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  • 1
    Online Resource
    Online Resource
    Springer Science and Business Media LLC ; 2023
    In:  Advances in Atmospheric Sciences Vol. 40, No. 1 ( 2023-01), p. 29-43
    In: Advances in Atmospheric Sciences, Springer Science and Business Media LLC, Vol. 40, No. 1 ( 2023-01), p. 29-43
    Type of Medium: Online Resource
    ISSN: 0256-1530 , 1861-9533
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2023
    detail.hit.zdb_id: 2228064-9
    SSG: 6,25
    SSG: 16,13
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  • 2
    In: Advanced Functional Materials, Wiley, Vol. 31, No. 24 ( 2021-06)
    Abstract: Stem cell therapy has been used as a potential approach for the treatment of myocardial infarction (MI) over the last two decades. Imaging cellular behaviors of the transplanted stem cells with deep tissue penetration and high precision imaging modalities is crucial for the clinical translation of stem cell therapy approaches for MI. Herein, a gold nanostar (Au‐Star) based second near‐infrared window (NIR‐II) fluorescence/surface enhanced Raman scattering dual‐modal imaging probe (gold nanostar‐3.3′‐diethylthiatricarbocyanine iodide‐silver sulfide nanoparticles, Au‐Star‐DTTC‐Ag 2 S NPs, GDS NPs) is designed for labeling and precise tracking of the stem cells. The Ag 2 S compartment generates strong NIR‐II emission, which compensates for the deficiencies of bioluminescent imaging and enables the dynamic observation of in vivo cellular behavior. Subsequently, the specific Raman signal of Au‐Star‐DTTC compartment enables high‐resolution imaging, which could effectively delineate stem cells from the surrounding normal tissues, even at a single‐cell resolution. Using this imaging and tracking approach, it is able to track stem cells in hypodermic and MI models, with high resolution and depth‐independent imaging capabilities, which have not been reported in any other cell tracking platform. This two‐armed imaging toolkit offers new opportunities for a wide range of mechanistic stem cell therapy investigations in different organs.
    Type of Medium: Online Resource
    ISSN: 1616-301X , 1616-3028
    URL: Issue
    Language: English
    Publisher: Wiley
    Publication Date: 2021
    detail.hit.zdb_id: 2029061-5
    detail.hit.zdb_id: 2039420-2
    SSG: 11
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  • 3
    Online Resource
    Online Resource
    American Meteorological Society ; 2005
    In:  Weather and Forecasting Vol. 20, No. 1 ( 2005-02-01), p. 63-81
    In: Weather and Forecasting, American Meteorological Society, Vol. 20, No. 1 ( 2005-02-01), p. 63-81
    Abstract: Real-time high-resolution mesoscale predictions using the fifth-generation Pennsylvania State University–NCAR Mesoscale Model (MM5) over the Great Lakes region are evaluated for the 2002/03 winter and 2003 summer seasons using surface and upper-air observations, with a focus on near-surface and boundary layer properties that are important for applications such as air quality and fire weather predictions. The summer season predictions produce a cold bias in maximum daily temperature and a warm bias in minimum temperature that together lead to a good prediction of daily mean temperature but a smaller-than-observed diurnal temperature cycle. In winter, the predicted near-surface temperatures are lower both day and night, yielding good agreement with the observed amplitude of the diurnal temperature cycle but relatively large cold bias in daily mean temperature. The predicted temperatures in the boundary layer are also systematically lower than the observed temperatures in the two seasons. The cold bias is consistent with the wetter-than-observed lower atmosphere in the model prediction, which in turn can be attributed to an inadequate specification of soil moisture. In both seasons, the model produced substantially more precipitation in all categories, especially in the heavy precipitation category, and the overprediction is primarily associated with more widespread area coverage in the model prediction. The chances of producing a false precipitation forecast are substantially higher than missing an observed precipitation event. Small systematic errors are found in the predictions of low-level winds, but above the boundary layer, the predicted winds are predominantly from the west, while the observed winds are from the west-northwest. The model is able to capture the general development and evolution of the lake–land breezes in areas surrounding Lake Michigan during summer, although errors exist in the strengths of the breezes and the timing of their transition. Predicted early morning inversions are slightly stronger than observed in winter and weaker than observed in summer. The weak summer morning inversion results in a rapid inversion breakup followed by an earlier growth of a mixed layer after sunrise. Despite the head start, the predicted mixed-layer heights in late afternoon are lower than those observed, suggesting that either the predicted surface sensible heat flux may be too low or the boundary layer flux divergence may be too high. Decreasing horizontal grid spacing from 12 to 4 km results in little improvement in the predictions of near-surface and boundary layer properties except for precipitation, for which the model bias is significantly reduced by the increase in horizontal resolution. The cold and wet biases and errors in inversion strengths and mixed-layer development call for extra caution when using products from mesoscale forecasts in applications such as air pollution and fire weather prediction.
