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  • 1
    Online Resource
    Online Resource
    EPMA-World Congress 2015 : Bonn, Germany. 3-5 September 2015
    Springer Science and Business Media LLC ; 2016
    In:  EPMA Journal Vol. 7, No. S1 ( 2016-5)
    Details
    In: EPMA Journal, Springer Science and Business Media LLC, Vol. 7, No. S1 ( 2016-5)
    Type of Medium: Online Resource
    ISSN: 1878-5077 , 1878-5085
    URL: Article
    DOI: 10.1186/s13167-016-0054-6
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2016
    detail.hit.zdb_id: 2545928-4
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  • 2
    Online Resource
    Online Resource
    P-348 : Derivation of Blood Vanadium Benchmark Concentration using Limiting Hazard Factor
    Ovid Technologies (Wolters Kluwer Health) ; 2012
    In:  Epidemiology Vol. 23 ( 2012-09), p. 1-
    Details
    In: Epidemiology, Ovid Technologies (Wolters Kluwer Health), Vol. 23 ( 2012-09), p. 1-
    Type of Medium: Online Resource
    ISSN: 1044-3983
    URL: Article
    DOI: 10.1097/01.ede.0000417350.09508.7b
    Language: English
    Publisher: Ovid Technologies (Wolters Kluwer Health)
    Publication Date: 2012
    detail.hit.zdb_id: 2042095-X
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  • 3
    Online Resource
    Online Resource
    The prospects of occupational risk management during reforms of regulatory legislation basis
    FSBI Research Institute of Occupational Health RAMS ; 2019
    In:  Occupational Health and Industrial Ecology , No. 10 ( 2019-02-18), p. 39-44
    Details
    In: Occupational Health and Industrial Ecology, FSBI Research Institute of Occupational Health RAMS, , No. 10 ( 2019-02-18), p. 39-44
    Abstract: Despite wide legislation basis of regulating relations in work safety and workers’ health, one third of workplaces demonstrate exceeded allowable normal levels of workers’ exposure to occupational hazards and present occupational risk for health disorders. In accordance to national legislation acts, evaluation should cover factors of occupational environment and working process, and occupational risk is understood in context of mandatory social insurance. This approach has been formed due to mostly compensatory trend in legal principles of work safety in Russia by now. Implementation of new preventive concept of work safety, based on idea of risk management for workers, necessitates development of legal acts that regulate requirements to evaluation of occupational risk and its reports with consideration of changes in Federal Law on 30 March 1999 №52 FZ “On sanitary epidemiologic well-being of population”. Those acts can include Sanitary Rules and Regulations “Evaluation of occupational risk for workers’ health”, that will contain main principles of risk assessment, requirements to risk assessment, including its characteristics which can serve as a basis of categorizing the risk levels with acceptability. To standardize requirements for informing a worker on the occupational risk, the expediency is specification of sanitary rules “Notifying a worker on occupational risk”. These rules should contain requirements: to a source of data on occupational risk level at workplace, to informational content and to ways of notifying the worker. Specification and implementation of the stated documents enable to fulfil legal requirements completely on work safety — that will provide preservation and increase of efficiency in using work resources.
