Note: Front Cover -- Imunologia Celular e Molecular -- Copyright Page -- Instruções para acesso on-line -- SUMÁRIO -- REVISÃO CIENTÍFICA E TRADUÇÃO -- DEDICATÓRIA -- APRESENTAÇÃO -- CAPÍTULO 1. Propriedades Gerais das Respostas Imunes -- IMUNIDADE INATA E ADAPTATIVA -- TIPOS DE RESPOSTA IMUNE ADAPTATIVA -- PRINCIPAIS CARACTERÍSTICAS DA RESPOSTA IMUNE ADAPTATIVA -- COMPONENTES CELULARES DO SISTEMA IMUNOLÓGICO ADAPTATIVO -- CITOCINAS, MEDIADORES SOLÚVEIS DO SISTEMA IMUNOLÓGICO -- VISÃO GERAL DAS RESPOSTAS IMUNES AOS MICRO-ORGANISMOS -- RESUMO -- LEITURAS SUGERIDAS -- CAPÍTULO 2. Células e Tecidos do Sistema Imune -- CÉLULAS DO SISTEMA IMUNE -- ANATOMIA E FUNÇÕES DOS TECIDOS LINFOIDES -- RESUMO -- LEITURAS SUGERIDAS -- CAPÍTULO 3. Migração dos Leucócitos para os Tecidos -- MOLÉCULAS DE ADESÃO DOS LEUCÓCITOS E DAS CÉLULAS ENDOTELIAIS ENVOLVIDAS NO RECRUTAMENTO DOS LEUCÓCITOS -- QUIMIOCINAS E RECEPTORES DE QUIMIOCINAS -- INTERAÇÕES DE LEUCÓCITOS COM AS CÉLULAS ENDOTELIAIS E EXTRAVASAMENTO DOS LEUCÓCITOS -- MIGRAÇÃO DOS NEUTRÓFILOS E DOS MONÓCITOS PARA OS LOCAIS DE INFECÇÃO OU DE LESÃO TECIDUAL -- MIGRAÇÃO E RECIRCULAÇÃO DOS LINFÓCITOS T -- MIGRAÇÃO DOS LINFÓCITOS B -- RESUMO -- LEITURAS SUGERIDAS -- CAPÍTULO 4. Imunidade Inata -- RECONHECIMENTO DE MICRO-ORGANISMOS E ESTRUTURAS ORGÂNICAS DANIFICADAS PELO SISTEMA IMUNE INATO -- RECEPTORES CELULARES DE RECONHECIMENTO DE PADRÕES DA IMUNIDADE INATA -- COMPONENTES CELULARES DO SISTEMA IMUNE INATO -- MOLÉCULAS SOLÚVEIS DE RECONHECIMENTO E MOLÉCULAS EFETORAS DA IMUNIDADE INATA -- A RESPOSTA INFLAMATÓRIA -- A RESPOSTA ANTIVIRAL -- ESTIMULAÇÃO DA IMUNIDADE ADAPTATIVA -- MECANISMOS DE RETROALIMENTAÇÃO QUE REGULAM A IMUNIDADE INATA -- RESUMO -- LEITURAS SUGERIDAS -- CAPÍTULO 5. Anticorpos e Antígenos -- ESTRUTURA DO ANTICORPO -- SÍNTESE, MONTAGEM E EXPRESSÃO DAS MOLÉCULAS DE IG -- LIGAÇÃO ENTRE ANTICORPOS E ANTÍGENOS. , RELAÇÕES ENTRE ESTRUTURA E FUNÇÃO NAS MOLÉCULAS DE ANTICORPOS -- RESUMO -- LEITURAS SELECIONADAS -- CAPÍTULO 6. Moléculas do Complexo Principal de Histocompatibilidade e Apresentação do Antígeno aos Linfócitos T -- PROPRIEDADES DOS ANTÍGENOS RECONHECIDOS PELOS LINFÓCITOS T -- CAPTURA DO ANTÍGENO E FUNÇÕES DAS CÉLULAS APRESENTADORAS DE ANTÍGENOS -- O COMPLEXO PRINCIPAL DE HISTOCOMPATIBILIDADE (MHC) -- PROCESSAMENTO DOS ANTÍGENOS PROTEICOS -- APRESENTAÇÃO DE ANTÍGENOS NÃO PROTEICOS A SUBTIPOS DE CÉLULAS T -- RESUMO -- LEITURAS SUGERIDAS -- CAPÍTULO 7. Receptores Imunológicos e Transdução de Sinais -- VISÃO GERAL DA TRANSDUÇÃO DE SINAIS -- A FAMÍLIA DOS RECEPTORES IMUNOLÓGICOS -- O COMPLEXO DO RECEPTOR DE ANTÍGENOS DO LINFÓCITO B -- ATENUAÇÃO DA SINALIZAÇÃO DOS RECEPTORES IMUNOLÓGICOS -- RECEPTORES DE CITOCINA E SINALIZAÇÃO -- RESUMO -- LEITURAS SUGERIDAS -- CAPÍTULO 8. Desenvolvimento dos Linfócitos e Rearranjo dos Genes dos Receptores de Antígenos -- VISÃO GERAL DO DESENVOLVIMENTO DOS LINFÓCITOS -- REARRANJO DOS GENES DOS RECEPTORES DE ANTÍGENOS DOS LINFÓCITOS B E T -- DESENVOLVIMENTO DOS LINFÓCITOS B -- MATURAÇÃO DOS LINFÓCITOS T -- RESUMO -- LEITURAS SUGERIDAS -- CAPÍTULO 9. Ativação dos Linfócitos T -- REVISÃO DA ATIVAÇÃO DOS LINFÓCITOS T -- SINAIS DE ATIVAÇÃO DOS LINFÓCITOS T -- RESPOSTAS FUNCIONAIS DOS LINFÓCITOS T -- RESUMO -- DECLÍNIO DAS RESPOSTAS DA CÉLULA T -- LEITURAS SUGERIDAS -- CAPÍTULO 10. Mecanismos Efetores da Imunidade Mediada por Células -- TIPOS DE REAÇÕES IMUNOLÓGICAS MEDIADAS POR CÉLULAS -- MIGRAÇÃO DOS LINFÓCITOS T EFETORES PARA OS SÍTIOS DE INFECÇÃO -- FUNÇÕES EFETORAS DAS CÉLULAS T CD4+ AUXILIARES -- FUNÇÕES EFETORAS DOS LINFÓCITOS T CITOTÓXICOS CD8+ -- FUNÇÕES DE OUTROS SUBGRUPOS DE CÉLULAS T -- RESUMO -- LEITURAS SUGERIDAS -- CAPÍTULO 11. Ativação da Célula B e Produção de Anticorpos. , CARACTERÍSTICAS GERAIS DAS