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  • 1
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    Individual codes, GenBank accession numbers and GenBank accession links for marine sponge-associated microbial metagenomes (2016)
    PANGAEA
    In:  Supplement to: Horn, Hannes; Slaby, Beate M; Jahn, Martin T; Bayer, Kristina; Moitinho-Silva, Lucas; Förster, Frank; Abdelmohsen, Usama Ramadan; Hentschel, Ute (2016): An Enrichment of CRISPR and Other Defense-Related Features in Marine Sponge-Associated Microbial Metagenomes. Frontiers in Microbiology, 7:1751, https://doi.org/10.3389/fmicb.2016.01751
    Details
    Publication Date: 2023-03-08
    Description: Dataset contains metainformation to the samples used in the given pulication: links to Bioprojects, Biosamples, metagenome assemblies and raw data.
    Keywords: Accession number; Accession number, link; Area/locality; Date/Time of event; Depth, bottom/max; Depth, top/min; DIVER; Event label; Latitude of event; Longitude of event; Milos_052013; Piran_052013; Piran, Slovenia; Project; Sample ID; Sample type; Sampling by diver; Sequence identifier; Species; Sponge Milos Collection
    Type: Dataset
    Format: text/tab-separated-values, 39 data points
    Location Call Number Limitation Availability
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    DATA PANGAEA
  • 2
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    Taxonomic identifiation, anti-trypanosomal activity, metabolomics analyses and GenBank accession data of Mediterranean marine sponge associated actinomycetes (2015)
    PANGAEA
    In:  Supplement to: Cheng, Cheng; MacIntyre, Lynsey; Abdelmohsen, Usama Ramadan; Horn, Hannes; Polymenakou, Paraskevi; Edrada-Ebel, RuAngelie; Hentschel, Ute (2015): Biodiversity, Anti-Trypanosomal Activity Screening, and Metabolomic Profiling of Actinomycetes Isolated from Mediterranean Sponges. PLoS ONE, 10(9), e0138528, https://doi.org/10.1371/journal.pone.0138528
    Details
    Publication Date: 2023-01-13
    Description: Marine sponge-associated actinomycetes are considered as promising sources for the discovery of novel biologically active compounds. In the present study, a total of 64 actinomycetes were isolated from 12 different marine sponge species that had been collected offshore the islands of Milos and Crete, Greece, eastern Mediterranean. The isolates were affiliated to 23 genera representing 8 different suborders based on nearly full length 16S rRNA gene sequencing. Four putatively novel species belonging to genera Geodermatophilus, Microlunatus, Rhodococcus and Actinomycetospora were identified based on a 16S rRNA gene sequence similarity of 〈 98.5% to currently described strains. Eight actinomycete isolates showed bioactivities against Trypanosma brucei brucei TC221 with half maximal inhibitory concentration (IC50) values 〈20 µg/mL. Thirty four isolates from the Milos collection and 12 isolates from the Crete collection were subjected to metabolomic analysis using high resolution LC-MS and NMR for dereplication purposes. Two isolates belonging to the genera Streptomyces (SBT348) and Micromonospora (SBT687) were prioritized based on their distinct chemistry profiles as well as their anti-trypanosomal activities. These findings demonstrated the feasibility and efficacy of utilizing metabolomics tools to prioritize chemically unique strains from microorganism collections and further highlight sponges as rich source for novel and bioactive actinomycetes.
    Type: Dataset
    Format: application/zip, 2 datasets
    Location Call Number Limitation Availability
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    DATA PANGAEA
  • 3
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    Individual codes, GenBank accession numbers and GenBank accession links for Mediterranean sponges (2015)
    PANGAEA
    In:  Supplement to: Horn, Hannes; Cheng, Cheng; Edrada-Ebel, RuAngelie; Hentschel, Ute; Abdelmohsen, Usama Ramadan (2015): Draft genome sequences of three chemically rich actinomycetes isolated from Mediterranean sponges. Marine Genomics, https://doi.org/10.1016/j.margen.2015.10.003
    Details
    Publication Date: 2023-01-13
    Description: Metabolomic analysis has shown the chemical richness of the sponge-associated actinomycetes Streptomyces sp. SBT349, Nonomureae sp. SBT364, and Nocardiopsis sp. SBT366. The genomes of these actinomycetes were sequenced and the genomic potential for secondary metabolism was evaluated. Their draft genomes have sizes of 8.0, 10, and 5.8Mb having 687, 367, and 179 contigs with a GC content of 71.6, 70.7, and 72.7%, respectively. Moreover, antiSMASH 3.0 predicted 108, 149, and 75 secondary metabolite gene clusters, respectively which highlight the metabolic capacity of the three actinomycete species to produce diverse classes of natural products.