    Type of Medium: Online Resource
    ISSN: 2618-8945 , 1026-9428
    URL: Issue
    URL: Article
    DOI: 10.31089/1026-9428-2018-10
    DOI: 10.31089/1026-9428-2018-10-39-44
    Language: Unknown
    Publisher: FSBI Research Institute of Occupational Health RAMS
    Publication Date: 2019
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  • 4
    Online Resource
    Online Resource
    Selection of food simulators for testing aluminum foil as a food packaging
    Federal Scientific Center for Hygiene F.F.Erisman ; 2020
    In:  Hygiene and sanitation Vol. 99, No. 11 ( 2020-12-22), p. 1280-1287
    Details
    In: Hygiene and sanitation, Federal Scientific Center for Hygiene F.F.Erisman, Vol. 99, No. 11 ( 2020-12-22), p. 1280-1287
    Abstract: Introduction. The wide distribution of aluminum foil in the consumer market and its active use in the home as a packaging material determine this study’s relevance. Because health risks associated with aluminum’s chronic consumption are still poorly understood, aluminum intake with food is potentially unsafe for health. In this regard, it is relevant to investigate the conformity of methods and food simulators to the tasks of testing aluminum foil for its safe use as food packaging. The aim of the study is to improve methodological approaches to the selection of food simulators for testing aluminum foil as packaging for food products. Material and methods. The study approach and critical analysis of the domestic and foreign regulatory framework and relevant scientific sources were applied to methodological approaches to study the level of aluminum content in food products and food simulators when testing aluminum foil for food packaging. The adequacy of the application of the methods of quantitative chemical analysis of the aluminum content in food simulators and food products was evaluated in testing household foil, indicated in various regulatory and methodological documents. An experiment was carried out to study the levels of aluminum in simulating media and directly in food. Results. The regulated food simulators do not fully consider the features of the use of aluminum foil as food packaging, for example, the modes of using aluminum foil at elevated temperatures. Conclusion. The current regulatory and methodological framework requires improvement. It is advisable to develop a special method for testing aluminum foil for household purposes with a description of temperature and time modes and conditions for simulating the process of baking food products.
    Type of Medium: Online Resource
    ISSN: 2412-0650 , 0016-9900
    URL: Issue
    URL: Article
    DOI: 10.47470/0016-9900-2020-99-11
    DOI: 10.47470/0016-9900-2020-99-11-1280-1287
    Language: Unknown
    Publisher: Federal Scientific Center for Hygiene F.F.Erisman
    Publication Date: 2020
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  • 5
    Online Resource
    Online Resource
    Analysis of comorbid pathology in oil producers
    Federal Scientific Center for Hygiene F.F.Erisman ; 2021
    In:  Hygiene and sanitation Vol. 100, No. 5 ( 2021-06-15), p. 464-470
    Details
    In: Hygiene and sanitation, Federal Scientific Center for Hygiene F.F.Erisman, Vol. 100, No. 5 ( 2021-06-15), p. 464-470
    Abstract: Aim of the study. To analyze the patterns of the comorbidity pathology formation in employees occupied in oil production. Materials and methods. Observation group - 292 employees of the oil production enterprise (100% men). The average age was 39.4 ± 10.6 (20-65) years. Average work experience is 13.1 ± 9.6 (3-22) years. The comparison group included 65 employees working in the management of the enterprise. The average age is 40.2 ± 9.8 (20-65) years. Average work experience is 18.5 ± 9.5 (5-23) years. Observation group - 292 oil and gas production operators (OGP) - 100% men. The study involved a comprehensive research program, results analysis, and mathematical modeling. Results. It is typical for oil and gas production operators to be exposed to a complex impact of harmful production factors: industrial noise, the intensity of work, and physical overload combined with chemical factors. A prior occupational risk to the employees under mentioned working conditions was classified from low (moderate) risk to medium (significant) risk. The age of employees with developed comorbid pathology in the observation group was 31.7 ± 5.4 years, work experience in the specified working conditions was 4.6 ± 1.1 years; the age of workers in the comparison group was 35.4 ± 3.9 years, work experience was 7.4 ± 2.7 years. The results of functional studies have demonstrated a complex of abnormalities in workers with little expressed clinical symptomatology. Analysis of comorbid pathology showed an increase in n according to CIRS score, increasing the working experience among oil and gas operators. Conclusion. Comorbid pathology occurs in oil production workers within ten years of working experience under conditions of combined occupational and non-occupational factors. In the comorbid pathology development, both induced intrasystemic and intersystemic disorders significantly worsens the working life prognosis.