RESPOSTAS IMUNES HUMORAIS -- RECONHECIMENTO DE ANTÍGENOS E ATIVAÇÃO DA CÉLULA B INDUZIDA PELO ANTÍGENO -- RESPOSTAS DE ANTICORPOS DEPENDENTES DE CÉLULA T AUXILIAR AOS ANTÍGENOS PROTEICOS -- RESPOSTAS DE ANTICORPOS A ANTÍGENOS INDEPENDENTES DE CÉLULAS T -- AUTORREGULAÇÃO DOS ANTICORPOS: REGULAÇÃO DAS RESPOSTAS IMUNES HUMORAIS POR RECEPTORES Fc -- RESUMO -- LEITURAS SUGERIDAS -- CAPÍTULO 12. Mecanismos Efetores da Imunidade Humoral -- VISÃO GERAL DA IMUNIDADE HUMORAL -- NEUTRALIZAÇÃO DE MICRO-ORGANISMOS E DE TOXINAS MICROBIANAS -- OPSONIZAÇÃO MEDIADA POR ANTICORPOS E FAGOCITOSE -- O SISTEMA COMPLEMENTO -- RESUMO -- IMUNIDADE NEONATAL -- LEITURAS SELECIONADAS -- CAPÍTULO 13. Imunidade Regional: Respostas Imunes Especializadas em Tecidos Epiteliais e Imunoprivilegiados -- CARACTERÍSTICAS GERAIS DA IMUNIDADE NAS BARREIRAS EPITELIAIS -- IMUNIDADE NO SISTEMA GASTROINTESTINAL -- IMUNIDADE EM OUTROS TECIDOS MUCOSOS -- O SISTEMA IMUNE CUTÂNEO -- TECIDOS IMUNOPRIVILEGIADOS -- RESUMO -- LEITURAS SUGERIDAS -- CAPÍTULO 14. Tolerância Imunológica e Autoimunidade -- CARACTERÍSTICAS GERAIS DA TOLERÂNCIA IMUNOLÓGICA -- TOLERÂNCIA DOS LINFÓCITOS T -- TOLERÂNCIA DOS LINFÓCITOS B -- TOLERÂNCIA INDUZIDA POR ANTÍGENOS PROTEICOS ESTRANHOS -- PATOGÊNESE DA AUTOIMUNIDADE -- RESUMO -- LEITURAS SUGERIDAS -- CAPÍTULO 15. Imunidade contra Micro-organismos -- CARACTERÍSTICAS GERAIS DAS RESPOSTAS IMUNOLÓGICAS CONTRA MICRO-ORGANISMOS -- IMUNIDADE CONTRA BACTÉRIAS EXTRACELULARES -- IMUNIDADE CONTRA BACTÉRIAS INTRACELULARES -- IMUNIDADE CONTRA FUNGOS -- IMUNIDADE CONTRA VÍRUS -- IMUNIDADE CONTRA PARASITAS -- ESTRATÉGIAS PARA O DESENVOLVIMENTO DE VACINAS -- RESUMO -- LEITURAS SELECIONADAS -- RESPOSTAS IMUNES AOS ALOENXERTOS -- CAPÍTULO 16. Imunologia do Transplante -- PADRÕES E MECANISMOS DE REJEIÇÃO DE ALOENXERTO. , PREVENÇÃO E TRATAMENTO DA REJEIÇÃO DE ALOENXERTOS -- TRANSPLANTE XENOGÊNICO -- TRANSFUSÃO DE SANGUE E OS GRUPOS DE ANTÍGENOS DE SANGUE ABO E RH -- TRANSPLANTE HEMATOPOIÉTICO DE CÉLULAS-TRONCO -- RESUMO -- LEITURAS SUGERIDAS -- CAPÍTULO 17. Imunidade Tumoral -- ASPECTOS GERAIS DA IMUNIDADE TUMORAL -- ANTÍGENOS TUMORAIS -- RESPOSTAS IMUNOLÓGICAS CONTRA TUMORES -- EVASÃO DE RESPOSTAS IMUNOLÓGICAS PELOS TUMORES -- IMUNOTERAPIA PARA TUMORES -- O PAPEL DO SISTEMA IMUNOLÓGICO NA PROMOÇÃO DO CRESCIMENTO TUMORAL -- RESUMO -- LEITURAS SUGERIDAS -- CAPÍTUO 18. Distúrbios de Hipersensibilidade -- CAUSAS DE DOENÇAS DE HIPERSENSIBILIDADE -- MECANISMOS E CLASSIFICAÇÃO DAS REAÇÕES DE HIPERSENSIBILIDADE -- DOENÇAS CAUSADAS POR ANTICORPOS -- DOENÇAS CAUSADAS POR LINFÓCITOS T -- ABORDAGENS TERAPÊUTICAS PARA DOENÇAS AUTOIMUNES -- DOENÇAS AUTOIMUNES ESPECÍFICAS: PATOGÊNESE E ESTRATÉGIAS TERAPÊUTICAS -- RESUMO -- LEITURAS SUGERIDAS -- CAPÍTULO 19. Respostas Imunes Dependentes de IgE e Doenças Alérgicas -- CARACTERÍSTICAS GERAIS DAS REAÇÕES IMUNES DEPENDENTES DE IgE -- PRODUÇÃO DE IgE -- PAPEL DOS MASTÓCITOS, BASÓFILOS E EOSINÓFILOS NA HIPERSENSIBILIDADE IMEDIATA -- REAÇÕES DEPENDENTES DE IgE E DE MASTÓCITOS -- SUSCETIBILIDADE GENÉTICA À HIPERSENSIBILIDADE IMEDIATA -- DOENÇAS ALÉRGICAS EM SERES HUMANOS: PATOGÊNESE E TERAPIA -- OS PAPÉIS DE PROTEÇÃO DAS REAÇÕES IMUNES MEDIADAS POR IgE E MASTÓCITOS -- RESUMO -- LEITURAS SUGERIDAS -- CAPÍTULO 20. Imunode. ciências Congênitas e Adquiridas -- CARACTERÍSTICAS GERAIS DAS DOENÇAS DE IMUNODEFICIÊNCIA -- IMUNODEFICIÊNCIAS CONGÊNITAS (PRIMÁRIAS) -- IMUNODEFICIÊNCIAS ADQUIRIDAS (SECUNDÁRIAS) -- VÍRUS DA IMUNODEFICIÊNCIA HUMANA E SÍNDROME DA IMUNODEFICIÊNCIA ADQUIRIDA -- RESUMO -- LEITURAS SUGERIDAS -- APÊNDICE I: GLOSSÁRIO -- APÊNDICE II: CITOCINAS -- APÊNDICE III: PRINCIPAIS CARACTERÍSTICAS DE MOLÉCULAS CD SELECIONADAS. , APÊNDICE IV: TÉCNICAS DE LABORATÓRIO COMUMENTE USADAS EM IMUNOLOGIA -- ÍNDICE.