    Keywords: Accession number; Accession number, link; Area/locality; Date/Time of event; Depth, bottom/max; Depth, top/min; DIVER; Latitude of event; Longitude of event; Milos_052013; Sample code/label; Sampling by diver; Species code; Sponge Milos Collection
    Type: Dataset
    Format: text/tab-separated-values, 21 data points
    Location Call Number Limitation Availability
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    DATA PANGAEA
  • 4
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    Individual codes, GenBank accession numbers and GenBank accession links for sponge-associated actinobacterial isolates (2015)
    PANGAEA
    In:  Supplement to: Horn, Hannes; Hentschel, Ute; Abdelmohsen, Usama Ramadan (2015): Mining Genomes of Three Marine Sponge-Associated Actinobacterial Isolates for Secondary Metabolism. Genome Announcements, 3(5), e01106-15, https://doi.org/10.1128/genomeA.01106-15
    Details
    Publication Date: 2023-01-13
    Description: Here, we report the draft genome sequences of three actinobacterial isolates, Micromonospora sp. RV43, Rubrobacter sp. RV113, and Nocardiopsis sp. RV163 that had previously been isolated from Mediterranean sponges. The draft genomes were analyzed for the presence of gene clusters indicative of secondary metabolism using antiSMASH 3.0 and NapDos pipelines. Our findings demonstrated the chemical richness of sponge-associated actinomycetes and the efficacy of genome mining in exploring the genomic potential of sponge-derived actinomycetes.
    Keywords: Accession number; Accession number, link; Area/locality; Date/Time of event; Depth, bottom/max; Depth, top/min; DIVER; Latitude of event; Longitude of event; Rovinj_082008; Sampling by diver; Species; Species code
    Type: Dataset
    Format: text/tab-separated-values, 21 data points
    Location Call Number Limitation Availability
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    DATA PANGAEA
  • 5
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    Taxonomic identifiation, anti-trypanosomal activity, and metabolomics analyses of Mediterranean marine sponge associated actinomycetes (2015)
    PANGAEA
    Details
    Publication Date: 2023-01-13
    Keywords: Comment of event; Crete_112013; Date/Time of event; DIVER; Event label; File size; Latitude of event; Longitude of event; Milos_052013; Optional event label; Sampling by diver; Sponge Crete Collection; Sponge Milos Collection; Uniform resource locator/link to file
    Type: Dataset
    Format: text/tab-separated-values, 4 data points
    Location Call Number Limitation Availability
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    DATA PANGAEA
  • 6
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    Individual codes, GenBank accession numbers and GenBank accession links for Mediterranean marine sponge associated actinomycetes (2015)
    PANGAEA
    Details
    Publication Date: 2023-01-13
    Keywords: Accession number; Accession number, link; Area/locality; Crete_112013; Date/Time of event; Depth, bottom/max; Depth, top/min; DIVER; Event label; Latitude of event; Longitude of event; Milos_052013; Sampling by diver; Species code; Sponge Crete Collection; Sponge Milos Collection
    Type: Dataset
    Format: text/tab-separated-values, 276 data points
    Location Call Number Limitation Availability
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    DATA PANGAEA
  • 7
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    Bacicyclin, a new antibacterial cyclic hexapeptide from Bacillus sp. strain BC028 isolated from Mytilus edulis (2018)
    Elsevier
    In:  Bioorganic & Medicinal Chemistry Letters, 28 (4). pp. 558-561.
    Details
    Publication Date: 2021-02-08
    Description: A new cyclic hexapeptide, cyclo-(Gly-Leu-Val-IIe-Ala-Phe), named bacicyclin (1), was isolated from a marine Bacillus sp. strain associated with Mytilus edulis. The sequences of the amino acid building blocks of the cyclic peptide and its structure were determined by 1D- and 2D-NMR techniques. Marfey's analysis showed that the amino acid building blocks had L-configuration in all cases except for alanine and phenylalanine, which had D-configuration. Bacicyclin (1) exhibited antibacterial activity against the clinically relevant strains Enterococcus faecalis and Staphylococcus aureus with minimal inhibitory concentration values of 8 and 12 μM, respectively. These results demonstrate the potential of marine bacteria as a promising source for the discovery of new antibiotics.
    Type: Article , PeerReviewed
    Format: text
    Format: text
    DOI: 10.1016/j.bmcl.2018.01.062
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    OceanRep: Article in a Scientific Journal - peer-reviewed
  • 8
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    Actinomycete Metabolome Induction/Suppression with N-Acetylglucosamine (2017)
    American Chemistry Society
    In:  Journal of Natural Products, 80 (4). pp. 828-836.