    Type of Medium: Online Resource
    ISSN: 2412-0650 , 0016-9900
    URL: Issue
    URL: Article
    DOI: 10.47470/0016-9900-2021-100-5
    DOI: 10.47470/0016-9900-2021-100-5-464-470
    Language: Unknown
    Publisher: Federal Scientific Center for Hygiene F.F.Erisman
    Publication Date: 2021
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  • 6
    Online Resource
    Online Resource
    Assessing adaptation capabilities in primary school children attending schools with different educational processes
    Federal Scientific Center for Hygiene F.F.Erisman ; 2021
    In:  Hygiene and sanitation Vol. 100, No. 5 ( 2021-06-15), p. 495-500
    Details
    In: Hygiene and sanitation, Federal Scientific Center for Hygiene F.F.Erisman, Vol. 100, No. 5 ( 2021-06-15), p. 495-500
    Abstract: Introduction. Innovative teaching and learning systems involve intensification of the educational process and greater academic loads; it results in the exertion of adaptation systems in a body, especially when it comes to primary school children. Purpose of the study. Our research goal was to assess peculiarities of adaptation capabilities in primary school children who attended schools with different educational processes. Material and methods. To study peculiarities of adaptation capabilities in primary school children, we performed a clinical examination of 183 children (51.4% boys and 48.6% girls, the average age being 9.51±0.17) who attended a lyceum (group A), a school with advanced studies of physics and mathematics (Group B), and an ordinary secondary school (Group C). We also analyzed how intense educational loads were in all three educational establishments. Children’s adaptation capabilities were assessed as per functional parameters of their cardiovascular and vegetative nervous systems and catecholamines’ contents in blood. Results. The entry-level secondary schools tend to have more intense educational processes. We established that primary school children who attended a lyceum faced 1.5 times greater intellectual and sensory loads; children who attended a school with advanced studies of physics and mathematics had educational loads that were 1.3-1.4 times more monotonous than in other establishments; children who attended an ordinary school had to bear 1.8 times higher emotional loads. ⅔ primary school children had exertion of functional reserves in their cardiovascular system caused by a longer educational load duration. 36% of primary school children who attended a school with advanced studies of physics and mathematics had tension in their adaptation mechanisms caused by monotonous educational loads combined with lower noradrenalin contents in blood. Those children also ran up to 4.9 times higher risks of adaptation mechanism exertion. 48.5-56.7% of children who attended a lyceum and an ordinary school had vegetative imbalance that became apparent via activated adaptation-trophic influence promoted by the sympathetic section in the vegetative nervous systems and related to the duration of learning activities. Conclusion. Intensification of the educational process results in disorders of compensatory-adaptation mechanisms in primary school children.
    Type of Medium: Online Resource
    ISSN: 2412-0650 , 0016-9900
    URL: Issue
    URL: Article
    DOI: 10.47470/0016-9900-2021-100-5
    DOI: 10.47470/0016-9900-2021-100-5-495-500
    Language: Unknown
    Publisher: Federal Scientific Center for Hygiene F.F.Erisman
    Publication Date: 2021
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  • 7
    Online Resource
    Online Resource
    Changes in biochemical parameters in children exposed to objects of accumulated environmental damage
    Federal Scientific Center for Hygiene F.F.Erisman ; 2022
    In:  Hygiene and sanitation Vol. 101, No. 6 ( 2022-06-30), p. 675-682
    Details
    In: Hygiene and sanitation, Federal Scientific Center for Hygiene F.F.Erisman, Vol. 101, No. 6 ( 2022-06-30), p. 675-682
    Abstract: Introduction. At present, the assessment and evidence of the impact of objects of accumulated environmental damage on the health of the population, primarily children, is extremely relevant, which is reflected in the priority goals of the Federal Project “General Cleaning”. The purpose of the study is to evaluate the changes in some biochemical indicators of negative effects in children exposed to objects of the former production of chemical products. Materials and methods. Risk assessment, chemical-analytical, biochemical and general clinical studies, statistical analysis were carried out. Results. In children exposed to objects of the former production of chemical products, relative to the comparison group, there were identified, toxic metabolites of epichlorohydrin, elevated concentrations of phenol, benzo (a) pyrene, manganese, nickel, lead, arsenic, chromium, zinc in the blood, mercury, cadmium, arsenic in the urine; more frequent registration of the development of negative effects was revealed, indicating a more pronounced development of general and specific sensitization to nickel and hypersensitivity to benzo(a)pyrene, mercury, phenol; a decrease in the filtering ability of the kidneys, the development of functional disorders of the liver and biliary tract, an increase in the synthesis of neurotransmitters and a violation of the neuro-endocrine regulation of the stress state associated with the negative impact of chemical risk factors. Limitations. The conducted study takes into account the influence of only chemical factors of accumulated environmental damage on the health of the child population aged 3-6 years. Conclusion. The relationship between public health disorders and the impact of factors of accumulated environmental damage as a result of the former economic activity for the production of chemical products was identified and evaluated.
