In:
Journal of Viral Hepatitis, Wiley, Vol. 25, No. 9 ( 2018-09), p. 1017-1025
Abstract:
The kinetics of serum hepatitis B surface antigen ( HB sAg) during the natural history of hepatitis B virus ( HBV ) infection has been studied, but the factors affecting them remain unclear. We aimed to investigate the factors affecting HB sAg titres, using data from multicentre, large‐sized clinical trials in China. The baseline data of 1795 patients in 3 multicentre trials were studied, and the patients were classified into 3 groups: hepatitis B early antigen ( HB eAg)‐positive chronic HBV infection (n = 588), HB eAg‐positive chronic hepatitis B (n = 596), and HB eAg‐negative chronic hepatitis B (n = 611). HB sAg titres in the different phases were compared, and multiple linear progression analyses were performed to investigate the implicated factors. HB sAg titres varied significantly in different phases ( P = .000), with the highest (4.60 log10 IU/mL [10%‐90% confidence interval: 3.52 log10 IU/mL‐4.99 log10 IU/mL]) in patients with HB eAg‐positive chronic HBV infection. In all phases, age and HBV DNA were correlated with serum HB sAg level. In HB eAg‐positive chronic hepatitis B patients, a negative correlation between HB sAg titres and fibrosis stage was observed. Alanine amonitransferase or necroinflammatory activity was also correlated with HB sAg titres in HB eAg‐negative chronic hepatitis B patients. In conclusion, decreased HB sAg titres may be associated with advancing fibrosis in HB eAg‐positive chronic hepatitis B patients or increased necroinflammation in those with HB eAg‐negative chronic hepatitis B. Our findings may help clinicians better understand the kinetics of HB sAg and provide useful insights into the management of this disease.
Type of Medium:
Online Resource
ISSN:
1352-0504
,
1365-2893
DOI:
10.1111/jvh.2018.25.issue-9
Language:
English
Publisher:
Wiley
Publication Date:
2018
detail.hit.zdb_id:
2007924-2
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