In:
Asia-Pacific Journal of Clinical Oncology, Wiley, Vol. 16, No. 1 ( 2020-02), p. 70-74
Abstract:
To investigate predictive and prognostic role of metabolic parameters using [ 18 F]‐2‐fluoro‐2‐deoxy‐D‐glucose positron emission tomography ( 18 F‐FDG PET) in patients with locally advanced non‐small cell lung cancer (NSCLC) treated with docetaxel‐platinum induction chemotherapy (IC). Methods Medical records of 31 patients with pre‐ and post‐IC 18 F‐FDG PET were reviewed. Using 18 F‐FDG PET, metabolic parameters, including metabolic tumor response, adjusted peak standardized uptake values using lean body mass at baseline (pre‐SUL peak ) and after IC (post‐SUL peak ), and percentage change of pre‐ and post‐SUL peak (ΔSUL peak ), were assessed. Results Response rate (RR) was 71%, with a metabolic RR of 83.9%. Nineteen (61.3%) patients underwent surgery, R0 resection was achieved for 17 (89.5%) patients. Median relapse‐free survival (RFS) and overall survival (OS) were 8.9 months (95% CI: 4.5‐12.1) and 24.1 months (95% CI: 17.1‐34.1), respectively. Post‐SUL peak 〈 2 was identified as a favorable prognostic factor for RFS (hazard ratio [HR]: 0.12; P = .004), while ΔSUL peak ≥60% and R0 resection were found as positive prognostic factors for OS (HR: 0.09 and 0.13; P = .011 and P = .042, respectively). Using a receiver operating characteristics curve, post‐SUL peak 〉 1.4 could predict recurrence with a sensitivity of 84% and a specificity of 100%. Conclusion In patients with locally advanced NSCLC receiving IC, post‐SUL peak and ΔSUL peak showed clinical significance for survival outcome.
Type of Medium:
Online Resource
ISSN:
1743-7555
,
1743-7563
Language:
English
Publisher:
Wiley
Publication Date:
2020
detail.hit.zdb_id:
2187409-8
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