    Type of Medium: Online Resource
    ISSN: 2412-0650 , 0016-9900
    URL: Issue
    URL: Article
    DOI: 10.47470/0016-9900-2022-101-6
    DOI: 10.47470/0016-9900-2022-101-6-675-682
    Language: Unknown
    Publisher: Federal Scientific Center for Hygiene F.F.Erisman
    Publication Date: 2022
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  • 8
    Online Resource
    Online Resource
    Methodical grounds and experience gained in implementing complex assessment of activities aimed at risk to public health and effectiveness of measures to improve the quality of drinking water in centralized water supply systems
    Federal Scientific Center for Hygiene F.F.Erisman ; 2022
    In:  Hygiene and sanitation Vol. 101, No. 11 ( 2022-11-30), p. 1403-1411
    Details
    In: Hygiene and sanitation, Federal Scientific Center for Hygiene F.F.Erisman, Vol. 101, No. 11 ( 2022-11-30), p. 1403-1411
    Abstract: Introduction. Safe and qualitative drinking water is among the most significant conditions for minimizing environmental risks to public health. Our research goal was to develop and test methodical approaches to complex assessment of activities aimed at improving drinking water quality in centralized water supply systems. Within these approaches, effectiveness of such activities should be estimated as per health risk criteria. Materials and methods. Fuzzy set theory (fuzzy logic) was selected as relevant methodical grounds for estimating effectiveness of implemented activities. Our research objects were activities performed within regional programs and indicators of drinking water quality. A rate of public health risk was selected as a criterion to estimate effectiveness of an activity. Results. We developed a set of methodical tools that allowed assessing drinking water quality considering a variety of heterogeneous and instrumentally measurable indicators that were divided into several groups. Overall, we included more than 100 indicators that were grouped as organoleptic, sanitary-microbiological and parasitological, sanitary-chemical and radiological ones. We suggested a weighting factor for each indicator of drinking water quality. This weighting factor correlated with severity of health disorders under exposure to improper values of a specific indicator. Ranges of values for each indicator were scaled as per a degree of its hazard for human health and weighting factors were established for each indicator group. The total risk considered effects produced by all the indicator groups, their share contribution to a negative health outcome also taken into account. We determined a value of the membership function to establish where a specific risk would be found on the scale with risk rates from low to extremely high. Health risks were assessed prior to implementation of activities and after it. We also suggested a scale to measure effectiveness of implemented activities. Those activities that resulted in health risk reduction by less than 20% were estimated as low-effective ones. If a risk went down by 20-60%, activities were estimated as moderate or average-effective; a reduction by more than 60% indicated that implemented activities were effective or even highly effective. Limitations. The use of the existing information database on adverse effects and reference levels under exposure to environmental factors. Should new relevant data become available, this might result in the necessity to revise risk scales and weighting factors of specific indicators. Conclusion. We tested the suggested methodical approaches within actual projects implemented currently. The testing revealed their relevance to the existing tasks since these approaches facilitate proper assessment of activities as per a system of heterogeneous qualitative and quantitative indicators.