    Type of Medium: Online Resource
    ISSN: 1520-0434 , 0882-8156
    Language: English
    Publisher: American Meteorological Society
    Publication Date: 2005
    detail.hit.zdb_id: 2025194-4
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  • 4
    Online Resource
    Online Resource
    American Meteorological Society ; 1996
    In:  Journal of Applied Meteorology Vol. 35, No. 12 ( 1996-12), p. 2162-2178
    In: Journal of Applied Meteorology, American Meteorological Society, Vol. 35, No. 12 ( 1996-12), p. 2162-2178
    Type of Medium: Online Resource
    ISSN: 0894-8763 , 1520-0450
    Language: English
    Publisher: American Meteorological Society
    Publication Date: 1996
    detail.hit.zdb_id: 242493-9
    detail.hit.zdb_id: 2027356-3
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  • 5
    Online Resource
    Online Resource
    American Meteorological Society ; 2004
    In:  Journal of Applied Meteorology Vol. 43, No. 11 ( 2004-11-01), p. 1679-1699
    In: Journal of Applied Meteorology, American Meteorological Society, Vol. 43, No. 11 ( 2004-11-01), p. 1679-1699
    Abstract: The diurnal evolution of the three-dimensional summer-season mean wind and temperature structure in California's Sacramento and San Joaquin Valleys (collectively called the Central Valley) is investigated using data from 22 radar wind profiler/radio acoustic sounding systems (RASS) operated as part of the Central California Ozone Study in 2000. The profiler network revealed, for the first time, that the persistent summer-season flow pattern documented by surface observations extends 800–1000 m above the surface. At most locations, up-valley winds persist during both day and night except at the upper ends of the valleys and close to the valley sidewalls where diurnal wind reversals occur. Wind speeds exhibit pronounced diurnal oscillations, with amplitudes decreasing with height. A low-level wind maximum occurs in the lowest 300 m, with a sharp decrease in speed above the maximum. Especially well defined nocturnal low-level jets occur at sites in the southern San Joaquin Valley, where maximum speeds of 10 m s−1 or more occur 1–2 h before midnight at heights near 300 m. The afternoon mixed layer, generally deeper than 1000 m, increases in depth with up-valley distance in both valleys. At night, temperature inversions develop in the lowest several hundred meters with near-isothermal layers above. Mean temperatures in the lowest 500 m of the valleys are always warmer than at the same altitude over the coast, and temperature increases from the lower to upper valleys. The diurnal oscillations of the coast– valley and along-valley temperature and pressure difference reach a maximum in late afternoon and a minimum in early morning. These oscillations are in phase with the diurnal variation of westerly onshore flows. The along-valley wind maxima, however, occur 1–2 h before midnight, whereas the along-valley pressure gradient maxima are usually found just before sunset.
    Type of Medium: Online Resource
    ISSN: 1520-0450 , 0894-8763
    Language: English
    Publisher: American Meteorological Society
    Publication Date: 2004
    detail.hit.zdb_id: 242493-9
    detail.hit.zdb_id: 2027356-3
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  • 6
    Online Resource
    Online Resource
    American Meteorological Society ; 1997
    In:  Journal of Applied Meteorology Vol. 36, No. 10 ( 1997-10), p. 1363-1376
    In: Journal of Applied Meteorology, American Meteorological Society, Vol. 36, No. 10 ( 1997-10), p. 1363-1376
    Type of Medium: Online Resource
    ISSN: 0894-8763 , 1520-0450
    Language: English
    Publisher: American Meteorological Society
    Publication Date: 1997
    detail.hit.zdb_id: 242493-9
    detail.hit.zdb_id: 2027356-3
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  • 7
    Online Resource
    Online Resource
    American Meteorological Society ; 2005
    In:  Journal of Applied Meteorology Vol. 44, No. 9 ( 2005-09-01), p. 1467-1483
    In: Journal of Applied Meteorology, American Meteorological Society, Vol. 44, No. 9 ( 2005-09-01), p. 1467-1483
    Abstract: The sensitivity of high-resolution mesoscale simulations to boundary layer turbulence parameterizations is investigated using the fifth-generation Pennsylvania State University–NCAR Mesoscale Model (MM5) and observations from two field campaigns. Three widely used turbulence parameterizations were selected for evaluation, two of which [Blackadar (BK) and Medium Range Forecast (MRF) schemes] are simple first-order nonlocal schemes and one [Gayno–Seaman (GS) scheme] of which is a more complex 1.5-order local scheme that solves a prognostic equation for turbulence kinetic energy (TKE). The two datasets are the summer 1996 Boundary Layer Experiment (BLX96) in the southern Great Plains and the autumn 2000 Vertical Transport and Mixing (VTMX) field campaign in the Salt Lake Valley in Utah. Comparisons are made between observed and simulated mean variables and turbulence statistics. Despite the differences in their complexity, all three schemes show similar skill predicting near-surface and boundary layer mean temperature, humidity, and winds at both locations. The BK and MRF schemes produced daytime boundary layers that are more mixed than those produced by the GS scheme. The mixed-layer depths are generally overestimated by the MRF scheme, underestimated by the GS scheme, and well estimated by the BK scheme. All of the schemes predicted surface latent heat fluxes that agreed reasonably well with the observed values, but they substantially overestimated surface sensible heat fluxes because of a significant overprediction of net radiation. In addition, each parameterization overestimated the sensible and latent heat flux aloft. The results suggest that there is little gain in the overall accuracy of forecasts with increasing complexity of turbulence parameterizations.
