell
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  • 7
    Publication Date: 2021-02-25
    Description: Mediterranean climates are characterized by strong seasonal contrasts between dry summers and wet winters. Changes in winter rainfall are critical for regional socioeconomic development, but are difficult to simulate accurately1 and reconstruct on Quaternary timescales. This is partly because regional hydroclimate records that cover multiple glacial-interglacial cycles2,3 with different orbital geometries, global ice volume and atmospheric greenhouse gas concentrations are scarce. Moreover, the underlying mechanisms of change and their persistence remain unexplored. Here we show that, over the past 1.36 million years, wet winters in the northcentral Mediterranean tend to occur with high contrasts in local, seasonal insolation and a vigorous African summer monsoon. Our proxy time series from Lake Ohrid on the Balkan Peninsula, together with a 784,000-year transient climate model hindcast, suggest that increased sea surface temperatures amplify local cyclone development and refuel North Atlantic low-pressure systems that enter the Mediterranean during phases of low continental ice volume and high concentrations of atmospheric greenhouse gases. A comparison with modern reanalysis data shows that current drivers of the amount of rainfall in the Mediterranean share some similarities to those that drive the reconstructed increases in precipitation. Our data cover multiple insolation maxima and are therefore an important benchmark for testing climate model performance.
    Description: Published
    Description: 256–260
    Description: 5A. Ricerche polari e paleoclima
    Description: JCR Journal
    Keywords: paleoclimate Mediterranean Pleistocene ; 04.04. Geology
    Repository Name: Istituto Nazionale di Geofisica e Vulcanologia (INGV)
    Type: article
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  • 8
    Publication Date: 2020-02-26
    Description: This study reviews and synthesises existing information generated within the SCOPSCO (Scientific Collaboration on Past Speciation Conditions in Lake Ohrid) deep drilling project. The four main aims of the project are to infer (i) the age and origin of Lake Ohrid (Former Yugoslav Republic of Macedonia/Republic of Albania), (ii) its regional seismotectonic history, (iii) volcanic activity and climate change in the central northern Mediterranean region, and (iv) the influence of major geological events on the evolution of its endemic species. The Ohrid basin formed by transtension during the Miocene, opened during the Pliocene and Pleistocene, and the lake established de novo in the still relatively narrow valley between 1.9 and 1.3 Ma. The lake history is recorded in a 584m long sediment sequence, which was recovered within the framework of the International Continental Scientific Drilling Program (ICDP) from the central part (DEEP site) of the lake in spring 2013. To date, 54 tephra and cryptotephra horizons have been found in the upper 460m of this sequence. Tephrochronology and tuning biogeochemical proxy data to orbital parameters revealed that the upper 247.8m represent the last 637 kyr. The multi-proxy data set covering these 637 kyr indicates longterm variability. Some proxies show a change from generally cooler and wetter to drier and warmer glacial and interglacial periods around 300 ka. Short-term environmental change caused, for example, by tephra deposition or the climatic impact of millennial-scale Dansgaard–Oeschger and Heinrich events are superimposed on the long-term trends. Evolutionary studies on the extant fauna indicate that Lake Ohrid was not a refugial area for regional freshwater animals. This differs from the surrounding catchment, where the mountainous setting with relatively high water availability provided a refuge for temperate and montane trees during the relatively cold and dry glacial periods. Although Lake Ohrid experienced significant environmental change over the last 637 kyr, preliminary molecular data from extant microgastropod species do not indicate significant changes in diversification rate during this period. The reasons for this constant rate remain largely unknown, but a possible lack of environmentally induced extinction events in Lake Ohrid and/or the high resilience of the ecosystems may have played a role.
    Description: Published
    Description: 2033–2054
    Description: 1A. Geomagnetismo e Paleomagnetismo
    Description: JCR Journal
    Keywords: Lake Ohrid, Pleistocene, ICDP ; Stratigraphy ; Environmental changes ; Lake sediments
    Repository Name: Istituto Nazionale di Geofisica e Vulcanologia (INGV)
    Type: article
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  • 9
    Publication Date: 2024-05-20
    Description: To ensure the long-term sustainable use of African Great Lakes (AGL), and to better understand the functioning of these ecosystems, authorities, managers and scientists need regularly collected scientific data and information of key environmental indicators over multi-years to make informed decisions. Monitoring is regularly conducted at some sites across AGL; while at others sites, it is rare or conducted irregularly in response to sporadic funding or short-term projects/studies. Managers and scientists working on the AGL thus often lack critical long-term data to evaluate and gauge ongoing changes. Hence, we propose a multi-lake approach to harmonize data collection modalities for better understanding of regional and global environmental impacts on AGL. Climate variability has had strong impacts on all AGL in the recent past. Although these lakes have specific characteristics, their limnological cycles show many similarities. Because different anthropogenic pressures take place at the different AGL, harmonized multilake monitoring will provide comparable data to address the main drivers of concern (climate versus regional anthropogenic impact). To realize harmonized long-term multi-lake monitoring, the approach will need: (1) support of a wide community of researchers and managers; (2) political goodwill towards a common goal for such monitoring; and (3) sufficient capacity (e.g., institutional, financial, human and logistic resources) for its implementation. This paper presents an assessment of the state of monitoring the AGL and possible approaches to realize a long-term, multi-lake harmonized monitoring strategy. Key parameters are proposed. The support of national and regional authorities is necessary as each AGL crosses international boundaries.
    Description: Published
    Description: 101988
    Description: JCR Journal
    Keywords: Fisheries ; Limnology ; Pollution ; Biodiversity ; Climate change ; Erosion
    Repository Name: Istituto Nazionale di Geofisica e Vulcanologia (INGV)
    Type: article
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