In:
Canadian Journal of Chemistry, Canadian Science Publishing, Vol. 83, No. 8 ( 2005-08-01), p. 1063-1070
Abstract:
Condensation of salicylaldehyde (2-HOC 6 H 4 C(O)H) with 5-aminosalicylic acid (5-H 2 NC 6 H 3 -2-(OH)-CO 2 H) afforded the Schiff base 2-HOC 6 H 4 C(H)=NC 6 H 3 -2-(OH)-5-CO 2 H (a). Similar reactivity with 5-bromosalicylaldehyde was also observed to give 5-Br-2-HOC 6 H 3 C(H)=NC 6 H 3 -2-(OH)-5-CO 2 H (b). Reaction of these salicylaldehydes with Pd(II), Cu(II), and Zn(II) salts gave the corresponding bis(N-arylsalicylaldiminato)metal complexes (M = Pd (1), Cu (2), Zn (3)). The molecular structure of the Schiff base compound a has been confirmed by an X-ray diffraction study. Crystals of a were monoclinic, space group P2(1)/c, a = 7.0164(7) Å, b = 11.0088(11) Å, c = 14.8980(15) Å, β = 102.917(2)°, Z = 4. The molecular structure of a novel zwitterionic conformer of 3a was also characterized by an X-ray diffraction study. Crystals of 4 were monoclinic, space group P2(1)/c, a = 9.5284(5) Å, b = 19.5335(11) Å, c = 8.6508(5) Å, β = 90.596(1)°, Z = 4. All new compounds have been tested for their antifungal activity against Aspergillus niger and Aspergillus flavus. Key words: 5-aminosalicylic acid (5-ASA), antifungal, copper, palladium, salicylaldimines, Schiff base, zinc.
Type of Medium:
Online Resource
ISSN:
0008-4042
,
1480-3291
Language:
English
Publisher:
Canadian Science Publishing
Publication Date:
2005
detail.hit.zdb_id:
1482256-8
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