Note: Front Cover -- Student Consult -- Cellular and Molecular Immunology -- Copyright Page -- Dedication -- Preface -- Online Resources for Instructors and Students -- Resources for Instructors -- Image Collection -- Animations -- Test Bank -- Resources for Students -- Textbook online -- Glossary -- Clinical Cases -- Self-Assessment Questions -- Animations -- Table Of Contents -- 1 Properties and Overview of Immune Responses -- Innate and Adaptive Immunity -- Innate Immunity: the Early Defense -- Adaptive Immunity -- Cardinal Features of Adaptive Immune Responses -- Overview of Humoral and Cell-Mediated Immunity -- Initiation and Development of Adaptive Immune Responses -- Humoral Immunity -- Cell-Mediated Immunity -- Summary -- Selected Readings -- Historical Ideas -- Evolution of the Immune System -- 2 Cells and Tissues of the Immune System -- Cells of the Immune System -- Phagocytes -- Neutrophils -- Mononuclear Phagocytes -- Development of Monocytes and Macrophages -- Subsets of Monocytes -- Functions of Macrophages -- Macrophage Receptors and Activation -- Subsets of Macrophages -- Mast Cells, Basophils, and Eosinophils -- Mast Cells -- Basophils -- Eosinophils -- Dendritic Cells (DCs) -- Development of Dendritic Cells -- Subsets of Dendritic Cells -- Lymphocytes -- Classes of Lymphocytes -- Subsets of B Lymphocytes -- Subsets of T Lymphocytes -- Development of Lymphocytes -- Populations of Lymphocytes Distinguished by History of Antigen Exposure -- Naive Lymphocytes -- Effector Lymphocytes -- Memory Lymphocytes -- Natural Killer Cells and Cytokine-Secreting Innate Lymphoid Cells -- Anatomy and Functions of Lymphoid Tissues -- Bone Marrow -- Thymus -- The Lymphatic System -- Lymph Nodes -- Anatomic Organization of B and T Lymphocytes -- Antigen Transport Through Lymph Nodes -- Spleen -- Cutaneous and Mucosal Immune Systems -- Summary. , Selected Readings -- Cells of the Immune System -- Tissues of the Immune System -- 3 Leukocyte Circulation and Migration into Tissues -- Overview of Leukocyte Migration -- Adhesion Molecules on Leukocytes and Endothelial Cells Involved in Leukocyte Recruitment -- Selectins and Selectin Ligands -- Integrins and Integrin Ligands -- Chemokines and Chemokine Receptors -- Chemokine Structure, Production, and Receptors -- Biologic Actions of Chemokines -- Leukocyte-Endothelial Interactions and Leukocyte Recruitment Into Tissues -- Migration of Neutrophils and Monocytes to Sites of Infection or Tissue Injury -- Migration and Recirculation of T Lymphocytes -- Recirculation of Naive T Lymphocytes Between Blood and Secondary Lymphoid Organs -- Migration of Naive T Cells Into Lymph Nodes -- Movement of T Cells Within Secondary Lymphoid Organs -- Exit of T Cells From Lymph Nodes -- Recirculation of T Cells Through Other Lymphoid Tissues -- Migration of Effector T Lymphocytes to Sites of Infection -- Memory T Cell Migration -- Migration of B Lymphocytes -- Summary -- Selected Readings -- Adhesion Molecules -- Chemokines -- Lymphocyte Migration Through Lymphoid Tissues -- 4 Innate Immunity -- Overview of Innate Immunity -- Functions and Reactions of Innate Immune Responses -- Comparative Features of Innate and Adaptive Immunity -- Evolution of Innate Immunity -- Recognition of Microbes and Damaged Self by the Innate Immune System -- Cell-Associated Pattern Recognition Receptors and Sensors of Innate Immunity -- Toll-Like Receptors -- Cytosolic Receptors for Pathogen-Associated Molecular Patterns and Damage-Associated Molecular Patterns -- NOD-Like Receptors: NOD1 and NOD2 -- Cytosolic DNA Sensors and the STING Pathway -- RIG-Like Receptors -- Inflammasomes -- Other Cell-Associated Pattern Recognition Receptors -- C-Type Lectin Receptors for Microbial Carbohydrates. , Scavenger Receptors -- Formyl-Peptide Receptors -- Cellular Components of the Innate Immune System -- Epithelial Barriers -- Phagocytes -- Dendritic Cells -- Cytokine-Producing Innate Lymphoid Cells -- Natural Killer Cells -- Functions of Natural Killer Cells -- Activating and Inhibitory Receptors of Natural Killer Cells -- T and B Lymphocytes With Limited Antigen Receptor Diversity -- Mast Cells -- Soluble Effector Molecules of Innate Immunity -- The Complement System -- Pentraxins -- Collectins and Ficolins -- The Inflammatory Response -- The Major Proinflammatory Cytokines of Innate Immunity -- Tumor Necrosis Factor -- Interleukin-1 -- Interleukin-6 -- Other Cytokines Produced During Innate Immune Responses -- Recruitment of Leukocytes to Sites of Infection -- Ingestion and Killing of Microbes by Activated Phagocytes -- Other Functions of Activated Macrophages -- Systemic and Pathologic Consequences of Inflammation -- The Antiviral Response -- Stimulation of Adaptive Immunity -- Mechanisms That Limit Innate Immune Responses -- Summary -- Suggested Readings -- Pattern Recognition Receptors -- Cells of the Innate Immune System -- Effector Molecules and Inflammatory Responses of Innate Immunity -- Diseases Caused by Innate Immunity -- 5 Antibodies and Antigens -- Antibody Structure -- General Features of Antibody Structure -- Structural Features of Antibody Variable Regions -- Structural Features of Antibody Constant Regions -- Monoclonal Antibodies -- Synthesis, Assembly, and Expression of Immunoglobulin Molecules -- Half-Life of Antibodies -- Antibody Binding of Antigens -- Features of Biologic Antigens -- Structural and Chemical Basis of Antigen Binding -- Structure-Function Relationships in Antibody Molecules -- Features Related to Antigen Recognition -- Specificity -- Diversity -- Affinity Maturation -- Features Related to Effector Functions. , Summary -- Suggested Readings -- Structure and Function of Antibodies -- Therapeutic Applications of Antibodies -- 6 Antigen Presentation to T Lymphocytes and the Functions of Major Histocompatibility Complex Molecules -- Properties of Antigens Recognized by T Lymphocytes -- Antigen Capture and the Functions of Antigen-Presenting Cells -- General Properties of Antigen-Presenting Cells -- Role of Dendritic Cells in Antigen Capture and Display -- Functions of Other Antigen-Presenting Cells -- The Major Histocompatibility Complex -- Discovery of the Major Histocompatibility Complex -- The Mouse Major Histocompatibility Complex (H-2 Complex) -- The Human Major Histocompatibility Complex (Human Leukocyte Antigen Locus) -- Immune Response Genes -- The Phenomenon of MHC Restriction -- MHC Genes -- Human and Mouse MHC Gene Loci -- Expression of MHC Molecules -- Structure of MHC Molecules -- General Properties of MHC Molecules -- Class I MHC Molecules -- Class II MHC Molecules -- Binding of Peptides to MHC Molecules -- Characteristics of Peptide-MHC Molecule Interactions -- Structural Basis of Peptide Binding to MHC Molecules -- Processing of Protein Antigens -- The Class I MHC Pathway for Processing and Presentation of Cytosolic Proteins -- Sources of Protein Antigens Degraded in Proteasomes -- Digestion of Proteins in Proteasomes -- Transport of Peptides From the Cytosol to the Endoplasmic Reticulum -- Assembly of Peptide-Class I MHC Complexes in the Endoplasmic Reticulum -- Surface Expression of Peptide-Class I MHC Complexes -- The Class II MHC Pathway for Presentation of Proteins Degraded in Lysosomes -- Targeting of Protein Antigens to Lysosomes -- Proteolytic Digestion of Antigens in Lysosomes -- Biosynthesis and Transport of Class II MHC Molecules to Endosomes -- Association of Processed Peptides With Class II MHC Molecules in Vesicles. , Expression of Peptide-Class II MHC Complexes on the Cell Surface -- Cross-Presentation -- Physiologic Significance of MHC-Associated Antigen Presentation -- Nature of T Cell Responses -- Immunogenicity of Protein Antigens -- Presentation of Nonprotein Antigens to T Cells -- Summary -- Suggested Readings -- The Role of Dendritic Cells in Antigen Capture and Presentation -- Structure of Major Histocompatibility Complex Genes, Major Histocompatibility Complex Molecules, and Peptide-Major Histocompatibility Complex Complexes -- Protein Antigen Processing and Major Histocompatibility Complex-Associated Presentation of Peptide Antigens -- Cross-Presentation -- "Nonclassical" Antigen Presentation -- 7 Immune Receptors and Signal Transduction -- Overview of Signal Transduction -- Modular Signaling Proteins and Adaptors -- Prion-Like Polymerization and Signaling -- The Immune Receptor Family -- General Features of Antigen Receptor Signaling -- The T Cell Receptor Complex and T Cell Signaling -- The Structure of the T Cell Receptor for Antigen -- Signal Initiation by the T Cell Receptor -- The Role of the CD4 and CD8 Coreceptors in T Cell Activation -- Activation of Tyrosine Kinases and a Lipid Kinase During T Cell Activation -- Recruitment and Modification of Adaptor Proteins -- Formation of the Immune Synapse -- Mitogen-Activated Protein Kinase Signaling Pathways in T Lymphocytes -- Calcium- and Protein Kinase C-Mediated Signaling Pathways in T Lymphocytes -- Activation of Transcription Factors That Regulate T Cell Gene Expression -- Modulation of T Cell Signaling by Protein Tyrosine Phosphatases -- Costimulatory Receptor Signaling in T Cells -- The CD28 Family of Costimulatory Receptors -- The CD2/Signaling Lymphocytic Activation Molecule Family of Costimulatory Receptors -- Metabolic Changes During T Cell Activation. , The B Lymphocyte Antigen Receptor Complex.

Note: Front cover -- Inside front cover -- アバス- リックマン- ピレ基礎免疫学 -- Front Matter -- Copyright page -- Dedication -- 原 第4版 序文 -- 原 第4版　 序文 -- 原 第2版　 序文 -- 原 第2版　 序文 -- Table of Contents -- 第1章 免疫系序 Introduction to the Immune System -- 然免疫と 応免疫 Innate and Adaptive Immunity -- 応免疫の型 Types of Adaptive Immunity -- 応免疫応答の特徴 Properties of Adaptive Immune Responses -- 特異性と多様性 Specificity and Diversity -- メモリー 憶 Memory -- 応免疫の他の特徴 Other Features of Adaptive Immunity -- 免疫系の細 Cells of the Immune System -- リンパ球 Lymphocyte -- 抗原提示細 APC Antigen Presenting Cell -- エフェクター 効果 細 Effector Cells -- 免疫系の組織 Tissues of the Immune System -- 末梢リンパ器官 Peripheral Lymphoid Organs -- リンパ球再循環と組織への Lymphocyte Recirculation and Migration into Tissues -- 微生物への免疫応答の概 Overview of Immune Responses to Microbes -- 微生物への初期の 然免疫応答 Early Innate Immune Response to Microbes -- 応免疫応答 Adaptive Immune Response -- 微生物抗原の捕捉と提示 Capture and Display of Microbial Antigens -- 細 性免疫 Tリンパ球の活性化と細 結合微生物の排 Cell-Mediated Immunity Activation of T Lymphocytes and Elimination of Cell-Associated Microbes -- 液性免疫 Bリンパ球の活性化と細 外微生物の排 Humoral Immunity Activation of B Lymphocytes and Elimination of Extracellular Microbes -- 免疫応答と免疫メモリー 憶 の減弱 Decline of Immune Responses and Immunologic Memory -- 復習問 Review Questions -- 第2章 然免疫 Innate Immunity -- 然免疫応答の一 的な特徴と特異性 General Features And Specificity of Innate Immune Responses -- 微生物とダメージ 損傷 細 に対する細 レセプター 受容体 Cellular Receptors for Microbes and Damaged cells -- Toll様レセプター 受容体 Toll-Like Receptors -- NOD様レセプター 受容体 とインフラマゾーム NOD-Like Receptors and the Inflammasome -- 然免疫の他の細 レセプター 受容体 Other Cellular Receptors of Innate Immunity -- 然免疫の構成 素 Components of Innate Immunity -- 上皮バリア Epithelial Barriers -- ファゴサイト 細 