    Type of Medium: Online Resource
    ISSN: 2412-0650 , 0016-9900
    URL: Issue
    URL: Article
    DOI: 10.47470/0016-9900-2022-101-11
    DOI: 10.47470/0016-9900-2022-101-11-1403-1411
    Language: Unknown
    Publisher: Federal Scientific Center for Hygiene F.F.Erisman
    Publication Date: 2022
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  • 9
    Online Resource
    Online Resource
    Distribution of micro-sized range solid particles in the human airways: field experiment
    Federal Scientific Center for Hygiene F.F.Erisman ; 2023
    In:  Hygiene and sanitation Vol. 102, No. 5 ( 2023-06-20), p. 412-420
    Details
    In: Hygiene and sanitation, Federal Scientific Center for Hygiene F.F.Erisman, Vol. 102, No. 5 ( 2023-06-20), p. 412-420
    Abstract: Introduction. Ambient air pollution is a widespread and pressing issue. This necessitates the development of methods for estimating and predicting progression of pathologies on the base of evolutionary mathematical models. Adaptation of the theoretical model to practice requires identification and verification procedures in real conditions of contamination of inhaled air with dust particles of various compositions. The purpose of the work was to investigate regularities of distribution of dust particles with a different disperse, component and morphological structure in the human airways after inhalation from ambient air. The study involved performing a field experiment. Materials and methods. We accomplished several investigations in 3 zones with different levels and structures of ambient air pollution. Disperse, component, and morphological structures of particles occurring in ambient (inhaled), deposited in various sections of the human airways, in exhaled air and blood were examined by electronic microscopy. Results. Air quality in zones 1 and 2 did not comply with hygienic standards for suspended particles, PM10, PM2.5, metal compounds, etc. (up to 3.29 MPCm.s., 3.2 MPCav.s., 2.91 MPCav.y.) and formed increased hazard quotient for manganese, copper, nickel and their compounds, inorganic fluorides, suspended particles (up to 5.48 HQac, 3.42 HQch), respiratory and other hazard indices (up to 5.48 HIac, 8.59 HIch). The degree of sedimentation of small particles (PM2.5 or less) in different parts of the respiratory tract is uneven, they are able to penetrate into the lower airways and lungs of humans. More than 65% of all the particles deposited in the upper airways had a diameter bigger than 10 µm. PM2.5 accounted for more than 60 % in sputum in the lower airways and the share of PM1.5 reached 46.7 %. Particles smaller than 1.5 μm (90.5%) were predominantly recorded in blood biosubstrates, of which up to 88.1% of the particles had a sphericity of 0.9–1.0. Limitations. Limited degree of precision of location of the examined sections in the respiratory system. Conclusion. Common deposition regularities are mostly determined by sizes and morphology of dust particles. The component structure of inhaled air has practically no effects on regularities of particle deposition in various sections of the respiratory system; however, it can have substantial influence on types of pathologies progressing in the body. High shares of PM1.5 identified in inhaled air, the lower airways and blood require considering levels of PM1.5 and smaller particles in ambient air in settlements to be covered by hygienic standards. In future, the study results will be used in numeric modelling of accumulation of functional respiratory disorders and associated pathologies of other organs and systems and in predicting development of pathologies based on evolution mathematical models.
    Type of Medium: Online Resource
    ISSN: 2412-0650 , 0016-9900
    URL: Issue
    URL: Article
    DOI: 10.47470/0016-9900-2023-102-5
    DOI: 10.47470/0016-9900-2023-102-5-412-420
    Language: Unknown
    Publisher: Federal Scientific Center for Hygiene F.F.Erisman
    Publication Date: 2023
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  • 10
    Online Resource
    Online Resource
    Regulation of Organism's Antiviral Immune Response: Mathematical Model, Qualitative Analysis, Results
    Institute of Mathematical Problems of Biology of RAS (IMPB RAS) ; 2023
    In:  Mathematical Biology and Bioinformatics Vol. 18, No. Suppl. ( 2023-07-08), p. t17-t37
    Details
    In: Mathematical Biology and Bioinformatics, Institute of Mathematical Problems of Biology of RAS (IMPB RAS), Vol. 18, No. Suppl. ( 2023-07-08), p. t17-t37
    Type of Medium: Online Resource
    ISSN: 1994-6538
    URL: Article
    DOI: 10.17537/2023.18.t17
    Language: Unknown
    Publisher: Institute of Mathematical Problems of Biology of RAS (IMPB RAS)
    Publication Date: 2023
    detail.hit.zdb_id: 2781035-5
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