    Type of Medium: Online Resource
    ISSN: 1520-0450 , 0894-8763
    Language: English
    Publisher: American Meteorological Society
    Publication Date: 2005
    detail.hit.zdb_id: 242493-9
    detail.hit.zdb_id: 2027356-3
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  • 8
    Online Resource
    Online Resource
    Institute of Electrical and Electronics Engineers (IEEE) ; 2023
    In:  IEEE Transactions on Multimedia
    In: IEEE Transactions on Multimedia, Institute of Electrical and Electronics Engineers (IEEE)
    Type of Medium: Online Resource
    ISSN: 1520-9210 , 1941-0077
    RVK:
    Language: Unknown
    Publisher: Institute of Electrical and Electronics Engineers (IEEE)
    Publication Date: 2023
    detail.hit.zdb_id: 2033070-4
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  • 9
    In: Monthly Weather Review, American Meteorological Society, Vol. 139, No. 9 ( 2011-09), p. 2811-2831
    Abstract: Numerical simulations of flow over steep terrain using 11 different nonhydrostatic numerical models are compared and analyzed. A basic benchmark and five other test cases are simulated in a two-dimensional framework using the same initial state, which is based on conditions during Intensive Observation Period (IOP) 6 of the Terrain-Induced Rotor Experiment (T-REX), in which intense mountain-wave activity was observed. All of the models use an identical horizontal resolution of 1 km and the same vertical resolution. The six simulated test cases use various terrain heights: a 100-m bell-shaped hill, a 1000-m idealized ridge that is steeper on the lee slope, a 2500-m ridge with the same terrain shape, and a cross-Sierra terrain profile. The models are tested with both free-slip and no-slip lower boundary conditions. The results indicate a surprisingly diverse spectrum of simulated mountain-wave characteristics including lee waves, hydraulic-like jump features, and gravity wave breaking. The vertical velocity standard deviation is twice as large in the free-slip experiments relative to the no-slip simulations. Nevertheless, the no-slip simulations also exhibit considerable variations in the wave characteristics. The results imply relatively low predictability of key characteristics of topographically forced flows such as the strength of downslope winds and stratospheric wave breaking. The vertical flux of horizontal momentum, which is a domain-integrated quantity, exhibits considerable spread among the models, particularly for the experiments with the 2500-m ridge and Sierra terrain. The differences among the various model simulations, all initialized with identical initial states, suggest that model dynamical cores may be an important component of diversity for the design of mesoscale ensemble systems for topographically forced flows. The intermodel differences are significantly larger than sensitivity experiments within a single modeling system.
    Type of Medium: Online Resource
    ISSN: 0027-0644 , 1520-0493
    RVK:
    Language: English
    Publisher: American Meteorological Society
    Publication Date: 2011
    detail.hit.zdb_id: 2033056-X
    detail.hit.zdb_id: 202616-8
    SSG: 14
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  • 10
    Online Resource
    Online Resource
    American Meteorological Society ; 2018
    In:  Journal of Climate Vol. 31, No. 10 ( 2018-05), p. 3909-3920
    In: Journal of Climate, American Meteorological Society, Vol. 31, No. 10 ( 2018-05), p. 3909-3920
    Abstract: The potential mechanisms underlying the observed increasing trend in Antarctic summertime sea ice cover for the 1979–2017 period have been investigated using a relatively novel method called the self-organizing map (SOM). Among the nine nodes generated to explain the variability of Antarctic sea ice cover, two (nodes 3 and 7) exhibit a statistically significant linear trend in the time series of the frequency of the SOM pattern occurrence that together explain 40% of the total trend in the sea ice cover. These two nodes have completely opposite spatial patterns and directions of trend and are associated with different atmospheric circulation patterns. Node 3, which represents an increase in sea ice over the Weddell Sea and the eastern Ross Sea and a decrease over the other coastal seas of West Antarctica, appears to be related to the positive phase of the southern annular mode (SAM) linked with the La Niña pattern of sea surface temperature (SST) over the tropical Pacific Ocean. The opposite spatial pattern and trend represented by node 7 is associated with a wave train originating over northern Australia. The anomalous wind field, surface downward longwave radiation, and surface air temperature generated by these circulation patterns are consistent with the spatial pattern and overall trends in the Antarctic sea ice cover.
    Type of Medium: Online Resource
    ISSN: 0894-8755 , 1520-0442
    RVK:
    Language: English
    Publisher: American Meteorological Society
    Publication Date: 2018
    detail.hit.zdb_id: 246750-1
    detail.hit.zdb_id: 2021723-7
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