好中球と単球/マクロファージ Phagocytes: Neutrophils and Monocytes/Macrophages -- 樹状細 DC Dendritic Cells. , マスト 満 細 Mast Cells -- ナチュラルキラー NK 細 Natural Killer Cells -- リンパ球の他の種 Other Classes of Lymphocytes -- 体系 Complement System -- 然免疫の他の 漿タンパク Other Plasma Proteins of Innate Immunity -- 然免疫のサイトカイン Cytokines of Innate Immunity -- 然免疫反応 Innate Immune Reactions -- 炎 症 Inflammation -- 感染 位と組織ダメージ 位へのファゴサイト 細 の動員 Recruitment of Phagocytes to Sites of Infection and Tissue Damage -- 微生物のファゴサイトーシス と破壊 Phagocytosis and Destruction of Microbes -- 抗ウイルス 御 Antiviral Defense -- 然免疫応答の制御 Regulation of Innate Immune Responses -- 微生物の 然免疫回 Microbial Evasion of Innate Immunity -- 応免疫応答を刺激する 然免疫の役割 Role of Innate Immunity in Stimulating Adaptive Immune Responses -- 復習問 Review Questions -- 第3章 抗原捕捉とリンパ球に対する抗原提示 Antigen Capture and Presentation to Lymphocytes -- Tリンパ球により される抗原 Antigens Recognized by T Lymphocytes -- 抗原提示細 によるタンパク 抗原の 捕捉 Capture of Proteins Antigens by Antigen-Presenting Cells -- 主 組織 合 伝子 合体 MHC 分子の構 と機 Structure and Function of Major Histocompatibility Complex Molecules -- MHC分子の構 Structure of MHC Molecules -- MHC 伝子とMHCタンパク の特性 Properties of MHC Genes and Proteins -- MHC分子へのペプチド結合 Peptide Binding to MHC Molecules -- タンパク 抗原のプロセシング 加工処理 と提示 Processing and Presentation of Protein Antigens -- クラスII MHC分子により提示される内在化抗原のプロセシング 加工処理 Processing of Internalized Antigens for Display by Class II MHC Molecules -- クラス MHC分子により提示されるサイトゾル抗原のプロセシング 加工処理 Processing of Cytosolic Antigens for Display by Class I MHC Molecules -- CD8+T細 への内在化抗原のクロスプレゼンテーション 交差提示 Cross-Presentation of Internalized Antigens to CD8+ T Cells -- MHC結合抗原提示の生理的 性 Physiologic Significance of MHC-Associated Antigen Presentation -- 抗原提示細 APC の抗原提示以外の 機 Functions of Antigen-Presenting Cells in Addition to Antigen Display -- B細 と他のリンパ球により される抗原 Antigens Recognized by B Cells and Other Lymphocytes -- 復習問 Review Questions. , 第4章 応免疫系における抗原 Antigen Recognition in the Adaptive Immune System -- リンパ球の抗原レセプター 受容体 Antigen Recepters of Lymphocytes -- 抗 体 Antibodies -- 抗原に対するT細 レセプター 受容体 T Cell Receptors for Antigens -- 免疫レパトワの発 Development of Immune Repertoires -- 初期リンパ球の発 Early Lymphocyte Development -- 多様な抗原レセプター 受容体 の生成 Production of Diverse Antigen Receptors -- Bリンパ球の成熟と 択 Maturation and Selection of B Lymphocytes -- Tリンパ球の成熟と 択 Maturation and Selection of T Lymphocytes -- 復習問 Review Questions -- 第5章 T細 性免疫応答 T Cell-Mediated Immunity -- T細 応答の相 Phases of T Cell Responses -- 抗原 とコスティミュレーション 共刺激 Antigen Recognition and Costimulation -- MHC結合ペプチドの Recognition of MHC-Associated Peptides -- T細 応答における接着分子の役割 Role of Adhesion Molecules in T Cell Responses -- T細 活性化におけるコスティミュレーション 共刺激 の役割 Role of Costimulation in T Cell Activation -- CD8+T細 の活性化に対する刺激 Stimuli for Activation of CD8+T Cells -- T細 活性化の生化学的経 Biochemical Pathways of T Cell Activation -- 抗原とコスティミュレーションに対するTリンパ球の機 的応答 Functional Responses of T Lymphocytes to Antigen and Costimulation -- サイトカイン分泌とサイトカインレセプター 受容体 の発現 Secretion of Cytokines and Expression of Cytokine Receptors -- クローン拡大 Clonal Expansion -- エフェクター 効果 細 へのナイーブ T細 の分化 Differentiation of Naive T Cells into Effector Cells -- サイトカインプロフィールにより区別されるCD4+ヘルパーT細 サブセット Subsets of CD4+ Helper T Cells Distinguished by Cytokine Profiles -- CD4+T細 サブセットの機 Functions of CD4+ T Cell Subsets -- TH1サブセット The TH1 Subset -- TH2サブセット The TH2 Subset -- TH17サブセット The TH17 Subset -- TH1 TH2 TH17サブセットの発 Development of TH1 TH2 and TH17 Subsets -- TH1分化 TH1 Differentiation -- TH2分化 TH2 Differentiation -- TH17分化 TH17 Differentiation -- CD8+T細 のCTLへの分化 Differentiation of CD8+ T Cells into CTLs -- メモリー 憶 Tリンパ球の発 Development of Memory T Lymphocytes -- 免疫応答の減弱 Decline of the Immune Response -- 復習問 Review Questions. , 第6章 T細 性免疫のエフェクター 効果 機構 Effector Mechanisms of T Cell-Mediated Immunity -- T細 性免疫反応の型 Types of T Cell-Mediated Immune Reactions -- 細 性免疫反応におけるTリンパ球の Migration of T Lymphocytes in Cell-Mediated immune Reactions -- CD4+ヘルパー リンパ球のエフェクター 効果 機 Effector Functions of CD4+ Helper T Lymphocytes -- 宿主 御におけるTH1細 の役割 Role of TH1 Cells in Host Defense -- 宿主 御におけるTH17細 の役割 Role of TH17 Cells in Host Defense -- 宿主 御におけるTH2細 の役割 Role of TH2 Cells in Host Defense -- CD8+細 傷害性 リンパ球のエフェクター 効果 機 Effector Functions of CD8+ Cytotoxic T Lymphocytes -- 病原性微生物の細 性免疫への抵抗性 Resistance of pathogenic Microbes to Cell-Mediated Immunity -- 復習問 Review Questions -- 第7章 液性免疫応答 Humoral Immune Responses -- 液性免疫応答の相と型 Phases and Types of Humoral Immune Responses -- 抗原によるBリンパ球の刺激 Stimulation of B Lymphocytes by Antigen -- 細 における抗原 導シグナル伝 Antigen-Induced Signaling in B Cells -- B細 活性化における 体タンパク と 他の 然免疫シグナルの役割 Role of Complement Proteins and Other Innate Immune Signals in B Cell Activation -- 抗原によるB細 活性化の機 的推移 Functional Consequences of B Cell Activation by Antigen -- 液性免疫応答におけるタンパク 抗原 に対するヘルパー リンパ球の機 Function of Helper T Lymphocytes in Humoral Immune Responses to Protein Antigens -- ヘルパーT細 の活性化と Activation and Migration of Helper T Cells -- Bリンパ球によるヘルパーT細 への抗原提示 Presentation of Antigens by B Lymphocytes to Helper T Cells -- Bリンパ球のヘルパーT細 媒介性活性化の機構 Mechanisms of Helper T Cell-Mediated Activation of B Lymphocytes -- 濾 外反応と 中心反応 Extrafollicular and Germinal Center Reactions -- H アイソタイプ クラス スイッチ Heavy Chain Isotype Class Switching -- アフィニティ 和性 成熟 Affinity Maturation -- T細 依存性抗原に対する抗体応答 Antibody Responses to T-independent Antigens -- 液性免疫応答の制御 抗体フィードバック Regulation of Humoral Immune Responses: Antibody Feedback -- 復習問 Review Questions -- 第8章 液性免疫のエフェクター 効果 機構 Effector Mechanisms of Humoral Immunity. , エフェクター 効果 機 を決定する 抗体の特性 Properties of Antibodies That Determine Effector