    Details
    Publication Date: 2020-02-06
    Description: The metabolite profiles of three sponge-derived actinomycetes, namely, Micromonospora sp. RV43, Rhodococcus sp. RV157, and Actinokineospora sp. EG49 were investigated after elicitation with N-acetyl-d-glucosamine. 1H NMR fingerprint methodology was utilized to study the differences in the metabolic profiles of the bacterial extracts before and after elicitation. Our study found that the addition of N-acetyl-d-glucosamine modified the secondary metabolite profiles of the three investigated actinomycete isolates. N-Acetyl-d-glucosamine induced the production of 3-formylindole (11) and guaymasol (12) in Micromonospora sp. RV43, the siderophore bacillibactin 16, and surfactin antibiotic 17 in Rhodococcus sp. RV157 and increased the production of minor metabolites actinosporins E–H (21–24) in Actinokineospora sp. EG49. These results highlight the use of NMR fingerprinting to detect changes in metabolism following addition of N-acetyl-d-glucosamine. N-Acetyl-d-glucosamine was shown to have multiple effects including suppression of metabolites, induction of new metabolites, and increased production of minor compounds.
    Type: Article , PeerReviewed
    Format: text
    DOI: 10.1021/acs.jnatprod.6b00673
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    OceanRep: Article in a Scientific Journal - peer-reviewed
  • 9
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    Strepoxazine A, a new cytotoxic phenoxazin from the marine sponge-derived bacterium Streptomyces sp. SBT345 (2016)
    Elsevier
    In:  Tetrahedron Letters, 57 (37). pp. 4196-4199.
    Details
    Publication Date: 2019-02-01
    Description: Highlights • One new phenoxazin analogue, strepoxazine A was identified from the solid culture of Streptomyces sp. SBT345. • Additionally, two known phenazine compounds phencomycin and tubermycin B were also reported. • Strepoxazine A (1) showed antiproliferative activity against leukaemia cells HL-60. Abstract One new phenoxazin analogue, strepoxazine A (1), along with two known antibiotic phenazines phencomycin (2) and tubermycin B (3) were isolated from the solid culture of Streptomyces sp. SBT345 which had previously been recovered from the Mediterranean sponge Agelas oroides. The structures of compounds 1, 2 and 3 were determined by spectroscopic analyses including 1D and 2D NMR, and HR-ESI-MS experiments as well as comparison to the literature. We further investigated the apoptotic effect of the three compounds on the human promyelocytic leukaemia cells HL-60 and human breast adenocarcinoma cells MCF-7. Only strepoxazine A (1) showed cytotoxicity against leukaemia cells HL-60 cells. These results demonstrate that sponge-associated actinomycetes are rich sources for natural products with new pharmacological activities and relevance to drug discovery.
    Type: Article , PeerReviewed , info:eu-repo/semantics/article
    Format: text
    DOI: 10.1016/j.tetlet.2016.08.005
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    OceanRep: Article in a Scientific Journal - peer-reviewed
  • 10
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    Antifungal potential of marine natural products (2017)
    Elsevier
    In:  European Journal of Medicinal Chemistry, 126 . pp. 631-651.
    Details
    Publication Date: 2020-02-06
    Description: Highlights: • Fungal infections represent an increasing threat to human health. • Fungal infections in plants are a worldwide problem to the agricultural industry. • Diverse antifungal compounds were isolated from different marine organisms. • The number of new antifungal marine natural products is rapidly developing. • Marine sponges and bacteria are the predominant sources for antifungal compounds. Abstract: Fungal diseases represent an increasing threat to human health worldwide which in some cases might be associated with substantial morbidity and mortality. However, only few antifungal drugs are currently available for the treatment of life-threatening fungal infections. Furthermore, plant diseases caused by fungal pathogens represent a worldwide economic problem for the agriculture industry. The marine environment continues to provide structurally diverse and biologically active secondary metabolites, several of which have inspired the development of new classes of therapeutic agents. Among these secondary metabolites, several compounds with noteworthy antifungal activities have been isolated from marine microorganisms, invertebrates, and algae. During the last fifteen years, around 65% of marine natural products possessing antifungal activities have been isolated from sponges and bacteria. This review gives an overview of natural products from diverse marine organisms that have shown in vitro and/or in vivo potential as antifungal agents, with their mechanism of action whenever applicable. The natural products literature is covered from January 2000 until June 2015, and we are reporting the chemical structures together with their biological activities, as well as the isolation source.
    Type: Article , PeerReviewed , info:eu-repo/semantics/article
    Format: text
    Format: text
    DOI: 10.1016/j.ejmech.2016.11.022
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    OceanRep: Article in a Scientific Journal - peer-reviewed
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