In:
Canadian Journal of Chemistry, Canadian Science Publishing, Vol. 80, No. 9 ( 2002-09-01), p. 1217-1222
Abstract:
Condensation of α-diketones (2,3-butanedione, benzil, and acenaphthenequinone) with 3-H 2 NC 6 H 4 Bpin (pin = 1,2-O 2 C 2 Me 4 ) gave the corresponding boron-containing α-diimines. The addition of these ligands to [MCl 2 (coe)] 2 (coe = cis-cyclooctene, M = Pd or Pt) gave complexes of the type cis-MCl 2 (α-diimine) in moderate to high yields. The platinum complexes have been examined for their ability to bind to DNA using enzyme digest studies. These complexes were found to bind to single-stranded DNA as well as, or better than, the non-boron containing controls, and showed binding similar to that of cisplatin (cis-PtCl 2 (NH 3 ) 2 ).Key words: boronate esters, diazabutadienes, DNA-binding, platinum.
Type of Medium:
Online Resource
ISSN:
0008-4042
,
1480-3291
Language:
English
Publisher:
Canadian Science Publishing
Publication Date:
2002
detail.hit.zdb_id:
1482256-8
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