Function -- 微生物と微生物トキシン 毒素 の中和 Neutralization of Microbes and Microbial Toxins -- オプソニン化とファゴサイトーシス Opsonization and Phagocytosis -- 抗体依存性細 傷害 Antibody-Dependent Cellular Cytotoxicity -- IgEおよび好 球/マスト 満 細 媒介性反応 Immunoglobulin E- and Eosinophil/Mast Cell-Mediated Reactions -- 体系 The Complement System -- 体活性化の経 Pathways of Complement Activation -- 体系の機 Functions of the Complement System -- 体活性化の制御 Regulation of Complement Activation -- 特別な 剖学的 位における抗体の機 Functions of Antibodies at Special Anatomic Sites -- 粘 免疫 Mucosal Immunity -- 新生児免疫 Neonatal Immunity -- 微生物の液性免疫からの回 Evasion of Humoral Immunity by Microbes -- ワクチン接種 Vaccination -- 復習問 Review Questions -- 第9章 免疫寛容と 己免疫 Immunological Tolerance and Autoimmunity -- 免疫寛容 トレランス 性と機構 Immunological Tolerance: Significance and Mechanisms -- 中枢性Tリンパ球寛容 トレランス Central T Lymphocyte Tolerance -- 末梢性Tリンパ球寛容 トレランス Peripheral T Lymphocyte Tolerance -- アナジー 痺 Anergy -- 制御性T細 Treg による免疫抑制 Immune Suppression by Regulatory T Cells -- デリッション 去 成熟リンパ球の アポトーシス Deletion: Apoptosis of Mature Lymphocytes -- Bリンパ球寛容 トレランス B Lymphocyte Tolerance -- 中枢性B細 寛容 トレランス Central B Cell Tolerance -- 末梢性B細 寛容 トレランス Peripheral B Cell Tolerance -- 己免疫 Autoimmunity -- 病 因 Pathogenesis -- 伝因子 Genetic Factors -- 感染と他の環境の影 の役割 Role of Infections and Other Environmental Influences -- 復習問 Review Questions -- 第10章 瘍と移植に対する免疫応答 Immune Responses against Tumors and Transplants -- 瘍に対する免疫応答 Immune Responses Against Tumors -- 瘍抗原 Tumor Antigens -- 瘍拒絶の免疫機構 Immune Mechanisms of Tumor Rejection -- 瘍による免疫応答の回 Evasion of Immune Responses by Tumors -- 癌治療のための免疫学的手法 Immunologic Approaches for Cancer Therapy -- 移植に対する免疫応答 Immune Responses against Transplants -- 移植抗原 Transplantation Antigens. , 移植片に対する免疫応答の 導 Induction of Immune Responses Against Transplants.

Note: Cover -- Inmunología celular y molecular -- Copyright -- Dedicatoria -- Prefacio -- Índice -- Capítulo 1 - Propiedades y generalidades de las respuestas inmunitarias -- Inmunidades innata y adaptativa -- Tipos de respuestas inmunitarias adaptativas -- Características principales de las respuestas inmunitarias adaptativas -- Componentes celulares del sistema inmunitario adaptativo -- Citocinas, mediadores solubles del sistema inmunitario -- Generalidades de las respuestas inmunitarias a los microbios -- La respuesta inmunitaria innata temprana a los microbios -- La respuesta inmunitaria adaptativa -- La captura y muestra de los antígenos microbianos -- Reconocimiento del antígeno por los linfocitos -- Inmunidad celular: activación de linfocitos T y eliminación de microbios intracelulares -- Inmunidad humoral: activación de linfocitos B y eliminación de microbios extracelulares -- Memoria inmunitaria -- Resumen -- Lecturas Recomendadas -- Capítulo 2 - Células y tejidos del sistema inmunitario -- Células del sistema inmunitario -- Fagocitos -- Neutrófilos -- Fagocitos mononucleares -- Mastocitos, basófilos y eosinófilos -- Mastocitos -- Basófilos -- Eosinófilos -- Células presentadoras de antígenos -- Células dendríticas -- Células presentadoras de antígenos para linfocitos T efectores -- Células dendríticas foliculares -- Linfocitos -- Subgrupos de linfocitos -- Desarrollo de los linfocitos -- Poblaciones de linfocitos que se distinguen por la historia de exposición al antígeno -- Linfocitos vírgenes -- Linfocitos efectores -- Linfocitos memoria -- Anatomía y funciones de los tejidos linfáticos -- Médula ósea -- Timo -- Sistema linfático -- Ganglios linfáticos -- Organización anatómica de los linfocitos B y T -- Transporte de antígenos a través de los ganglios linfáticos -- Bazo -- Sistemas inmunitarios regionales -- Resumen. , Lecturas Recomendadas -- Células del sistema inmunitario -- Tejidos del sistema inmunitario -- Capítulo 3 - Migración del leucocito a los tejidos -- Moléculas de adhesión en leucocitos y células endoteliales implicadas en el reclutamiento de leucocitos -- Selectinas y ligandos de selectinas -- Integrinas y ligandos de integrinas -- Quimiocinas y receptores para quimiocinas -- Estructura, producción y receptores de las quimiocinas -- Acciones biológicas de las quimiocinas -- Interacciones entre el leucocito y el endotelio y extravasación del leucocito -- Migración de neutrófilos y monocitos a lugares de infección o lesión tisular -- Migración y recirculación de linfocitos T -- Recirculación de linfocitos T vírgenes entre la sangre y los órganos linfáticos secundarios -- Migración de linfocitos T vírgenes a los ganglios linfáticos -- Salida de linfocitos T vírgenes de los ganglios linfáticos -- Recirculación de linfocitos T a través de otros tejidos linfáticos -- Migración de linfocitos T efectores a zonas de infección -- Migración de linfocitos T memoria -- Migración de linfocitos B -- Resumen -- Lecturas Recomendadas -- Moléculas de adhesión -- Quimiocinas -- Migración del linfocito a través de los tejidos linfáticos -- Capítulo 4 - Inmunidad innata -- Reconocimiento por el sistema inmunitario innato de los microbios y de lo propio dañado -- Receptores celulares para el reconocimiento del patrón de la inmunidad innata -- Receptores del tipo toll -- Receptores citosólicos para pamp y damp -- Receptores del tipo nod -- Receptores del tipo rig -- Otros receptores celulares para el reconocimiento del patrón -- Receptores para glúcidos -- Receptores basurero -- Receptores para n-formil met-leu-fe -- Componentes celulares del sistema inmunitario innato -- Barreras epiteliales -- Fagocitos -- Células dendríticas -- Linfocitos citolíticos naturales. , Reconocimiento de células infectadas y estresadas por los linfocitos nk -- Funciones efectoras de linfocitos NK -- Linfocitos T y B con especificidades limitadas del receptor para el antígeno -- Mastocitos -- Reconocimiento y moléculas efectoras solubles de la inmunidad innata -- Anticuerpos naturales -- El sistema del complemento -- Pentraxinas -- Colectinas y ficolinas -- La respuesta inflamatoria -- Las principales citocinas proinflamatorias TNF, IL-1 e IL-6 -- Factor de necrosis tumoral -- Interleucina 1 -- Interleucina 6 -- Reclutamiento de leucocitos en los lugares de infección -- Fagocitosis y muerte de microbios por los fagocitos activados -- Otras funciones de los macrófagos activados -- Otras citocinas producidas durante las respuestas inmunitarias innatas -- Consecuencias sistémicas y patológicas de las respuestas inflamatorias agudas -- La respuesta antivírica -- Estimulación de la inmunidad adaptativa -- Mecanismos de retroalimentación que regulan la inmunidad innata -- Resumen -- Lecturas Recomendadas -- Receptores para el reconocimiento del patrón -- Células del sistema inmunitario innato -- Moléculas efectoras de la inmunidad innata -- Enfermedades causadas por la inmunidad innata -- Capítulo 5 - Ant icuerpos y antígenos -- Estructura del anticuerpo -- Características generales de la estructura del anticuerpo -- Características estructurales de las regiones variables del anticuerpo -- Características estructurales de las regiones constantes del anticuerpo -- Anticuerpos monoclonales -- Síntesis, ensamblaje y expresión de moléculas de Ig -- Semivida de los anticuerpos -- Unión del anticuerpo a los antígenos -- Características de los antígenos biológicos -- Base estructural y química de la unión al antígeno -- Relaciones entre estructura y función en las moléculas de anticuerpo. , Características relacionadas con el reconocimiento del antígeno -- Especificidad -- Diversidad -- Maduración de la afinidad -- Características relacionadas con las funciones efectoras -- Resumen -- Lecturas Recomendadas -- Estructura y función de los anticuerpos -- Aplicaciones terapéuticas de los anticuerpos -- Capítulo 6 - Moléculas del complejo principal de histocompatibilidad y presentación del antígeno a los linfocitos t -- Propiedades de los antígenos reconocidos por los linfocitos T -- Captura del antígeno y funciones de la célula presentadora de antígenos -- Papel de las células dendríticas en la captura ymuestra del antígeno -- Morfología y poblaciones de células dendríticas -- Captura y transporte del antígeno por las células dendríticas -- Función presentadora de antígeno de las células dendríticas -- Funciones de otras células presentadoras de antígenos -- El complejo principal de histocompatibilidad (MHC) -- Descubrimiento del MHC -- El mhc múrido (complejo H-2) -- El mhc humano (HLA) -- Genes de la respuesta inmunitaria -- El fenómeno de la restricción por el mhc -- Genes del mhc -- Loci del mhc humanos y múridos -- Expresión de moléculas del mhc -- Moléculas del mhc -- Propiedades generales de las moléculas del mhc -- Moléculas de la clase i del mhc -- Moléculas de la clase ii del mhc -- Unión de péptidos a moléculas del mhc -- Características de las interacciones entre el péptido y el mhc -- Base estructural de la unión del péptido a las moléculas del mhc -- Procesamiento de antígenos proteínicos -- La vía de la clase i del mhc para el procesamiento y presentación de proteínas citosólicas -- Fuentes de antígenos proteínicos citosólicos -- Digestión proteolítica de proteínas citosólicas -- Transporte de péptidos desde el citosol al retículo endoplásmico -- Ensamblaje de los complejos péptido-clase i del mhc en el retículo endoplásmico. , Expresión en la superficie de los complejos péptido-clase i del mhc -- La vía de la clase II del mhc para el procesamiento y presentación de proteínas vesiculares -- Generación de proteínas vesiculares -- Digestión proteolítica de proteínas en las vesículas -- Biosíntesis y transporte de moléculas de la clase ii del mhc a los endosomas -- Asociación de los péptidos procesados con moléculas de la clase ii del mhc en las vesículas -- Expresión de complejos péptido-clase ii del mhc en la superficie celular -- Presentación cruzada -- Significado fisiológico de la presentación del antígeno asociada al mhc -- Naturaleza de las respuestas de los linfocitos T -- Inmunogenicidad de los antígenos proteínicos -- Presentación de antígenos no proteínicos asubgrupos de linfocitos T -- Resumen -- Lecturas Recomendadas -- La función de las celulas dendríticas en la captura y presentació -- n del antigeno -- Estructura de los genes del MHC, las moléculas del MHC y los complejos péptido-MHC -- Procesamiento del antígeno proteínico y presentación asociada al MHC de los antígenos peptídicos -- Presentación «no clásica» del antígeno -- Capítulo 7 - Receptores inmunitarios y transducción de señales -- Generalidades de la transducción de señales -- Proteínas modulares transmisoras de señales y adaptadores -- La familia de receptores inmunitarios -- Características generales de las señales generadas por el receptor para el antígeno -- El complejo receptor del linfocito T y señales en el linfocito T -- La estructura del receptor del linfocito T para el antígeno -- Inicio de la señal por el receptor del linfocito T -- La función de los correceptores CD4 y CD8 en la activación del linfocito T -- Activación de tirosina cinasas y una lípido cinasa durante la activación del linfocito t -- Reclutamiento y modificación de proteínas adaptadoras. , Formación de la sinapsis inmunológica.

Note: Front cover -- Copyright page -- Dedication -- PREFACE -- Instructions for online access -- Table of contents -- Chapter 1: Properties and Overview of Immune Responses -- Innate and Adaptive Immunity -- Types of Adaptive Immune Responses -- Cardinal Features of Adaptive Immune Responses -- Cellular Components of the Adaptive Immune System -- Cytokines, Soluble Mediators of the Immune System -- Overview of Immune Responses to Microbes -- Summary -- Selected Readings -- Chapter 2: Cells and Tissues of the Immune System -- Cells of the Immune System -- Anatomy and Functions of Lymphoid Tissues -- Summary -- Suggested Readings -- Chapter 3: Leukocyte Migration into Tissues -- Adhesion Molecules on Leukocytes and Endothelial Cells Involved in Leukocyte Recruitment -- Chemokines and Chemokine Receptors -- Leukocyte-Endothelial Interactions and Leukocyte Extravasation -- Migration of Neutrophils and Monocytes to Sites of Infection or Tissue Injury -- Migration and Recirculation of T Lymphocytes -- Migration of B Lymphocytes -- Summary -- Suggested Readings -- Chapter 4: Innate Immunity -- Recognition of Microbes and Damaged Self by the Innate Immune System -- Cell-Associated Pattern Recognition Receptors of Innate Immunity -- Cellular Components of the Innate Immune System -- Soluble Recognition and Effector Molecules of Innate Immunity -- The Inflammatory Response -- The Antiviral Response -- Stimulation of Adaptive Immunity -- Feedback Mechanisms that Regulate Innate Immunity -- Summary -- Suggested Readings -- Chapter 5: Antibodies and Antigens -- Antibody Structure -- Synthesis, Assembly, and Expression of Ig Molecules -- Antibody Binding of Antigens -- Structure-Function Relationships in Antibody Molecules -- Summary -- Selected Readings -- Chapter 6: Major Histocompatibility Complex Molecules and Antigen Presentation to T Lymphocytes. , Properties of Antigens Recognized by T Lymphocytes -- Antigen Capture and the Functions of Antigen-Presenting Cells -- The Major Histocompatibility Complex (MHC) -- Processing of Protein Antigens -- Presentation of Nonprotein Antigens to subsets of T Cells -- Summary -- Selected Readings -- Chapter 7: Immune Receptors and Signal Transduction -- An Overview of Signal Transduction -- The Immune Receptor Family -- The B Lymphocyte Antigen Receptor Complex -- The Attenuation of Immune Receptor Signaling -- Cytokine Receptors and Signaling -- Summary -- Selected Readings -- Chapter 8: Lymphocyte Development and Antigen Receptor Gene Rearrangement -- Overview of Lymphocyte Development -- Rearrangement of Antigen Receptor Genes in B and T Lymphocytes -- B Lymphocyte Development -- Maturation of T Lymphocytes -- Summary -- Selected Readings -- Chapter 9: Activation of T Lymphocytes -- Overview of T Lymphocyte Activation -- Signals for T Lymphocyte Activation -- Functional Responses of T Lymphocytes -- Decline of T Cell Responses -- Summary -- Selected Readings -- Chapter 10: Effector Mechanisms of Cell-Mediated Immunity -- Types of Cell-Mediated Immune Reactions -- Migration of Effector T Lymphocytes to Sites of Infection -- Effector Functions of CD4+ Helper T Cells -- Effector Functions of CD8+ Cytotoxic T Lymphocytes -- Functions of Other T Cell Subsets -- Summary -- Selected Readings -- Cellular and Molecular Immunology -- Chapter 11: B Cell Activation and Antibody Production -- General Features of Humoral Immune Responses -- Antigen Recognition and Antigen-Induced B Cell Activation -- Helper T Cell-Dependent Antibody Responses to Protein Antigens -- Antibody Responses to T Cell-Independent Antigens -- Antibody Feedback: Regulation of Humoral Immune Responses by Fc Receptors -- Summary -- Selected Readings. , Chapter 12: Effector Mechanisms of Humoral Immunity -- Overview of Humoral Immunity -- Neutralization of Microbes and Microbial Toxins -- Antibody-Mediated Opsonization and Phagocytosis -- The Complement System -- Neonatal Immunity -- Summary -- Selected Readings -- Chapter 13: Regional Immunity: -- General Features of Immunity at Epithelial Barriers -- Immunity in the Gastrointestinal System -- Immunity in other Mucosal Tissues -- The Cutaneous Immune System -- Immune Privileged Tissues -- Summary -- Suggested Readings -- Chapter 14: Immunologic Tolerance and Autoimmunity -- General Features of Immunologic Tolerance -- T Lymphocyte Tolerance -- B Lymphocyte Tolerance -- Tolerance induced by Foreign Protein Antigens -- Pathogenesis of Autoimmunity -- Summary -- Selected Readings -- Chapter 15: Immunity to Microbes -- General Features of Immune Responses to Microbes -- Immunity to Extracellular Bacteria -- Immunity to Intracellular Bacteria -- Immunity to Fungi -- Immunity to Viruses -- Immunity to Parasites -- Strategies for Vaccine Development -- Summary -- Selected Readings -- Chapter 16: Transplantation Immunology -- Immune Responses to Allografts -- Patterns and Mechanisms of Allograft Rejection -- Prevention and Treatment of Allograft Rejection -- Xenogeneic Transplantation -- Blood Transfusion and the ABO and Rh Blood Group Antigens -- Hematopoietic Stem Cell Transplantation -- Summary -- Selected Readings -- Chapter 17: Immunity to Tumors -- General Features of Tumor Immunity -- Tumor Antigens -- Immune Responses to Tumors -- Evasion of Immune Responses by Tumors -- Immunotherapy for Tumors -- The Role of the Immune System in Promoting Tumor Growth -- Summary -- Selected Readings -- Chapter 18: Hypersensitivity Disorders -- Causes of Hypersensitivity Diseases -- Mechanisms and Classification of Hypersensitivity Reactions. , Diseases Caused by Antibodies -- Diseases Caused by T Lymphocytes -- Therapeutic Approaches for Immunologic Diseases -- Selected Immunologic Diseases: pathogenesis and therapeutic strategies -- Summary -- Selected Readings -- Chapter 19: IgE-Dependent Immune Responses and Allergic Disease -- General Features of IgE-Dependent Immune Reactions -- Production of IgE -- Role of Mast Cells, Basophils, and Eosinophils in Immediate Hypersensitivity -- IgE- and Mast Cell-Dependent Reactions -- Genetic Susceptibility to Immediate Hypersensitivity -- ALLERGIC Diseases in Humans: Pathogenesis and Therapy -- The Protective Roles of IgE- and Mast Cell-Mediated Immune Reactions -- Summary -- Selected Readings -- Chapter 20: Congenital and Acquired Immunodeficiencies -- General Features of Immunodeficiency Diseases -- Congenital (Primary) Immunodeficiencies -- Acquired (Secondary) Immunodeficiencies -- Human Immunodeficiency Virus And The Acquired Immunodeficiency Syndrome -- Summary -- Selected Readings -- Glossary -- Cytokines -- Principal Features of Selected CD Molecules -- Laboratory Techniques Commonly Used in Immunology -- Laboratory Methods Using Antibodies -- Transgenic Mice and Gene Targeting -- Methods for Studying T Lymphocyte Responses -- Methods for Studying B Lymphocyte Responses -- INDEX.